OBJECTIVE: To determine which regimen for controlled ovarian hyperstimulation is the most effective in achieving pregnancy after intrauterine insemination in the treatment of unexplained infertility. MATERIALS AND METHODS: From March 1996 to February 2000, a total of 67 cycles of intrauterine insemination after controlled ovarian hyperstimulation were treated in 39 patients under 40 years old who diagnosed as unexplained infertility. Two methods of controlled ovarian hyperstimulation were used. The one is clomiphene citrate/hMG and the other is hMG only. These were compared the pregnancy rate respectively. RESULTS: Mean age of study group was 32+/-2.7 years old (28-38 years old) and mean duration of infertility was 46+/-17.8 months (15-96 months). The overall clinical pregnancy rate was 17.9% (12/67 cycle) per cycle and 30.7% (12/39 patient) per patient. According to the methods of controlled ovarian hyperstimulation, pregnancy rate was 16.7% (8/48 cycle) after clomiphene citrate/hMG used, 21.1% (4/19 cycle) after hMG only used. 4 cases of ovarian hyperstimulation syndrome developed (clomiphene citrate/hMG 1 case, hMG only 3 cases) and all of them were self-regressed. CONCLUSION: Compared with using hMG only as controlled ovarian hyperstimulation before intrauterine insemination, using clomiphene citrate/hMG was more effective regimen and considered as the first choice in the treatment of unexplained infertility.
Adult ; Clomiphene ; Female ; Humans ; Infertility* ; Insemination* ; Ovarian Hyperstimulation Syndrome ; Pregnancy ; Pregnancy Rate

The immature teratoma is the 3rd most common germ cell tumor and represents 10-20% of all ovarian malignancies occurring in the first two decades of life. The initial clinical manifestation is abdominal/pelvic mass with pain. This tumor is usually unilateral and large, and has a prominent solid component with cystic elements. It is composed of mature and immature tissues derived from the three germ cell layers. Tumor grading is based on the amount of immature tissues which mostly derives from neuroectodermal origin. The prognosis and treatment depend on the clinical stage and histological grade of the tumor. The initial treatment should include unilateral salpingo-oophorectomy and removal of as much extraovarian tumor as possible. Adjuvant chemotherapy is not necessary for the patients with stage IA, grade 1 tumor or those with mature glial implants. Combination chemotherapy is recommended for the patients with grade 2 or 3 tumors or those with immature metastases. Although the immature teratoma was considered aggressive tumor type before the prevalent use of chemotherapy, the advances in combination chemotherapy have leaded to the better prognosis than before. We have experienced three cases of immature teratoma and report them with brief review of literatures.
Chemotherapy, Adjuvant ; Drug Therapy ; Drug Therapy, Combination ; Female ; Germ Cells ; Humans ; Neoplasm Grading ; Neoplasm Metastasis ; Neoplasms, Germ Cell and Embryonal ; Neural Plate ; Ovary* ; Prognosis ; Teratoma*

Primary peritoneal serous papillary carcinoma (PPSPC) is very rare and not well identified. Because of developmental, biological and histologic similarity to papillary serous carcinoma of ovary its diagnosis and treatment, prognosis and post treatment follow up schedule is similar that of epithelial ovarian cancer. We have experienced two cases of primary peritoneal serous papillary carcinoma and report this with brief review of the concerned literatures.
Appointments and Schedules ; Carcinoma, Papillary* ; Diagnosis ; Female ; Follow-Up Studies ; Ovarian Neoplasms ; Ovary ; Prognosis

Primary peritoneal serous papillary carcinoma (PPSPC) is very rare and not well identified. Because of developmental, biological and histologic similarity to papillary serous carcinoma of ovary its diagnosis and treatment, prognosis and post treatment follow up schedule is similar that of epithelial ovarian cancer. We have experienced two cases of primary peritoneal serous papillary carcinoma and report this with brief review of the concerned literatures.
Appointments and Schedules ; Carcinoma, Papillary* ; Diagnosis ; Female ; Follow-Up Studies ; Ovarian Neoplasms ; Ovary ; Prognosis

In adult women, hypothyroidism has significant effect on reproduction. Hypothyroidism is associated with oligomenorrhea, amenorrhea, anovulation, hypermenorrhea, menorrhagia, infertility, spontaneous abortion, stillbirth or preterm delivery. It can cause ovarian tumor, which clinically resembles ovarian hyperstimulation syndrome or multicystic ovarian tumor. We have experienced a case of spontaneously regressed huge ovarian tumor which was found in patient. With hypothyroidism. So we report this case with a brief review of literature.
Abortion, Spontaneous ; Adult ; Amenorrhea ; Anovulation ; Female ; Humans ; Hypothyroidism* ; Infertility ; Menorrhagia ; Oligomenorrhea ; Ovarian Hyperstimulation Syndrome ; Pregnancy ; Reproduction ; Stillbirth

Holoprosencephaly is a rare developmental defect due to incomplete cleavages of the prosencephalon during the third week of fetal development. It was associated with chromosomal anomalies, genetic syndrome, teratogen, or genetic disorder of non-syndromic HPE. Early antenatal detection of holoprosencephaly was done by high resolution ultrasonography. According to its severity and prognosis, it was capable of proper treatment of holoprosencephaly. We report one case of holoprosencephaly with a brief review of the literature
Fetal Development ; Holoprosencephaly* ; Prognosis ; Prosencephalon ; Ultrasonography