4.Delayed Post-hypoxic Leukoencephalopathy after Carbon Monoxide Intoxication Improved by High-dose Steroid Treatment
Journal of the Korean Neurological Association 2024;42(3):259-261
Delayed post-hypoxic leukoencephalopathy (DHPL) is a demyelinating syndrome characterized by acute onset of neuropsychiatric symptoms within days to weeks following apparent recovery from coma after a period of prolonged cerebral hypo-oxygenation. The majority of DPHL cases are associated with carbon monoxide intoxication. There is no specific treatment, and the prognosis is usually poor. However, we present a case of DHPL patient with akinetic mutism, parkinsonism, stool and urine incontinence, and severe cognitive impairment improved after treatment with high-dose steroid therapy.
5.Mild Cognitive Impairment.
Journal of the Korean Neurological Association 2016;34(3):167-175
Mild cognitive impairment (MCI) is an intermediate cognitive state between normal aging and dementia. It has disparate features in activities of daily life which is interfered notably in dementia. Recently, there have been consistent reports of MCI which is predementia, however significant controversy exist. In this review, we make out the diagnostic criteria, classification, risk factor, prevalence, diagnostic test including neuroimaging and biomarkers, management, and prognosis of MCI. This review will cover current knowledge and future directions on MCI.
Aging
;
Biomarkers
;
Classification
;
Dementia
;
Diagnostic Tests, Routine
;
Mild Cognitive Impairment*
;
Neuroimaging
;
Prevalence
;
Prognosis
;
Risk Factors
7.Validity and Reliability of the Korean Versions of the 9- and 19-Item Wearing-Off Questionnaires in Parkinson’s Disease
Jinse PARK ; Wooyoung JANG ; Jinyoung YOUN ; Eungseok OH ; Suyeon PARK ; Yoonsang OH ; Hee-Tae KIM ; Soohyun LIM
Journal of Clinical Neurology 2024;20(5):487-492
Background:
and Purpose The wearing-off (WO) phenomenon is the most common motor complication in advanced Parkinson’s disease (PD), but its identification remains challenging. The 9- and 19-item Wearing-off Questionnaires (WOQ-9 and WOQ-19) are self-assessment tools for motor and nonmotor symptoms that are widely used for WO screening. We produced Korean versions of the WOQ-19 and WOQ-9 (K-WOQ-19 and K-WOQ-9) and investigated their validity and reliability.
Methods:
We used the translation–back translation method to produce K-WOQ-19 and KWOQ-9, which were self-administered by 124 patients with PD. We conducted in-depth 10-minute interviews for confirming the presence of the WO phenomenon, and then stratified the participants into groups with and without WO. Diagnostic accuracy was assessed by analyzing receiver operating characteristic curves. Concurrent validity was assessed using the Movement Disorder Society–Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) and the Hoehn and Yahr stage with Spearman’s rank correlation analysis. Reliability was assessed based on test–retest Cohen’s kappa (κ) values and intraclass correlation coefficients (ICCs).
Results:
The optimal cutoff scores on the K-WOQ-19 and K-WOQ-9 for WO screening were 4 and 2, respectively. The test–retest ICCs of K-WOQ-19 and K-WOQ-9 were 0.943 and 0.938, respectively. Nineteen of the combined 20 items in K-WOQ-19 and K-WOQ-9 showed moderate-to-substantial agreement (κ=0.412–0.771, p<0.001). The scores on the translated scales were significantly correlated with MDS-UPDRS IV scores.
Conclusions
K-WOQ-19 and K-WOQ-9 are reliable and valid tools for detecting WO, with optimal cutoff scores of 4 and 2, respectively.
8.Sleep Disorders Associated With Movement Disorders and Dementia.
Daeyoung KIM ; Eungseok OH ; Ae Young LEE
Journal of the Korean Neurological Association 2013;31(4):219-225
Sleep disorders are common, occurring in both healthy elderly people and in association with neurodegenerative diseases, sometimes preceding other clinical manifestations of those diseases. The sleep disorders of neurodegenerative diseases include insomnia, hypersomnia, parasomnia, excessive nocturnal motor activity, circadian sleep-wake rhythm disturbances, and sleep breathing disorders. This review addresses the neuroanatomical basis of sleep, the associated regulatory mechanisms and neurotransmitters, and the relationship between cognitive function and sleep. Furthermore, the clinical features of sleep disorders in a wide variety of neurodegenerative diseases are reviewed, including movement disorders and dementia.
Aged
;
Dementia*
;
Disorders of Excessive Somnolence
;
Humans
;
Motor Activity
;
Movement Disorders*
;
Neurodegenerative Diseases
;
Neurotransmitter Agents
;
Parasomnias
;
Respiration
;
Sleep Wake Disorders*
;
Sleep Initiation and Maintenance Disorders
9.Reversible Cerebellar Leukoencephalopathy Associated With Oral Methotrexate.
Juyoun LEE ; Eungseok OH ; Seong Hae JEONG ; Eun Hee SOHN ; Ae Young LEE
Journal of the Korean Neurological Association 2014;32(3):168-170
Methotrexate (MTX)-induced leukoencephalopathy is the most often reported leukoencephalopathy following intrathecal or intravenous administration. A 72-year-old woman developed leukoencephalopathy localized to the cerebellum after treatment with oral MTX at a dose of 15 mg/week for 3 years. She complained of subtle imbalance during walking and reported having fallen. Her symptoms improved after discontinuation of MTX, and the leukoencephalopathy resolved. This is therefore a case report of selective cerebellar reversible leukoencephalopathy associated with oral MTX.
Administration, Intravenous
;
Aged
;
Cerebellum
;
Female
;
Humans
;
Leukoencephalopathies*
;
Methotrexate*
;
Walking
10.Hemichorea following Temporo-Parietal Infarction.
Dan A OH ; Eungseok LEE ; Soo Jeong KIM ; Hee Kwon PARK ; Joung Ho RHA ; Cindy W YOON
Journal of the Korean Neurological Association 2016;34(2):130-132
Hemichorea after cortical infarction has rarely been reported. We report a female patient in which hemichorea of the right extremities developed following a left temporo-parietal infarction. An acute infarction in the territory of the inferior division of the left middle cerebral artery was evident in diffusion-weighted imaging, but the basal ganglia, thalamus, and brainstem appeared normal. Her choreic movement gradually improved after administering haloperidol, and the hemichorea disappeared after 4 days.
Basal Ganglia
;
Brain Stem
;
Chorea
;
Extremities
;
Female
;
Haloperidol
;
Humans
;
Infarction*
;
Middle Cerebral Artery
;
Thalamus