Objective To evaluate the accuracy of selective laser melting of cobalt-chromium(CoCr)clasps with different build angles and support densities.Methods The 3D software constructed a sample clasp(reference object)with an undercut depth of 0.50 mm,which was then imported to a metal 3D printer to form CoCr clasps at different build angles(0°,45°,and 90°)and support densities(0.50,0.70,0.90,and 1.10 mm).A model scanner was used to obtain scans of all clasps(test objects);the test objects were aligned with the reference object and test subjects were aligned with each other through a best-fit alignment method using Geomagic software to obtain root mean square error(RMSE)values for the accuracy of the clasps.The data were statistically analyzed using one-way analysis of variance or non-parametric rank sum test(α=0.05).Results In terms of trueness,the different build angle groups with support density of 0.50 mm were ranked by RMSE values as follows:90°group>0°group>45°group.For the different build angle groups with support densities of 0.70,0.90,and 1.10 mm,the RMSE values ranked as follows:45°group>90°group>0°group.In terms of precision,the different build angle groups with support density of 0.50 mm were ranked by RMSE values as follows:90°group>0°group>45°group.For support density of 0.70 mm,the ranking was 90°group>45°group>0°group,while for support densities of 0.90 and 1.10 mm,the ranking was 45°group>90°group>0°group.Conclusion The accuracy of CoCr clasps varies with the build angle and support density.However,clasps produced at a build angle of 0°and a support density of 0.90 mm exhibit higher accuracy and are recommended for use in clinical and technical laboratories.

This paper describes the clinical pharmacists ’participation in the diagnosis and treatment for a case of disseminated neonatal herpes simplex virus （HSV）type Ⅱ infection with fever as the initial symptom and without skin and mucous membrane involvement. Clinical pharmacists assessed the newborn ’s condition ，inquired about the disease history and medication status of the child’s mother hospitalized in the department of obstetrics ，reviewed the literature ，analyzed that the fever of the child might be related to the medical history of the mother ，and considered that the child might have neonatal HSV infection . It was suggested to use acyclovir 20 mg/kg intravenously for q 8 h immediately after completing virus -related testing ，and closely monitor the common adverse drug reactions of acyclovir . The doctors accepted the consultation advice . The newborn was diagnosed as disseminated neonatal HSV type Ⅱ infection. After treatment ，the child ’s condition was relatively stable and the doctors consulted clinical pharmacists again to help formulate the follow -up drug treatment plan and monitoring plan for the patient . After reviewing relevant literature，clinical pharmacists suggested that after 21 days of intravenous acyclovir treatment ，oral acyclovir 300 mg/m2 q8 h should be continued for 6 months；moreover，common adverse drug reactions should be monitored and neurological development should be evaluated during oral acyclovir treatment ，all of which were accepted by physicians . No adverse drug reactions occurred during intravenous administration of acyclovir ， serum creatinine and urea increased in the 4th week of oral acyclovir administration，but returned to normal after drug withdrawal . The baby was followed up to 1 year old ，and the prognosis was good without neurological sequelae . Clinical pharmacists enabled the clinicians to clarify the treatment strategy and also reduced the risk of medication for the patient by participating in the pharmaceutical consultation . Clinical pharmacists play an cstc active and effective role in the medication treatment ，which fully embodies the professional value in multidisciplinary collaborative diagnosis and treatment .