The clinical observations regarding cutaneous manifestations of in-and outpatients with diabetes mellitus was performed in the Diabetic Clinic, Seoul National University Hospital during the period of 11 months from April, 1979 to March, 1980. The number of patients were total 525, 268 in male and 257 in female. The average age of patients was 51. 1 year-old. Results were as follows, 1. In the 525 patients, 270 patients (51. 1%) revealed various cutaneous manifestations. 2. There were statistical significant differences in sex distributions of infection, pruritus, shin spots, rubeosis and bullosis diabeticorum. 3. Systemic complications sush as retinopathy, neuropathy, nephropathy and hypertension were more frequently observed in the patients with skin microangiopathy than with infection or pruritus. 4. There were not any correlations between fasting blood sugar and cutaneous manifestations
Blood Glucose ; Diabetes Mellitus* ; Epidemiologic Studies* ; Fasting ; Female ; Humans ; Hypertension ; Korea* ; Male ; Outpatients ; Pruritus ; Seoul ; Sex Distribution ; Skin

Rectal prolapse is defined as a protrusion of the rectum beyond the anus. Although rectal prolapse was recognized as early as 1500 BC, the optimal surgical procedure is still debated. The varied operative procedures available for treating rectal prolapsed can be confusing. The aim of treatment is to control the prolapse, restore continence, and prevent constipation or impaired evacuation. In elderly and high-risk patients, perineal approaches, such as Delorme's operation and Altemeier's operation, have been preferred, although the incidence of recurrence and the rate of persistent incontinence seem to be high when compared with transabdominal procedures. Abdominal operations involve dissection and fixation of the rectum and may include a rectosigmoid resection. From the late twentieth century, the laparoscopic procedure has been applied to the treatment of rectal prolapse. Current laparoscopic surgical techniques include suture rectopexy, stapled rectopexy, posterior mesh rectopexy with artificial material, and resection of the sigmoid colon with colorectal anastomosis with or without rectopexy. The choice of surgery depends on the status of the patient and the surgeon's preference.
Aged ; Anal Canal ; Colon, Sigmoid ; Constipation ; Humans ; Incidence ; Laparoscopy ; Prolapse ; Rectal Prolapse ; Rectum ; Recurrence ; Surgical Procedures, Operative ; Sutures

Uterine papillary serous carcinoma is a morphologically distinct variant of endometrial carcinoma that is associated with an aggressive behavior with rapid progression and high recurrence, and poor response to salvage treatment. The most common type of malignancy developing in the uterus after radiation therapy is the malignant mixed mullerian tumor, however, the papillary serous carcinomas have rarely been reported.Here we report a case of uterine papillary serous carcinoma which had developed 7 years after radiation therapy for invasive cervical cancer.
Endometrial Neoplasms ; Female ; Recurrence ; Uterine Cervical Neoplasms ; Uterus

No abstract available.
Peripheral Nerves* ; Upper Extremity*

No abstract available.
Cytomegalovirus* ; Humans* ; Polymerase Chain Reaction*

Fibronectin is involved in various cellular activities such as adhesion, proliferation and migration as a substratum. Since the metabolic turnover of fibronectin is much slower than other cellular components, it may be affected by the oxygen free radicals produced in the aging process. Hydroxyl radicals are known to be generated during inflammation and aging process. The purpose of this study is to investigate the influence of fibronectin treated with hydroxyl radicals generated by the H2O2-Cu2+ systems on osteoblast. The bone nodule formation, alkaline phosphatase activity, cell proliferation study and secretion of type I collagen were compared among non-coated, fibronectin-coated and hydroxyl radical treated fibronectin-coated groups. SDS-PAGE and Western blot analysis showed that fibronectin was degradated with hydroxyl radical treatment. The bone nodule formation in the fibronectin-coated group was significantly greater than that in non-coated or hydroxyl radical treated fibronectin-coated group. Alkaline phosphatase activity and cell proliferation were reduced in hydrokyl radical treated fibronectin coated group. In hydrosyl radical treated fibronectin-coated group, mRNA level of type I collagen by RT-PCR was also decreased. This study suggested that fibronectin played important roles in osteoblast activity and fibronectin damaged by the hydrokyl radicals reduced the bone formation of osteoblast through the inhibition of cell proliferation, differentiation and calcification processed.
Aging ; Alkaline Phosphatase ; Animals ; Blotting, Western ; Cell Proliferation ; Collagen Type I ; Electrophoresis, Polyacrylamide Gel ; Fibronectins* ; Free Radicals ; Hydroxyl Radical ; Inflammation ; Osteoblasts* ; Osteogenesis ; Oxygen ; Rats* ; RNA, Messenger

