1.The Correlations between Cardiorespiratory Fitness Levels and Body Mass Index, Metabolic Syndrome Risk Factors, Homeostasis Model Assessment-Insulin Resistance and High Sensitivity C-Reactive Protein in Male High School Students.
Soo Youn KIM ; Eun Sung KIM ; Jung Ho CHO
Korean Journal of Health Promotion 2011;11(4):227-233
BACKGROUND: The purpose of this study was to analyze the relationships between cardiorespiratory fitness and body mass index (BMI), metabolic syndrome risk factors, homeostasis model assessment-insulin resistance (HOMA-IR), and high sensitivity C-reactive protein (hsCRP) in male high school students in Korea. Furthermore, the effects of the cardiorespiratory fitness levels on these four factors were examined. METHODS: The level of cardiorespiratory fitness, BMI, percent body fat, waist circumference (WC), systolic blood pressure, glucose, triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), HOMA-IR, and hsCRP of 227 male high school students were measured. Analyses of multiple correlation and simple regression were applied. RESULTS: The results showed that the level of cardiorespiratory fitness correlated negatively with BMI, percent body fat, WC, TG, and HDL-C, in addition to HOMA-IR and hsCRP, and strongly influenced BMI, percent body fat, WC, TG, HDL-C, HOMA-IR, and hsCRP. Comparative analysis of our subjects showed that higher cardiorespiratory fitness levels had positive effects on BMI, metabolic syndrome risk factors, HOMA-IR, and hsCRP. CONCLUSIONS: This study found that there are close correlations between cardiorespiratory fitness and BMI, metabolic syndrome risk factors, HOMA-IR, and hsCRP. It also showed that, compared to lower levels of cardiorespiratory fitness, higher levels had beneficial effects on BMI, metabolic syndrome risk factors, diabetes, and cardiovascular disease risk factors.
Adipose Tissue
;
Adolescent
;
Blood Pressure
;
Body Mass Index
;
C-Reactive Protein
;
Cardiovascular Diseases
;
Glucose
;
Homeostasis
;
Humans
;
Insulin
;
Korea
;
Male
;
Physical Fitness
;
Risk Factors
;
Triglycerides
;
Waist Circumference
2.Abnormal Development and Apoptosis Observed in Brains of the Trisomy 16 Mouse.
Eun youn CHO ; Yeon Lim SUH ; Je Geun CHI
Korean Journal of Pathology 1999;33(8):570-580
We have studied morphologic characteristics and apoptosis on the fetal brain of the trisomy 16 mouse, a model for human trisomy 21 syndrome. This study was based on serial sections of the whole brain from a sample of sixteen trisomy 16 mice and forty-six age-matched control littermates from embryonic day (ED) 12 to ED 18. Trisomy 16 brains showed a reduction of telencephalic size and abnormal cortical development. At ED 13 trisomy 16 and control brains appeared similar. By ED 14 difference in the cortical thickness and telencephalic growth became evident, and by ED 16 a marked size difference had developed between the trisomy 16 and control brains. By ED 18, however, the thickness of the trisomy 16 cortex had increased considerably and was not significantly different with respect to the thickness and cross-sectional areas of the pallium and its constituent cortical layers. The cell density of the trisomy 16 cortex had persistently decreased before ED 17, when the cell density of control and trisomy 16 corteces was similar within each layer. At ED 18 cell density of trisomy 16 cortex in each layer increased. There was inverse relationship between a number of TUNEL positive apoptotic cells and cell density in the trisomy 16 brains. Our results suggest that developmental abnormalities of the trisomy 16 brain indicated developmental delay of the telencephalon growth, which may be caused by apoptosis rather than by a proliferation defect.
Animals
;
Apoptosis*
;
Brain*
;
Cell Count
;
Down Syndrome
;
Humans
;
In Situ Nick-End Labeling
;
Mice*
;
Telencephalon
;
Trisomy*
3.A case of anosacral cutaneous amyloidosis.
Sang Eun MOON ; Jai Il YOUN ; Kwang Hyun CHO
Korean Journal of Dermatology 1993;31(3):403-407
We report a case of anosacral cutaneous amyloidosis in a 74 year-old-man. The skin finding is a patch of the size of a childs palm on the sacral area, consisting of brownish macular lines that radiate frorn the anus. Histopathology revealed defiosits of homogenous eosinophilic mateial s in the papillary dermis. Congo red staining and dylon staining was positive. Immuohistochemical staining using anti SAP antibodies and anti-keratin antibodies showed positive reactions.
