Alopecia areata(AA) is a common dermatologic disease, the origin of which is still unknown. At least, it has been associated with some genetic influences in the etiopathogenesis. We have now evaluated AA patients to study the actual association of the genetic role by fingerprint analysis. The incidences of six or more arches were determined in 74 female and 86 male patients excluding alopecia totalis and universalis, and in healthy 167 female controls, based on Selmanowitz's thesis (1974). The results of this study are follows: 1. The difference between the frequency in AA patients(7. 5%) and in controls (3.3%) reaches the statistical significance(p<0.05 by x2-test). 2. The association of genetic background in AA is strengthened in the group of female patients(p<0. 01), recurrent episode(p<0.01). and multiplex farm (p<0.01). 3. Twenty patients(12. 5%) have family history. The incidence in 3(15.0%) of these patients is considerably common but not statistically significant. A correlation of biologic relevance and family predisposition in AA is not precluded. 4. The frequency of arches in patients and in controls is increased on both second fingers and decreased on both fourth fingers. It is more common on both second and left third fingers in female patients. The incidence of arches averages about 6 67% in patients and 4. 58% in controls.
Alopecia Areata* ; Alopecia* ; Dermatoglyphics* ; Female ; Fingers ; Humans ; Incidence ; Male

We experienced 12 cases of 8 patients Duputren's contracture, which is a rare disease entity and characterized by proliferative fibroplasia of the subcutaneous palmar aponeurosis and contracture of the palmar fascia and result in the deformity of the hand and fingers. Among 12 cases, we operated 11 cases and the result was excellent in 2 cases and good in 6 cases, and there were no evidence of recurrence over the follow-up period, average 4.1 years.
Congenital Abnormalities ; Contracture ; Dupuytren Contracture ; Fascia ; Fingers ; Follow-Up Studies ; Hand ; Humans ; Rare Diseases ; Recurrence

We report herein a case of polymorphic pemphigoid in a 65-year-old woman, who had one-year history of generlized polymorphic eruption with intensely pruritic excoriated vesicobiullous lesions and residual pigmentation. Face and oral mucosa were spared. The skin biopsy specimen showed a subepidermal blister containing many eosinophils. Linear deposition of 1gG and C3 along the basement membrane was noticed on direct irnmunofluorescerice. Polyclonal garnmopathy with a tendency of beta-gamma bridging and increased IgG, IgA and kappachain, was frund on serum protein electrophoresis and immunoelectrophoresis. Skin lesions were well coritrolled by a combined therapy of prednisolone(20 mg/d), dapsone(100 mg/d) and cyclophosphamide(100 mg/d) for 4 months. Direct immunofluorescence performed 11 rnonths after the cnmpletion of the therapy was negative.
Aged ; Basement Membrane ; Biopsy ; Blister ; Electrophoresis ; Eosinophils ; Female ; Fluorescent Antibody Technique, Direct ; Humans ; Immunoelectrophoresis ; Immunoglobulin A ; Immunoglobulin G ; Mouth Mucosa ; Pemphigoid, Bullous* ; Pigmentation ; Skin

We experienced a case of granulation tissue occuring in lateral sulci of the right thumb, index, middle and left thumb, middle finger nails in 71-year-old psoriatic male patient taking 5pmg daily(0.6mg/kg/day) during 4th week of etretinate therapy. The excision of the granulation lesion and partial nail ablation was performed and his doses was lowered to 25mg daily (0. 3mg/kg/day). The condition were resolved with no recurrence 4 weeks later after the operation.
Acitretin* ; Aged ; Etretinate* ; Fingers ; Granulation Tissue* ; Humans ; Male ; Nails ; Recurrence ; Thumb

No abstract available.
Pancreatitis*

A new fibrinogen system, consisting of highly concentrated fibrinogen and thrombin, is going to be applied in many clinical fields. Especially in injuries of the cartilagenous joint surface as chondral or osteochondral fractures, replantation of the fragments must be considered mandarory in order to preserve joint congruence and to prevent further destruction of the articular cartilage. The authors have an encouraging results by using this fibrin adhesive system (F.A.S.) in the experimental works.
Cartilage, Articular ; Fibrin Tissue Adhesive ; Fibrinogen ; Joints ; Replantation ; Thrombin

