Genetic and clinical observations were recorded on 16 patients with xeroderma pigmentosum, 14 of them having visited the Department of Dermatology, Chonnam National University Hospital, Kwangju, Korea from 1968 through 1982, and 3 of them having visited the Department of Dermatology, Chosun University Hospital located in the same city during same period(one patient was duplicated). Xeroderma pigmentosum was found to occur with a frequency higher than one in 183,000 births in Chonnam province, Korea. It waa recognized that xeroderma pigmentosum is a disease of autosomal recessive inheritance. The sex ratio of xeroderma pigmentosum was male to female l. 7 to 1. The age of onset was between 5 months and 10 years, and the age when the patients visited the hospital for the first time was 6 months and 25 years. The skin malignancies were observed in 9 patients, among which squamous cell carcinomas occurred in 6, basal cell carcinomas in 2, and actinic keratosis in l. The associated ocular abnormalities were photophobia in 4 patients, chalazion in 1, blepharoconjunctivitis in 1, pterygium in 1 and squamous cell carcinomas in 1. Only cerebral galsy as a neurological abnormality was observed in 1 patient.
Age of Onset ; Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Chalazion ; Dermatology ; Female ; Gwangju ; Humans ; Ichthyosis* ; Jeollanam-do ; Keratosis, Actinic ; Korea ; Male ; Parturition ; Photophobia ; Pterygium ; Sex Ratio ; Skin ; Wills ; Xeroderma Pigmentosum*

Dysplasia Epiphysealis Hemimelica is a rare developmental disorder of epiphyseal growth characterized by asymmetrical cartilagenous overgrowth. This disorder was first described with the “la tarsomegalie” by Mouchet and Belot in 1926 but this name, Dysolasia Epiphysealis Hemimelica, was first proposed by Fairbank in 1956. This disorder is usually limited to either the medial or lateral half of a single extremity in childhood. It is asymptomatic until the protruding epiphyseal mass interferes joint function. The character istic abnormalities are deformities, restricted motion and pain. The most frequent finding at the initial examination is an irregular, often multicentric radiopacity, and when the lesion is matured it looks irregular, and frequently there is a lobulated osseous mass protruding from the epiphysis of tarsal and carpal bones. Diagnosis by the roentgenogram requires primarily knowledge of this condition. The lesion is often microscopically indistinguishable from an osteochondroma. A case of Dysplasia Epiphysealis Hemimelica in a 17 year old male, showing typical roentgenographic appearances, is reported together with a brief review of literature in this paper.
Carpal Bones ; Congenital Abnormalities ; Diagnosis ; Epiphyses ; Extremities ; Humans ; Joints ; Male ; Osteochondroma

No abstract available.

Leiomyosarcoma arising in the skin is rare tumor, and diagnosis usually is made microscopically. After local excision, these lesions recur in large proportion of pat ients. The authors herein report a 53-year-old male with leiomyosarcoma appeared in the skin of the right forearm and presenting as a dark reddish colored, 5*6cm in diameter, superficial ulcerated single firm nodule with intermittent pain. Histopathological examination showed poorly circumscribed tumor consisting of interlacing bundles of spindle shaped smooth muscle cells in the middle and lower parts of the dermis. The nuclei were hyperchromatic, large, vacuolated, and irregular in shape. Electron microscopic findings revealed cytoplasmic organelles such as rough endoplasmic reticulum and mitochondria of malignant smooth muscle cells in the paranuclear area, Characteristic subsarcoelmmal caveolae and dense plaque were noted and myofilaments were distributed in the peripheral cytoplasm. The tumor did not recur in 10 months' follow-up.
Caveolae ; Cytoplasm ; Dermis ; Diagnosis ; Endoplasmic Reticulum, Rough ; Follow-Up Studies ; Forearm ; Humans ; Leiomyosarcoma* ; Male ; Middle Aged ; Mitochondria ; Myocytes, Smooth Muscle ; Myofibrils ; Organelles ; Skin* ; Ulcer

