Cytokeratin 7 has been known to be present in various types of human epithelial cells including the ovarian neoplasms, but not in colon cancers. The antibody to colon ovarian tumor antigen (COTA) has been introduced as a marker of colon and ovarian tumors. The aim of this study was to evaluate the usefulness of cytokeratin 7 and COTA in the differential diagnosis between ovarian primary and metastatic tumors. Nineteen primary ovarian epithelial tumors, seven metastatic carcinomas of the ovary from the stomach, three metastatic carcinomas of the ovary from the colon, one mucinous tumor of the ovary associated with a mucinous tumor of the appendix and pseudomyxoma peritonei, and nineteen colonic and twenty gastric adenocarcinomas were stained with monoclonal antibodies to cytokeratin 7 and COTA. The results are summerized as follows; In the primary ovarian tumors, 94.4% were positive for cytokeratin 7 and 50% were positive for COTA. In the primary colonic adenocarcinomas, 94.7% were negative for cytokeratin 7 and 68% were positive for COTA. In the metastatic ovarian tumor from the colonic adenocarcinomas, 100% were negative for cytokeratin 7 and positive for COTA. In the primary gastric adenocarcinomas, 40% were negative for cytokeratin 7 and 85% were negative for COTA. In the metastatic ovarian tumor from the gastric adenocarcinomas, 43% were negative for cytokeratin 7 and 14% were negative for COTA. From the results of this study, it could be concluded that in the differential diagnosis of primary ovarian tumors from metastatic colonic carcinomas, positive reaction for cytokeratin 7 suggests a primary ovarian tumor but a negative reaction for cytokeratin 7 and positive reaction for COTA suggest metastatic colonic carcinomas. The results of this study also reveal that cytokeratin 7 and COTA are not useful in the differential diagnosis of primary ovarian tumors from metastatic gastric carcinomas.
Adenocarcinoma ; Antibodies, Monoclonal ; Appendix ; Colon* ; Colonic Neoplasms ; Diagnosis, Differential* ; Epithelial Cells ; Female ; Humans ; Keratin-7* ; Keratins* ; Mucins ; Ovarian Neoplasms ; Ovary ; Pseudomyxoma Peritonei ; Stomach

With the increasing number of the occupational accidents proportionate to the rapid development of modern culture, fractures of the hand have become one of the commonest fractures of the human body. The authors have reviewed 211 cases of injured hand in industry which were treated in the department of orthopedic surgery, InCheon Severance hospital from Jan. to Dec. in 1989. The following results were obtained; 1. The peak incidence was in the age group from 21 to 30 years in 87 cases (41.2%). Injured males outnumbered females predominantly by 92.9% vs 7.1%. 2. The hand injuries happened most commonly in the day time (from 8 oclock A.M. to 6 oclock P.M.) but there were no differences between month in the year. 3. Most of patients injured hand (73.9%) arrived at hospital within 1 hour after accidents. 4. The commonest cause of the injury was due to electric saw (21.9% ). 5. Of the 98 fracture cases left hand was more frequently involved than right hand and 64 cases monodigit and remained were polydigits. 6. 43 (32.6%) of total 132 fractured sites were index finger and 74 (56.1%) were distal phalanx. 7. The index finger was also most vulnerable to amputation (56.8% out of 44 amputation cases) and the most distal part was more vulnerable to amputation. 8. The most common method was primary closure and splint. The method of treatment was affected in part by the economic and social status of the patients. 9. In order to prevent hand injuries in industry, preventive policy should be established by improvement of working environments, machines and education.
Accidents, Occupational ; Amputation ; Education ; Female ; Fingers ; Hand Injuries ; Hand ; Human Body ; Humans ; Incheon ; Incidence ; Male ; Methods ; Orthopedics ; Splints

