Bioinformatics is the information technology to deal with biological data. Recently emerging systems biology has drawn great interest inspired by world-wide efforts for modeling and analyzing biological processes with a systems perspective. Bioinformatics, which has analyzed multi-omics data such as genomics, transcriptomics, and proteomics, and explored novel biological patterns embedded within the data, now has a transition to its application to systems biology, called systems bioinformatics. Systems bioinformatics includes various research areas: system modeling, system structure and dynamics analysis, causality analysis, and multi-omics data fusion. In this review, we introduce bioinformatics for genomics, transcriptomics, proteomics, and systems biology according to the different aspects of biological processes.
Biological Processes ; Computational Biology ; Genomics ; Proteomics ; Systems Biology

Gallstone composition has changed over the past decades in the Korean with a prominent increase in the prevalence of cholesterol gallstone. This trend is possibly due to the westernization of dietary habits. The purpose of this study was descriptive of GB patient's health related eating behaviors and nutrient consumption patterns. One hundred and six gallstone patients who have had cholecystitis surgery enrolled in this study. Anthropomertic indices, such as height, weight, waist circumference, and hip circumference were measured and calculated BMI and WHR. As the biomarker, TC, TG, LDL-C, HDL-C, FBG level and SBP/DBP were measured and analyzed the relationship with GB stone formation. The structured checklist of health related eating behavior and the semiquantitative food frequency questionnaire after pre-test was used in the face to face interview study. The mean age was 54.9 +/- 13.3 and gallstone disease was more frequent in the fifties and sixties. Mean BMI was 24.3 +/- 2.8 in males, and 23.4 +/- 3.9 in females, the average of waist circumference was 91.1 +/- 7.0 cm in males and females were 85.4 +/- 9.6 cm. The WHR of men and women was 0.93 +/- 0.0, 0.90 +/- 0.1, respectively. The obesity and overweight trend was observed in gallstone patients. The mean blood sugar was researched at 114.5 +/- 35.0 mg/ dL. And the ratio of both symptoms DM and gallstone was 26.4%. The rate of dramatic eating repast was significantly higher in the females (p < 0.01). Males tended to more frequently consume meat, of high fat content meats and greasy food consumption when eating out. The CPF ratio was 57 : 16.5 : 26.5. There was a significant positive correlation between WC and energy (r = 0.252, p < 0.05), carbohydrate (r = 0.255, p < 0.05) and niacin (r = 0.227, p < 0.05). In addition, carbohydrate were significantly correlatied with TC (r = 0.230, p < 0.05). BMI appeared positive in correlation of protein (r = 0.201, p < 0.05) and fat (r = 0.205, p < 0.05). These findings provide a little association that dietary habits are related with cholesterol gallstone formation.
Blood Glucose ; Checklist ; Cholecystitis ; Cholesterol ; Eating ; Feeding Behavior ; Female ; Food Habits* ; Gallstones* ; Hip ; Humans ; Male ; Meat ; Niacin ; Nutritional Status* ; Obesity ; Overweight ; Prevalence ; Waist Circumference ; Waist-Hip Ratio

This research was performed to evaluate the effects of nutrition education on food waste reduction at school food service. A dietitian conducted nutrition education on environmental protection and proper eating attitude and poor eating habits for 3rd and 5th graders at an elementary school in Seoul. The effectiveness of the education was evaluated by surveying the students before and after the education; 375 responses were analyzed. A questionnaire was designed to compare changes of the students' attitudes and plate waste before and after education. Plate wastes of boiled black rice(p<0.05), potato soup(p<0.05), amaranthus herb salad(p<0.01), and cabbage kimchi(p<0.05) decreased significantly after education. Students' eating attitudes improved significantly(t= -6.22, p<0.01) after nutrition education. Major reasons the students did not eat all foods they were served were large portion sizes (30.59%), low menu preference (29.79%), and tastes (17.82%). The menus with high plate waste rates were cooked vegetable items (35.64%) and soup items (26.6%). After education, students' attitudes on 'food waste pollutes the Earth(p=0.013)', 'food preparation for birthday parties(p<0.01)', and 'restaurant selection for eating out (p<0.01)' changed significantly. After education, plate waste and portion sizes that the students perceived were not negatively correlated. In conclusion, nutrition education on proper eating habits and source reduction is an effective method to reduce food waste generation and to improve students' eating attitudes and awareness on environment.
Amaranthus ; Brassica ; Natural Resources ; Eating ; Education* ; Food Services ; Humans ; Nutritionists ; Portion Size ; Surveys and Questionnaires ; Seoul ; Solanum tuberosum ; Vegetables

