No abstract available.
Child* ; Cholesterol* ; Humans

No abstract available.

BACKGROUND: Paraquat is a widely used herbicide, known to cause lethal toxicity in humans. Most studies about paraquat have concentrated on systemic toxicity, however several cases of paraquat-induced dermatitis have been reported. OBJECTIVE: The purpose of this study was to confirm the cutaneous toxic effect of paraquat and to select potential antidotes in paraquat-induced dermatitis. METHODS: Keratinocyte toxicity due to paraquat and the toxicity reduction capacity of several drugs were investigated in eitro. Topical effects of these drugs on paraquat-induced dermatitis in guinea pig skin was also investigated. RESULTS: Over 50% of keratinocytes failed to survive at a concentration of 2X10-4M paraquat by a neutral red uptake assay. Skin irritation by paraquat was observed at 2% concentration by non-invasive methods as well as a skin biopsy. Dexamethasone, glutathione and tocopherol showed some capacity to reduce paraquat-induced keratinocyte toxicity in vitro. Only dexamethasone, however, showed a reduction of cutaneous blood flow volume and dermal inflammatory cell infiltration in the guinea pig study. CONCLUSION: This result indicates the possible in eitro protective effect of paraquat toxicity in glutathione and tocopherol. Dexamethasone was capable of reducing paraquat-induced cytotoxicity and dermatitis both in vitro and in vivo.
Animals ; Antidotes* ; Biopsy ; Dermatitis ; Dexamethasone ; Glutathione ; Guinea Pigs ; Humans ; In Vitro Techniques ; Keratinocytes ; Neutral Red ; Paraquat* ; Skin* ; Tocopherols

Histiocytosis X(Langerhans cell histiocytosis) is a rare prolifertive disorder of Langerhans cells that includes Lettere-Siwe disease, Hand-Shiiller-Christian his ase and eosinophilic granuloma. Since many authors have reported in anintermediate and poarl classified form histiocytosis X has a namenclatural had nosologic problem. We report a case benign cutaneous variant of histiocytisis X. A four-month-old boy had shown multiple skin-colour papules on the trunk, head and nik for one month. Extensive in- vestigations failed to detcct any systemic involvement. The clixron microscopic findings of the skin biopsy specimen were Qefinitely diagnostic for histiocytosi. X Since he did not sbow evidence of internal organ involvernent and any further progression of he skin lesion, no therapy was given. Over the next two months the disease underwent spontane us and complete remission.
Biopsy ; Eosinophilic Granuloma ; Head ; Histiocytosis* ; Histiocytosis, Langerhans-Cell* ; Humans ; Langerhans Cells ; Male ; Remission, Spontaneous* ; Skin

No abstract available.
Hypopituitarism* ; Hypothyroidism*

Melkersson-Rosenthal (M-R) syndrome consists of a triad of (1) recurrent peripheral facial nerve paralysis which develops alternatively on both sides of face, (2) non-inflammatory facial edema, and (3) furrowed tongue. Since the cause of M-R syndrome is unknown, various forms of therapy have been tried, but there were no conclusive evidence that they altered the course of the disease. A 27-year-old female and a 44-year-old male patient with recurrent facial nerve paralysis were diagnosed with M-R syndrome. We report the two cases of M-R syndrome with the brief review of literatures.
Adult ; Edema ; Facial Nerve ; Female ; Humans ; Male ; Melkersson-Rosenthal Syndrome* ; Paralysis ; Tongue, Fissured

We investigated the fibrovascular ingrowth and fibrovascular tissue maturation of hydroxyapatite-coated, porous alumina sphere (Alumina sphere) in comparison with the hydroxyapatite sphere (HAp sphere) in rabbits. Alumina spheres and HAp spheres were implanted in the left orbits of 42 New Zealand white rabbits after enucleation. Fibrovascular ingrowth and maturation were graded from 1 to 5 at postoperative 1, 2, 3, 4, 8, 12 and 24 weeks. We defined 4 phases: postoperative 1-2 weeks as phase I, 3-4 weeks as phase II, 8-12 weeks as phase III, and 24 weeks as phase IV. The grade was analyzed at each phases. There was no significant difference in fibrovascular ingrowth and maturation between the two groups at all 4 phases, except phase II at which the Alumina sphere showed significantly lower maturation grade (p< 0.05). We concluded that the Alumina sphere is an ideal orbital implant material and an ideal substitute for the HAp sphere in clinical practice.
*Aluminum Oxide ; Animals ; *Coated Materials, Biocompatible ; *Durapatite ; Eye Enucleation ; Female ; Fibroblasts/cytology/physiology ; Microscopy, Electron, Scanning ; Neovascularization, Physiologic/*physiology ; *Orbital Implants ; Prosthesis Implantation ; Rabbits ; Research Support, Non-U.S. Gov't

PURPOSE: The purpose of this study was to evaluate the effect of smart health care service in the breast cancer patients through a systematic review. METHODS: For the study, 10 studies were selected by using PubMed, ScienceDirect, ProQuest, CINAHL, RISS4U, KISS, DBpia and the National Assembly Library. The Risk of Bias Assessment Tool was used by two reviewers to evaluate independently the quality of the selected articles. RESULTS: 10 studies for the analysis of the effect of smart health care service using mobile applications on breast cancer patients since 2000 were found. The purpose of mobile based intervention was to check whether post-operative outpatient follow up could be substituted with mobile apps to measure and monitor weight loss or weight management, sleep, mood, depression and mental state, exercise, uncertainty management and feedback. CONCLUSION: Although mobile research is still limited, it may be sufficient to monitor the symptoms of breast cancer patients and to provide dietary and exercise interventions. This study suggests that various mobile apps can be used for breast cancer patients in various situations. Future study is recommended for repeated intervention studies on the effect of apps.
Bias (Epidemiology) ; Breast Neoplasms* ; Breast* ; Delivery of Health Care ; Depression ; Follow-Up Studies ; Humans ; Mobile Applications ; Outpatients ; Telemedicine* ; Uncertainty ; Weight Loss

Bronchoalveolar lavage (BAL) has emerged as a useful technique for the study of pulmonary interstitial disorders. Several types of information are provided by the evaluation of lavage fluid. Identification of cellular constituents helps to separate inflammatory process. Recently we have studied cellular constituents of BAL from three cases with histologically confirmed pulmonary sarcoidosis, idiopathic pulmonary fibrosis and hypereosinophilic syndrome. Pulmonary sarcoidosis showed a marked increase in lymphocytes, idiopathic pulmonary fibrosis revealed a predominance of neutrophils, and hypereosinophilic syndrome presented a marked increase in eosinophils in the lavage fluids.
Bronchoalveolar Lavage ; Child* ; Eosinophils ; Humans ; Hypereosinophilic Syndrome ; Idiopathic Pulmonary Fibrosis ; Lymphocytes ; Neutrophils ; Sarcoidosis ; Sarcoidosis, Pulmonary ; Therapeutic Irrigation ; Urinary Tract Infections* ; Urinary Tract*

The ovarian hyperstimulation syndrome (OHSS) is one of the notorious complications of assisted reproduction procedure. Severe and moderate OHSS associated with a spontaneous pregnancy is rare. We experienced a case of two normal, spontaneously conceived pregnancies with OHSS and her past obstetric history included prior spontaneous OHSS in the first trimester and term vaginal delivery of normal baby.
Female ; Humans ; Ovarian Hyperstimulation Syndrome* ; Pregnancy Trimester, First ; Pregnancy* ; Reproduction