Transient synovitis is characterized by the development of pain arising from the hip and often felt in the thigh or knee in children between the ages of 2 and 12 years. The benign self-limiting nature of this condition has made it difficult to establish the caus'e. However, the condition is generally conceded to be the commonest cause of a painful hip in childhood. The disease is of interest, not because of its disabling condition, but because of the difficulty in differentiating it from more serious diseases of the hip, such as tuberculosis, osteomyelistis, or Legg-Perthes disease. The author had studied the clinical symptoms and signs, roentgenologic findings, and treatment of the 34 patients who had admitted to Severance Hospital Yonsei Medical Center in Seoul, Korea from January 1970 to December 1979, under the diagnosis of the transient synovitis of the hip and summerized the results as follows; 1. There was probably associated with predisposing factors such as infection and allergy. 2. Among the 34 patients, 28 cases(82.4%) were male and 6 cases(17.6%) were female. The most prevalent age were between 6 and 10 years old. 3. Pain and limitation of motion of the hip joint were the most common symptoms. In 56.5% of the patients, roentgenographic findings were positive. In 50% of the patients, the erythrocyte sedimentation rates were increased. 4. The treatment was conservative including bed rest, skin traction on the affected leg, non-weight bearing, antibiotics, and sedatives. Most of all patients had improved symtoms and signs within two weeks of treatment. 5. The course of this condition was short and benign with complete resolution. The occasional hip with chronic or recurrent symptoms could be distinguished from Legg-Perthes disease by the short history, normal radiographs, and the complete resolution.
Anti-Bacterial Agents ; Bed Rest ; Blood Sedimentation ; Causality ; Child ; Clinical Study ; Diagnosis ; Female ; Hip Joint ; Hip ; Humans ; Hypersensitivity ; Hypnotics and Sedatives ; Knee ; Korea ; Leg ; Legg-Calve-Perthes Disease ; Male ; Seoul ; Skin ; Synovitis ; Thigh ; Traction ; Tuberculosis

BACKGROUND: When one of family members must be treated, the others are required to get various forms of changes including modification of their proper roles in the family. Particularily when he or she can not perform his or her activities of daily living(ADL) owing to functional impairment by himself or herself, there seems to be greater dependence upon his or her family. Accordingly, we tried to give help in the treatment of patients through the comparative analysis concerning functional impairment in both groups on the assumption that there is difference of family function between two family groups which have a patient in family, or not. METHODS: This study was carried out to 83 inpatients in Sun Hospital in Dae Jeon and local rehabilitation clinics in Iksan from 1. July. 1995 to 31. Jun. 1996. We evaluated activites of daily living by using modified Barthel Index(MBI) and classified them into dependent group with 60 points or less(6roup I ), and independent group with more than 60 points(Group II). We also used Family APGAR score and FACES III to evaluate their family functions. RESULTS: MBI scores to evaluate ADL were 42.9+/-15.6 in Group I and 82.1+/-17.9 in Group II. Family APGAR scores were 6.93+/-2.52 in Group I and 7.24+/-17.9 in Group II but there was no significance between two groups. Types of family according to Family APGAR score were highly functional, morderate dysfunctional, and severly dysfunctional one in order of frequency in both groups, but there was no significance in their frequencies in both groups. Types of Family in view of cohesion was disengaged, separated, connected, and enmeshed one in order of frequency in Group I, and separated, disengaged, connected, and enmeshed one in order of frequency in Group II but there was no significance between two groups. Types of family in view of adaptability were rigid, chaotic structured,and flexible one in order of frequency in Group I, and were flexible, structured, rigid, and chaotic one in orders in Group II, which showed significance between two groups. Extremal types of family structure were large in numbers in Group I, but it didnt show significance. CONCLUSIONS: Assuming that there were large numbers of rigid and chaotic family in Group I, it is considered that tne family which has a patient with severely impaired function seems to have weaker adaptability to their family stresses than otherwise. Therefore, it is desirable that physicians who take charge of such patients provide continuous and comprehensive medical care for them including their family with greater concerns and through analysis and assessment of their family functions.
Activities of Daily Living ; Apgar Score ; Daejeon ; Humans ; Inpatients* ; Jeollabuk-do ; Rehabilitation* ; Solar System

