1.Echocontrast cystosonography versus micturating cystourethrography in the detection of vesicoureteric reflux
Faizah MZ* ; Kanaheswari Y ; Thambidorai CR ; Zulfiqar MA
Biomedical Imaging and Intervention Journal 2011;7(1):1-8
Purpose: To compare echocontrast cystosonography (ECS) using in-vivo agitated saline with fluoroscopic
micturating cystourethrography (MCU) in the detection and grading of vesicoureteric reflux (VUR).
Materials and methods: This was a prospective study of 25 children, who had MCU between 2007 and 2009. ECS
was performed and findings documented prior to MCU. Baseline renal and bladder sonograms were obtained. The
bladder was filled with normal saline followed by introduction of 10–20 mls of air to generate microbubbles. Detection of VUR was based on two sonographic criteria: (1) presence of microbubbles in the pelvicaliceal system (PCS), and (2) increase in dilatation of the PCS. VUR was graded as (1) Grade I: microbubbles seen in ureter only; (2) Grade II: microbubbles seen in non-dilated PCS; and (3) Grade III-V: microbubbles seen in dilated PCS. The ECS findings were compared using MCU as the gold standard.
Results: Of the 50 kidney-ureter (K-U) units studied, ECS detected 9 of 10 K-U units with VUR on MCU. ECS did
not detect a Grade II VUR. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value for criterion 1 was 90%, 87.5%, 88%, 64.3% and 97%, respectively, compared to criterion 2 which was 70%, 90%, 86%, 64% and 92%, respectively. The grading of VUR was similar on both ECS and MCU except for one case.
Conclusion: ECS using agitated saline was a sensitive technique for the detection of VUR. ECS grading was
comparable with MCU grading of VUR.
2.Precocious puberty in children: A review of imaging findings
Faizah MZ ; Zuhanis AH ; Rahmah R ; Raja AA ; Wu LL ; Dayang AA ; Zulfiqar MA
Biomedical Imaging and Intervention Journal 2012;8(1):1-8
Objectives: This review was aimed at determining the imaging findings in patients with precocious puberty.
Results: Within a period of 8 years (from 2002 to 2010) there were 53 patients diagnosed with precocious puberty. Out of the 53 patients, 37 had undergone diagnostic imaging to detect the possible organic causes of precocious puberty. Imaging findings were positive in 31 patients and out of that, 3 patients had 2 findings each (34 abnormalities). Of the patients with positive imaging findings, central precocious puberty (gonadotrophin-dependent) was more common (81%; 25/31) and the causes included: tuber cinereum hamartoma (n = 10), glioma (n = 6), pineal gland tumour (n = 4), hydrocephalous (n = 3), arachnoid cyst (n = 2) and others (n = 3). Peripheral precocious puberty (gonadotrophin-independent) causes included: testicular adrenal rest tumour (n = 3), adrenal carcinoma (n = 1), ovarian granulosa thecal cell tumour (n = 1), and tuberous sclerosis (n = 1).
Conclusion: Positive imaging findings were observed in 84% (31/37) of the subjects. Hypothalamic hamartoma was the most common imaging finding in central precocious puberty while testicular adrenal rest tumour was the most common imaging finding in peripheral precocious puberty