Objective To investigate the effect of modified Huangqi-Jianzhong decoction on healing quality of gastric ulcer in rats and to explore its mechanism. Methods 40 Wistar rats were randomly divided into a normal group, a model group, a modified Huangqi-Jianzhong decoction group and a omeprazole group (n=10) according to the random number table method. These rats were used to model of chronic gastric ulcer induced by acetic acid 100%. On third day after surgery, the rats in the modified Huangqi-Jianzhong decoction group were treated with 10% of the modified Huangqi-Jianzhong decoction according to the dose of 20 ml per kilogram of body weight. The rats in the omeprazole group were treated with a 3% omeprazole suspension according to the of 20 ml per kilogram of body weight. The rats in the normal group and the model group were treated with the same volume of saline. After treated with corresponding treatment for 16 days, the gastric mucosa pathology, ulcer index, regenerative mucosal thickness, mucosal surface mucus thickness, muscularis mucosal layer width of the defect, cystically dilated glands number and level of serum prostaglandin (6-K-PGF1α), epidermal growth factor (EGF), nitric oxide (NO) were observed. Results Compared with the model group, the rat ulcer index (8.95 ± 2.78 mm2 vs. 20.82 ± 5.12 mm2), mucosal muscularis defect width (123.56 ± 32.89 μm vs. 229.32 ± 49.69 μm), cystic glandular expansion (1.65 ± 0.76 vs. 6.12 ± 1.23) were lower in the modified Huangqi-Jianzhong decoction group (P<0.01). Thickness of regenerated mucosa (329.55 ± 32.22 μm vs. 198.22 ± 5.83 μm), the surface thickness of mucus (44.3 ± 2.8 μm vs. 24.5 ± 7.8 μm), serum 6-K-PGF1α (93.7 ± 8.9 pg/ml vs. 58.5 ± 5.8 pg/ml), EGF (2.11 ± 0.29 ng/L vs. 0.82 ± 0.20 ng/L) , NO (0.51 ± 0.03 μmol/L vs. 0.22 ± 0.05 μmol/L) was higher (P<0.01). In addition to the ulcer index, other each target improvement flavored were better in the modified Huangqi-Jianzhong decoction group than in the omeprazole group (P<0.05). Conclusion Modified Huangqi-Jianzhong decoction can improve the quality of ulcer healing by promoting gastric mucosa ulcer repair, reducimg ulcer index, mucous muscularis layer defect width and cystic glandular expansion and improving the thickness of regenerative mucosa, mucosal surface mucus thickness and cyst, EGF, NO level and thus improve the experimental gastric ulcer healing quality.

Objective To explore the relationship between serum levels of unconjugated estriol (uE3)and human placental lacto-gen (hPL)and preeclampsia.Methods 123 cases of pregnant women diagnosed as preeclampsia were enrolled into observational group,and 1 50 cases of healthy pregnant women were enrolled into control group.Blood specimen were collected from the two groups in 28-<32 gestational weeks and 32-36 gestational weeks.Serum levels of uE3 and hPL were determined and compared between the two groups.Results The pregnancy outcomes of the control group were better than those of the observation group. With the increase of gestational age,there was increasing trend of serum levels of uE3 and hPL in the two groups.However,com-pared with the observation group,the serum levels of uE3 and hPL were higher in the control group,and the differences were statis-tically significant(P <0.05).Conclusion The decrease of serum levels of uE3 and hPL in pregnant women with preeclampsia may be associated with the pregnancy outcomes.

Objective:To study the accessibility and the effect of group counseling which aim at the internet-dependence college students in China.Methods:According to the internet dependence standard which was established in the author's former research, chose 24 internet dependence students from Tsinghua University and JiLi University as the experimental group, and another 24 students as the control group.The experimental group and the control group had no difference in the scores of adapted CIAS-R before group counseling.There were a pre-test, a post-test and a tracing-test separately set when the group counseling was started, finished, and had a period of 6 weeks after it was finished.Results:In the post-test and tracing-test, the scores of adapted CIAS-R of experimental group were significantly lower than those of the control group(39.5?8.1/46.4?6.0,F=11.38,P

Acute appendicitis is the most common general surgical problem encountered during pregnancy, which may be associated with serious maternal and /or fetal complications such as appendiceal perforation or premature delivery.Clinical presentation and imaging remains vital in the diagnosis of appendicitis.As a general rule,the clinical suspicion of acute appendicitis during pregnancy is an indication for an urgent surgical intervention.Appendectomy is the preferred treatment.Laparoscopic appendicectomy(LA)can also be performed safely and effectively in pregnant patients without bringing additional maternal complications.

