1.Medicine in the Fourth Industrial Revolution: What Should We Prepare?
Journal of Korean Diabetes 2020;21(1):1-5
The power of the Internet, mobile devices, and data science including artificial intelligence is making a big difference in our daily lives. The introduction and proliferation of electronic health records, personal health records, and artificial intelligence in the medical field raises expectations that the future of medical practice will change. Both individuals and medical institutions will receive or perform multiple medical services based on much larger and more complete health and medical datasets. Medicine is also expected to increasingly make use of real world evidence (RWE), based on data supplied in the form of real world data (RWD), that will be applied in the clinical setting in real time. Further, the learning healthcare system will complete the data-driven medicine that will be used to deliver future medical care. For these reasons, doctors need to be more data-friendly and respond to these changes.
2.Medicine in the Fourth Industrial Revolution: What Should We Prepare?
Journal of Korean Diabetes 2020;21(1):1-5
The power of the Internet, mobile devices, and data science including artificial intelligence is making a big difference in our daily lives. The introduction and proliferation of electronic health records, personal health records, and artificial intelligence in the medical field raises expectations that the future of medical practice will change. Both individuals and medical institutions will receive or perform multiple medical services based on much larger and more complete health and medical datasets. Medicine is also expected to increasingly make use of real world evidence (RWE), based on data supplied in the form of real world data (RWD), that will be applied in the clinical setting in real time. Further, the learning healthcare system will complete the data-driven medicine that will be used to deliver future medical care. For these reasons, doctors need to be more data-friendly and respond to these changes.
3.Quantitative Assessment of Global and Regional Air Trappings Using Non-Rigid Registration and Regional Specific Volume Change of Inspiratory/Expiratory CT Scans: Studies on Healthy Volunteers and Asthmatics.
Eunsol LEE ; Joon Beom SEO ; Hyun Joo LEE ; Eun Jin CHAE ; Sang Min LEE ; Sang Young OH ; Namkug KIM
Korean Journal of Radiology 2015;16(3):632-640
OBJECTIVE: The purpose of this study was to compare air trapping in healthy volunteers with asthmatics using pulmonary function test and quantitative data, such as specific volume change from paired inspiratory CT and registered expiratory CT. MATERIALS AND METHODS: Sixteen healthy volunteers and 9 asthmatics underwent paired inspiratory/expiratory CT. DeltaSV, which represents the ratio of air fraction released after exhalation, was measured with paired inspiratory and anatomically registered expiratory CT scans. Air trapping indexes, DeltaSV0.4 and DeltaSV0.5, were defined as volume fraction of lung below 0.4 and 0.5 DeltaSV, respectively. To assess the gravity effect of air-trapping, DeltaSV values of anterior and posterior lung at three different levels were measured and DeltaSV ratio of anterior lung to posterior lung was calculated. Color-coded DeltaSV map of the whole lung was generated and visually assessed. Mean DeltaSV, DeltaSV0.4, and DeltaSV0.5 were compared between healthy volunteers and asthmatics. In asthmatics, correlation between air trapping indexes and clinical parameters were assessed. RESULTS: Mean DeltaSV, DeltaSV0.4, and DeltaSV0.5 in asthmatics were significantly higher than those in healthy volunteer group (all p < 0.05). DeltaSV values in posterior lung in asthmatics were significantly higher than those in healthy volunteer group (p = 0.049). In asthmatics, air trapping indexes, such as DeltaSV0.5 and DeltaSV0.4, showed negative strong correlation with FEF25-75, FEV1, and FEV1/FVC. DeltaSV map of asthmatics showed abnormal geographic pattern in 5 patients (55.6%) and disappearance of anterior-posterior gradient in 3 patients (33.3%). CONCLUSION: Quantitative assessment of DeltaSV (the ratio of air fraction released after exhalation) shows the difference in extent of air trapping between health volunteers and asthmatics.
Adult
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Aged
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Asthma/*physiopathology
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Exhalation/physiology
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Female
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Healthy Volunteers
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Humans
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Lung/*physiopathology/radiography
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Male
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Middle Aged
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*Respiratory Function Tests
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Tomography, X-Ray Computed/methods
4.Pharmacokinetic comparison between fixed-dose combination of fimasartan/amlodipine 60/10 mg and the corresponding loose combination through partial replicated crossover study in healthy subjects
Eunsol YANG ; Soyoung LEE ; Heechan LEE ; Inyoung HWANG ; In Jin JANG ; Kyung Sang YU ; SeungHwan LEE
Translational and Clinical Pharmacology 2019;27(4):134-140
Combination therapies of antihypertensive drugs are recommended in cases where hypertension is not controlled by monotherapy. This study aimed to compare the pharmacokinetics (PKs) between fixed-dose combination (FDC) of fimasartan/amlodipine 60/10 mg and the corresponding loose combination. Because of the high intra-subject variability for maximum plasma concentration (C(max)) of fimasartan, a randomized, open-label, 3×3 partial replicated crossover design was adopted. Subjects received a single dose of FDC of fimasartan/amlodipine 60/10 mg or the corresponding loose combination in each period. Blood samples for PK analysis were collected up to 48 hours for fimasartan and 144 hours for amlodipine, respectively. Geometric mean ratios (GMRs) and its 90% confidence intervals (CIs) of the FDC to the loose combination for C(max) and area under the concentration-time curve from time 0 to the last quantifiable time point (AUC(last)) were calculated. Sixty healthy subjects were randomized, and 57 subjects completed the study. The concentration-time profiles of fimasartan and amlodipine were similar between the FDC and loose combination. The GMRs (90% CIs) of the FDC to the loose combination for C(max) and AUC(last) were 1.0440 (0.9202–1.1844) and 1.0412 (0.9775–1.1090) for fimasartan, and 1.0430 (1.0156–1.0711) and 1.0339 (1.0055–1.0631) for amlodipine, respectively. The GMRs and its 90% CIs for C(max) and AUC(last) of fimasartan and amlodipine were included not only in the scaled bioequivalence criteria but also in the conventional bioequivalence criteria. In conclusion, FDC of fimasartan/amlodipine 60/10 mg showed comparable PK profiles with the corresponding loose combination, which suggests their bioequivalence.