Background/Aims: Recent studies have shown a cumulative dose-dependent association between the use of hydrochlorothiazide (HCTZ) and skin cancer, including melanoma and non-melanoma skin cancer (NMSC) in Western Europe. However, whether this pattern is present in East Asia countries is unknown. The aim of this study was to examine the association between HCTZ use and the risk of skin cancer among a cohort of hypertensive patients in South Korea. Methods: This was a retrospective, population-based cohort study using the database from the Health Insurance Review and Assessment Service between January 1, 2007 and June 30, 2017 in South Korea. We identified patients diagnosed with melanoma and NMSC in the cohorts of essential hypertensive patients who were treated with HCTZ or antihypertensive agents other than HCTZ. Using Cox proportional hazards regression models, the hazard ratios (HR) for skin cancer associated with HCTZ users were calculated. Results: The risk of melanoma was significantly lower in HCTZ-users compared with non-HCTZ users (HR, 0.85; 95% confidence interval [CI], 0.75 to 0.97; p = 0.016), and the risk of NMSC was lower in the HCTZ users but no statistically significant association was seen (HR, 0.96; 95% CI, 0.91 to 1.02; p = 0.236). High cumulative doses (≥ 50,000 mg) of HCTZ were associated with decreased risk of both NMSC (HR, 0.20; 95% CI, 0.10 to 0.38; p < 0.001) and melanoma (HR, 0.18; 95% CI, 0.04 to 0.70; p = 0.001), respectively. Conclusions High cumulative use of HCTZ may have a chemopreventive effect against the development of melanoma and NMSC with clear cumulative dose-response and duration-response relationships in South Korea.

Purpose: This systematic review and meta-analysis investigated the effects of parenting education programs (PEPs) for refugee and migrant parents. Methods: A systematic review was conducted according to PRISMA guidelines. Relevant studies published from 2000 to 2020 were identified through a systematic search of six electronic databases (PubMed, Embase, Cochrane Library, CINAHL, RISS, KMBASE). A meta-analysis of the studies was then undertaken. Results: Of the 14,996 published works identified, 23 studies satisfied the inclusion criteria, and 19 studies were analyzed to estimate the effect sizes (standardized mean differences) of the PEPs using random-effect models. PEPs were effective for parenting efficacy (effect size [ES]=1.40; 95% confidence interval [CI]: 1.14-1.66), positive parenting behaviors (ES=0.51; 95% CI: 0.30-0.73), parent-child relationships (ES=0.38; 95% CI: 0.22-0.53), and parenting stress (ES=0.64; 95% CI: 0.50-0.79). There were statistically significant differences in the effect sizes of PEPs that included mothers only (ES=0.93), included children under 7 years of age(ES=0.91), did not include child participation (0.77), continued for 19 or more sessions (ES=0.80), and were analyzed in quasi-experimental studies (ES=0.86). The overall effect of publication bias was robust. Conclusion PEPs were found to be effective at improving parenting efficacy, positive parenting behaviors, parent-child relationships, and parenting stress.