Amyloidosis*
;
Anal Canal
;
Antibodies
;
Child
;
Congo Red
;
Dermis
;
Eosinophils
;
Humans
;
Skin
4.The discharge patterns and the caloric response of the primary afferent vestibular neurons.
Sang Heun LEE ; Jong Joub YOUN ; Eun Kyung CHO ; Tae Hwan CHO ; Chang Sup SEONG
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(5):921-928
No abstract available.
Neurons*
5.Increased Expression of Caveolin-1 in Renal Cell Carcinoma.
Wook OK ; Eun Kyung BAE ; Sung Soo YOUN ; Kwang Sung AHN ; Han Yong CHO
Korean Journal of Urology 2000;41(5):602-608
No abstract available.
Carcinoma, Renal Cell*
;
Caveolin 1*
6.A Clinicopathological Study of Chronic Cutaneous Lupus Erythematosus.
Tae Eun KWON ; Oh Sang KWON ; Jin Ho CHUNG ; Kwang Hyun CHO ; Jai Il YOUN
Korean Journal of Dermatology 1999;37(4):459-467
BACKGROUND: Chronic cutaneous lupus erythematosus(CCLE) is a well-known disease entity. But there has been no data about its clinical behavior and histopathologic features in Korea. OBJECTIVES: This study was conducted to elucidate the clinical, laboratory, and histopathologic features of CCLE, and the relationship between CCLE and SLE. MATERIALS AND METHODS: We investigated 48 cases of CCLE that visited the department of dermatology at the Seoul National University Hospital from January 1990 to June 1997. Medical records and biopsy slides were reviewed.
Biopsy
;
Dermatology
;
Korea
;
Lupus Erythematosus, Cutaneous*
;
Medical Records
;
Seoul
7.Clinical Study of Lichen Planus : An Analysis of 35 Cases.
Phil Soo AHN ; Kwang Hyun CHO ; Jai Il YOUN ; Sang Eun MOON
Korean Journal of Dermatology 1995;33(4):655-660
BACKGROUND: Lichen planus is a papulosquarnous disease characterized by pruritic violaceous papules most commonly an the extremities of middle-aged adults. It may or may not be accompanied by oral and genital mucous membrane involvement. Its course is generally self-limited for a period of several months to years, but it may last indefinitely. OBJECTIVE: This study was performed to find the clinical characteristics of lichen planus. METHODS: Thirty-five cases of lichen planus comfirrned clinically and histopathologically were analyzed. RESULTS: The incidenc of lichen planus was 0.073% of the total number of dermatologic patients. The age distribution was in the range of 14-63 years old being most prevalent in the 6th decade and there was ariequal sex ratio. The most common site of involvement was the mucous membrane, and the extremities were more common than the trunk. Pruitus or pain and discomfort developed in 28 pat,ients(80% ). In most cases, the treatment was topical corticosteroid and antihistamine. Sixteen cses improved within 1 month to 2 years. Five cases recurred in the improved cases. CONCLUSION: The clinical analysis of 35 patients with lichen planus was performed. The incidence of lichen planus was 0.073% of the total number of dermatologic patients. Males and females were equally affected Mucous membrane involvement was detected in 21 patients(60%).
Adult
;
Age Distribution
;
Extremities
;
Female
;
Humans
;
Incidence
;
Lichen Planus*
;
Lichens*
;
Male
;
Mucous Membrane
;
Sex Ratio
8.A case of bronchial arterial embolization of massive hemoptysis.
Youn Sik LIM ; Jung Eun SUH ; Suk JEONG ; Dong Ill CHO ; Jae Won KIM
Tuberculosis and Respiratory Diseases 1991;38(4):396-400
No abstract available.
Hemoptysis*
9.Histological Changes in the Skin with Innate Ageing.
