In an attempt ultrastructural study of alcohol-induced gastric mucosal change, we selected sixty Sprague-Dawley rats. The rats were administrated with 4 ml of 10% and 40% ethanol enterically and examined by light and electron microscopy. Light microscopically, the thickness of the mucus layer of both 10% and 40% ethanol groups was decreased. The antral mucosa revealed focal inflammatory infiltrates, disturbed glandular arrangements, and significant decrease of mucosal thichness and proper glands. On scanning electron microscopy, flattened or swollen mucosal epithelium and irregularly distributed gastric pits were seen in both experimental groups, and these changes were more severe in the groups of higher concentration and longer duration. On transmission electron microscopy, mitochondrial abnormalities with myelin-like materials and dilatation of endoplasmic reticulum and cytoplasmic blebs were observed. Also the mucus cells show significantly decreased mucus globules, increased fat vacuoles, and large autophagic vacuoles. These alterations were similar to those produced by ethanol in the liver and small intestine. This study indicates that, prolonged administration of ethanol induced chronic gastritis, especially chronic atrophic gastritis.
Rats ; Animals

PURPOSE: This study was conducted to identify awareness levels in regard to preconception care and gender differences targeting single undergraduate students in their 20s. METHODS: The study participants were 867 single undergraduate students aged 20~29 (523 women, 344 men). This was a descriptive research, in which awareness levels of preconception care and pregnancy were identified the through questionnaire surveys. RESULTS: Gender differences in the awareness of reproductive care before conception were found. Generally, women's awareness of issues related to preconception care and pregnancy was higher than that of men. Women recognized risk factors in pregnancy (chi2=22.85, p<.001) and positive behaviors (chi2=10.91, p = .012) better than men. Women's awareness of preconception care was significantly higher than that of men (t=8.37, p<.001). The awareness levels of the students who completed a reproduction related class (t=3.16, p = .002) and the students who knew about folic acid (t=-10.78, p<.001) in preconception care were statistically significantly higher. CONCLUSION: The results indicate that the ways to educate and alert students to major risk factors before pregnancy and other reproductive care content before conception is to provide education both single women and single men.
Education ; Female ; Fertilization ; Folic Acid ; Humans ; Male ; Preconception Care* ; Pregnancy* ; Surveys and Questionnaires ; Reproduction ; Risk Factors

The purpose of this study was to dcvclop nd test the validity of standardized Korean nome clature based on Nursing Intervention Classi ications (MC), developed by McCloskey and Bul chek at the University of Iowa, The four phases of the study were 1. Two professors and 15 graduate stude ts, who were taking a nursing intervention cours, translated the 433 nursing interventions of IC into Korean 2. 12 nurses with various clinical bac rounds reviewed the nomenclature, taking into nsider ation the definition and activities for each Korean nursing intervention. The Delphi method was used to determine the best appropriate nomenclature for each intervention ~. 20 academic and clinical experts in nursing were given a questionnaire to rate the validity of each Korean nomenclature using a 5 point Likert scale ranging from very inappropriate to very appropriate 4. five members of the Korean Nurses Association Research Committee reviewed the survey results and determined the most appropriate Korean nomenclature for each nursing intei veiition of NIC system. Most nomenclature had a score of more than 4.0, but seven nursing interventions had a score lower than 4.0: Critical Path Development (2.71), Calming Technique ~3.4l), Grief Work Facilitation (3.44), Order Transcription (3.44), Self Modification Assistance (3.44), and Teaching Psycho-motor Skills (3.47). These research results will be included in the nursing vocabulary dictionary to be published by Korean Nurses Association.
Critical Pathways ; Grief ; Iowa ; Nursing ; Vocabulary ; Surveys and Questionnaires

