PURPOSE: The purpose of this study was to develop and test the validity and reliability of the Korean version of the Contraceptive Self-efficacy (K-CSE) scale. METHODS: The K-CSE scale was developed through forward-backward translation methods. Construct and criterion validity and internal consistency reliability were calculated using SPSS/WIN 21.0. Data were collected from 257 women students from two universities in G city, South Korea. RESULTS: The factor structure of the K-CSE scale showed the cumulative variance as 62.9% in the factor analysis. Factor loading of 13 items on four subscales ranged from .47 to .88. Factors were named as 'initiative of contraceptive use', 'sexual assertiveness', 'refusal of sexual intercourse', and 'autonomic sexual behavior'. Criterion validity compared to the Sexual Autonomy Measurement (SAM) showed significant correlation. Cronbach's α for the reliability of each subscale were .50~.82 and .76 for the total scale. CONCLUSION: The findings of this study demonstrate that the K-CSE scale is a satisfactory valid and reliable scale. Therefore, the CSE scale can be useful in measuring contraceptive self-efficacy among women university students in Korea.
Contraception ; Female ; Humans ; Korea ; Reproducibility of Results*

PURPOSES: This study examined the relationship between risk behaviors and sexual knowledge, sexual attitudes, and sexual experiences of male high school students. METHOD: A cross-sectional, descriptive study was conducted. Data were collected from 2 male high schools in metropolitan Gwangju. Five hundred forty-eight boys were enrolled in this study. Descriptive statistics, factor analysis, t-test or ANOVA, and Pearson's correlation were used for data analysis. RESULTS: The mean sexual knowledge and sexual experience scores were relatively low, 0.60 out of 1 point, and 0.75 out of 4 points, respectively. Three attitude types of the students were identified: permissible, conservative and pleasure seeking attitude. The score of the permissible type was affected by the subjects' exposure to pornographic material. The score of the conservative type was affected by alcohol consumption and acquaintances with a heterosexual friend. The score of the pleasure seeking type was affected by their exposure to pornographic material, alcohol consumption, smoking, going to a video-room, and acquaintances with a heterosexual friend. There was a negative correlation between the permissible type and sexual knowledge, and a positive correlation between the conservative and pleasure seeking types and sexual experience. CONCLUSION: Male high school students who have been exposed to risk behaviors have a higher likelihood of indulging in sexual activity, and the pleasure seeking type appears to be related to sexual experience. An educational program may be needed to prevent risky behaviors and sexual experiences in male high school students considering their sexual attitude type.
Alcohol Drinking ; Friends ; Gwangju ; Heterosexuality ; Humans ; Male* ; Pleasure ; Risk-Taking* ; Sexual Behavior ; Smoke ; Smoking ; Statistics as Topic

PURPOSE: To determine association of contraceptive knowledge, sexual double standard, and contraceptive self-efficacy among unmarried women in their 30s and 40s. METHODS: With a survey design, data were collected from 119 unmarried women in their 30s and 40s in G city of Korea from September 2017 to March 2018. Data were analyzed by descriptive statistics, independent t-test, one-way ANOVA, Scheffé test, Pearson's correlation coefficients, and stepwise multiple regression. RESULTS: Contraceptive knowledge, sexual double standard, and contraceptive self-efficacy scores of participants were 8.97±2.22, 18.54±5.57, and 45.84 ± 6.90, respectively. Contraceptive self-efficacy was negatively correlated with sexual double standard. Factors influencing contraceptive self-efficacy were sexual double standard (β =−.26, p=.003), existence of boyfriend (β=.25, p=.004), and contraceptive education need for adults (β=.17, p=.044). They explained 19% of contraceptive self-efficacy of participants. CONCLUSION: To increase contraceptive self-efficacy of unmarried women in their 30s and 40s, lowering sexual double standard and developing customized contraceptive education according to age and knowledge level are needed. Research on factors related to contraceptive self-efficacy of unmarried women in their 30s and 40s from various regions are also needed in the future.
Adult ; Contraception ; Education ; Female ; Humans ; Korea ; Self Efficacy ; Single Person

