Adolescent ; Adult ; Aged ; Endoscopy ; Female ; Humans ; Male ; Middle Aged ; Neck ; surgery ; Thyroidectomy ; methods ; Young Adult

Adult ; Clavicle ; injuries ; Female ; Fracture Fixation, Internal ; methods ; Fractures, Bone ; surgery ; Humans ; Male ; Middle Aged ; Minimally Invasive Surgical Procedures ; methods

OBJECTIVETo observe the influence of Fuzheng Huayu Tablet on mental state and social activity of patients with post-hepatitis B liver cirrhosis (LC-HB).

METHODSAdopting grouped randomized double-blinded control method, 180 LC-HB patients in 3 research centers were distributed to 2 groups, the treated group and the control group, 90 in each group. Patients in the treated group were administered with FZHYT; while those in the control group treated with conventional therapy combined with placebo, the course for all patients were 6 months. Their mental state and social activity were evaluated before treatment, after 3 months' treatment and at terminal of the 6-month therapeutic course by estimating with Zung self-rating anxiety scale (SAS), self-rating depression scale (SDS) and social deficit screening scale (SDSS). Additionally, the basic demographic materials, liver function, cirrhosis index, hepatic and splenic images, blood coagulation function, etc. in the patients were tested and compared as well.

RESULTSAs compared with before treatment, the normal rate of SAS and SDS scores increased and the social deficit rate decreased in the treated group significantly after treatment, showing statistical significance (P<0.05 or P<0.01); while in the control group, change was only shown in the social deficit (P<0.01), inter-group comparisons after treatment showed significant differences in all the three indexes (P<0.05 or P<0.01). Additionally, after treatment, levels of liver function, cirrhosis, blood coagulation function and splenomegaly in the treated group were all improved significantly P<0.05 or P<0.01), and the improvements were better than those in the control group (P<0.01) in levels of total bilirubin (TBIL), albumin (ALB), type IV collagen (IV-C), prothrombin time (PT), prothrombin activity (PTA).

CONCLUSIONMost patients of LC-HB have mental disturbance and social activity deficit, which could definitely be improved by intervention with Chinese FZHYT.

Blood Coagulation ; Drugs, Chinese Herbal ; adverse effects ; therapeutic use ; Hepatitis B ; complications ; drug therapy ; physiopathology ; Humans ; Liver Cirrhosis ; drug therapy ; etiology ; physiopathology ; psychology ; Liver Function Tests ; Patient Dropouts ; Social Behavior ; Tablets

Objective To evaluate the feasibility and safety of endoscopic thyroidectomy via anterior chest approach for early papillary thyroid cancer(T1N0M0).Methods From July 2004 to December 2010,91 patients with early papillary thyroid cancer underwent minimally invasive endoscopic thyroidectomy via anterior chest approach.The clinical and pathologic characteristics of patients,operation types,operative time,postoperative hospital stay time,and postoperative complications were analyzed retrospectively.Results All 91 operations were successfully performed endoscopically.There was no case conversed to open surgery.The mean tumor size was (0.96 ± 0.71 ) cm.The operation types included unilateral lobectomy (41 cases),unilateral subtotal lobectomy (3cases),ipsilateral lobectomy and contralateral subtotal lobectomy (42 cases),and bilateral total thyroidectomy (5 cases).Central compartment node dissection was carried out in 39 cases with the tumor diameter less than 1.0 cm and in 29 cases with the tumor diameter of 1.0-2.0 cm.The mean operating time was (99 ± 17) min,the mean bleeding volume was (18 ± 12) ml,and the mean post-operative hospital stay time was (3 ± 1 ) days.Temporary recurrent laryngeal nerve ( RLN),paresis occurred in 2 cases and recovered within 1 to 2 months after the surgery.One patient showed permanent RLN paralysis.Two patients showed temporary hypoparathyroidism.No patient showed post-operative seroma and tracheal injury.There was no case with injury to the superior laryngeal nerve.No further complications,such as irritating cough,tetany,and emphysema developed after the operation.With the anterior chest wall approach,all patients had no surgical scar on the neck and thus they were satisfied with the cosmetic outcomes.All patients were disease free by follow-up of 7 to 85 (58.4 ± 17.2) months.Conclusions Minimally invasive endoscopic thyroid surgery through anterior chest approach is a feasible and safe method for the treatment of early papillary thyroid cancer.This technique had better cosmetic results and the long-term effect of this technique needs further evaluation.

Objective To evaluate the efficacy and safety of the loratadine paracetamol and pseudoephedrine(LPP)sustained-release tablets in the treatment of common cold and influenza compared with compound pseudoephedrine hydrochloride tablets.Methods Multi-center,randomized,double-blinded controlled clinical trial.One hundred eighteen patients were given LPP sustained-release tablets as trial group,119 were given pseudoephedrine hydrochloride as control group.Results Non-inferiority statistics showed that the improvement rate of clinical symptoms in trial group were not lower than that in control group(P<0.05).The total symptom score did not differ in trial group and control group(P>0.05).The effective rate in trial group and control group were 96.33% and 96.36%(P>0.05).The incidence of adverse drug reactions in trial group and control group was 7.02% and 11.82%,respectively(P>0.05).Conclusion LPP sustained-release tablets is effective and safe in the treatment of common cold and influenza.

