Purpose: This study aimed to identify the relationship between the attitudes toward doping, sport orientation, and perceived motivational climate in sport, and to provide useful information on the anti-doping strategy. Methods: A total of 567 athletes in 21 sports completed four questionnaires Performance Enhancement Attitude Scale (PEAS), Sport Orientation Questionnaire (SOQ; competitiveness orientation, win orientation, goal orientation), Task and Ego Orientation in Sport Questionnaire (TEOSQ; task orientation, ego orientation), and Perceived Motivational Climate in Sport Questionnaire-2 (PMCSQ-2; ego-involving and task-involving climates). They were divided into four categories: speed/power (n=201), endurance (n=154), motor skill (n=119), and team (n=93). We identified the difference of variables among four categories and verified possible factors significantly associated with attitudes toward doping. Results: The PEAS of athletes in both speed/power sports and Team sports was higher than motor skill sports, and the team sports athletes also showed higher PEAS than endurance sports athletes. In speed/power sports, the task of TEOSQ and the win of SOQ were related to PEAS, and in endurance sports, the task of TEOSQ and the ego-involving of PMCSQ were related to PEAS. In motor skill sports and Team sports, the task-involving of PMCSQ and the goal of SOQ were associated with PEAS, respectively. Conclusion The results of this study provided new insights into the psychosocial mechanisms of attitudes toward doping, and it would contribute significantly to effective anti-doping strategies based on sports characteristics.

Purpose: This study aimed to identify the relationship between the attitudes toward doping, sport orientation, and perceived motivational climate in sport, and to provide useful information on the anti-doping strategy. Methods: A total of 567 athletes in 21 sports completed four questionnaires Performance Enhancement Attitude Scale (PEAS), Sport Orientation Questionnaire (SOQ; competitiveness orientation, win orientation, goal orientation), Task and Ego Orientation in Sport Questionnaire (TEOSQ; task orientation, ego orientation), and Perceived Motivational Climate in Sport Questionnaire-2 (PMCSQ-2; ego-involving and task-involving climates). They were divided into four categories: speed/power (n=201), endurance (n=154), motor skill (n=119), and team (n=93). We identified the difference of variables among four categories and verified possible factors significantly associated with attitudes toward doping. Results: The PEAS of athletes in both speed/power sports and Team sports was higher than motor skill sports, and the team sports athletes also showed higher PEAS than endurance sports athletes. In speed/power sports, the task of TEOSQ and the win of SOQ were related to PEAS, and in endurance sports, the task of TEOSQ and the ego-involving of PMCSQ were related to PEAS. In motor skill sports and Team sports, the task-involving of PMCSQ and the goal of SOQ were associated with PEAS, respectively. Conclusion The results of this study provided new insights into the psychosocial mechanisms of attitudes toward doping, and it would contribute significantly to effective anti-doping strategies based on sports characteristics.

Purpose: Osteoporosis is a common calcium and metabolic skeletal disease which is characterized by decreased bone mass, microarchitectural deterioration of bone tissue and impaired bone strength, thereby leading to enhanced risk of bone fragility.In this study, we aimed to identify novel genes for susceptibility to osteoporosis and/or bone density. Materials and Methods: To identify differentially expressed genes (DEGs) between control and osteoporosis-induced cells, annealing control primer-based differential display reverse-transcription polymerase chain reaction (RT-PCR) was carried out in pre-osteoblast MC3T3-E1 cells. Expression levels of the identified DEGs were evaluated by quantitative RT-PCR. Association studies for the quantitative bone density analysis and osteoporosis case-control analysis of single nucleotide polymorphism (SNPs) were performed in Korean women (3,570 subjects) from the Korean Association REsource (KARE) study cohort. Results: Comparison analysis of expression levels of the identified DEGs by quantitative RT-PCR found seven genes, Anxa6, Col5a1, Col6a2, Eno1, Myof, Nfib, and Scara5, that showed significantly different expression between the dexamethasontreated and untreated MC3T3-E1 cells and between the ovariectomized osteoporosis-induced mice and sham mice. Association studies revealed that there was a significant association between the SNPs in the five genes, ANXA6, COL5A1, ENO1, MYOF, and SCARA5, and bone density and/or osteoporosis. Conclusion Using a whole-genome comparative expression analysis, gene expression evaluation analysis, and association analysis, we found five genes that were significantly associated with bone density and/or osteoporosis. Notably, the association P-values of the SNPs in the ANXA6 and COL5A1 genes were below the Bonferroni-corrected significance level.