OBJECTIVES: The purpose of this study was to examine the relationship between self-care agency and health self-efficacy measures, in patients with viral hepatitis. METHODS: Data were collected from 116 outpatients over the age of 19 years who were diagnosed with viral hepatitis between February 20, 2019 and April 30, 2019. This study used the Appraisal of Self-care Agency Scale-Revised and the Health Self-Efficacy measures. Descriptive statistics, Pearson’s correlation coefficients, and canonical correlations were used during data analysis [SPSS version 25.0 for Windows (SPSS, Chicago, IL, USA)]. RESULTS: The first canonical correlation coefficient was 0.65 (Wilks’ λ = 0.44, F = 5.63, p < 0.001) and the second was 0.42 (Wilks’ λ = 0.76, F = 3.08, p = .001). The first variate indicated a higher perception of having power for self-care (0.85) and developing power for self-care (0.92), and this was related to exercise (0.66), illness (0.76), emotion (0.75), nutrition (0.81), stress (0.60), and health practice (0.85). The second variate indicated a higher perception of having power for self-care (0.42), whilst lacking power for self-care (−0.82), was related to illness (0.35) and stress (0.72). CONCLUSION: Nursing interventions and education aimed at enhancing the self-care of viral hepatitis patients are needed to assist patients to improve their health care behaviors.
Delivery of Health Care ; Education ; Hepatitis ; Humans ; Nursing ; Outpatients ; Self Care ; Statistics as Topic

PURPOSE: To determine the effect of sex communication with friends and sexual double standard on contraceptive self-efficacy among university students. METHODS: With a survey design, data were collected from 251 university students from three universities in G city from September 2016 to October 2016. Data were analyzed by descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient, and stepwise multiple regression. RESULTS: Sex communication with friends, sexual double standard, and contraceptive self-efficacy scores of participants were 58.82±8.78, 21.73±6.00, and 44.20±5.91, respectively. Sex communication with friends and sexual double standard were related to contraceptive self-efficacy. Sexual double standard, sex communication with friends, female, contraceptive education, and contraceptive experience explained 33% of contraceptive self-efficacy of participants. CONCLUSION: Sexual double standard and sex communication with friends were influencing factors of contraceptive self-efficacy. To improve contraceptive self-efficacy of university students, a program is needed to eliminate sexual double standard and improve sex communication with friends among university students in Korea.
Contraception ; Education ; Female ; Friends* ; Humans ; Korea

OBJECTIVES: This study aimed to investigate the factors affecting the health-related quality of life (HRQOL) of patients with chronic hepatitis C (CHC). METHODS: This study is based on a descriptive survey and involved 125 gastroenterology outpatients visiting a university hospital in South Korea as the participants. HRQOL was assessed using the Liver Disease Quality of Life 1.0, which consisted of Short Form-36 (SF-36) and the Liver Disease Targeted Scale. Data were collected from December 2015 to April 2016, which were then analyzed through multiple regression analysis. RESULTS: HRQOL had a statistically significant correlation with age, sex, educational level, living type, employment status, monthly income level, and comorbidity status. This study showed that age > 51 years, female sex, high educational level, living alone, unemployment status, low monthly income, and presence of comorbidity had negative effects on the HRQOL of patients with CHC (R² = 8.7%–34.6%). CONCLUSION: Based on the result of this study, intervention for patients with CHC needs to be developed to enhance their HRQOL. The findings can serve as a useful reference for nursing personnel in the development of therapeutic plans to upgrade the care of CHC patients.
Comorbidity ; Employment ; Female ; Gastroenterology ; Hepatitis C, Chronic* ; Hepatitis, Chronic* ; Humans ; Korea ; Liver Diseases ; Nursing ; Outpatients ; Quality of Life* ; Unemployment

BACKGROUND/AIMS: JX-594 is an oncolytic virus derived from the Wyeth vaccinia strain that causes replication-dependent cytolysis and antitumor immunity. Starting with a cross-examination of clinical-trial samples from advanced hepatocellular carcinoma patients having high levels of aldosterone and virus amplification in JX-594 treatment, we investigated the association between virus amplification and aldosterone in human cancer cell lines. METHODS: Cell proliferation was determined by a cell-counting-kit-based colorimetric assay, and vaccinia virus quantitation was performed by quantitative polymerase chain reaction (qPCR) and a viral plaque assay. Also, the intracellular pH was measured using a pH-sensitive dye. RESULTS: Simultaneous treatment with JX-594 and aldosterone significantly increased viral replication in A2780, PC-3, and HepG2 cell lines, but not in U2OS cell lines. Furthermore, the aldosterone treatment time altered the JX-594 replication according to the cell line. The JX-594 replication peaked after 48 and 24 hours of treatment in PC-3 and HepG2 cells, respectively. qPCR showed that JX-594 entry across the plasma membrane was increased, however, the changes are not significant by the treatment. This was inhibited by treatment with spironolactone (an aldosterone-receptor inhibitor). JX-594 entry was significantly decreased by treatment with EIPA [5-(N-ethyl-N-isopropyl)amiloride; a Na+/H+-exchange inhibitor], but aldosterone significantly restored JX-594 entry even in the presence of EIPA. Intracellular alkalization was observed after aldosterone treatment but was acidified by EIPA treatment. CONCLUSIONS: Aldosterone stimulates JX-594 amplification via increased virus entry by affecting the H+ gradient.
Aldosterone/*pharmacology ; Aldosterone Antagonists/pharmacology ; Amiloride/analogs & derivatives/pharmacology ; Animals ; Carcinoma, Hepatocellular/blood/virology ; Cell Line, Tumor ; Humans ; Hydrocortisone/blood ; Hydrogen-Ion Concentration ; Liver Neoplasms/blood/virology ; Neuroprotective Agents/pharmacology ; Oncolytic Virotherapy ; Rabbits ; Spironolactone/pharmacology ; Vaccinia virus/*drug effects/genetics/metabolism/*physiology ; Virus Replication/*drug effects