PURPOSE: We evaluated the ability of endo-rectal coil MRI (ER-MRI) to predict the local pathological stage of prostate cancer prior to radical prostatectomy and compared the results with those of transrectal ultrasonography (TRUS). MATERIALS AND METHODS: ER-MRI using high field magnets (1.5 Tesla) were performed in 22 patients (mean age 62.8 years, range 51-73) with clinically localized prostate cancer before radical prostatectomy. Of the 22 patients, 17 patients were also assessed by TRUS. The results of the imaging techniques were compared with the post-operative histopathological findings. As one patient with pelvic lymph node metastasis, which was detected on frozen-section examination during surgery, was spared radical prostatectomy, the final evaluation included 21 patients. RESULTS: DSeven of the 21 patients (33%) were found to have extraprostatic extension (EPE), and 5 had seminal vesicle invasion (SVI). The sensitivity and specificity for diagnosing EPE using ER-MRI were 62.5% and 84.6%, respectively, and 16.7% and 100% with TRUS. The sensitivity and specificity for diagnosing SVI were 80.0% and 93.8%, respectively with ER-MRI, and 0% and 92.3% with TRUS. The accuracy of predicting SVI was 90.5% with ER-MRI compared to 70.6% with TRUS. CONCLUSIONS: ER-MRI was significantly better than TRUS for determining the local extent of prostatic cancer and for prediction of SVI in the preoperative staging of clinically localized prostate cancer.
Humans ; Lymph Nodes ; Magnetic Resonance Imaging* ; Neoplasm Metastasis ; Prostate* ; Prostatectomy ; Prostatic Neoplasms* ; Seminal Vesicles ; Sensitivity and Specificity ; Ultrasonography

STUDY DESIGN: A retrospective clinical study about problems in distal ends of long segment fusion to L5 and S1. Authors compared the incidence of fixation failure and analized the problematic cases. OBJECTIVES: To verify the causes and associated conditions for high incidence of fixation failure in distal ends of long segment fusion. SUMMARY OF LITERATURE REVIEW: In Degenerative lumbar diseases, degenerative kyphosis, degenerative scoliosis with revision surgery and multiple stenosis require long level fusion which is accompanied by various fixation problems extending to sacrum. Fusion to sacrum provides excellent correction of deformity. However, it results in the loss of movable segment and concentration of the force on lumbosacral region. Moreover it may foresee the problems of fixation or fusion and S-I joint problems. But long fusion to L5 leaving one movable segment below can result in early degenerative change of this segment. MATERIAL AND METHODS: Among 65 patients given long level fusion involving more than 3 segment in National Medical Center from January 1991 to may 2000, 45 patients were selected and were followed for more than 2 years. First group (G1) involving L5 were 14 cases. Second group (G2) involving S1 were 31 cases. We evaluated loosening of implant-hallo around screw, pull out screw, breakage of screw or rod, change of adjacent segment and pseudarthrosis by means of radiologic modality. RESULTS: Follow up radiologic findings showed 28.6% of loosening of implant on L5 in G1. G2 showed 41.9% of hallo around screw in S1. Among cases with more than 4 level fusion, G1 showed 33.3% lower segment screw loosening and G2 showed 57.9%. In G2, group performed more than 3 level fusion showed 16.7% lower segment screw loosening. More than 4 level fusion showed higher loosening rate (57.9%) with the statistical segmental corellation (P=0.023). Lower end screw loosening occured 16% in cases with interbody fusion and 55% in cases without interbody fusion and it showed statistical corellation (P=0.047). Also cases with deformity correction by posterior instrumentation showed higher loosening rate (60%) and showed 18.2% in situfusion cases and it showed statistical corellation (P=0.049). In second case, sacral screw loosening occured more frequently in patients of osteoporosis (54%), sagittal imbalance postoperatively (38%), correction loss (31%). Only 1 case of G1 showed an increased degenerative change between L5-S1. CONCLUSION: In fusion to S1 in degenerative lumbar disease, factors such as long level fusion more than 4 segments by posterior instrumented correction, correction loss, sagittal imbalance and accompanied osteoporosis is related to high incidense sacral implant loosening-hallo around screw, pull out screw, breakage of screw or rod. So if these kind of risk factor exist, it seems that the anteriorposterior interbody fusion in necessary. Postoperative L5-S1 degenerative change did not occur in follow up period in patient with well preserved sagittal balance postoperatively in this follow up periods.
Congenital Abnormalities ; Constriction, Pathologic ; Follow-Up Studies ; Humans ; Incidence ; Joints ; Kyphosis ; Lumbosacral Region ; Osteoporosis ; Pseudarthrosis ; Retrospective Studies ; Risk Factors ; Sacrum ; Scoliosis ; Spine*

