1.Omental Patching and Purse-String Endosuture Closure after Endoscopic Full-Thickness Resection in Patients with Gastric Gastrointestinal Stromal Tumors
Faisal INAYAT ; Aysha ASLAM ; Mathew D GRUNWALD ; Qulsoom HUSSAIN ; Abu HURAIRAH ; Shahzad IQBAL
Clinical Endoscopy 2019;52(3):283-287
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, primarily arising from the stomach. With the widespread utilization of and technical advancements in endoscopy, gastric GISTs are being increasingly detected at an early stage, enabling complete endoscopic resection. Endoscopic full-thickness resection (EFTR) is an advanced technique that has been recognized as a treatment tool for neoplasms in the digestive tract in selected patients. Although a number of methods are available, closing large iatrogenic defects after EFTR can be a concern in clinical practice. If this potential problem is appropriately solved, patients with gastric GISTs would be suitable candidates for resection utilizing this technique. To our knowledge, this is the first study to propose omental patching and purse-string endosuture closure following EFTR as a feasible endoscopic option in patients with gastric GISTs.
Endoscopy
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Gastrointestinal Stromal Tumors
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Gastrointestinal Tract
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Humans
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Omentum
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Stomach
2.Is CRT‑D superior to CRT‑P in patients with nonischemic cardiomyopathy?
Mohammed AL‑SADAWI ; Faisal ASLAM ; Michael TAO ; Shafqat SALAM ; Mahmoud ALSAIQALI ; Abhijeet SINGH ; Roger FAN ; Eric J. RASHBA
International Journal of Arrhythmia 2023;24(1):3-
Background:
Recent studies have questioned the role of implanted cardiac defibrillators (ICDs) in nonischemic cardiomyopathy (NICM). Cardiac resynchronization therapy (CRT) can be delivered by a pacemaker (CRT-P) or an ICD (CRT-D). This meta-analysis assessed the effect of CRT-P versus CRT-D on mortality in patients with NICM.
Methods:
Databases were searched for studies reporting the effect of CRT on all-cause mortality in patients with nonischemic cardiomyopathy (Ovid MEDLINE, EMBASE, Scopus, Web of Science, Google Scholar, and EBSCO CINAHL). The primary endpoint was all-cause mortality. The minimum duration of follow-up required for inclusion was one year. The search was not restricted to time or publication status.
Results:
The literature search identified 955 candidate studies, 15 studies and 22,763 patients were included. Mean follow-up was 53 months (17–100 months). CRT-D in NICM was associated with lower all-cause mortality (log HR − 0.169, SE 0.055; p = 0.002) compared to CRT-P. Heterogeneity: df = 15 (p 0.03), I2 = 43; test for overall effect: Z = − 3.043 (p = 0.002).
Conclusion
CRT-D in NICM was associated with lower all-cause mortality than CRT-P.