PURPOSE: This study was conducted to examine effects of a small group-based cardiocerebrovascular disease (CVD) prevention education program on knowledge, stage of change and health behavior among male bus drivers with CVD risk factors. METHODS: A non-equivalent control group pretest-posttest design was used. Participants were 68 male bus drivers recruited from two urban bus companies. Participants from the two groups were selected by matching age, education and risk factors. Experimental group (n=34) received a small group-based CVD prevention education program 8 times over 6 weeks and 3 times through telephone interviews at 2-week intervals. Data were collected between December, 2010 and March, 2011, and were analyzed using chi-square test, t-test, and repeated measure analysis of variance with SPSS/Win18.0. RESULTS: Experimental group showed significantly higher scores in CVD prevention knowledge (p<.001) and health behavior (p<.001) at 6 and 12 weeks after intervention. Participants in pre-contemplation and contemplation stages made progress to contemplation and action. This was significantly better at 6 and 12 weeks after intervention (p<.001). CONCLUSION: Results suggest that small group-based education programs for CVD prevention are effective in increasing knowledge, stage of change, and health behavior to prevent CVD among male bus drivers with CVD risk.
Adaptation, Psychological ; Adult ; Aged ; Alcohol Drinking ; Automobile Driving/*psychology ; Cardiovascular Diseases/*prevention & control ; Dietary Fats ; Exercise ; Health Behavior ; *Health Education ; Health Knowledge, Attitudes, Practice ; Humans ; Interviews as Topic ; Male ; Middle Aged ; Program Development ; *Program Evaluation ; Risk Factors ; Smoking ; Time Factors

PURPOSE: The purpose of this study is to identify factors that affect coping with fatigue in middle-aged men according to Q-methodology and to provide basic strategies for health promotion. METHOD: 25 subjects in Seoul, Incheon, Chung-buk classified 24 selected Q-statements in to 9 points standard. The collected data were analyzed by using a QUNAL pc program. RESULT: Principal component analysis identified 3 types of coping with fatigue among middle-aged Korean men. 1st Type: Coping with fatigue through various kinds of game, using alcohol, smoking cigarette other than rest and sleep. 2nd Type : Coping with fatigue through rest and sleep, taking medicine or food which helps relieving fatigue. 3rd Type : Coping with fatigue through acitivities such as sports or trip other than sleep. CONCLUSION: We have found how Korean middle-aged men cope against fatigue through this research. To setup and apply different nursing intervention on each type based on this result is needed.
Adaptation, Psychological ; Fatigue* ; Health Promotion ; Humans ; Incheon ; Male ; Middle Aged ; Nursing ; Principal Component Analysis ; Seoul ; Smoke ; Smoking ; Sports ; Tobacco Products

PURPOSE: A low birth weight (LBW) rate is associated with perinatal morbidity and mortality. Many different factors are related to birth weight and LBW. This study examined the effects of various factors on birth weight. METHODS: The study was conducted from January 1997 to August 1997 through direct interview with mother and medical history. Sample were drawn from 1,248 pairs of mothers and infants. The variables assessed included birth weight, gender, gestation age, birth order, maternal age, education, frequency of antenatal care, maternal complication and illness, parental smoking habit, alcohol and caffeine intake. The obtained data were coded and inputted into a computer using a SAS statistic package and estimated by multiple regression and logistic regression. RESULTS: The rate of LBW was 7.9% and premature rate was 3.4%. The variables affecting birth weight were maternal smoking habits, maternal complication and illness, gestation age, caffeine intake and gender. After adjusting for extraneous factors through multiple regression, we found that shortened gestation age, female infant, maternal complication and illness significantly played an important role in the decrease of birth weight. After logistic regression in the group of LBW infants, it was shown that the variables associated with LBW were maternal complication and illness, shortened gestation age, old age over 35 years, inadequate prenatal care, and female infant. CONCLUSION: Birth weight and LBW were more related to gestation age, gender, maternal complication and illness than maternal smoking habit, alcohol and caffeine intake.
Birth Order ; Birth Weight* ; Caffeine ; Education ; Female ; Humans ; Infant ; Infant, Low Birth Weight ; Infant, Newborn ; Logistic Models ; Maternal Age ; Mortality ; Mothers ; Parents ; Parturition* ; Pregnancy ; Prenatal Care ; Smoke ; Smoking