No abstract available.
Osseointegration*

No abstract available.
Spinal Stenosis*

The antiphospholipid antibody syndrome is an acquired multisystemic disorder characterized by persistent elevated antiphospholipid antibodies and/or hypercoagulation in veins or arteries, or both. The clinical manifestations of the antiphospholipid antibody syodrome are recurrent thrombosis, fetal loss, thrcenbocytopenia, and various cutaneous lesions. Skin lesions are the first sign of this syndrome in 41% of patients and systemic thrombosis develops in 40% of them. Livedo reticularis is the most common cutaneous finding of the antiphosphotipid antibody syndrome. Although vasculitis has not been frequently noted in antiphospholipid antibody syndrome, some vasculitis such as polyarteritis nodosa, giant cell arteritis, and other nonspecific vasculitides have been found in association with antiphospholipid antibody syndrome. We present a male patient with typical manifestations of leukocytoclastic vasculitis with deep vein thrombosis and positive antiphospholipid antibodies. It suggests that a case of antiphospholipid antibody syndorme was accompanied with cutaneous leukocytoclastic vasculitis.
Antibodies, Antiphospholipid* ; Antiphospholipid Syndrome ; Arteries ; Giant Cell Arteritis ; Humans ; Livedo Reticularis ; Male ; Polyarteritis Nodosa ; Skin ; Thrombosis ; Vasculitis* ; Vasculitis, Leukocytoclastic, Cutaneous ; Veins ; Venous Thrombosis

PURPOSE: To evaluate the effects of the prophylactic use of mitomycin C in low concentration and short duration (0.01%, 60 sec) in inhibiting haze formation after laser epithelial keratomileusis (LASEK). METHODS: Forty-two eyes of 71 patients with refractive error from -5.0 D to -8.50 D were enrolled in this study. The eyes were divided into 2 groups according to the use of mitomycin C. All eyes were examined for refraction, UCVA, BCVA, and the incidence and degree of corneal haze before surgery and at 1, 3, 6 months after operation. RESULTS: Fifty-one eyes were operated by LASEK with intraoperative application of 0.01% mitomycin C for 60 seconds and 20 eyes were operated by LASEK without mitomycin C. There was no statistical difference in UCVA, BCVA, and spherical equivalent between 2 groups. In the study group, the degree of corneal haze was 0.54+/-0.39. 0.38+/-0.48, 0.30+/-0.50 at 1, 3, 6 months after operation and in the control group, 0.92+/-0.58, 0.79+/-0.66, 0.50+/-0.60 at 1, 3, 6 months after operation respectively. The difference in the postoperative corneal haze between 2 groups was statistically significant at 1, 3 months after operation, but at 6 months the difference was not statistically significant. CONCLUSIONS: In this study, intraoperative single use of mitomycin C in lower concentration and short duration could reduce the formation of corneal haze effectively in early postoperative period after LASEK. A more longterm period of follow up will be required to assess the continuous effect of mitomycin C on inhibiting corneal haze after LASEK.
Follow-Up Studies ; Humans ; Incidence ; Keratectomy, Subepithelial, Laser-Assisted* ; Mitomycin* ; Postoperative Period ; Refractive Errors