Purpose: In spite of the recent application of a general infection control method, central line-associated infections is still relatively high in Korea. Central line bundle with Chlorhexidine gluconate (CHG) tegaderm dressing was reported to be effective in reducing catheter colonization and central line-associated bloodstream infections (CLABSI). Therefore, this study aimed to examine the incidences of catheter colonization occurrence and CLABSI while using Tegaderm vs. CHG Tegaderm dressings. Methods: We used a descriptive design. 400 patients who had central venous catheters were selected from four hospitals in the Korean National Healthcare-associated Infections Surveillance System. Of all subjects, 200 used Tegaderm TM (Tegaderm group), and the remaining 200 used CHG Tegaderm (CHG Tegaderm group) dressing at the catheter insertion site. Data were analyzed using the c 2 test or Fisher’s exact test, t-test, and logistic regression analysis using SPSS WIN 21.0. Results: In the Tegaderm and CHG Tegaderm groups, CLABSI incidences were 5.89 and 1.79 per 1,000 catheter-days, catheter colonization incidences were 3.93 and 1.43 per 1,000 catheter-days, and central line bundle compliance rates were 26.0% and 49.0%, respectively. Catheter colonization risk factors were ‘reinsertion after failure’ and ‘Tegaderm dressing’ at the central line insertion site. CLABSI risk factors were ‘incomplete performance of 7 central line bundle items’ and ‘Tegaderm dressing’ at the central line insertion site. Conclusion A further prospective study is needed to examine the effects of central line bundle with CHG Tegaderm dressing, avoiding central line reinsertion after failure, and improving the bundle compliance in reducing catheter colonization and CLABSI.

Cataract is a common eye disease in the elderly. It is affected by various factors including oxidative stress which cause inflammation and damage to the lens. In this study, we aimed to analyze the relationship between the dietary inflammatory index (DII), which indicates the contribution of various dietary components to inflammation, and cataract. The study was a cross-sectional study using data from the 2019∼2021 Korea National Health and Nutrition Examination Survey (KNHANES) and included 3,427 people aged 65 years and older. The DII was derived using a 24-hour recall method. To analyze the association between dietary inflammation and cataracts, we divided the DII into tertiles and performed logistic regression analysis. All analyses were performed using SPSS version 29.0. The results showed that 1,457 (42.5%) patients had cataracts.The DII was 1.56±0.1 in the cataract group and 1.18±0.1 in the non-cataract group (P＜0.001). Logistic regression analysis with adjusted variables to analyze the association of DII with cataracts showed that the odds ratio (OR) of cataract incidence was lower from T1 to T3 (OR, 0.82; 95% CI, 0.68∼0.99, P for trend=0.040). This study shows that a lower DII score is associated with a lower OR of cataract development in the Korean elderly. This suggest that dietary strategies focusing on anti-inflammatory foods are needed to delay and effectively manage cataract development.

Cataract is a common eye disease in the elderly. It is affected by various factors including oxidative stress which cause inflammation and damage to the lens. In this study, we aimed to analyze the relationship between the dietary inflammatory index (DII), which indicates the contribution of various dietary components to inflammation, and cataract. The study was a cross-sectional study using data from the 2019∼2021 Korea National Health and Nutrition Examination Survey (KNHANES) and included 3,427 people aged 65 years and older. The DII was derived using a 24-hour recall method. To analyze the association between dietary inflammation and cataracts, we divided the DII into tertiles and performed logistic regression analysis. All analyses were performed using SPSS version 29.0. The results showed that 1,457 (42.5%) patients had cataracts.The DII was 1.56±0.1 in the cataract group and 1.18±0.1 in the non-cataract group (P＜0.001). Logistic regression analysis with adjusted variables to analyze the association of DII with cataracts showed that the odds ratio (OR) of cataract incidence was lower from T1 to T3 (OR, 0.82; 95% CI, 0.68∼0.99, P for trend=0.040). This study shows that a lower DII score is associated with a lower OR of cataract development in the Korean elderly. This suggest that dietary strategies focusing on anti-inflammatory foods are needed to delay and effectively manage cataract development.

