OBJECTIVE: The purpose of this study is to investigate the effect of chronic deprivation of estradiol on the serotonin level in Sprague-Dawley rat's cerebral cortex and hippocampus. METHODS: One hundred of female Sprague-Dawley rats were taken care for seven to eight weeks, then they were randomly assigned into two group; fifty rats underwent bilateral oophorectomy & the remaining rats were the control group. Six months after oophorectomy, brain tissue was extracted from cerebral cortex and hippocampus and then homogenated: this was done in the both groups. The upper layer of the homogenated substance was taken and frozen and finally dried up. The next process was marking with PITC, quantification through HPLC and comparing with authentic serotonin. Protein quantity was measured by using Bradford method. RESULTS: Comparison between the bilateral oophorectomy group and the control group for serotonin content in the cerebral cortex was 134.2+/-14.3 nmol/mg protein(mean+/-SEM) and 122.5+/-11.6 nmol/mg protein in each group. As for the serotonin content in the hippocampus was 148.8+/-13.9 nmol/mg protein and 132.9+/-13.7 nmol/mg protein in each group. It shows that, there was no significant difference in the serotonin level, in the two areas mentioned above. CONCLUSION: The effect of estradiol on the serotonin level may be dependent on the hormonal change duration. Chronic effect of hypoestrogenism might have no effect on tryptophan hydroxylase and monoamine oxidase, thus not changin the serotonin level. These data supported the previous findings that chronic hypoestrogenism had no effect on serotonin level.
Animals ; Brain ; Cerebral Cortex* ; Chromatography, High Pressure Liquid ; Estradiol ; Female ; Female* ; Hippocampus* ; Humans ; Monoamine Oxidase ; Ovariectomy* ; Rats* ; Rats, Sprague-Dawley* ; Serotonin* ; Tryptophan Hydroxylase

PURPOSE: The purpose of this study was to identify the influencing factors on maternal role adjustment among the primiparous women in the first year after childbirth. METHODS: The study subjects were 210 healthy primiparous women who have delivered at one of four women's health hospitals and revisited the out-patient department for the routine check-up and baby's vaccination during the first year after childbirth. Data were collected by a self-report questionnaire which consisted of general characteristics, maternal role adjustment, spousal rearing support, childcare stress, and postpartum depression. Collected data were analyzed by using the SPSS Win 18.0 program with descriptive statistics, t-test, one way ANOVA, Pearson correlation coefficient and multiple regression. RESULTS: The maternal role adjustment was significantly correlated with spousal rearing support (r=.649, p<.001), childcare stress (r=-.596, p<.001), postpartum depression (r=-.569, p<.001), and subjective health condition (r=.204, p=.003). The multiple regression analysis showed that the maternal role adjustment were significantly affected by spousal rearing support (t=6.542, p<.001). childcare stress (t=-3.268, p=.001), and postpartum depression (t=-2.238, p=.018). CONCLUSION: From these results, it is concluded that the nursing intervention for enhancing spousal support in childcare and decreasing the childcare stress and depression should be developed for improving maternal role adjustment in the first time mother, especially within one year after childbirth.
Depression ; Depression, Postpartum ; Diagnostic Self Evaluation ; Female ; Humans ; Maternal Behavior ; Mothers ; Nursing ; Outpatients ; Parity ; Parturition* ; Vaccination ; Women's Health

The authors evaluated ultlrasonographic findings of surgically or pathologically proven anterior abdominalwall lesion in 17 cases. The results were follows; 1. Ultrasonography is an accurate, convenient and noninvasive method to detect and determine the extent of anterior abdominal wall lesion. 2. Peritoneal fascia interface is animportant landmark in differenciation between intraperitoneal and abdominal wall lesion. 3. Sonographic differenciation of abscess and hematoma from tumor was impossible.
Abdominal Wall ; Abscess ; Fascia ; Hematoma ; Methods ; Ultrasonography

: The purpose of this study was to understand the transition experience of nursing students from non-face-to-face classes to face-to-face classes in the COVID-19 situation. Methods : This study was to a qualitative research conducted using focus group interviews. The participants in this study were 11 nursing students at K University in Seoul, and were 4th grade students who experienced non-face-to-face classes, face-to-face classes, and clinical practice from 2020 to 2022, when COVID-19 began. The data collection period is from November 24 to December 7, 2022, and the collected data were analyzed by applying Colaizzi’s method. Results : As a result of the study, 4 categories, 8 theme clusters, and 20 themes were derived. The four categories were ‘starting face-to-face classes in anxiety’, ‘disappointed with half school life’, ‘an arduous effort to restore everyday life’, and ‘pride in being well prepared as a pre-nurse’. Conclusion : This study is meaningful in that it analyzed the difficulties and various experiences of nursing students in the process of transitioning to face-to-face classes, and can be used as basic data to plan learner-centered educational strategies and teaching methods in the post-COVID-19.

