1. Antidiabetic potential of methanol extracts from leaves of Piper umbellatum L. and Persea americana Mill.
Guy Sedar Singor NJATENG ; Larissa CHIMI ; Cesaire FEUDJIO ; Donatien GATSING ; Jules-Roger KUIATE ; Guy Sedar Singor NJATENG ; Sumera ZAIB ; Ezekiel ADEWOLE ; Jamshed IQBAL ; Raymond Simplice MOUOKEU ; Ezekiel ADEWOLE
Asian Pacific Journal of Tropical Biomedicine 2018;8(3):160-165
Objective: To determine inhibitory activity of methanolic leaf extract of Piper umbellatum and Persea americana (P. americana) (traditionally used in Cameroon against diabetes) on α-glucosidase, β-glucosidase, maltase-glucoamylase, aldose reductase and aldehyde reductase activities, enzymes involved in starch digestion or diabetic complications. Methods: The methanol extracts from Piper umbellatum and P. americana were prepared by maceration. To assess relative efficacy of these extracts, the determination of concentrations that were needed to inhibit 50% of enzyme activity was done, whereas, gas chromatography-mass spectrum was used to identify components from extracts that may be responsible for the activities. Results: The tested extracts strongly inhibited α-glucosidase, maltase-glucoamylase, aldose reductase and aldehyde reductase activities with IC
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