The ligamentum nuchae is a midline structure extending from the occiput to the spinous process of the 7th cervical vertebra. Radio-opaque formations in the soft tissues behind the processes of the cervical spine has been known to radiologists since Barsony's description in 1929. It may actually be a normal sesamoid, or it may have developed as a result of previous trauma. But this remains hypothetical in that histological endochondral ossification sequence has not yet been demonstrated. These are generally asymptomatic and of clinical significance only in so far as they may be confused with fracture or tumors. Two patients who had clinical symptoms with or without previous trauma visited and they were relieved of their clinical symptoms by surgical excision. Then, we report on two unusual cases which were symptomatic.
Humans ; Spine

We report here-in a case of benign hemangioendothelioma occurring in a 2 day-old male neonate on central portion of lumbar area. The lesion was movable, and elevated firm nodule, measuring 1.5x2.0 cm in size. For the purpose of diagnosis and therapy, excisional biopsy was performed, which revealed typical histopathologic pictures in the deep dermis and subcutaneous area. The lesion showed no recurrence at follow-up check after 6 months.
Biopsy ; Dermis ; Diagnosis ; Follow-Up Studies ; Hemangioendothelioma* ; Hemangioma ; Humans ; Infant, Newborn ; Male ; Recurrence

Plexiform neurofibroma is considered a pathognomic of Von Recklinghousen's disease, which involves the deep and large nerve trunk. These are large irregular nerve fascicles which result from an increase in endoneural matrix within individual nerve facicles, without an increased number of nerve fibers. We experenced a case of Von Recklinghausen's disease in a 24 year-old male who had variable cutaneous skeletal, and CNS lesions. He presented multiple neurofibromas, cafe-au-lait spots, and axillary freckles as common cutaneous lesions of NF-I and giant pigmentation, sacral hypertrichosis, and plexiform neurofibroma as unusual cutaneous lesions. Also he had a scoliosis, bowing deformity of the humerous and wedging deformity of the body of the 5th cervical spine as a skeletal manifestation and cortical calcification in the occipital area as a CNS manifestation.
Cafe-au-Lait Spots ; Congenital Abnormalities ; Humans ; Hypertrichosis ; Male ; Melanosis ; Nerve Fibers ; Neurofibroma, Plexiform* ; Neurofibromatoses ; Neurofibromatosis 1 ; Pigmentation* ; Scoliosis ; Spine ; Young Adult

PURPOSE: To determine the role of cytokines in the apoptosis of rat's liver following irradiation. MATERIALS AND METHODS: Sprague-Dawley rats were irradiated to entire body with a single dose of 8 Gy. The rats were divided into 5 groups according to the sacrifice day after irradiation. The liver and blood after 1, 3, 5, 7, and 14 days irradiation were sampled for evaluation of mechanism of apoptosis and role of cytokine in relation to radiation-induced tissue damage. The study was composed of microscopic evaluation of liver tissue, in situ detection method for apoptosis, immunohistochemical stain of IL-1, IL-4, IL-6 and TNF, bioassay and radioimmunoassay of IL-6 in liver tissue and blood. RESULTS: Radiation-induced liver damage was noted from first day of radiation, and most severe parenchymal damage associated with infiltration of chronic inflammatory cells was seen in the groups of 5 days after radiation. A number of apoptosis were observed 1 day after radiation on both light microscope and in situ method. Afterwards, the number of apoptosis was gradually diminished. On immunohistochemical study, IL-1 and TNF were expressed 1, 3 days after radiation, but not expressed after that. IL-4 was not expressed in the entire groups. IL-6 was expressed with strong positivity in 1, 3 days after radiation. Bioassay and RIA of IL-6 in liver tissue and blood showed the highest value in 1 day after radiation, and the value is diminished after then. CONCLUSION: Apoptosis seemed to be the important mechanism of radiation-induced liver damage, and is possibly induced by the release of cytokines, such as IL-1, IL-6, TNF in view the simultaneously increased appearance of apoptosis and cytokines.
Animals ; Apoptosis* ; Biological Assay ; Cytokines* ; Interleukin-1 ; Interleukin-4 ; Interleukin-6 ; Liver* ; Radioimmunoassay ; Rats ; Rats, Sprague-Dawley