Thread-embedding therapy has been widely applied for cosmetic purposes such as wrinkle reduction and skin tightening. Particularly, gold thread was reported to support connective tissue regeneration, but, its role in hair biology remains largely unknown due to lack of investigation. When we implanted gold thread and Happy Lift™ in human patient for facial lifting, we unexpectedly found an increase of hair regrowth in spite of no use of hair growth medications. When embedded into the depilated dorsal skin of mice, gold thread or polyglycolic acid (PGA) thread, similarly to 5% minoxidil, significantly increased the number of hair follicles on day 14 after implantation. And, hair re-growth promotion in the gold threadimplanted mice were significantly higher than that in PGA thread group on day 11 after depilation. In particular, the skin tissue of gold thread-implanted mice showed stronger PCNA staining and higher collagen density compared with control mice. These results indicate that gold thread implantation can be an effective way to promote hair re-growth although further confirmatory study is needed for more information on therapeutic mechanisms and long-term safety.
Animals ; Biology ; Collagen ; Connective Tissue ; Hair Follicle ; Hair Removal ; Hair* ; Humans* ; Lifting ; Mice* ; Minoxidil ; Polyglycolic Acid ; Proliferating Cell Nuclear Antigen ; Regeneration ; Skin

Human adipose tissue-derived mesenchymal stem cell (hATMSC) have emerged as a potentially powerful tool for bone repair, but an appropriate evaluation system has not been established. The purpose of this study was to establish a preclinical assessment system to evaluate the efficacy and safety of cell therapies in a nude rat bone defect model. Segmental defects (5 mm) were created in the femoral diaphyses and transplanted with cell media (control), hydroxyapatite/tricalcium phosphate scaffolds (HA/TCP, Group I), hATMSCs (Group II), or three cell-loading density of hATMSC-loaded HA/TCP (Group III-V). Healing response was evaluated by serial radiography, micro-computed tomography and histology at 16 weeks. To address safety-concerns, we conducted a GLP-compliant toxicity study. Scanning electron microscopy studies showed that hATMSCs filled the pores/surfaces of scaffolds in a cell-loading density-dependent manner. We detected significant increases in bone formation in the hATMSC-loaded HA/TCP groups compared with other groups. The amount of new bone formation increased with increases in loaded cell number. In a toxicity study, no significant hATMSC-related changes were found in body weights, clinical signs, hematological/biochemical values, organ weights, or histopathological findings. In conclusion, hATMSCs loaded on HA/TCP enhance the repair of bone defects and was found to be safe under our preclinical efficacy/safety hybrid assessment system.
Adipose Tissue/*cytology ; Animals ; Biocompatible Materials/therapeutic use ; Bone Diseases/pathology/radiography/*therapy ; Bone Regeneration/physiology ; Calcium Phosphates/therapeutic use ; Diaphyses/radiography/surgery/ultrastructure ; Disease Models, Animal ; Durapatite/therapeutic use ; Femur/*pathology/radiography/surgery ; Humans ; Male ; *Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/*cytology ; Rats ; Rats, Nude ; Tissue Engineering ; Tomography, X-Ray Computed ; Transplantation, Heterologous

To study neurobehavioral effects for manganese fume exposure of welders, we administrated questionnaire about subjective symptom, related with manganese exposure. Neurobehavioral Core Test Battery of World Health Qrganization(NCTB) and finger tapping for 98 welders and 29 non-welding workers. We adopted welding duration as a criterion for exposure assessment, because of the lack of the longitudinal valid data and differences in airborne concentrations of manganese in welding types, such as shielded metal arc and CO2 arc welding. Neurologic, musculoskeletal and concentration symptoms were significantly increased by increase of welding duration. Performance of finger tapping preferred hand, Santa Ana dexterity test preferred hand and correct number of pursuit aiming were significantly decreased by increase of welding duration. These results comparable with previous studies that suggest neurobehavioral test, especially motor test, to be an appropriate tool to detect early neurobehavioral abnormalities related with manganeses exposure.
Fingers ; Hand ; Manganese* ; Questionnaires ; Welding ; World Health