Cataract is a common eye disease in the elderly. It is affected by various factors including oxidative stress which cause inflammation and damage to the lens. In this study, we aimed to analyze the relationship between the dietary inflammatory index (DII), which indicates the contribution of various dietary components to inflammation, and cataract. The study was a cross-sectional study using data from the 2019∼2021 Korea National Health and Nutrition Examination Survey (KNHANES) and included 3,427 people aged 65 years and older. The DII was derived using a 24-hour recall method. To analyze the association between dietary inflammation and cataracts, we divided the DII into tertiles and performed logistic regression analysis. All analyses were performed using SPSS version 29.0. The results showed that 1,457 (42.5%) patients had cataracts.The DII was 1.56±0.1 in the cataract group and 1.18±0.1 in the non-cataract group (P＜0.001). Logistic regression analysis with adjusted variables to analyze the association of DII with cataracts showed that the odds ratio (OR) of cataract incidence was lower from T1 to T3 (OR, 0.82; 95% CI, 0.68∼0.99, P for trend=0.040). This study shows that a lower DII score is associated with a lower OR of cataract development in the Korean elderly. This suggest that dietary strategies focusing on anti-inflammatory foods are needed to delay and effectively manage cataract development.

Purpose: This study examined the influence of patient safety management systems, leadership, and communication types on nurses’ patient safety management activities. Methods: Participants were 237 nurses who has been working in medical institutes for over 6 months. Online self-report questionnaires were conducted. Measures included patient safety management systems, transformational leadership, authentic leadership, communication types, and patient safety management activities. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson’s correlation coefficients, and multiple regression with SPSS/WIN 24.0. Results: According to the general characteristics, patient safety management activities were higher among nurses who were female (t=4.27, p<.001), charge nurses (t=-2.41, p=.016), had healthcare accreditation experience (t=4.36, p<.001), and worked in nursing units implementing a team nursing method (F=6.26, p=.002) with more than 30 nurses (F=6.28, p=.043). Female nurses (β=.16, p=.015) with high authentic leadership (β=.21, p=.002), low informal communication (β=-.21, p=.004), and high downward communication (β=.19, p=.009) showed higher patient safety management activities. The models' explanatory power was 21.0%. Conclusion Based on the results of this study, further research is needed to investigate the differences in patient safety management activities according to gender, the number of nurses per ward, and the nursing delivery system. Lowering informal communication and strengthening authentic leadership and downward communication may improve nurses’ patient safety management activities.

Purpose: This study examined the influence of patient safety management systems, leadership, and communication types on nurses’ patient safety management activities. Methods: Participants were 237 nurses who has been working in medical institutes for over 6 months. Online self-report questionnaires were conducted. Measures included patient safety management systems, transformational leadership, authentic leadership, communication types, and patient safety management activities. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson’s correlation coefficients, and multiple regression with SPSS/WIN 24.0. Results: According to the general characteristics, patient safety management activities were higher among nurses who were female (t=4.27, p<.001), charge nurses (t=-2.41, p=.016), had healthcare accreditation experience (t=4.36, p<.001), and worked in nursing units implementing a team nursing method (F=6.26, p=.002) with more than 30 nurses (F=6.28, p=.043). Female nurses (β=.16, p=.015) with high authentic leadership (β=.21, p=.002), low informal communication (β=-.21, p=.004), and high downward communication (β=.19, p=.009) showed higher patient safety management activities. The models' explanatory power was 21.0%. Conclusion Based on the results of this study, further research is needed to investigate the differences in patient safety management activities according to gender, the number of nurses per ward, and the nursing delivery system. Lowering informal communication and strengthening authentic leadership and downward communication may improve nurses’ patient safety management activities.

Purpose: This study examined the influence of patient safety management systems, leadership, and communication types on nurses’ patient safety management activities. Methods: Participants were 237 nurses who has been working in medical institutes for over 6 months. Online self-report questionnaires were conducted. Measures included patient safety management systems, transformational leadership, authentic leadership, communication types, and patient safety management activities. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson’s correlation coefficients, and multiple regression with SPSS/WIN 24.0. Results: According to the general characteristics, patient safety management activities were higher among nurses who were female (t=4.27, p<.001), charge nurses (t=-2.41, p=.016), had healthcare accreditation experience (t=4.36, p<.001), and worked in nursing units implementing a team nursing method (F=6.26, p=.002) with more than 30 nurses (F=6.28, p=.043). Female nurses (β=.16, p=.015) with high authentic leadership (β=.21, p=.002), low informal communication (β=-.21, p=.004), and high downward communication (β=.19, p=.009) showed higher patient safety management activities. The models' explanatory power was 21.0%. Conclusion Based on the results of this study, further research is needed to investigate the differences in patient safety management activities according to gender, the number of nurses per ward, and the nursing delivery system. Lowering informal communication and strengthening authentic leadership and downward communication may improve nurses’ patient safety management activities.