The diagnosis of postradiation nasopharyngeal skull base lesions in petients with nasopharyngeal carcinoma (NPC) is still a tough problem in clinical practice. An early and accurate diagnosis is important for subsequent management. We prospectively evaluated the diagnostic value of plasma Epstein-Barr virus(EBV) DNA in detecting postradiation nasopharyngeal skull base lesions in NPC patients. From July 2006 to September 2010, 90 patients with postradiation NPC (34 women and 56 men; median age: 42 years) met the selection criteria and were recruited in this study. All postradiation nasopharyngeal skull base lesions were found in the latest magnetic resonance imaging (MRI) examinations before endoscopic surgery, and the nasopharyngeal cavity was normal under flexible nasopharyngoscopy. Plasma EBV DNA detection was performed within 2 weeks before endoscopic surgery. A total of 90 endoscopic operations were successfully performed without any postoperative complications. Recurrences confirmed by postoperative pathology were found in 30 patients. The specificity, positive and negative predictive values of plasma EBV DNA detection were better than those of MRI. In addition, combining plasma EBV DNA detection with MRI improved the specificity and positive predictive values of MRI. Plasma EBV DNA detection followed by MRI would help to diagnose recurrence whereas MRI was unable. These results indicate that plasma EBV DNA is an effective and feasible biomarker for detecting postradiation nasopharyngeal skull base lesions in NPC patients.
Adult ; Carcinoma, Squamous Cell ; blood ; radiotherapy ; virology ; DNA, Viral ; blood ; Endoscopy ; Female ; Follow-Up Studies ; Herpesvirus 4, Human ; genetics ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Nasopharyngeal Neoplasms ; blood ; radiotherapy ; virology ; Nasopharynx ; pathology ; Neoplasm Recurrence, Local ; diagnosis ; virology ; Neoplasm, Residual ; Osteoradionecrosis ; diagnosis ; surgery ; Prospective Studies ; Skull Base ; pathology

Objective To investigate the feasibility of the endoscope-assisted styloidectomy.Methods Sixty patients with Eagle's syndrome undergoing the endoscope-assisted styloidectomy via postauricular incision,including 7 unilateral and 53 bilateral,between June 2010 and March 2013 were reviewed.Results The styloid processes in all patients were resected successfully via this approach,with the incision length range of 2.0 to 2.5 cm.The mean operative time was (21.3 ± 4.8) min (x-± s),for unilateral surgery and (48.5 ± 11.4) min for bilateral surgery.Fifty-four patients symptom showed complete remission of symptom,3 cases with decrease in symptom and other 3 cases with no significant relief of symptom after surgery.None case recurred for follow-up of 3 to 70 months.There were 3 sides with ear numbness after surgery for 3 months,and one case had transient facial paralysis and recovered after 3 months.Conclusions The endoscope-assisted styloidectomy via postauricular incision is effective and feasible.

Objective To study on thyroid bilateral gland lobe disease with endoscopic monolateral anterior chest approach. Methods Twenty patients experienced thyroid bilateral gland lobe surgery with endoscopic monolateral anterior chest approach;24 experienced conventional surgery simultaneously and were enrolled in control group. Two groups were compared at surgical style, complications, surgical time, length of stay in hospital, incision cosmetic result and incision pain etc. Criteria of patients selected for thyroid bilateral gland lobe surgery with endoscopic monolateralanterior chest approach: with no surgical history of thyroid or other neck-related diseases and no chemotherapy; diagnosed with benign tumor according to presurgery CT result and thyroid functional examination. Diameter of tumor on both sides should be smaller than 4 cm, one side smaller than 2 cm, located at lower middle part of gland lobe and near to glandsurface. Results Patients in both groups matched in age and sex; scorings on surgical style, hospital stay, postoperative drainage, and postoperative pain were not significantly distinctive. Endoscopic group had less bleeding volumm than conventional group during surgery, better cosmetic results, but longer surgical duration and higher cost of hospitalization. Both groups occurred no permanent glottic paralysis and hypocalcemia, norecurrence. Endoscopic group had one case ecchymoma; one case temporary glottic paralysis; both recoveredin one month. Complication incidence in both groups was not significantly distinctive(x~2=2.514,P=0.201).Conclusions Gasless endoscopic monolateral anterior chest approach can well treat selected thyroid bilateral gland lobe disease and with a better cosmetic result than conventional surgery.

Coronary perforation is when a contrast agent or blood flows outside a blood vessel through a tear in a coronary artery.In this case,we reported a case of percutaneous coronary intervention for coronary calcified lesions,which led to iatrogenic coronary perforation and cardiac tamponade after the use of Shockwave balloon to treat intracoronary calcified nodules,and the management of PCI-related CAP was systematically reviewed through the literature.

Humans ; Charcot-Marie-Tooth Disease/complications* ; Hoarseness/etiology*