PURPOSE: The purpose of this study was to investigate the present status of falls among inpatients in general hospitals and to identify the fall risk factors that reflect the characteristics of domestic hospitals. METHODS: Data were collected between December 15, 2016 and January 15, 2017 from 32 Korean hospitals having 500 or more beds. First, 42 risk factors were extracted based on literature review and expert opinions. Then the importance of each factor was evaluated by 223 nurses from medical and surgical adult ward and intensive care units in 40 hospitals. RESULTS: The incidence rate of falls in 18 hospitals was 3.87 per 1,000 total discharged patients and 0.55 per 1,000 patient-days, and the rate of injury-related falls was 40.5%. Major risk factors for falling were identified as the following: being over 65 years of age, history of falls during admission, physical mobility disorders requiring assistance, physical factors (dizziness or vertigo, unstable gait, general weakness, walking aids, visual problems), cognitive factors (delirium, lack of understanding on limitations), neurological disease, CNS medications CONCLUSION: The findings provide information that can be in the development of a fall risk assessment tool for inpatients in general hospitals in Korea.
Accidental Falls ; Adult ; Audiovisual Aids ; Expert Testimony ; Gait ; Hospitals, General ; Humans ; Incidence ; Inpatients ; Intensive Care Units ; Korea ; Risk Assessment ; Risk Factors ; Vertigo ; Walking

BACKGROUND: In this prospective, randomized, double-blind, placebo-controlled trial, we tried to find out appropriate amounts of single-dose dexmedetomidine to prolong the duration of spinal anesthesia in a clinical setting. METHODS: Sixty patients who were scheduled for unilateral lower limb surgery under spinal anesthesia were randomized into three groups receiving normal saline (control group, n = 20) or 0.5 or 1.0 ug/kg dexmedetomidine (D-0.5 group, n = 20; D-1, n = 20) intravenously prior to spinal anesthesia with 12 mg of bupivacaine. The two-dermatome pinprick sensory regression time, duration of the motor block, Ramsay sedation score (RSS), and side effects of dexmedetomidine were assessed. RESULTS: The two-dermatome pinprick sensory regression time (57.6 +/- 23.2 vs 86.5 +/- 24.3 vs 92.5 +/- 30.7, P = 0.0002) and duration of the motor block (98.8 +/- 34.1 vs 132.9 +/- 43.4 vs 130.4 +/- 50.4, P = 0.0261) were significantly increased in the D-0.5 and D-1 groups than in the control group. The RSS were significantly higher in the D-0.5 and D-1 groups than in the control group. However, there were no patients with oxygen desaturation in dexmedetomidine groups. The incidences of hypotension and bradycardia showed no differences among the three groups. CONCLUSIONS: Both 0.5 and 1.0 ug/kg of dexmedetomidine administered as isolated boluses in the absence of maintenance infusions prolonged the duration of spinal anesthesia.
Anesthesia, Spinal* ; Bradycardia ; Bupivacaine ; Dexmedetomidine* ; Humans ; Hypotension ; Incidence ; Lower Extremity ; Oxygen ; Prospective Studies

