2.The effectiveness of selective posterior rhizotomy in cerebral palsy.
Chang Il PARK ; Eun Sook PARK ; Dong Soo LEE ; Jong Eun CHOI
Journal of the Korean Academy of Rehabilitation Medicine 1993;17(1):105-111
No abstract available.
Cerebral Palsy*
;
Rhizotomy*
3.Clinical Courses of Cavitary Lesions in Pulmonary Tuberculosis.
Seung Kyu PARK ; Eun Soo KWEON ; Sun Dae SONG
Tuberculosis and Respiratory Diseases 2001;50(4):484-492
BACKGROUND: Pulmonary tuberculosis with a remaining cavitary lesion is considered to be a problem with the course of treatment. In particular, re-treatment cases tend to respond poorly to current anti-tuberculosis agents. Therefore the factors that are related with the poor closure of a cavitary lesion in pulmonary tuberculosis during treatment were evaluated. METHODS: A retrospective review of the medical records and chest X-ray films of 68 patients who had chemotherapy for the pulmonary tuberculosis with cavitary lesions was made. All the patients had been followed up for more than 12 months at National Masan Tuberculosis Hospital as of Aug. 2000. RESULTS: The male to female ratio was 3.9:1. 72.4% of the patients were between 20 to 50 years of age. 66.2% of the cavitary lesions on the chest X-ray films were confined to the upper lung fields : 36.8% in the right upper lung field and 29.4% in the left upper lung field. 82.4% of the cavities were less than 40mm in their size, and 83.8% were less than 6mm thick. The cavitary lesions were closed in 48 cases and remained in 20 cases during a follow-up period of more than 12 months. The factors that are though to affect ot the outcomes of the cavities were age, past medication history, the number of unused drugs, and the number of sensitive drugs. CONCLUSION: In the treatment courses of pulmonary tuberculosis with cavitary lesions, the following factors are associated with less desirable outcome:an age over 45, a past medication history of more than 2 courses of treatment, The number of unused drugs not exceeding average 6 and the number of sensitive drugs not exceeding average 7.
Drug Therapy
;
Female
;
Follow-Up Studies
;
Hospitals, Chronic Disease
;
Humans
;
Lung
;
Male
;
Medical Records
;
Retrospective Studies
;
Thorax
;
Tuberculosis, Pulmonary*
;
X-Ray Film
4.Unilateral Parotitis and Kawasaki Disease in a Child.
Soo Young LYU ; Gil Ho BAN ; Su Eun PARK
Korean Journal of Pediatric Infectious Diseases 2014;21(3):214-218
Kawasaki disease is generally diagnosed base on its clinical features. Sometimes unusual or atypical presentations make the diagnosis of Kawasaki disease difficult. We experienced an unusual case of Kawasaki disease presented with unilateral parotitis in a 23-month old girl. Despite of intravenous antibiotics treatment, fever and unilateral parotid swelling persisted. Skin rashes, conjunctival injections, and coronary abnormalities showed up on the 8th day of fever. After the intravenous immunoglobulin and salicylates treatment, all symptoms disappeared. Although unilateral parotitis is very unusual presentation of Kawasaki disease, in case of no response to antibiotics, Kawasaki disease should be included in the differential diagnosis.
Anti-Bacterial Agents
;
Child*
;
Diagnosis
;
Diagnosis, Differential
;
Exanthema
;
Female
;
Fever
;
Humans
;
Immunoglobulins
;
Mucocutaneous Lymph Node Syndrome*
;
Parotitis*
;
Salicylates
5.Mitomycin C vs. bacillus calmette-guerin: comparison of prophylactic efficacy to high risk superficial bladder tumor.
Eun Sik LEE ; Moon Soo PARK ; Chongwook LEE
Journal of the Korean Cancer Association 1991;23(1):101-106
No abstract available.
Bacillus*
;
Mitomycin*
;
Urinary Bladder Neoplasms*
;
Urinary Bladder*
6.A Study on Free Fatty Acid and Albumin Levels in Breast Milk.
Eun Young KWAK ; Sang Kee PARK ; Chang Soo RA
Journal of the Korean Pediatric Society 1990;33(3):291-298
No abstract available.
Breast*
;
Milk, Human*
7.Transrectal Ulterasonographic Parameters Prediciting Acute Urinary Retention in BPH.
Jeong Yoon KANG ; Moon Soo PARK ; Sang Eun LEE
Korean Journal of Urology 2000;41(12):1485-1489
No abstract available.
Urinary Retention*
9.Relationship between stress and health behaviors practice.
Eun Young PARK ; Hyung Cheol PARK ; Kyeong Soo PARK ; Seok Joon SOHN
Journal of the Korean Academy of Family Medicine 2000;21(11):1436-1450
No Abstract Available.
Health Behavior*
10.Inactivation of p73 Protein by Cervical Cancer-inducing HPV E6 Protein Novel p53-independent function of E6.
Sung Eun NAMKOONG ; Seung Jo KIM ; Eun Joo KIM ; Soo Jong UM ; Jong Sup PARK
Korean Journal of Obstetrics and Gynecology 1998;41(11):2827-2834
OBJECTIVE: Human papillomavirus (HPV) is strongly implicated as a causative agent in the etiology of cervical cancer. Of its gene products, E6 and E7 oncoproteins play major roles by inactivation of cellular p53 and pRb tumor suppressor proteins, respectively. However, it has been recently suggested that p53 and/or pRb-independent functions of E6 and E7 are involved in cervical carcinogenesis. The purpose of this study is to identify novel a cellular target, p73, of E6 and to determine how E6 inactivates p73 function, METHODS: The interaction between E6 and p73 were identified by the yeast two-hybrid assay in vivo and the GST pull-down assay in vitro. The function of the interaction was determined by transient transfections using p21 promoter-CAT reporter plasmid. The molecular mechanism underlying the functional significance of the interaction was further assessed by in vivo and in vitro protein degradation assays, and gel mobility shift assays. RESULTS: Yeast two-hybrid and GST pull-down assays indicate a physical interaction between p73 and either HPV-16 or HPV-11 E6 proteins in vivo and in vitro, respectively. Transactivation domain (amino acid residues 1-49) is found to be absolutely required for this interaction. Transient co-expression of E6 significantly inhibits the p73-mediated activation of p21WAF1 promoter in a p53-defective C33A cell line. Using Ga14-p73 fusion protein, we demonstrate that E6 inhibition of p73 transactivation function is independent of sequence-specific DNA binding, which is confirmed by direct electrophoretic mobility shift assay. Moreover, E6 inhibits p73 function by interfering with the activity of the amino-terminal activation domain. The protein degradation assays in vivo and in vitro indicate that p73, unlike p53, is not susceptible to E6-dependent proteolysis. CONCLUSION: Throughout this study, we identified p73 as a novel cellular target of HPV-E6 protein and found that E6 binds p73 through the amino-terminal transactivation domain, and inhibits its transactivation function independent of the protein degradation and DNA binding. These overall results, consequently, suggest that in addition to the inactivation of p53, the functional interference of p73 by HPV-E6 may, at least in part, contribute to E6-mediated cellular transformation.
Carcinogenesis
;
Cell Line
;
DNA
;
Electrophoretic Mobility Shift Assay
;
Human papillomavirus 11
;
Human papillomavirus 16
;
Humans
;
Oncogene Proteins
;
Plasmids
;
Proteolysis
;
Transcriptional Activation
;
Transfection
;
Tumor Suppressor Proteins
;
Two-Hybrid System Techniques
;
Uterine Cervical Neoplasms
;
Yeasts