1.The major aortopulmonary collateral arteries in pulmonary atresia with ventricular septal defect: chest radiologic findings.
Sung Jin KIM ; Yeon Hyeon CHOE ; Ji Eun KIM ; Kil Sun PARK ; Dae Yeong KIM
Journal of the Korean Radiological Society 1992;28(6):875-880
The chest radiographs and angiograms were retrospectively evaluated in 47 patients with pulmonary atresia (PA) and ventricular septal defect (VSD) to determine the characteristic findings of major aortopulmonary collateral arteries (MAPCSs) on the chest radiographs. Of 47 patients, 23 had MAPCAs and 24 had only PDA for blood supply of whole right and left lung. Chest radiographs enabled identification of 16 of 23 patients with MAPCAs. The most common finding of MAPCAs was inappropriately large peripheral pulmonary vasculature (n=16, 69.6%). The other findings were tortuosity of pulmonary vasculature (n=12, 52.2%), focal unevendistribution of pulmonary vasculature (n=12, 52.2%), and two descending pulmonary arteries (n=4, 17.4%). When chest radiographs showed two or more findings of MAPCAs, MAPCAs could be differentiated from PDA with statistical significance (p<0.005). It is concluded that chest radiographs may help to identify MAPCAs before angiography if two-dimensional echo ardiography suggests PA with VSD.
Angiography
;
Arteries*
;
Heart Septal Defects, Ventricular*
;
Humans
;
Lung
;
Pulmonary Artery
;
Pulmonary Atresia*
;
Radiography, Thoracic
;
Retrospective Studies
;
Thorax*
2.Application of FISH(Fluorescence In Situ Hybridization) in uncultured chorionic villus cells.
Eun Ju CHANG ; Do Yeong HWANG ; Hyeh Sook CHOI ; Kyung Soon CHEONG ; Ki Chul KIM ; Jin CHOE ; Young Min CHOI ; Shin Yong MOON
Korean Journal of Obstetrics and Gynecology 2000;43(2):248-253
OBJECTIVE: The cytogenetic analysis for earlier detection of fetal chromosome aneuploidies is performed from chorionic villus using either long-term culture or direct chromosome preparation. To analyze the cause of pregnancy loss, we also attempt the cytogenetic study in product of conception(POC) using chorionic villi or fetal tissue. But the failure of analysis often occurs in direct preparation of villus cells and product of conception(POC). We studied to evaluate the clinical usefulness of FISH in uncultured chorionic villus cells of culture-failed cases. METHODS: According to the patient's indication, we performed FISH for chromosome 18, 21, X and Y in chorionic villi as well as POC and compared FISH results with their chromosomal studies. RESULTS: We found one trisomy 18 and one trisomy 21 in Chorionic Villus Sampling and one trisomy 18 and one monosomy X(45, X) in POC. The averages for accuracy of FISH were 83-91% and all cases are represented consistent results with their chromosomal studies. Among them, we could analyze using FISH only in 5 cases of culture failure including one case of monosomy X in POC. CONCLUSION: We could detect aneuploidy with uncultured chorionic villus cells in case of culture failure, using FISH, it may be the potential method to assist the cytogenetic study.
Aneuploidy
;
Chorion*
;
Chorionic Villi Sampling
;
Chorionic Villi*
;
Chromosomes, Human, Pair 18
;
Cytogenetic Analysis
;
Cytogenetics
;
Down Syndrome
;
Female
;
Fetus
;
Monosomy
;
Pregnancy
;
Trisomy
;
Turner Syndrome
3.Facial Palsy as a Presenting Symptom of Wegener's Granulomatosis.
Yun Jong LEE ; Young Joo CHOE ; Eun Bong LEE ; Hyun Ah KIM ; Yeong Wook SONG
The Journal of the Korean Rheumatism Association 2000;7(3):286-290
Wegener's granulomatosis is a serious multi-systemic disease pathologically characterized by necrotizing vasculitis and granuloma. Although nervous system is one of major target organs in Wegener's granulomatosis, the involvement of facial nerve was rarely reported as an initial symptom. We experienced a female patient with Wegener's granulomatosis presenting otitis media, sinusitis and right facial palsy. Nasal mucosal biopsy revealed necrotizing vasculitis with granuloma formation, which was consistent with Wegener's granulomatosis. During steroid and cyclophosphamide therapy, she developed paralysis of abducens nerve. Methyprednisolone pulse therapy was administrated with symptomatic improvement. We describe a case of Wegener's granulomatosis presenting facial nerve palsy.