Kwang Ho HAN ; Kwang Hyun CHO ; Dong Young NOH ; Hee Chul EUN ; Jai Il YOUN
Korean Journal of Dermatology 1998;36(6):971-980
BACKGROUND: It is a popular notion that cutaneous ageing includes two distinct phenomenon; true ageing, a universal presumably inevitable change attributable to the passage of time alone, and photoageing, changes attributable to chronic habitual sun exposure that are neither universal nor inevitable. Numerous investigations with experimental animals, in vitro skin models have been conducted, although, few histological studies to date have attempted to announce fundamental morphological changes with innate ageing. OBJECTIVE: We compared skin derived from the breast of old and young persons using light microscopy to discern structural changes in epidermal and dermal morphology with advancing age. METHODS: The histological, immunohistochemical studies were performed with normal skin sections of thirty donors who were diagnosed with breast cancer. They were classified into three age cohort groups; nine into group I (22 to 38), twelve into group II(40 to 52), and nine into group III(54 to 87). We chose the breast as an area that might closely resemble intrinsically aged skin. This region is relatively shielded from photoageing by its anatomical location. Analysis of data was performed using the Kruskal-Wallis and ANOVA test for dermal parameters based on a 5-point rating scale, and a simple regression test for a positive rate of immunoreactants. Results : 1. Light microscopic appearance of aged skin revealed a more flattened epidermis than young skin. There was no trend for an increase in epidermal melanin content per unit area on Fontana-Masson staining. There was an age-associated decrease in the Ki-67 positive rate(p<0.001), the density of Ki-67 positive cells declined approximately 1.16% per decade in photoprotected skin(p<0.001). The number of S-100 positive cells declined approximately 4.4/mm width along the dermo-epidermal juction per decade in photoprotected skin(p<0.001). The expression of differentiation markers(keratin 1, involucrin, filaggrin, loricrin) were not different among the three age cohort groups. 2. With advancing age, there was an attenuation in the number and diameter of elastic fibers in the papillary dermis and an increase in the number and straightness of the same fibers in the reticular dermis. The collagen fibers are arranged in sparse bundles in disarray, and/or aggregates of loosely woven, straight fibers in the aged skin. There was an apparent, age-related decrease in the stainability of ground substances in the papillary dermis on colloidal iron staining. Conclusions : Our data documents semi-quantitative differences among three groups in intrinsically aged breast skin and provide the framework for future research to evaluate the ageing process.
Animals
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Breast
;
Breast Neoplasms
;
Cohort Studies
;
Collagen
;
Colloids
;
Dermis
;
Elastic Tissue
;
Epidermis
;
Humans
;
Iron
;
Melanins
;
Microscopy
;
Skin*
;
Solar System
;
Tissue Donors
10.A Statistical Study of Cutaneous Malignant Tumors.
Sang Eun MOON ; Kwang Hyun CHO ; Ji Hwan HWANG ; Jeong Aee KIM ; Jai Il YOUN
Korean Journal of Dermatology 1998;36(1):7-15
BACKGROUND: There is concem about the rising incidence of skin cancer. However, few articles have reported the change in the clinical and epidemiological aspects of skin cancer. OBJECTIVE: We performed this study in order to clarifiy the recent changes in cutaneous premalignant and malignant lesions. METHODS: A statistical analysis was made using 101 cases of cutaneous premalignant lesions and 205 cases of ma]ignant tumors out of a total number of 20,175 new outpatients that visited the Department of Dermatology at the Seoul National University Hospital during a 6 year period(1990-1995). RESULTS: The frequency of premalignant lesions was 0.50% and that of malignant tumors was 1.02%. The frequency showed an increasing tendency compared to previous reports. In the premalignant lesion cases, actinic keratosis was most common and represented a figure of 82.2%. Among the malignant tumors, basal cell carcinoma was most frequent at 24.4%. Age, sex and anatomical site distribution of basal cell carcinoma, malignant melanoma was no different. The mean age of squamous cell carcinoma was greater than in previous reports and main preceding lesions were actinic keratosis and cheilitis. The frequency of lymphoma was markedly increased but the reason for this remains to be determined. CONCLUSION: Our findings showed the continous increasing incidence of skin cancers and emphasize the need for public eduacation, early diagnosis and proper treatment.
Carcinoma, Basal Cell
;
Carcinoma, Squamous Cell
;
Cheilitis
;
Dermatology
;
Early Diagnosis
;
Humans
;
Incidence
;
Keratosis, Actinic
;
Lymphoma
;
Melanoma
;
Outpatients
;
Seoul
;
Skin Neoplasms
;
Statistics as Topic*