Objective:To explore the effect of mifepristone combined with methotrexate intracapsular injection on pregnancy at scar site of endogenous cesarean section.Methods:From June 2014 to June 2019, 106 cases of pregnancy at scar site of endogenous cesarean section admitted to Jinhua Maternal and Child Health Hospital were selected in the research.According to the random number table method, the patients were divided into control group and observation group, with 53 cases in each group.The control group received hysteroscopy curettage only, routine anti-infection, curettage under the guidance of B-ultrasound.The observation group was given mifepristone and methotrexate intracapsular injection on the basis of the control group.The clinical effect, recovery time of serum β-HCG, intraoperative blood loss, postoperative complications and hospitalization time were compared between the two groups.Results:The total effective rate of the observation group[92.45%(49/53)] was higher than that of the control group[75.47%(40/53)](χ 2=5.675, P<0.05). The recovery time of β human chorionic gonadotropin (β-HCG) in the observation group[(17.58±2.54)d] was faster than that in the control group[(21.83±4.13)d], and the intraoperative blood loss[(25.42±5.46)mL] was less than that in the control group[(87.93±18.47)mL], the differences were statistically significant ( t=6.381, 23.628, all P<0.05). The incidence of postoperative complications of the observation group (1.89%) was lower than that of the control group (9.43%), but there was no statistically significant difference between the two groups (χ 2=1.590, P>0.05). The hospitalization time of the observation group[(7.83±1.52)d]was shorter than that of the control group[(9.68±2.19)d]( t=5.052, P<0.05). Conclusion:Mifepristone combined with methotrexate intracapsular injection has good clinical effect on endogenous cesarean scar pregnancy.It can accelerate the recovery time of blood β-HCG, which is worthy of clinical reference.