No abstract available.
Appendix* ; Lymphoma*

No abstract available.
Appendicitis* ; Child* ; Humans

Forty cases of infiltrating duct carcinoma of the breast were examined immunohistochemically for expression of TGF-beta and angiogenesis in order to analyze significant correlation with prognostic parameters including tumor size, axillary lymph node metastasis, clinical stage, histologic grade, estrogen receptor and progesterone receptor status. The TGF-beta expression was observed in tumors center and advancing edges of tumors. To determine microvessel density for angiogenesis, we stained endothelial cells for Factor VIII related antigen and counted microvessel within tumor. The results were as follows: 1) The strong immunohistochemical expression of TGF-beta and higher counts of microvessels were observed in advancing edges of tumors (p<0.05). 2) The TGF-beta expression in the advancing edges of tumors was closely related to clinical stage and presence of axillary lymph node metastasis (p<0.05). 3) The mean microvessel counts were significantly higher in tumors from patients with axillary lymph node metastasis and increased with increasing clinical stage (p<0.05). 4) The TGF-beta expression was not related to histologic grade, estrogen receptor and progesterone receptor status(p>0.05). Therefore, the results suggested that the TGF-beta expression and angiogenesis in infiltrating duct carcinoma of the breast may play an important part in prognostic factors, closely related to the lymph node metastasis and clinical stage.
Neoplasm Metastasis

A primary squamous cell carcinoma of the thyroid is extremely rare disease. We evaluated this disease by fine needle aspiration cytology in a 43 year-old female. On physical examination, the thyroid was moderately enlarged and palpated with hard consistency. The cytologic aspirate revealed nests of squamous cells, malignant squame and thyroid follicular cells in the necrotic background. We diagnosed this tumor as squamous cell carcinoma with cytologic evidence. Surgically resected thyroid revealed well differentiated squamous cell carcinoma. Immunohistochemical staining for antithyroglobulin proved that this tumor was primary in origin and clinical study confirmed this lesion to be of primary thyroid origin rather than metastasis or direct invasion from contiguous structures.
Adult ; Biopsy, Fine-Needle* ; Carcinoma, Squamous Cell* ; Female ; Humans ; Neoplasm Metastasis ; Physical Examination ; Rare Diseases ; Thyroid Gland*

PURPOSE: To find characteristic MRI features of vermian medulloblastoma. MATERIALS AND METHODS: MRI studiesand medical records were retrospectively reviewed for 12 patients with surgically proven midline medulloblastoma. The assessment concerned appearance of the mass in relation to surrounding structures ; MR signal intensity ; the enhancement pattern ; the mass's location and size ; presence of a cystic/necrotic area, calcification, or vascular void ; extension through the foramen Luschka ; degree of hydrocephalus ; and presence of tonsillarherniation. RESULTS: The midline medulloblastoma commonly showed roundish moon-surface appearance, especially onthe axial T2-weighted images. All tumors showed heterogeneous signal intensities mainly due to intratumoralcystic/necrotic or hemorrhagic changes. The tumors were commonly located at mid- and/or inferior vermis. Occasionally the tumors extended through the foramen Luschka, and caused obstructive hydrocephalus of moderate tosevere degree. Post-con-trast study showed heterogeneous, dense contrast enhancement in the majority of patients. CONCLUSION: The MR finding of the moon-surface appearance formed by both the mass and the intratumoralcystic/necrotic change as seen on axial T2-weighted images could be helpful in the diagnosis of vermianmedulloblastoma.
Diagnosis ; Humans ; Hydrocephalus ; Magnetic Resonance Imaging* ; Medical Records ; Medulloblastoma* ; Retrospective Studies

