Inherited ocular diseases comprise a heterogeneous group of rare and complex diseases, including inherited retinal diseases (IRDs) and inherited optic neuropathies. Recent success in adeno-associated virus-based gene therapy, voretigene neparvovec (Luxturna^®) for RPE65-related IRDs, has heralded rapid evolution in gene therapy platform technologies and strategies, from gene augmentation to RNA editing, as well as gene agnostic approaches such as optogenetics. This review discusses the fundamentals underlying the mode of inheritance, natural history studies and clinical trial outcomes, as well as current and emerging therapies covering gene therapy strategies, cell-based therapies and bionic vision.
Humans ; Eye Diseases/therapy*

Clinical experiences of acupuncture treatment on ophthalmic diseases over the years are summarized and analyzed to study the therapeutic capacity of acupuncture. Ophthalmic disorders are categorized into diseases with acupuncture treatment as the predominant or supplementary therapy, or as the therapeutic or prevention regimen. At the same time, various treating courses are designed for different phases of the diseases. And effects of acupuncture on different categories of ophthalmic disorders are discussed so as to improve the level of clinical application of acupuncture.
Acupuncture Therapy ; Eye Diseases ; therapy ; Humans

Acupuncture Therapy ; adverse effects ; Adolescent ; Adult ; Eye ; blood supply ; Eye Diseases ; therapy ; Hemorrhage ; etiology ; Humans ; Male

Professor GAO Wei-bin's clinical experience of electric eye acupuncture and stagnant-moving needling for ophthalmopathy was introduced. The indications of electric eye acupuncture and stagnant-moving needling include external ophtalmoplegia and visual impairment. Professor GAO has proposed new acupoints at the ocular muscles attachment of eyeball, and put forward five experience points: Shangming point, Neiming point, Xiaming point, Waiming point and Tijian point. The points are selected according to different pathological changes of ocular muscles. In the treatment of ophthalmopathy, the tendons and vessels are often regulated at the same time. Neiming point, Shangming point, Xiaming point and Qiuhou point are the main points, with Fengchi (GB 20) and Gongxue (Extra) as the matching points. In addition, attention is paid to the application of stagnant-moving needling and electroacupuncture (continuous dense wave, frequency of 50 Hz).
Acupuncture ; Acupuncture Points ; Acupuncture Therapy ; Electroacupuncture ; Eye Diseases ; Humans

Data studies are adopted to do systematic analysis on diseases described in theses on effect observation of acupuncture in Chinese Bio-Medical Literature and Retrieval System during 1978 to 2005. Numbers (frequency) of the disease mentioned are counted so as to analyze the acupuncture spectrum of ocular and adnexal diseases. The result indicates that the number of acupuncture spectrum of ocular and adnexal diseases is 31, which includes 22 diseases and 5 symptoms defined with western medicine as well as 4 syndromes of TCM. Thus, it can be concluded that ocular and adnexal disease is the one of the major component of acupuncture spectrums, and it is worth to popularize and apply that acupuncture for illness of this kind in clinic.
Acupuncture Therapy ; Adnexal Diseases ; therapy ; Eye Diseases ; therapy ; Female ; Humans ; Medicine, Chinese Traditional

"Wentong needling method" is professor ZHENG Kui-shan's needling manipulation of original creation for treatment of various difficult and complicated cases with distinguishing feature in clinical practice of dozens of years, which has both reinforcing and reducing actions, with functions of promoting the flow of qi by warming the channels, removing the phlegm, dispelling wind and cold, promoting flow of qi and blood circulation, and strengthening the body resistance to eliminate pathogenic factors. Clinically, it is used for treatment of difficult diseases such as coronary disease, diseases of the head, face and five sense organs, brain diseases, and wind-cold-dampness arthralgia, etc. with good results.
Acupuncture Points ; Acupuncture Therapy ; methods ; Brain Diseases ; therapy ; Coronary Disease ; therapy ; Eye Diseases ; therapy ; Facial Paralysis ; therapy ; Humans

OBJECTIVETo evaluate a new technique for treatment of the symblepharon caused by physical and chemical burn.

METHODSThirty-eight patients with 40 eyes were undergoing the treatment. It was carried out to reconstruct the conjunctival fornix by pulling the remained conjunctive backward from the corneal limbus in serious stages.

RESULTSThirty-eight patients (40 eyes) were treated with this technique, with the successful results of 13 patients (13 eyes) in 2 times, 19 patients (21 eyes) in 3 and 6 patients (6 eyes) in 1. Only one case was failure.

CONCLUSIONThe above mentioned technique could be a safe and effective way for treatment of symblepharen.

Amnion ; Conjunctival Diseases ; etiology ; therapy ; Eye Burns ; complications ; Eyelid Diseases ; etiology ; therapy ; Humans ; Reconstructive Surgical Procedures ; Tissue Adhesions ; etiology ; therapy

Acupuncture Therapy ; Aged, 80 and over ; Eye Diseases ; etiology ; therapy ; Humans ; Male ; Retinal Artery Occlusion ; complications

Mechanism and case study on treatment of refractory diseases of oculopathy with Dr. Shen Feng-ren's abdominal eight-diagram holotherapy are introduced in the article. The accurate location of acupoints, comprehensive understanding of the theory and features of the eight-diagram are held as the prerequisites of the application of the therapy. The combination of the theories of five wheels, five zang organs, and mother and son relation among the five elements are taken as the theoretical foundation of the treatment. And clinical analyses on three cases treated with the theory are provided as well.
Abdomen ; Acupuncture Points ; Acupuncture Therapy ; Adult ; Eye Diseases ; therapy ; Female ; Humans ; Male ; Middle Aged

Acupuncture and moxibustion treatment has good therapeutic effects on the intractable eye diseases including pigmentary degeneration of retina, macular degeneration, glaucoma and optic atrophy, etc. This paper reviews acupuncture and moxibustion treatment of these diseases from selection of acupoints, treatment methods, effectiveness and mechanism studies, and raises the problems in existence and the prospect.
Acupuncture Points ; Acupuncture Therapy ; methods ; Eye Diseases ; therapy ; Humans ; Moxibustion ; methods