TGF-beta was identified as a homeodimeric peptide with a molecular mass f 25,000 D, and is a multifuntional peptide controls proliferation, differentiation, and other functions in many cell type, Many cells synthesize TGF-beta and essentially all them have specific receptors for this peptide. TGF-beta regulates of many other peptide growth factors and determines a positive or negative direction of their effects. At present there is relatively little information about the intrinsic physiologic role of TGF-beta n vivo. Experimental study was performed to observe the expreession of TGF-beta2 in the craniomaxillofacial devalopment of a rat embryo. Four male rats each weighting about 250g and twelve female rats each weighing about 200g were used, and induced to pregnancy. The embryos were serially sacrificed on the 13. 15. 18day after coitus. The embryos were serially sectioned by 4 micrometer and stained with H&E and immunohistochemical stain with TGF-beta2 and the histological examinations were carried out under the light microscope. After examination and comparision of specimens, the results of study were as follows : 1. In a 15, 18d emdryos, low grade strain of TGF-beta2 id found in the detal papillar of developing incisor, and around the Meckles cartilage and the other cartilage TGF-beta 2 is positive. In the formation of palate. TGF-beta is highly positive. 2. Ina devalopment of teeth in 15, 18d embryos, THG-beta2 is seen in the enameloblast derived from oral epithelium and the mesenchymal primordium of the plup. 3. In a epithelium of 13, 15, 18d emubryos, TGF-beta2 Is seen at a high levels. 4. In a 13, 15, 18d embryos, TGF-beta2 positivity of nasal cavity epithelium is related to the sensory organ epithelium. In a 15, 18d embryos, the lens of the eye derived from the surface embryonic ectoderm is TGF-beta2 positive. From above results, staining of TGF-beta is associated wiht tissues derived from neural crest mesenchyme and tissues of sensory organ derived from ectoderm. masked is also seen when remodeling of mesenchyme or mesoderm occurs, as during formation of palate and catilage.
Animals ; Cartilage ; Coitus ; Ectoderm ; Embryonic Structures* ; Epithelium ; Female ; Humans ; Incisor ; Intercellular Signaling Peptides and Proteins ; Male ; Masks ; Maxillofacial Development* ; Mesoderm ; Nasal Cavity ; Neural Crest ; Palate ; Pregnancy ; Rats* ; Tooth ; Transforming Growth Factor beta ; Transforming Growth Factor beta2*

Leiomyoma is a benign smooth muscle tumor that usually arise in the uterus, skin and gastrointestinal system. Only 2 percent are located in the head and neck. Leiomyomas of oral cavity are uncommon as only two cases have been reported in the Korean literature. The common location of oral cavity has been tongue, but other sites include buccal mucosa, lips, palate. mouth floor, and gingiva. Our patient was 30 years old female who complained of swelling and discomfort in the mouth floor. Microscopically this tumor showed bundles of intertwining spindle cells within fibrous connective tissue stroma. The nuclei were generally pale staining and blunt ended. Masson's trichrome stain was positive for muscle, and immunohistochemical study for alpha -smooth muscle actin revealed strong positivity. It was treated by surgical excision. We experienced a case of leiomyoma of oral cavity, so we report with literature reviews
Actins ; Adult ; Connective Tissue ; Female ; Gingiva ; Head ; Humans ; Leiomyoma* ; Lip ; Mouth ; Mouth Floor ; Mouth Mucosa ; Neck ; Palate ; Skin ; Smooth Muscle Tumor ; Tongue ; Uterus