1.Treatment of uterine myoma with a gonadotropin-releasing agonist (D-Trp-6-LHRH).
Eung Gi MIN ; Young Min CHOI ; Jin Yong LEE
Korean Journal of Obstetrics and Gynecology 1991;34(5):673-682
No abstract available.
Leiomyoma*
2.Mechanisms of Increase in Renal Blood Flow During Partial Ureteral Obstruction in Dogs.
Hun Mo YANG ; Young Gi MIN ; Jae Eung YOO
Korean Journal of Nephrology 1998;17(5):686-691
Although tubuloglomerular feedback (TGF) is involved in ureteral obstruction-induced increase in renal blood flow (RBF), its contribution to RBF is not well established due to the concommitant increases in prostaglandin (PG) and renal interstitial fluid pressure (Pisf), both of which affect RBF one way or the other. Since Pisf and TGF are closely affected by renal hemodynamics, RBF will respond differently to increases in ureteral pressure depending on renal hemodynamic conditions. Therefore, the purpose of the present study was to investigate how the changes in renal hemodynamics affect the response of RBF to increases in ureteral pressure. The effect of PG on RBF was assessed by comparing the effects obtained before and after indomethacin, a cyclooxygenase inhibitor. Six anesthetized dogs were prepared with flow probes and inflatable silastic occluder around the renal artery, the ureteral catheter with its free end attached to a water reservoir, and the arterial and venous catheters. RBFs were obtained at ureteral pressures of 0, 15, and 40cmH2O during the maintenance of the renal artery pressure (RAP) at the level of systemic arterial pressure, 10mmHg above and below the lower autoregulatory limit of RBF (65+/-4 mmHg) both before and after indomethacin administration (10mg/kg). In response to the ureteral pressure of 40cmH2O, RBF increased from 172+/-6 to 185+/-10ml/min when RAP's were equal to systemic arterial pressure and decreased from 162+/-10 to 120+/-9 ml/min when RAP's were 55+/-4mmHg. Indomethacin pretreatment, depending on the level of RAP either prevented an increase or augmented a decrease in RBF in response to ureteral pressure elevation. This suggests that RAP-dependent changes in susceptibility of the renal venous system to compression by increased Pisf is the main mechanism by which the changes in renal perfusion pressure modulate the response of RBF to ureteral pressure elevation.
Animals
;
Arterial Pressure
;
Catheters
;
Dogs*
;
Extracellular Fluid
;
Hemodynamics
;
Indomethacin
;
Perfusion
;
Prostaglandin-Endoperoxide Synthases
;
Renal Artery
;
Renal Circulation*
;
Ureter*
;
Ureteral Obstruction*
;
Urinary Catheters
;
Water
3.Selective termination in multiple pregnancy guided by transvaginal sonography.
Eung Gi MIN ; Seung Jae LEE ; Sung Il ROH ; Jong Min PARK ; Jong Young JUN
Korean Journal of Obstetrics and Gynecology 1993;36(3):312-320
No abstract available.
Female
;
Pregnancy
;
Pregnancy, Multiple*
4.Comparison of cryopreservation protocol in human spermatozoa.
Kyung Soon CHEONG ; Eun Suk YOON ; Chung Hyon KIM ; So Hyun PARK ; Ki Chul KIM ; Eung Gi MIN
Korean Journal of Obstetrics and Gynecology 1993;36(7):947-953
No abstract available.
Cryopreservation*
;
Humans*
;
Spermatozoa*
5.The polycystic ovary syndrome.
Korean Journal of Obstetrics and Gynecology 2008;51(8):805-819
The polycystic ovary syndrome (PCOS) is a heterogeneous disorder that is characterized principally by oligomenorrhea or amenorrhea with clinical or laboratory evidence of hyperandrogenemia. Furthermore, it is now recognized that a significant proportion of overweight women with PCOS have hyperinsulinemia. Three features are generally recognized to compose this syndrome, including androgen excess, ovulatory dysfunction, and polycystic ovaries. Because its etiology and natural history are poorly understood, there is controversy about the diagnostic criteria and clinical evaluation of the syndrome. But the diagnosis of PCOS entails two principal steps: (a) to determine whether features suggestive of PCOS are present and (b) to exclude related androgen excess or ovulatory disorders. The PCOS results in a number of immediate and long-term morbidities that are associated with a significant impact on quality of life and on economic costs. Immediate morbidities include menstrual dysfunction and abnormal uterine bleeding, subfertility and infertility, and androgen excess-related dermatologic abnormalities including hirsutism, acne, and androgenic alopecia, and an increased risk of obstetrical complications such as pregnancy-induced hypertension and gestational diabetes. However, PCOS is also associated with an increased risk of various other long-term complications or morbidities including cancer, type 2 diabetes mellitus, the metabolic syndrome, and possibly cardiovascular disease. For the management of PCOS, we should consider not only immediate but also the long-term morbidities.
Acne Vulgaris
;
Alopecia
;
Amenorrhea
;
Cardiovascular Diseases
;
Diabetes Mellitus, Type 2
;
Diabetes, Gestational
;
Female
;
Hirsutism
;
Humans
;
Hyperinsulinism
;
Hypertension, Pregnancy-Induced
;
Infertility
;
Natural History
;
Obesity
;
Oligomenorrhea
;
Ovary
;
Overweight
;
Polycystic Ovary Syndrome
;
Pregnancy
;
Quality of Life
;
Uterine Hemorrhage
6.Heterotopic pregnancies after IVF-ET.
