Leprosyleads to chronic granulomatous inflammation in skin and peripheral nerves thatcan lead to sensory, motor and autonomic impairments. Autonomic dysfunctions mayresult in dryness and cracking of the skin. In this study, we present the useof ozone provided by a high-frequency device to treat hand ulcers (wounds) inan 80-year-old man who was diagnosed asmultibacillary in 2007. In the first visit, the patient was evaluated andreceived verbal and written instructions about self-care. Treatment consistedof five sessions, once per week. The ozone provided by a high-frequency device seemed tobe useful in the treatment of ulcers, thus, contributing to the healingprocess. Research that investigates theuse of high frequencies in thetreatment of ulcers associated or not with other interventions (self-carestrategies, protective clothing, adaptedtools and footwear adaptation) is strongly recommended.