BACKGROUND: In this prospective, randomized, double-blind, placebo-controlled trial, we tried to find out appropriate amounts of single-dose dexmedetomidine to prolong the duration of spinal anesthesia in a clinical setting. METHODS: Sixty patients who were scheduled for unilateral lower limb surgery under spinal anesthesia were randomized into three groups receiving normal saline (control group, n = 20) or 0.5 or 1.0 ug/kg dexmedetomidine (D-0.5 group, n = 20; D-1, n = 20) intravenously prior to spinal anesthesia with 12 mg of bupivacaine. The two-dermatome pinprick sensory regression time, duration of the motor block, Ramsay sedation score (RSS), and side effects of dexmedetomidine were assessed. RESULTS: The two-dermatome pinprick sensory regression time (57.6 +/- 23.2 vs 86.5 +/- 24.3 vs 92.5 +/- 30.7, P = 0.0002) and duration of the motor block (98.8 +/- 34.1 vs 132.9 +/- 43.4 vs 130.4 +/- 50.4, P = 0.0261) were significantly increased in the D-0.5 and D-1 groups than in the control group. The RSS were significantly higher in the D-0.5 and D-1 groups than in the control group. However, there were no patients with oxygen desaturation in dexmedetomidine groups. The incidences of hypotension and bradycardia showed no differences among the three groups. CONCLUSIONS: Both 0.5 and 1.0 ug/kg of dexmedetomidine administered as isolated boluses in the absence of maintenance infusions prolonged the duration of spinal anesthesia.
Anesthesia, Spinal* ; Bradycardia ; Bupivacaine ; Dexmedetomidine* ; Humans ; Hypotension ; Incidence ; Lower Extremity ; Oxygen ; Prospective Studies

PURPOSE: The aim of this study was to estimate total sugar intake and sugar intake-related dietary habit and nutrient intake of elementary school students. METHODS: Subjects included 701 elementary school students (351 boys and 350 girls) residing in Jeju. The research analyzed a sample and was carried out using the 24 hour recall method and one day consumption of total sugar. RESULTS: The average daily total sugar intake was 55.3 g (male 53.1 g, female 57.6 g). Total sugar intake per meal was 6.3 g (11.4%) from breakfast, 6.9 g (12.5%) from lunch, and 7.2 g (13.0%) from dinner, 34.9 g (63.1%). Major food groups of total sugar were milks (17.04 g), grains and their products (12.79 g), fruits and their products (9.40 g), and sugars and sweets (7.30 g). In analysis of the amount of total sugar consumption from several recipes, much was taken in from dessert and snacks such as dairy products (15.08 g), bread and snacks (6.4 g), beverages (5.5 g), fruits (5.1 g), and ice cakes (4.8 g). Total sugar consumption was high for rices and side dishes such as noodles (5.1 g), stir-fried foods (2.3 g), fried foods (1.4 g), cooked rice with seasoning (1.4 g), and hard-boiled foods (1.1 g). In comparison of total sugar consumption for sugar sources, daily intake of natural sugar, added sugar, and natural and added sugar were 25.8 g, 23.3 g, and 6.2 g, respectively. High sugar intake group, which was over 20% of the energy from total sugar intakes, consumed significantly less Fe, Zn, and niacin than the low sugar intake group, which was below 20%. CONCLUSION: Total sugar intake of fifth graders of elementary schools on Jeju Island was 55.4 g/day, and it was usually intake from snacks. Therefore, elementary school students need nutritional education for proper selection of better snacks and for reduction of dietary sugar intake.
Beverages ; Bread ; Breakfast ; Carbohydrates* ; Edible Grain ; Dairy Products ; Education ; Female ; Food Habits ; Fruit ; Humans ; Ice ; Lunch ; Meals ; Milk ; Niacin ; Seasons ; Snacks

No abstract available.
Amnion* ; Endometriosis* ; Endometrium* ; Female

PURPOSE: The purpose of this study was to develop a valid Adult Fall Assessment Scale Korean version (FAS-K) for inpatients in general hospitals in Korea. METHODS: This a 14 item FAS-K was developed based on a review of national and international research and expert opinions in related field. Interrater reliability of FAS-K was analyzed using the ICC (Intraclass Correlation Coefficients). To examine the validity of FAS-K, a CVI (Content Validity Index), the Pearson correlation coefficients between FAS-K and two widely used scales, the Morse Fall Scale (MFS) and the Johns Hopkins Hospital Fall Risk Assessment Tool (JHFRAT), and the Mann-Whitney test were used. RESULTS: The ICC was .958. The CVI ranged from .70 to 1.00. The FAS-K was significantly associated with the MFS (r=.74, p<.001) and with the JHFRAT (r=.87, p<.001), verifying the concurrent validity of FAS-K. As for the construct validity of FAS-K, significant differences between the fall and non-fall groups were found not only in the MFS (Z=−3.23, p=.001) but also in the FAS-K (Z=−3.10, p=.002). CONCLUSION: The findings indicate that the FAS-K is a reliable fall risk assessment tool with high validity.
Accidental Falls ; Adult ; Expert Testimony ; Hospitals, General ; Humans ; Inpatients ; Korea ; Risk Assessment ; Weights and Measures