Objective To investigate the morphology and the cause of the ascending aortic aneurysm induced by ascending aorta banding. Methods Forty young Wistar rats were divided into two groups:the control group (10 rats) and the experiment group (30 rats).The rat models induced by ascending aorta banding were made.The ascending aortas were taken after operation in 3-5 months,and special staining and immuohistochemical staining technique were performed and observed under light microscope. Results The ascending aortic aneurysms were induced by ascending aorta banding of the young Wistar rats 3-5 months after operation.The occurrence of the aneurysm is 63.3%,and the occurrence of dissecting aneurysms is 36.7%.The expression of MMP-2 and MMP-3 is strong in the ascending aortic aneurysm.Conclusion The occurrence of ascending aortic induced by banding ascending aorta of the young Wistar rat is high,and the expression of MMP-2 and MMP-3 is strong.

Objective To investigate the urinary arsenic levels of exposed population in various forms of and total arsenic (TAs) content as well as their relationship with arsenic poisoning in southern Shaanxi arsenic poisoning area.Methods According to the historical data of the investigation on arsenic poisoning,11 disease villages were chosen as survey sites in Ziyang and Pingli counties,Ankang city;three neighbor villages were chosen as control sites in Baihe.Baihe was a non-endemic arsenic poisoning area county,which had the same natural environment and living habits.In the survey sites,people over the age of 40 were selected for epidemiological investigation in both heating and non-heating seasons,and 40 urine samples were collected at each severity levels of the disease and in different seasons.Meantime,20 urine samples of the same age group were collected in the control sites in each season.Hydride generation-atomic fluorescence spectrometry (HG-AFS) was used to determine TAs,liquid chromatography-hydride generation-atomic fluorescence spectrometry (LC-HG-AFS) was used to determine the amount of inorganic trivalent arsenic (As3+),dimethylarsine (DMA),monomethylarsine (MMA) and inorganic pentavalent arsenic (AS5+),and the various forms and TAs were compared between different survey sites,severity levels,ages,sexes,and seasons.Results The medians of TAs,As3+,DMA,primary methylation index (PMI),and secondary methylation index (SMI) in diseased area (35.3,2.2,24.5 μg/L;0.84,0.90) were significantly higher than those of the control group (16.0,0.6,10.3 μg/L;0.78,0.81;Z =-9.069,-7.314,-8.913,-2.183,-3.853,P ＜ 0.01 or ＜ 0.05),and the medians of TAs,As3+,DMA,and SMI (31.6,2.0,23.1 μg/L;0.91) of the normal population in the diseased area were significantly higher than those of the control group (16.0,0.6,10.3 μg/L;0.81;Z =-7.164,-6.136,-7.023,-2.916,all P ＜ 0.01).Illness had positive correlations with TAs,DMA,and ages (r =0.370,0.367,0.594,all P ＜ 0.01).Men arsenic poisoning detection rate,TAs,As3+,and DMA (59.9％,37.4,2.5,25.2 μg/L) were significantly higher than those of women (22.4％,30.0,1.6,20.9 μg/L;x2 =54.878,P ＜ 0.01;Z =-3.332,-4.449,-2.681,all P ＜ 0.01).The medians of As3+,MMA,As5+,PMI,and SMI in the heating season (1.5,2.1,1.4 μg/L;0.87,0.92) were significantly different from those in the non-heating season (2.6,3.3,3.0 μg/L;0.82,0.88;Z =-6.870,-5.512,-8.542,-2.262,-4.544,P ＜ 0.01 or ＜ 0.05).Conclusions The TAs,As3+,and DMA of urine samples are related to local arsenic background,so they have some reference value for determination of diseased areas.Men are more susceptible to arsenic poisoning than women.

Implantation window is the transient period when the embryos develop into blastocysts and the uterus differentiates into the receptive state synchronically. Estrogen and progesterone are the comprehensive regulating molecules during this process. They influence the proliferation and differentiation of multiple cell types in the uterus through the modulation of various local-signaling molecules.Uterus and blastocyst interact by the paracrine effects of prostaglandin, histamine, calcitonin, cytokines and growth factors at implantation window. This molecular cross-talk modulates the interaction between trophectoderm and uterine luminal epithelium. Once the implantation window is open, it then switches into unreceptive state spontaneously.

PTH-related protein (PTHrP) is an abundant factor in bone which shows paracrine,endocrine,autocrine functions combined with PTHrP receptor and plays an important role in bone metabolism.Rencent years have witnessed that PTHrP plays a significant therapeutic effect on osteoporosis and exhibits some new functions.

Asthma, Occupational ; therapy ; Drainage ; methods ; Humans ; Sputum

Asthma, Occupational ; etiology ; pathology ; Humans ; Inflammation ; pathology ; Neutrophil Infiltration ; Neutrophils ; pathology