Abducens Nerve
;
Biopsy
;
Cyclophosphamide
;
Facial Nerve
;
Facial Paralysis*
;
Female
;
Granuloma
;
Humans
;
Nervous System
;
Otitis Media
;
Paralysis
;
Sinusitis
;
Vasculitis
;
Wegener Granulomatosis*
4.Rapid detection of aneuploidy in uncultured fetal cord blood cells by FISH ( Fluorescence In Situ Hybridization ).
Young Min CHOI ; Eun Ju CHANG ; Jong Kwan JUN ; Do Yeong HWANG ; Kyung Soon CHEONG ; Ki Chul KIM ; Eung Gi MIN ; Jin CHOE ; Shin Yong MOON
Korean Journal of Obstetrics and Gynecology 2000;43(3):386-390
OBJECTIVE: To determine the fetal aneuploidy in fetal blood cells from cordocentesis. METHODS: We analyzed their karyotype and performed fluorescence in situ hybridization(FISH) for chromosome 18, 21, X, and Y in 14 cases of fetal blood cells from cordocentesis at Department of Obstetrics & Gynecology, College of Medicine, Seoul National University and Hamchoon Women's Clinic. RESULTS: In all cases we obtained the consistent results in both methods and were able to rapidly detect aneuploidy in uncultured fetal blood cells using FISH before karyotyping with culture for 48 hr. The averages for accuracy of FISH were from 84.6 % to 93.9%. CONCLUSION: In this study we suggest that the rapid detection in uncultured fetal blood using FISH is possible and that this diagnostic method will be clinically useful when rapid result would be demanded.
Aneuploidy*
;
Chromosomes, Human, Pair 18
;
Cordocentesis
;
Fetal Blood*
;
Fluorescence*
;
Gynecology
;
In Situ Hybridization*
;
Karyotype
;
Karyotyping
;
Obstetrics
;
Seoul
5.A case of Klinefelter's syndrome associated with systemic lupus erythematosus.
Yun Jong LEE ; Young Ju CHOE ; Ki Chyul SHIN ; Eun Bong LEE ; Hyun Ah KIM ; Yeong Wook SONG
Korean Journal of Medicine 2000;59(3):331-334
The incidence of systemic lupus erythematosus (SLE) is known to be affected by sex hormone. Patients with Klinefelter's syndrome were reported to have abnormal sex hormonal metabolism and their chronic estrogenic stimulation seems to affect the pathogenesis of SLE. Therefore, association of SLE and Klinefelter's syndrome has been considered as a clue of the effect of sex hormone on SLE. We report the first case of Klinefelter's syndrome in a patient with SLE in Korea and discuss the association of SLE with Klinefelter's syndrome.
Estrogens
;
Humans
;
Incidence
;
Klinefelter Syndrome*
;
Korea
;
Lupus Erythematosus, Systemic*
;
Metabolism
6.Predictive costs in medical care for Koreans with metabolic syndrome from 2009 to 2013 based on the National Health Insurance claims dataset
Jeong Seon YOO ; Eun Yeong CHOE ; Yoo Mee KIM ; Se Hwa KIM ; Young Jun WON
The Korean Journal of Internal Medicine 2020;35(4):936-945
Background/Aims:
Although metabolic syndrome has been associated with increasing medical costs worldwide, there have been no studies using a nationwide and longitudinal South Korean dataset. We investigated trends in subsidized medical costs among Korean adults with metabolic syndrome.
Methods:
This study was based on the National Sample Cohort database of South Korea. We used data of national health checkups in 2009 as well as data of subsidized prescription drugs and the Korean Classification of Disease diagnosis codes from claims in 2007 to 2008 to identify underlying diseases. We calculated the direct medical costs, which were subsidized by the Korean National Health Insurance, among 204,768 individuals older than 20 years from 2009 to 2013.
Results:
The proportion of subjects with metabolic syndrome was 27.2%. Direct medical costs for 5 years differed by a magnitude of 2.16 between subjects with and without metabolic syndrome. The costs increased by approximately 41.8% in the metabolic syndrome group in 5 years. Direct medical costs increased with every additional risk factor, even if a subject had less than three risk factors of metabolic syndrome. Metabolic syndrome per se and all of its components, except low serum high-density lipoprotein cholesterol level, resulted in a significant increase in medical costs.