Purpose: This study examined the influence of patient safety management systems, leadership, and communication types on nurses’ patient safety management activities. Methods: Participants were 237 nurses who has been working in medical institutes for over 6 months. Online self-report questionnaires were conducted. Measures included patient safety management systems, transformational leadership, authentic leadership, communication types, and patient safety management activities. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson’s correlation coefficients, and multiple regression with SPSS/WIN 24.0. Results: According to the general characteristics, patient safety management activities were higher among nurses who were female (t=4.27, p<.001), charge nurses (t=-2.41, p=.016), had healthcare accreditation experience (t=4.36, p<.001), and worked in nursing units implementing a team nursing method (F=6.26, p=.002) with more than 30 nurses (F=6.28, p=.043). Female nurses (β=.16, p=.015) with high authentic leadership (β=.21, p=.002), low informal communication (β=-.21, p=.004), and high downward communication (β=.19, p=.009) showed higher patient safety management activities. The models' explanatory power was 21.0%. Conclusion Based on the results of this study, further research is needed to investigate the differences in patient safety management activities according to gender, the number of nurses per ward, and the nursing delivery system. Lowering informal communication and strengthening authentic leadership and downward communication may improve nurses’ patient safety management activities.

Purpose: DNA damage and repair responses are induced by metabolic diseases and environmental stress. The balance of DNA repair response and the antioxidant system play a role in modulating the entire body’s health. This study uses a high-fat and high-calorie (HFC) drink to examine the new roles of a plant-based multivitamin/mineral supplement with phytonutrients (PMP) for regulating the antioxidant system and cellular DNA repair signaling in the body resulting from metabolic stress. Methods: In a double-blind, randomized, parallel-arm, and placebo-controlled trial, healthy adults received a capsule containing either a PMP supplement (n = 12) or a placebo control (n = 12) for 8 weeks. Fasting blood samples were collected at 0, 1, and 3 hours after consuming a HFC drink (900 kcal). The blood samples were analyzed for the following oxidative stress makers: areas under the curve reactive oxygen species (ROS) levels, plasma malondialdehyde (MDA), erythrocytes MDA, urinary MDA, oxidized low-density lipoprotein, and the glutathione:oxidized glutathione ratio at the time points. We further examined the related protein levels of DNA repair signaling (pCHK1 (Serine 345), p-P53 (Serine 15), and γH2AX expression) in the plasma of subjects to evaluate the time-dependent effects of a HFC drink. Results: In a previous study, we showed that PMP supplementation for eight weeks reduces the ROS and endogenous DNA damage in human blood plasma. Results of the current study further show that PMP supplementation is significantly correlated with antioxidant defense. Compared to the placebo samples, the blood plasma obtained after PMP supplementation showed enhanced DNA damage response genes such as pCHK1(Serine 345) (a transducer of DNA response) and γH2AX (a hallmark of DNA damage) during the 8 weeks trial on metabolic challenges. Conclusion Our results indicate that PMP supplementation for 8 weeks enhances the antioxidant system against oxidative stress and prevents DNA damage signaling in humans.

Objective: The aim of the present study was to investigate the influence of comorbid oppositional defiant disorder (ODD) on clinical features and neuropsychological profiles of children with attention-deficit/hyperactivity disorder (ADHD). Methods: We divided the participants into three groups: the ADHD with ODD (ADHD/ODD) (n=36), ADHD without ODD (ADHDoODD) (n=307), and control groups (n=128). Parents of the participants completed the ADHD Rating Scale, Social Responsiveness Scale (SRS), Korean Personality Rating Scale for Children (K-PRC), and 10-item mania scale from the Parent General Behavior Inventory (P-GBI-10M). Neuropsychological profiles were assessed using the Advanced Test of Attention (ATA), Children’s Color Trails Test, and Stroop Color and Word Test. Results: The ADHD/ODD group had more ADHD symptoms and functional impairments in relationships with teachers and peers, and self-esteem than the ADHDoODD group. The ADHD/ODD group scored higher in Social Communication (p<0.001) and Autistic Mannerisms (p<0.001) subscales of SRS, P-GBI-10M (p<0.001), and Delinquency (p<0.001) and Psychosis (p<0.001) subscales of K-PRC than the ADHDoODD group. Commission Errors (p<0.001) and Response-Time Variability (p<0.001) in Visual ATA and Commission Errors (p<0.001) in Auditory ATA were significantly higher in the ADHD/ODD group than in the ADHDoODD group. Conclusion The present study suggests that patients with ADHD with ODD experience more ADHD symptoms and neuropsychological deficits than those with ADHD without ODD. These results also imply that comorbid ODD is associated with greater social impairment and emotional dysregulation.