The purpose of this study was to evaluate effects of a nutrition education focused on Food Exchange System for the higher grades elementary children. Nutrition education lessons (40 min/lesson, 4 times), '5 major nutrients and functions', '6 food groups', 'daily needed energy and food exchange units', 'good choice of snacks and balanced exercise' were provided to elementary students (5th grade students). This research was based on the data from two groups of elementary school children in the 'education' group (n = 31) and 'non-education' group (n = 31). We assessed the changes in dietary attitude, food habit and nutrition knowledge using questionnaire and nutrient intake using 24hr recall method by nutrition education using the developed pamphlet. After education, there was a significant difference in the dietary attitude score only in attitude of 'balanced meal' (p < 0.001) in the education group compared to the non-education group. In food habit, there were significant positive changes in the type of breakfast and in the priority of choosing snack in the educated group. In nutrition knowledge, there were significant increases in scores of 'function of carbohydrate' (p < 0.05), 'function of fat' (p < 0.01), 'function of vitamin' (p < 0.01), 'foods of carbohydrate' (p < 0.01), and 'foods of vitamin' (p < 0.01) in the educated group. After education,carbohydrate: protein: fat (CPF) ratio was significantly different between the two groups (education group, 59 : 16 : 26 vs. non-education group, 63 : 15 : 23). In evaluation of nutrient intake by Dietary Reference Intakes for Koreans (KDRIs), there were significant positive effects in energy (p < 0.05), thiamin (p < 0.05), riboflavin (p < 0.05), vitamin C (p < 0.05), phosphorus (p < 0.01), Fe (p < 0.01) and zinc (p < 0.01) in the education group compared to the non-education group. In conclusion, the developed 4 times' nutritional education pamphlet focused on individual daily energy requirements and food exchange units using food exchange system for higher grades' elementary student may positively change nutrition knowledge and dietary intakes.
Ascorbic Acid ; Breakfast ; Child ; Food Habits ; Humans ; Pamphlets ; Phosphorus ; Surveys and Questionnaires ; Riboflavin ; Snacks ; Zinc

PURPOSE: The main purpose of this study was to explore the adaptation experience of adolescent cancer survivors during and after cancer treatment, and their perceived social support networks. METHODS: This study was a qualitative descriptive study using the in-depth interview. Eight adolescent cancer survivors who were diagnosed with cancer between 11 to 18 years old participated in the study. RESULTS: The adaptation experiences of adolescent cancer survivors over time were identified within five categories for during their treatment such as “being catapulted from one's life,”“standing at the center of discomfort,”“falling behind the line,”“accepting the change,”“being developed”, and another five categories for after the treatment including “being shackled,”“encountering the forgotten reality,”“overcoming and emerging from the reality,”“growing into adulthood,”“entering into a new orbit.” Participants reported the various members of their social support network and their roles during and after the treatment as well. CONCLUSION: While adolescent cancer survivors adjusted to their changing situations after the cancer diagnosis, their internalized adaptation, as well as perceived social support from their diverse surrounding network, played significant roles. These findings will become a valuable asset for developing age-appropriate nursing interventions to promote psychosocial adjustment of adolescents with cancer.
Adaptation, Psychological ; Adolescent* ; Diagnosis ; Humans ; Nursing ; Survivors*

Terminal or interstitial deletions of Xp (Xp22.2-->Xpter) in males have been recognized as a cause of contiguous gene syndromes showing variable association of apparently unrelated clinical manifestations such as Leri-Weill dyschondrosteosis (SHOX), chondrodysplasia punctata (CDPX1), mental retardation (NLGN4), ichthyosis (STS), Kallmann syndrome (KAL1), and ocular albinism (GPR143). Here we present a case of a 13.5 yr old boy and sister with a same terminal deletion of Xp22.2 resulting in the absence of genes from the telomere of Xp to GPR143 of Xp22. The boy manifested the findings of all of the disorders mentioned above. We began a testosterone enanthate monthly replacement therapy. His sister, 11 yr old, manifested only Leri-Weill dyschondrosteosis, and had engaged in growth hormone therapy for 3 yr. To the best of our knowledge, this is the first report of a male with a 9.7 Mb terminal Xp deletion including the OA1 locus in Korea.
Abnormalities, Multiple/*genetics ; Adolescent ; Child ; Chromosome Deletion ; *Chromosomes, Human, X ; Eye Proteins/genetics ; Female ; Genetic Loci ; Growth Hormone/therapeutic use ; Humans ; Male ; Membrane Glycoproteins/genetics ; Telomere/genetics ; WAGR Syndrome/*diagnosis/genetics/therapy

