The writers, herein, report clinical findings and results of hormonal therapy applied on 10 eunuchs and 35 eunuchoids for the 10-year period from 1960 to 1969. The clinical findings of these subjects are summarized in the tables 1~4, and the results of the treatment, in table 5. Seven anorchisms in 10 eunuchs lost their testes and scrotum by dog bites and the remaining 3 cases, by industrial injuries. Ten cases of eunuchs and 8 cases of hypergonadotropic eunuchoids were given intramuscular injections of testosterone depot "MIRO-DEPO" (Hanil Pharm. Mfg. Co.), 100 mg every 10 days for 6~12 months. The remaining 27 cases of hypogonadotropic eunuchoids were administered injections of human chorionic gonadotropin "PUBEROGEN" (Tong-A Pharm. Mfg. Co. Tomoda Pharm. Mfg. Co.), 1,000 I.U. every 3 days combined with the testosterone depot, 100mg every 15 days, for 6 to 12 months. Improvements of male secondary sex characters such as sex hair growth, voice change, enlargement of penile size and masculine fat distribution were observed three to six months after the treatments. Such improvements were found in 90 per cent of eunuchs, 96 per cent of hypogonadotropic eunuchoids and 80 per cent of hypergonadotropic eunuchoids. Two of the hypogonadotropic eunuchoids were proved to become fertile (fertile eunuchoid) with long-term treatment of Puberogen.
Animals ; Chorionic Gonadotropin ; Dogs ; Eunuchism* ; Hair ; Humans ; Injections, Intramuscular ; Male ; Scrotum ; Testis ; Testosterone ; Voice

Klinefelter syndrome is usually characterized by eunuchoidism, gynecomastia, small testes, infertility, elevated gonadotropins, mental retardation, and a constitutional extra X chromosome. Several reports have suggested an association between leukemia and Klinefelter syndrome, although two cohort studies failed to show a clear association between the two. We report the first Korean case of acute myeloid leukemia with the 11q23 rearrangement in a 27-year-old man with Klinefelter syndrome.
Adult ; Cohort Studies ; Eunuchism ; Gonadotropins ; Gynecomastia ; Humans ; Infertility ; Intellectual Disability ; Klinefelter Syndrome* ; Leukemia ; Leukemia, Myeloid, Acute* ; Male ; Testis ; X Chromosome

The Klinefelter's syndrome is characterized by azoospermia, gynecomastia, a variable degree of eunuchoidism elevated urinary gonadotropins, atrophic testis and hyalinization of the seminiferous tubules in which Leydig cells were preserved. Reviewing some world literatures, we have reported a case of Klinefelter's syndrome associated with right inguinal hernia in 22 year-old Korean male.
Azoospermia ; Eunuchism ; Gonadotropins ; Gynecomastia ; Hernia, Inguinal ; Humans ; Hyalin ; Klinefelter Syndrome* ; Leydig Cells ; Male ; Seminiferous Tubules ; Testis ; Young Adult

Klinefelter syndrome is the most common form of male hypogonadism. It is characterized by small, firm testis, gynecomastia, a variable degree of eunuchoidism, azoospermia, elevated gonadotropin level. Increased frequency of diabetes mellitus, breast cancer, empysema, chronic bronchitis, varicose vein, germ cell neoplasia occurs in Klinefelter syndrome. We report a 19 year-old male patient with diabetes mellitus in association with Klinefelter syndrome, which was confirmed by chromosome analysis. The patient is being treated with insulin for diabetes mellius and with testostrone replacement for Klinefelter syndrome.
Azoospermia ; Breast Neoplasms ; Bronchitis, Chronic ; Diabetes Mellitus ; Eunuchism ; Germ Cells ; Gonadotropins ; Gynecomastia ; Humans ; Hypogonadism ; Insulin ; Klinefelter Syndrome ; Male ; Testis ; Varicose Veins