Byeng Kwan LEE ; Sung Keun ROH ; Moon Yung KIM ; Eung Gi MIN ; Jung Hae HWANG ; Jong Min PARK ; Seung Jae LEE
Korean Journal of Obstetrics and Gynecology 1993;36(7):2319-2327
No abstract available.
Pregnancy, Heterotopic*
7.Heterotopic pregnancies after IVF-ET.
Byeng Kwan LEE ; Sung Keun ROH ; Moon Yung KIM ; Eung Gi MIN ; Jung Hae HWANG ; Jong Min PARK ; Seung Jae LEE
Korean Journal of Obstetrics and Gynecology 1993;36(7):2319-2327
No abstract available.
Pregnancy, Heterotopic*
8.Rapid detection of aneuploidy in uncultured fetal cord blood cells by FISH ( Fluorescence In Situ Hybridization ).
Young Min CHOI ; Eun Ju CHANG ; Jong Kwan JUN ; Do Yeong HWANG ; Kyung Soon CHEONG ; Ki Chul KIM ; Eung Gi MIN ; Jin CHOE ; Shin Yong MOON
Korean Journal of Obstetrics and Gynecology 2000;43(3):386-390
OBJECTIVE: To determine the fetal aneuploidy in fetal blood cells from cordocentesis. METHODS: We analyzed their karyotype and performed fluorescence in situ hybridization(FISH) for chromosome 18, 21, X, and Y in 14 cases of fetal blood cells from cordocentesis at Department of Obstetrics & Gynecology, College of Medicine, Seoul National University and Hamchoon Women's Clinic. RESULTS: In all cases we obtained the consistent results in both methods and were able to rapidly detect aneuploidy in uncultured fetal blood cells using FISH before karyotyping with culture for 48 hr. The averages for accuracy of FISH were from 84.6 % to 93.9%. CONCLUSION: In this study we suggest that the rapid detection in uncultured fetal blood using FISH is possible and that this diagnostic method will be clinically useful when rapid result would be demanded.
Aneuploidy*
;
Chromosomes, Human, Pair 18
;
Cordocentesis
;
Fetal Blood*
;
Fluorescence*
;
Gynecology
;
In Situ Hybridization*
;
Karyotype
;
Karyotyping
;
Obstetrics
;
Seoul
9.Late-onset MELAS with Chronic Kidney Disease.
Il Yeon CHOO ; Eung Joon LEE ; Young Gi MIN ; Hyung Min KWON
Journal of the Korean Neurological Association 2017;35(4):237-239
Mitochondrial encephalomyopathy with lactic acid and stroke-like episodes (MELAS) is a multisystem mitochondrial disorder that typically presents in childhood. We report a case of MELAS syndrome diagnosed in a 45-year-old man presented with chronic kidney disease before a stroke-like episode. Genetic testing revealed a m.3243A>G point mutation in the mtDNA. The original diagnostic criteria for MELAS required the onset of stroke-like episodes prior to 40 years of age but this case demonstrates that disease onset may delay in certain individuals.
DNA, Mitochondrial
;
Genetic Testing
;
Humans
;
Lactic Acid
;
Late Onset Disorders
;
MELAS Syndrome*
;
Middle Aged
;
Mitochondrial Diseases
;
Mitochondrial Encephalomyopathies
;
Point Mutation
;
Renal Insufficiency, Chronic*
;
Stroke
10.Detection of Down Syndrome & Edward Syndrome in uncultured amniocytes using FISH ( Fluorescence In Situ Hybridization.
Shin Yong MOON ; Jin CHOI ; Do Yeong HWANG ; Young Min CHOI ; Eun Ju CHANG ; Kyung Soon CHEONG ; Ki Chul KIM ; Eung Gi MIN ; Jin Yong LEE
Korean Journal of Obstetrics and Gynecology 1998;41(11):2859-2863
FISH is suggested as a possible method to detect the numerical and structural abnormalities of chromosomes in interphase nucleus. We performed this study to discuss the clinical usefulness of FISH in uncultured amniocytes and to set up the cut-off value for further study. We collected amniotic fluid samples from patients whose chromosome studies were recommended due to screen positive for Down and Edword syndrome in triple marker test using maternal serum. The centromeric probe for chromosome 18 and the locus-specific probe for chromosome 21 were used and the results were compared to their karyotypes. We could find 2 cases of trisony 21 and 2 cases of trisony 18 and the other cases represented normal karyotypes. The accuracies were 91% for disomy 18, 89% for trisomy 18, 92% for disomy 21 and 88% for trisomy 21. Therefore FISH technique is a possible method to detect the chromosomal abnormalities in uncultured amniocytes and the use of locus-specific probe for chromosome 21 would be more useful for detecting the aneuploidy of chromosome 21 than 13/21 centromeric probe.
Amniotic Fluid
;
Aneuploidy
;
Chromosome Aberrations
;
Chromosomes, Human, Pair 18
;
Chromosomes, Human, Pair 21
;
Down Syndrome*
;
Female
;
Fluorescence*
;
Humans
;
In Situ Hybridization*
;
In Situ Hybridization, Fluorescence
;
Interphase
;
Karyotype
;
Trisomy