All solid tumors require the induction of new blood vessel to grow. The neovascularization of tumor tissue(angiogenesis) is considered essential for tumor growth, proliferation and eventually metastasis. Recent reports have demonstrated that the intensity of tumor angiogenesis in prostate and other tumors may be of prognostic value. We analyzed the prognostic significance of microvessel quantitation in bladder carcinoma. Microvessels were identified by immunohistochemistry using antibodies to endothelial marker, factor VIII-related antigen. The three most vascular area within a tumor were selected, and the microvessels within a x200 microscopic field of each area were counted by an investigator. The significant relationship was observed between microvessel counts and recurrence rate in 17 patients with superficial bladder cancer. Microvessel counts correlated with stage, grade, lymph node and distant metastasis, and 2 year disease free survival rate in 28 patients with invasive bladder cancer. In 15 patients with invasive cancer who were not showed distant metastasis, tumors from patients who experienced distant metastasis had higher microvessel counts than did tumors from patients who were disease- free(75.7118.59 and 61.7517.78), these values were not significantly different(p=0.081). These findings suggest that assessment of angiogenesis by microvessel quantitation may be a valuable method to predict metastatic potential of tumors, survival and the candidates for adjuvant therapy in patients with invasive bladder cancer.
Antibodies ; Blood Vessels ; Disease-Free Survival ; Humans ; Immunohistochemistry ; Lymph Nodes ; Microvessels ; Neoplasm Metastasis ; Prostate ; Recurrence ; Research Personnel ; Urinary Bladder Neoplasms* ; Urinary Bladder* ; von Willebrand Factor

Nucleolar organizer regions(NORs) are intranucleolar segments of DNA coding for ribosomal RNA and contribute to the regulation of cellular protein synthesis. Since NOR-associated proteins are argyrophilic, silver staining method has been used for demonstration of NORs. The numbers of argyrophilic NORs(AgNORs) have been shown to be correlated with DNA ploidy and have prognostic value in diverse human neoplasms. However, the prognostic value of AgNORs in renal cell carcinoma(RCC) remain ill defined. We herein investigated the prognostic value of AgNORs in 39 patients with RCC. There was no significant relationship between mean number of AgNORs (m AgNORs) per nucleus and Robson stage and Fuhrman nunlear grade. However, there was significant relationship between the percentage of tumor cells with more than five AgNORs per nucleus (p AgNORs) and Robson stage and nuclear grade (p<0.05). There was significant difference in survival rate between patients with RCC in whom AgNORs were two or less and in whom AgNORs were greater than two(p<0.05). The patients with a low p AgNORs(less than 8%) have a better prognosis than those with a high p AgNORs. These results suggest that number of AgNORs may be a clinically useful prognostic marker for patients with RCC.
Carcinoma, Renal Cell* ; Clinical Coding ; DNA ; Humans ; Nucleolus Organizer Region* ; Ploidies ; Prognosis ; RNA, Ribosomal ; Silver Staining ; Survival Rate

An accurate preoperative evaluation of lymph nodes(LNs) in gastric cancer is a prerequisite for successful surgery and favorable prognosis. We retrospectively analyzed the Ct accuracy in perigastric LN localization and LN staging of gastric cancer as well as the size criteria for the metastasized LN in 64 patients who hed undergone a surgery for gastric cancer. The results of perigastric LNs evaluation by CT are as follows; sensitivity 67%(64/95), specificity 90%(839/929), accuracy 88%(903/1024). Of 95 pathologically metastasized LN groups, 66 could be retrospectively identified on Ct scans(69%). In LN staging, CT was correct in 60%(38/64), overstaged in 32%(21/64), and understaged in 8%(5/64). The perigastric LN groups which were easily localized on CT were #3, 7, 8, and 13. The mean size of metastasized LNs on CT according to the I.N group was #3 (13mm), #4(9mm), #6 (10mm), #7(10.5mm), #8 (10mm), #9 (11mm), #13 (9mm).
Humans ; Lymph Nodes* ; Prognosis ; Retrospective Studies ; Sensitivity and Specificity ; Stomach Neoplasms*

No abstract available.
Cardiotocography* ; Meconium* ; Pregnancy*

Percutaneous aspiration needle biopsy of the intrathoracic disease is a safe, easy, and accurate diagnostic method. It usually causes mild pain or discomfort during the procedure. We had a patient who complained of severe sharp pain, well localized at the biopsy site of the target mass during CT-guided transthoracic aspiration biopsy. It was pathologically confirmed as an intrathoracic schwannoma after special staining. To our knowledge, there has been no published report of such a painful percutaneous needle biopsy in a patient with schwannoma in Korea. Two cases were reported in other radiologic journals. The severe sharp pain developed during the transthoracic aspiration needle biopsy is a reliable sign of neurogenic tumor, therefore the participating radiologist should recommend specific immumochemical stain for neurogenic tumor to pathologist.
Biopsy ; Biopsy, Needle* ; Humans ; Korea ; Needles* ; Neurilemmoma*