BACKGROUND: Despite the importance of burn-induced encephalopathy, cerebral hemodynamics after burn injury and during resuscitation remains undefined. The aim of our study was to evaluate the effects of a large cutaneous burn injury on the cerebral circulation. METHODS: Anesthetized sheep(n=8) were prepared with vascular catheters, a urinary catheter and a Richmond bolt for intracranial pressure monitoring. A scald injury was inflicted on 70% of total body surface area with hot water. Resuscitation was started 30 minutes after scald with Ringer's lactate to restore and then maintain baseline oxygen delivery. Resuscitation maintained blood pressure, cardiac output and urine output at normal levels. Brain blood flow was measured with colored microspheres. RESULTS: During resuscitation intracranial pressure rose slowly from 10.6+/-1.5 to 17.0+/- 4.0 mmHg(P<0.05) and cerebral perfusion pressure was reduced from 86.4+/- 6.8 to 64.1+/- 2.8 mmHg(P<0.05). During early resuscitation cerebrovascular resistance declined to maintain brain blood flow and oxygen delivery at baseline or better. After 6 hours, cerebrovascular resistance was inappropriately increased during a period of reduced cerebral perfusion pressure which resulted in brain blood flow being half the baseline levels. CONCLUSIONS: These data suggest that autoregulation maintains brain blood flow immediately after burn shock and early resuscitation, but autoregulation may be less effective as burn resuscitation proceeds.
Blood Pressure ; Body Surface Area ; Brain ; Burns* ; Cardiac Output ; Hemodynamics ; Homeostasis ; Intracranial Pressure ; Lactic Acid ; Microspheres ; Oxygen ; Perfusion ; Resuscitation* ; Shock ; Skin ; Urinary Catheters ; Vascular Access Devices ; Water

In 1971, for purpose of reduction of peak stress occuring in cement and trabecular bone of the acetabulum, Harris reported a series of metal-backed acetabular components with removable polyethylene liners that could be replaced if excessive wear occured. Modular designs of hip prostheses have become popular recently, but they introduce the risk of disassembly of the components postoperatively. And introduce of loosening and infection of femoral or acetabular components by debris of polyethylene liner. We report a case of mechanical disassembly of polyethylene liner in cementless metal backed cup, and review previously reported articles.
Acetabulum ; Hip Prosthesis ; Polyethylene

No abstract available.
Carpal Tunnel Syndrome*

Aggressive fibromatosis is a rare benign soft tissue tumor that is difficult to cure because of its infiltrative nature and high tendency to recur locally. The authors retrospectively analyzed 20 patients with histologically-confirmed fibromatosis. All patients underwent surgery with a wide or marginal margin. Five (25%) cases with histologically-negative margins had recurred. External beam radiotherapy was administered to patients whose margins were positive or who had local recurrence. However, out of concern for safety, radiotherapy was not given to two babies and a reproductive-aged woman. The average dose was 5,020 cGy. During the follow-up (mean 32.6 months), all the patients undergoing radiotherapy showed no evidence of local recurrence. A wide local excision has traditionally been the treatment of choice. However, postoperative radiotherapy could be an effective measure for preventing local recurrence in patients with a histologically-positive surgical margin and recurrence independent of any signs of relapse.
Adolescence ; Adult ; Aged ; Child ; Child, Preschool ; Combined Modality Therapy ; Female ; Fibromatosis, Aggressive/radiotherapy* ; Human ; Male ; Middle Age ; Neoplasm Recurrence, Local/radiotherapy