No abstract available.
Emergencies* ; Emergency Service, Hospital* ; Hospitals, General* ; Humans

No abstract available.
Erythema Infectiosum*

Recent advance in the field of microvacular surgery has popularized the reattachment of severed digit, with increasing success rate and improving functional regain. Reattachment surgery was performed in six digits, two thumbs and four fingers, which had been amputated at or distal to the level of DIP joint. Microvascular anastomosis of one digital artery was done and the venous drainage was reestablished with blood letting from the pulp of each digit. There was one failure in which hypersensitivity to heparin was present, while all other five showed success. Postoperatively considerable sensory recovery was present in all.
Arteries ; Drainage ; Fingers ; Heparin ; Hypersensitivity ; Joints ; Linear Energy Transfer ; Thumb

No abstract available.
Hemophilia A* ; Humans

No abstract available.
Leukemia*

BACKGROUND: The purpose of this study was to analyze the relationships between cardiorespiratory fitness and body mass index (BMI), metabolic syndrome risk factors, homeostasis model assessment-insulin resistance (HOMA-IR), and high sensitivity C-reactive protein (hsCRP) in male high school students in Korea. Furthermore, the effects of the cardiorespiratory fitness levels on these four factors were examined. METHODS: The level of cardiorespiratory fitness, BMI, percent body fat, waist circumference (WC), systolic blood pressure, glucose, triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), HOMA-IR, and hsCRP of 227 male high school students were measured. Analyses of multiple correlation and simple regression were applied. RESULTS: The results showed that the level of cardiorespiratory fitness correlated negatively with BMI, percent body fat, WC, TG, and HDL-C, in addition to HOMA-IR and hsCRP, and strongly influenced BMI, percent body fat, WC, TG, HDL-C, HOMA-IR, and hsCRP. Comparative analysis of our subjects showed that higher cardiorespiratory fitness levels had positive effects on BMI, metabolic syndrome risk factors, HOMA-IR, and hsCRP. CONCLUSIONS: This study found that there are close correlations between cardiorespiratory fitness and BMI, metabolic syndrome risk factors, HOMA-IR, and hsCRP. It also showed that, compared to lower levels of cardiorespiratory fitness, higher levels had beneficial effects on BMI, metabolic syndrome risk factors, diabetes, and cardiovascular disease risk factors.
Adipose Tissue ; Adolescent ; Blood Pressure ; Body Mass Index ; C-Reactive Protein ; Cardiovascular Diseases ; Glucose ; Homeostasis ; Humans ; Insulin ; Korea ; Male ; Physical Fitness ; Risk Factors ; Triglycerides ; Waist Circumference

Plant dermatitis can be classified as primary irritant dermatitis, allergic contact dermatitis, phytophotodermatitis and pseudophytophotodermatitis. Among these, allergic contact dermatitis is seen most freguently. It is generally known that dermatitis causing plants have various characteristics depending on the habitat af different plants. Until now we have had great difficulty in finding the causative factors in plant dermatitis in Korea. This is due to the fact that we do not have anr comprehensive reports regarding domestic or imported timbers concerned in contact dermatiti. The purpose of this thesis is to gather the basic materials necessary to discover the cauae of plant contact dermatitis. All kinds of trees, flowers, and grasses in Korea and imported timbers concerned with contact dermatitis were considered in this study. We strove to ascertain whether the species in our country are the same as found in foreign countries or other different speceies are in our country under the sarne genus found in foreign countries. The basis for our study is several Korean plant books as well as interviews with several native botanists. Vie also discussed major families af plants causing or possible causing plant dermatitis in Korea.
Dermatitis ; Dermatitis, Allergic Contact ; Dermatitis, Contact* ; Dermatitis, Irritant ; Ecosystem ; Flowers ; Humans ; Korea ; Plants ; Poaceae ; Trees

OBJECTIVE: Human papillomavirus (HPV) is strongly implicated as a causative agent in the etiology of cervical cancer. Of its gene products, E6 and E7 oncoproteins play major roles by inactivation of cellular p53 and pRb tumor suppressor proteins, respectively. However, it has been recently suggested that p53 and/or pRb-independent functions of E6 and E7 are involved in cervical carcinogenesis. The purpose of this study is to identify novel a cellular target, p73, of E6 and to determine how E6 inactivates p73 function, METHODS: The interaction between E6 and p73 were identified by the yeast two-hybrid assay in vivo and the GST pull-down assay in vitro. The function of the interaction was determined by transient transfections using p21 promoter-CAT reporter plasmid. The molecular mechanism underlying the functional significance of the interaction was further assessed by in vivo and in vitro protein degradation assays, and gel mobility shift assays. RESULTS: Yeast two-hybrid and GST pull-down assays indicate a physical interaction between p73 and either HPV-16 or HPV-11 E6 proteins in vivo and in vitro, respectively. Transactivation domain (amino acid residues 1-49) is found to be absolutely required for this interaction. Transient co-expression of E6 significantly inhibits the p73-mediated activation of p21WAF1 promoter in a p53-defective C33A cell line. Using Ga14-p73 fusion protein, we demonstrate that E6 inhibition of p73 transactivation function is independent of sequence-specific DNA binding, which is confirmed by direct electrophoretic mobility shift assay. Moreover, E6 inhibits p73 function by interfering with the activity of the amino-terminal activation domain. The protein degradation assays in vivo and in vitro indicate that p73, unlike p53, is not susceptible to E6-dependent proteolysis. CONCLUSION: Throughout this study, we identified p73 as a novel cellular target of HPV-E6 protein and found that E6 binds p73 through the amino-terminal transactivation domain, and inhibits its transactivation function independent of the protein degradation and DNA binding. These overall results, consequently, suggest that in addition to the inactivation of p53, the functional interference of p73 by HPV-E6 may, at least in part, contribute to E6-mediated cellular transformation.
Carcinogenesis ; Cell Line ; DNA ; Electrophoretic Mobility Shift Assay ; Human papillomavirus 11 ; Human papillomavirus 16 ; Humans ; Oncogene Proteins ; Plasmids ; Proteolysis ; Transcriptional Activation ; Transfection ; Tumor Suppressor Proteins ; Two-Hybrid System Techniques ; Uterine Cervical Neoplasms ; Yeasts

No abstract available.
Cisplatin* ; Glutathione* ; Humans* ; Urinary Bladder Neoplasms* ; Urinary Bladder*

No abstract available.
Cisplatin* ; Glutathione* ; Humans* ; Urinary Bladder Neoplasms* ; Urinary Bladder*