Purpose: This study aimed to examine associations among inner strength, mood status, symptom experience, and quality of life in women with lung cancer and to investigate whether inner strength has a moderating effect on these relationships. Methods: This study used a cross-sectional design to analyze 106 women with lung cancer in the National Cancer Center. A hierarchical regression analysis was conducted on the influence of quality of life. For the moderating effects, the Johnson–Neyman methods were applied using the SPSS PROCESS macro. Results: The significant factors of quality of life were inner strength, symptom experiences, total mood disturbance, accounting for 70.7% of the variance. Inner strength had a moderating effect on the relationship between total mood disturbance and quality of life. This means that when women have higher inner strength, there is a significantly less negative effect of total mood disturbance on quality of life. Conclusion Female patients with lung cancer who experienced inner strength can improve the quality of life as well as reduce the negative impact of mood status on the quality of life. Therefore, these findings support the theory of inner strength and provide nurses with an opportunity to foster the development of this theory in female cancer survivors.

Purpose: Sleep disturbance is among commonly reported symptoms associated with leukemia and its treatment. The purpose of this study was to identify the symptom experience, anxiety and depression, and sleep disturbance in patients with acute leukemia undergoing chemotherapy. Methods: A total of 82 patients with acute leukemia who were undergoing chemotherapy were recruited. Data were collected using a self-reported questionnaire, which included the M. D. Anderson Symptom Inventory, the Hospital Anxiety Depression Scale, the Pittsburgh Sleep Quality Index, and the Patient Activation Measure 13. Results: Sleep disturbance and symptom experience, and anxiety and depression were shown to be positively correlated, and patient activation was shown to be negatively correlated. Use of sleeping pills and symptom severity were significantly associated with sleep disturbance. Conclusion The psychological and physical symptoms patients experience during treatment should be accurately identified, and effective nursing interventions should be provided. In addition, patient activation in patients with acute leukemia under inpatient treatment was not correlated with symptoms. However, supportive care should be provided to develop and accurately measure patient activation tools suitable for disease characteristics to increase patient activation.

Purpose: This study aimed to examine associations among inner strength, mood status, symptom experience, and quality of life in women with lung cancer and to investigate whether inner strength has a moderating effect on these relationships. Methods: This study used a cross-sectional design to analyze 106 women with lung cancer in the National Cancer Center. A hierarchical regression analysis was conducted on the influence of quality of life. For the moderating effects, the Johnson–Neyman methods were applied using the SPSS PROCESS macro. Results: The significant factors of quality of life were inner strength, symptom experiences, total mood disturbance, accounting for 70.7% of the variance. Inner strength had a moderating effect on the relationship between total mood disturbance and quality of life. This means that when women have higher inner strength, there is a significantly less negative effect of total mood disturbance on quality of life. Conclusion Female patients with lung cancer who experienced inner strength can improve the quality of life as well as reduce the negative impact of mood status on the quality of life. Therefore, these findings support the theory of inner strength and provide nurses with an opportunity to foster the development of this theory in female cancer survivors.

Purpose: Sleep disturbance is among commonly reported symptoms associated with leukemia and its treatment. The purpose of this study was to identify the symptom experience, anxiety and depression, and sleep disturbance in patients with acute leukemia undergoing chemotherapy. Methods: A total of 82 patients with acute leukemia who were undergoing chemotherapy were recruited. Data were collected using a self-reported questionnaire, which included the M. D. Anderson Symptom Inventory, the Hospital Anxiety Depression Scale, the Pittsburgh Sleep Quality Index, and the Patient Activation Measure 13. Results: Sleep disturbance and symptom experience, and anxiety and depression were shown to be positively correlated, and patient activation was shown to be negatively correlated. Use of sleeping pills and symptom severity were significantly associated with sleep disturbance. Conclusion The psychological and physical symptoms patients experience during treatment should be accurately identified, and effective nursing interventions should be provided. In addition, patient activation in patients with acute leukemia under inpatient treatment was not correlated with symptoms. However, supportive care should be provided to develop and accurately measure patient activation tools suitable for disease characteristics to increase patient activation.