1.Effect of antipsychotic drugs on life quality of schizophrenic patients: one year follow-up study.
Maosheng FANG ; Lehua LI ; Jingping ZHAO ; Honghui CHEN ; Meng YE ; Xiaofeng GUO ; Zheng LU ; Xueli SUN ; Chuanyue WANG ; Shiping XIE ; Bin HU ; Tiansheng GUO ; Cui MA ; Bo WANG ; Luxian LÜ ; Na LIU ; Hong DENG ; Qi CHEN ; Xiaofang SHANG ; Fajin GONG ; Xiyan ZHANG ; Xiaolin HE ; Jianchu ZHOU ; Yingli ZHANG
Journal of Central South University(Medical Sciences) 2009;34(9):850-855
OBJECTIVE:
To compare the effect of 7 antipsychotic drugs on the life quality of schizophrenia patients including chlorpromazine, sulpiride, clozapine, risperidone, olanzapine, quetiapine, and aripiprazole.
METHODS:
A total of 1,227 stable schizophrenic patients within 5 years onset who took 1 of the 7 study medications as maintenance treatment were followed up for 1 year at 10 China sites. Patients were evaluated by the short form-36 health survey (SF-36) at the baseline and at the end of 1 year.
RESULTS:
The life quality was improved obviously at the end of the follow-up. There was significant difference in body pain, vitality, and mental health (P<0.05) among these antipsychotic drugs.
CONCLUSION
All 7 antipsychotic drugs can improve the life quality of schizophrenia patients. Atypical antipsychotic drugs, especially olazapine and quetiapine, are superior to typical antipsychotic drugs in improving life quality.
Adolescent
;
Adult
;
Antipsychotic Agents
;
therapeutic use
;
Benzodiazepines
;
therapeutic use
;
Dibenzothiazepines
;
therapeutic use
;
Female
;
Follow-Up Studies
;
Humans
;
Male
;
Middle Aged
;
Olanzapine
;
Quality of Life
;
Quetiapine Fumarate
;
Schizophrenia
;
drug therapy
;
Surveys and Questionnaires
;
Young Adult
Result Analysis
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