Conclusions
The medical costs of subjects with metabolic syndrome were higher than that of those without metabolic syndrome and it increased with the number of risk factors. Further research using cumulative data of more than 10 years, including unsubsidized and indirect costs, is needed in the future.
7.Effects of Dipeptidyl Peptidase-4 Inhibitors on Hyperglycemia and Blood Cyclosporine Levels in Renal Transplant Patients with Diabetes: A Pilot Study.
Jaehyun BAE ; Min Jung LEE ; Eun Yeong CHOE ; Chang Hee JUNG ; Hye Jin WANG ; Myoung Soo KIM ; Yu Seun KIM ; Joong Yeol PARK ; Eun Seok KANG
Endocrinology and Metabolism 2016;31(1):161-167
BACKGROUND: The use of dipeptidyl peptidase-4 (DPP-4) inhibitors is increasing among renal transplant patients with diabetes. However, the glucose-lowering efficacies of various DPP-4 inhibitors and their effects on blood cyclosporine levels have not been fully investigated. We compared the glucose-lowering efficacies of DPP 4 inhibitors and evaluate their effects on the blood levels of cyclosporine in renal transplant recipients with diabetes. METHODS: Sixty-five renal allograft recipients who received treatment with DPP-4 inhibitors (vildagliptin, sitagliptin, or linagliptin) following kidney transplant were enrolled. The glucose-lowering efficacies of the DPP-4 inhibitors were compared according to the changes in the hemoglobin A1c (HbA1c) levels after 3 months of treatment. Changes in the trough levels of the cyclosporine were also assessed 2 months after treatment with each DPP-4 inhibitor. RESULTS: HbA1c significantly decreased in the linagliptin group in comparison with other DPP-4 inhibitors (vildagliptin –0.38%±1.03%, sitagliptin –0.53%±0.95%, and linagliptin –1.40±1.34; P=0.016). Cyclosporine trough levels were significantly increased in the sitagliptin group compared with vildagliptin group (30.62±81.70 ng/mL vs. –24.22±53.54 ng/mL, P=0.036). Cyclosporine trough levels were minimally changed in patients with linagliptin. CONCLUSION: Linagliptin demonstrates superior glucose-lowering efficacy and minimal effect on cyclosporine trough levels in comparison with other DPP-4 inhibitors in kidney transplant patients with diabetes.
Allografts
;
Cyclosporine*
;
Diabetes Mellitus
;
Dipeptidyl-Peptidase IV Inhibitors
;
Humans
;
Hyperglycemia*
;
Kidney
;
Kidney Transplantation
;
Pilot Projects*
;
Transplantation
8.Glycemic Effects of Once-a-Day Rapid-Acting Insulin Analogue Addition on a Basal Insulin Analogue in Korean Subjects with Poorly Controlled Type 2 Diabetes Mellitus.
Eun Yeong CHOE ; Yong Ho LEE ; Byung Wan LEE ; Eun Seok KANG ; Bong Soo CHA ; Hyun Chul LEE
Diabetes & Metabolism Journal 2012;36(3):230-236
BACKGROUND: The present study investigates the efficacy in glycemic control by adding once-a-day glulisine to glargine as a basal plus regimen and factors influencing glycemic control with the basal plus regimen in Korean subjects with type 2 diabetes. METHODS: In the present retrospective study, subjects previously treated with the basal plus regimens for at least 6 months were reviewed. Changes in glycemic profiles and clinical parameters were evaluated. RESULTS: A total of 87 subjects were ultimately enrolled in this study. At baseline, mean glycated hemoglobin (A1c) and glycated albumin were 8.5% (8.0% to 9.6%) and 25.2+/-7.6%, respectively. After treatment with the basal plus regimen, patients had significant reductions of A1c at 6 months (0.8+/-0.1%, P<0.001) and their postprandial glucose levels were decreased by 48.7+/-10.3 mg/dL (P<0.001). Multiple logistic regression showed old age (odds ratio [OR], 1.25; 95% confidence interval [CI], 1.02 to 1.55), high initial A1c (OR, 22.21; 95% CI, 2.44 to 201.78), and lower amounts of glargine (OR, 0.85; 95% CI, 0.76 to 0.99), and glimepiride (OR, 0.23; 95% CI, 0.06 to 0.93) at baseline were independently associated with good responders whose A1c reduction was more than 0.5%. CONCLUSION: The authors suggest a basal plus regimen may be effective in reducing glucose levels of subjects with old age, high initial A1c, and patients on low doses of glimepiride and glargine. Despite the use of high doses of hypoglycemic agents, elderly patients with poorly-controlled diabetes are preferred for early initiation of the basal plus regimen.