BACKGROUND: Although current dietary guidelines recommend to increase the consumption of whole grain, these recommendations are mainly derived from the belief that replacing fats with carbohydrate may reduce risk of coronary artery disease (CAD) by improving serum lipids. Our objective was to evaluate whether the isocalorical replacement of refined rice with whole grain reduce CAD risk factors such as insulin demand and lipid peroxidation in CAD patients. METHODS: Thirty-eight male patients with CAD were provided with 70 g powder of whole grain (220 kcal) for 16 weeks, replacing cooked refined rice as a carbohydrate source of breakfast. An oral glucose tolerance test (OGTT) was performed in all subjects to determine the effect of whole grain consumption on serum concentrations of insulin and glucose in CAD patients with different degree of glucose tolerance. RESULTS: With the substitution of whole grain for refined rice, serum glucose concentrations decreased by 24% without altering body weight and energy intake. Estimates of daily fiber and vitamin E intakes increased by 24% and 50%, respectively. Whole grain consumption in CAD patients without diabetes decreased fasting glucose (22%) and the area under the curve (AUC) for insulin (26%) and glucose (19%) during an OGTT. CAD patients with diabetes also showed reductions in fasting glucose (27%) and AUC for glucose (25%) during the OGTT, compared with baseline values. Whole grain consumption reduced plasma malondialdehyde and homocysteine and urinary 8-epi-prostaglandin F 2alpha concentrations by about 30%. Lipid-corrected concentrations of alpha-carotene, retinol, alpha- and gamma-tocopherol and lycopene increased by 22-46%, compared with baseline values. Whole grain consumption decreased the percentage composition of w6 fatty acids of serum phospholipid increased by 14%. CONCLUSION: The replacement of refined rice with whole grain as a carbohydrate source of a meal showed significant beneficial effects on glucose, insulin and homocysteine concentrations and lipid peroxidation in CAD patients. These effects are likely to substantially reduce the risk factors of CAD and diabetes in CAD patients.
Area Under Curve ; Blood Glucose ; Body Weight ; Breakfast ; Edible Grain* ; Coronary Artery Disease* ; Coronary Vessels* ; Energy Intake ; Fasting ; Fats ; Fatty Acids ; gamma-Tocopherol ; Glucose ; Glucose Tolerance Test ; Homocysteine* ; Humans ; Insulin* ; Lipid Peroxidation* ; Male ; Malondialdehyde ; Meals ; Nutrition Policy ; Plasma* ; Risk Factors ; Vitamin A ; Vitamin E ; Vitamins

PURPOSE: The purpose of this study is to investigate the perception of nursing students' on-site clinical experience at intensive care unit(ICU), which will help on developing fundamental tool to enhance the effect of their clinical practice. METHOD: Van Manens hermeneutic-phenomenological method has been used to analyze the data. Participants consisted of 74 third-year nursing students who performed the clinical practice at an ICU in C university hospital. The students got the group interviews and kept the clinical diaries. Data was collected from series of group interviews and contents of the students clinical diaries. RESULT: Major concerns related to students clinical practice were found as follows: [being nervous about unfamiliar machines and situations], [being frustrated about the patients], [feeling of helplessness], [being stupefied from witnessing a death], [realizing the importance of health], [realizing individual patient's precious value through family's love], [realizing the importance of treating a patient as human being], [realizing the differences between theory and practice], [modelizing two aspects of nursing: professional and personal], [readiness to become a capable nurse]. CONCLUSION: We are able to obtain in-depth understandings about the nursing students lived experience of clinical practice at the ICU. Based upon this, there is a need to develop a better nursing intervention enhance the effectiveness of the nursing students clinical practice.
Humans ; Intensive Care Units* ; Critical Care* ; Interviews as Topic ; Nursing* ; Students, Nursing

No abstract available.
Spinal Muscular Atrophies of Childhood*