Amlodipine
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Antihypertensive Agents
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Cross-Over Studies
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Healthy Volunteers
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Hypertension
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Pharmacokinetics
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Plasma
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Therapeutic Equivalency
5.Added Value of Magnetic Resonance Imaging in Staging of Malignant Pleural Mesothelioma.
Eunsol LEE ; Eun Jin CHAE ; Sunji KANG ; Yoo Kyeong YEOM ; Hyun Joo LEE ; Jong Chun PARK ; So Youn SHIN ; Yoon Young CHOI ; Joon Ho CHOI ; Kyung Hyun DO
Journal of the Korean Society of Magnetic Resonance in Medicine 2013;17(3):232-238
PURPOSE: We investigated the possible added value of magnetic resonance imaging (MR) in staging of malignant pleural mesothelioma (MPM) compared to computed tomography (CT). MATERIALS AND METHODS: We retrospectively enrolled 20 patients (M;F = 14:6; mean age, 53.5 yrs) who diagnosed as MPM by histology and underwent CT and MR at initial evaluation from Jan 1997 to Dec 2012. Two radiologists performed clinical staging by using CT alone or MR alone in consensus. In patients underwent surgery (n = 13), we evaluated the diagnostic accuracy of CT and MR in terms of staging compared to surgical staging. In all patients, we compared clinical staging of CT only and CT with MR. RESULTS: The diagnostic accuracy for T staging of CT only was 23.1% (3/13) and that of combined CT and MR was 38.5% (5/13), respectively. Among 13 patients underwent surgery, surgical stage was higher than combined CT and MR stage in 5 patients, but lower in 3 patients. CT only and combined CT and MR agreed in 85.0% (17/20). In cases of disagree (15.0%, 3/20), combined CT and MR showed higher stage than CT only. CONCLUSION: Combined CT and MR increases the diagnostic accuracy in staging of MPM compared to CT only and is important in determining the appropriate treatment in patients being considered for surgery.
Consensus
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Humans
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Magnetic Resonance Imaging
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Magnetic Resonance Spectroscopy
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Magnetics
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Magnets
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Mesothelioma
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Neoplasm Staging
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Retrospective Studies
6.Evaluation of food effects on the pharmacokinetics of Pelargonium sidoides and Coptis with each bioactive compound berberine and epicatechin after a single oral dose of an expectorant and antitussive agent UI026 in healthy subjects
Yewon PARK ; WonTae JUNG ; Eunsol YANG ; Kyu-Yeol NAM ; Woo-Ri BONG ; Jaehee KIM ; Kyu Yeon KIM ; SeungHwan LEE ; Joo-Youn CHO ; Jang-Hee HONG ; JaeWoo KIM
Translational and Clinical Pharmacology 2022;30(1):49-56
UI026 is an expectorant and antitussive agent which is a new combination of Pelargonium sidoides extract andCoptis extract. The bioactive compounds of Pelargonium sidoides and Coptis extracts were identified as epicatechin and berberine, respectively. This study evaluated the effect of food on the pharmacokinetics (PKs) and safety of UI026. A randomized, openlabel, single-dose, 2-treatment, parallel study in 12 healthy male subjects was performed. Subjects received a single oral dose of UI026 (27 mL of syrup) under a fed or fasted condition according to their randomly assigned treatment. Blood samples for the PK analysis were obtained up to 24 hours post-dose for berberine and 12 hours post-dose for epicatechin. The PK parameters were calculated by non-compartmental analysis. In the fed condition, the mean maximum plasma concentration (C max ) and mean area under the plasma concentrationtime curve from time zero to the last observed time point (AUC last ) for berberine were approximately 33% and 67% lower, respectively, compared with the fasted condition, both showing statistically significant difference. For epicatechin, the mean C max and mean AUC last were about 29% and 45% lower, respectively, compared to the fasting condition, neither of which showed a statistically significant difference. There were no drug-related adverse events. This finding suggests that food affects the systemic exposure and bioavailability of berberine and epicatechin.