No abstract available.
Glomerulonephritis, IGA* ; Immunoglobulin A*

This study was carried out to investigate the morphologic characteristics and localization of antigenic molecules of Pneumocystis carinii in experimentally induced P. carinii pneumonia in rats. After six weeks of administration of low protein diet and dexamethasone, Sprague-Dawley rats were sacrificed to submit lungs or bronchoalveolar lavage for the study. Monoclonal (092, 900, 902, and 904) and polyclonal (SP-D) antibodies were used for immunohistochemistry and immunoelectron microscopy (ITEM and ISEM). Immunohistochemically P. carinii organisms were well identified as clusters or separated forms in the alveolar spaces being frequently attached to the alveolar walls. Immunoelectron microscopically the adherences of gold particles were observed on the surface of all stages of the P. carinii. Occasionally positive immunogold labeling was observed in the cytoplasm of the trophozoites and on the pellicle of the intracystic bodies within the cysts. The monoclonal antibodies 092, 900, 902, and 904 reacted mainly with pellicles of P. carinii, whereas SP-D labeled on the pellicles, intracystic bodies, cytoplasms of the alveolar macrophages, and free floated surfactant material in the alveolar spaces. The immunogold particles were observed more diffusely and intensely in the cysts than in the trophozoites. These results indicate that antigen is mainly localized on the pellicles, and accumulated during development from the trophozoite to the cyst stages.
Animals ; Antibodies ; Antibodies, Monoclonal ; Bronchoalveolar Lavage ; Cytoplasm ; Dexamethasone ; Diet, Protein-Restricted ; Immunohistochemistry ; Lung ; Macrophages, Alveolar ; Microscopy, Electron ; Microscopy, Immunoelectron ; Pneumocystis carinii* ; Pneumocystis* ; Pneumonia ; Pulmonary Surfactant-Associated Protein D ; Rats ; Rats, Sprague-Dawley ; Trophozoites

PURPOSE: The purpose of the study was to identify and explain the essences and structures of maternal conflicts in Vietnamese married immigrant women in Korea. METHODS: A phenomenological methodology was used for the study. Eleven Vietnamese married immigrant women participated in the study. Verbatim transcripts were analyzed using Colaizzi's method. RESULTS: Four categories, 10 clusters and 26 themes emerged from the data for the experience in maternal conflicts of Vietnamese married immigrant women. The four categories were 'An unprepared young motherhood in another culture', 'Feeling left out of the mother's place along the bands of Nap tai tradition', 'My image is like not-being able to stand alone/be independent' and 'Finding hope in motherhood despite of conflicts and stigmas'. CONCLUSION: Vietnamese married immigrant women experienced not only the negative aspects but also sublimation of maternal conflicts. Based on the results, health professionals need to develop effective nursing interventions toward a positive maternal identity and approach with interculturalism for the Vietnamese married immigrant women in Korea.
Adaptation, Psychological ; Adult ; Communication Barriers ; Emigrants and Immigrants/*psychology ; Family/psychology ; Female ; Humans ; Interviews as Topic ; Marriage ; Maternal Behavior/*psychology ; Pregnancy ; Quality of Life ; Questionnaires ; Republic of Korea ; Vietnam

PURPOSE: This research was conducted to investigate perceived health status, health promoting behaviors and depression level in Korean and foreign students at women's university. METHODS: The sample group of this study consists of 100 Korean students at a women's university and 98 foreign students from China and Vietnam who were enrolled at the same university in G City. The research results were analyzed using the SAS program (Version 8.2) with Chi-square test, Fisher's exact test and t-test. RESULTS: 1) The Korean students showed a significantly higher score in drinking and smoking than foreign students. Also, age, religion, part time job, stress and allowance were significantly different between the two groups. 2) The foreign students showed a significantly higher score in perceived health status and health promoting behavior than the Korean students. 3) The foreign students showed a significantly higher score in depression than the Korean students. CONCLUSION: In the development of health programs for foreign students, it is necessary to focus on reducing depression and to consider the traditions of their own countries. It is desired to conduct further study about health promoting behavior and factors affecting health with respect to the countries where the foreign students originated.
China ; Depression* ; Drinking ; Health Promotion ; Humans ; Smoke ; Smoking ; Vietnam