Aged
;
Diabetes Mellitus, Type 2
;
Glucose
;
Hemoglobins
;
Humans
;
Hypoglycemic Agents
;
Insulin
;
Insulin, Long-Acting
;
Insulin, Short-Acting
;
Logistic Models
;
Retrospective Studies
;
Serum Albumin
;
Sulfonylurea Compounds
;
Insulin Glargine
9.Molecular Genetic Diagnosis of Hemophilia A by Linkage Analysis of XbaI/intron 22 DNA Polymorphism Using PCR.
Young Min CHOI ; Sung Hyo PARK ; Ko Eun BACK ; Do Yeong HWANG ; Jin CHOE ; Seung Yup KU ; Chang Suk SUH ; Seok Hyun KIM ; Jung Gu KIM ; Mi Ran LEE ; Eun Joo KIM
Korean Journal of Obstetrics and Gynecology 2003;46(4):771-775
OBJECTIVE: To set up the methodology for PCR analysis of XbaI/intron 22 polymorphism of the factor VIII gene, and to identify the usefulness of XbaI/intron 22 polymorphism analysis for carrier detection and prenatal diagnosis of hemophilia A in the Korean population. DESIGN: A laboratory analysis. MATERIALS AND METHODS: A XbaI/intron 22 polymorphism of the factor VIII gene was analyzed in 56 unrelated Korean mothers of patients with severe hemophilia A, using polymerase chain reaction. RESULTS: Analysis of XbaI/intron 22 polymorphisms of the factor VIII gene were feasible by PCR method. The expected heterozygosity rates of XbaI/intron 22 polymorphism of the factor VIII gene were 44.8%. Analysis of XbaI/intron 22 polymorphism revealed heterozygous patterns in 22 (39.3%) of 56 mothers studied. Using linkage analysis with XbaI/intron 22 polymorphism, we have attempted one case of carrier detection and two cases of prenatal diagnosis in two families of patients with severe hemophilia A. CONCLUSION: These results suggest that PCR analysis of the XbaI/intron 22 polymorphism within the factor VIII gene is very useful in the carrier detection and prenatal diagnosis of hemophilia A in the Korean population.
Diagnosis*
;
DNA*
;
Factor VIII
;
Hemophilia A*
;
Humans
;
Molecular Biology*
;
Mothers
;
Polymerase Chain Reaction*
;
Prenatal Diagnosis
10.A Case of Gabapentin-induced Myoclonus in a Type 2 Diabetic Patient with End-stage Renal Disease.
Eun Yeong CHOE ; Byung Wan LEE ; Kyeong Hye PARK ; Hannah SEOK ; Daham KIM ; Eun Seok KANG ; Bong Soo CHA ; Hyun Chul LEE
Journal of Korean Diabetes 2011;12(3):171-173
Development of myoclonus can manifest as a side effect of antiepileptic drugs in subjects with preexisting epilepsy, post-traumatic brain injury, encephalopathy, or focal and multifocal brain lesions. A 69-year-old male showed new onset severe myoclonus and confusion two days after taking 1200 mg gabapentin. The patient had end-stage renal disease secondary to type 2 diabetes and was receiving hemodialysis twice a week. After increasing hemodialysis to three times a week and discontinuing gabapentin, myoclonus spontaneously resolved. Here we report the first case of myoclonus in a Korean subject with diabetic renal failure. We recommend caution in the administration of gabapentin for diabetic subjects with renal disease.
Aged
;
Amines
;
Anticonvulsants
;
Brain
;
Brain Injuries
;
Cyclohexanecarboxylic Acids
;
Diabetic Neuropathies
;
Epilepsy, Post-Traumatic
;
gamma-Aminobutyric Acid
;
Humans
;
Kidney Failure, Chronic
;
Male
;
Myoclonus
;
Renal Dialysis
;
Renal Insufficiency