For the evaluation and management of male infertility, measurements of testicular size (volume) and plasma hormones (FSH, LH and testosterone) have been considered as very important procedures besides the routine examinations of history, physical examination, laboratory works including semen analyses and testicular biopsy and special studies. A total of 99 infertile males with small testes which were less than 1Oml in volume was subjected to the assessment of plasma FSH, LH and testosterone levels. They were divided into 6 study groups; such as Group I. Control: 28 men with normal semen parameters and plasma hormone values. Group II. Oligospermia: 12 patients with sperm density of less than 20 X 10 6/ml. Group III. Testicular azoospermia: 22 patients with testicular biopsy of better than germ cell arrest. Group IV Sertoli cell only syndrome: 25 patients proved by testicular histology. Group V. Klinefelter`s syndrome: 30 patients proved by karyotype studies. Group VI. Eunuchoidism: 10 patients proved by laboratory and physical examinations. The results obtained in this clinical study were as follows (Table 1): Testicular sizes were decreased in Groups IV. Sertoli cell only syndrome, V. klinefelter`s syndrome, and VI. Eunuchoidism. Plasma LH levels were increased in Groups IV. Sertoli cell only syndrome, and V Klinefelter`s syndrome. Plasma FHS levels were increased in Groups IV. Sertoli cell only syndrome, and V. Klinefelter`s syndrome. The long-term hormonal therapy with high doses of human chorionic gonadotropin and human menopausal gonadotropin combined with testosterone was applied to a total of 216 infertile patients with small tests (less than 10ml in volume) for 12 months (range: 3-24 months). Semen parameters were improved in 10 patients who were severe oligozoospermia before the treatment and spermatogenesis was induced in 14 patients who were azoospermic before the treatment following the hormonal therapy. In conclusion, an infertile male with small testis (less than 10ml, should be adequately evaluated before declaration of final diagnosis of sterility.
Azoospermia ; Biopsy ; Chorionic Gonadotropin ; Diagnosis ; Eunuchism ; Germ Cells ; Gonadotropins ; Humans ; Infertility ; Infertility, Male ; Karyotype ; Male* ; Oligospermia ; Physical Examination ; Plasma* ; Semen ; Semen Analysis ; Sertoli Cell-Only Syndrome ; Spermatogenesis ; Spermatozoa ; Testis ; Testosterone

Male sexual dysfunction refers to a phenomenon in which a man experiences difficulty at any stage during the process of sexual intercourse. In general, erectile dysfunction is regarded as the most representative form of sexual dysfunction, but various other diseases can also be categorized as male sexual dysfunction, including sexual arousal disorder, decreased libido, ejaculation disorder, and Peyronie's disease. Causes of sexual dysfunction include chronic diseases, such as diabetes, hypertension, dyslipidemia, and obesity. In addition, some medications, surgical procedures, and traumas can cause sexual dysfunction. However, aging is the most important cause of male sexual dysfunction. To diagnose and treat elderly patients who complain of male sexual dysfunction, it is first necessary to become familiar with the characteristics of sexual dysfunction in elderly men. The prevalence rates of metabolic syndrome, hypertension, diabetes, dyslipidemia, coronary artery disease, stroke, and depression are higher among elderly men than among younger men; furthermore, the elderly are at a higher risk for the development of kidney, hepatic, spinal cord, and neurological diseases. Notably, anti-hypertensive agents can affect erectile function in elderly men: sexual dysfunction may be severe or the response to treatment may be poor. For satisfactory treatment, spousal factors should also be considered.
Aged ; Aging ; Antihypertensive Agents ; Chronic Disease ; Coitus ; Coronary Artery Disease ; Depression ; Diagnosis ; Dyslipidemias ; Ejaculation ; Erectile Dysfunction ; Eunuchism ; Humans ; Hypertension ; Kidney ; Libido ; Male ; Obesity ; Penile Induration ; Prevalence ; Sexual Dysfunction, Physiological ; Sexual Dysfunctions, Psychological ; Spinal Cord ; Stroke ; Testosterone