1.Continent ileal reservoir after radical cystectomy for bladder tumor.
Journal of the Korean Cancer Association 1991;23(2):366-374
No abstract available.
Colonic Pouches*
;
Cystectomy*
;
Urinary Bladder Neoplasms*
;
Urinary Bladder*
2.Morphological Change with the Induction of Cisplatin Resistance from the Bladder Cell Lines.
Korean Journal of Urology 2001;42(2):139-146
PURPOSE: When Managing metastatic bladder tumors, to overcome the resistance mechanism of cisplatin is a main problem to be solved. The objective is to confirm the changes of general and ultrastructural morph ology with the induction of cisplatin resistance from the bladder cell line. MATERIALS AND METHODS: The samples of this investigation are 2ng/ml-cisplatin resistant human bladder cell lines T24R2 established by SNUH Urology and the drug resistant bladder cell lines T24 was obtained from ATCC, as a control group. We cultured the resistant cell line on the slide and observed it using light microscopy to see the general morphology. For the ultrastructural morphology, we fixed cultured cells, made an epon block, sliced an ultrathin section and observed it using H-71000 EM. RESULTS: Under light microscopy, the cytoplasm of the resistant cell line shows a plumper pattern than that of the parent cell. Under electronmicroscopy, the chromatin of the resistant cell line has a relatively finely dispersed chromatin pattern when compared to the parent cell line, which shows a coarse and aggregated chromatin pattern. Within the cytoplasm, the mitochondrial volume, dilated rough endoplasmic reticulum, polyribosomes and ribosomes are moderately increased in the resistant cell line when compared to the parent cell line. In particular, we found a great amount of double membrane vesicle near the cell surface and pinocytic vesicles on the surface, which are seldom observed within the parent cells. CONCLUSIONS: We concluded that the cisplatin resistant human bladder cell lines (T24R2) underwent a morphological change with the induction of cisplatin resistance, and we hypothesize that the resistant cell's ultrastructure, which shows morphological change, will be involved in the drug resistance mechanism. Regarding this matter, further research will be needed.
Cell Line*
;
Cells, Cultured
;
Chromatin
;
Cisplatin*
;
Cytoplasm
;
Drug Resistance
;
Endoplasmic Reticulum, Rough
;
Humans
;
Membranes
;
Microscopy
;
Mitochondrial Size
;
Parents
;
Polyribosomes
;
Ribosomes
;
Urinary Bladder Neoplasms
;
Urinary Bladder*
;
Urology
3.Clinical analysis of the effect of maternal age on primary cesarean birth rate.
Ahm KIM ; In Sik LEE ; Jung Eun MOK
Korean Journal of Perinatology 1993;4(1):57-65
No abstract available.
Birth Rate*
;
Maternal Age*
;
Parturition*
4.The efficacy of NST and fetal umbilical artery doppler velocimetry in prenatal surveillance of high-risk pregnancy.
In Sik LEE ; Ahm KIM ; Jung Eun MOK
Korean Journal of Perinatology 1993;4(1):37-45
No abstract available.
Pregnancy, High-Risk*
;
Rheology*
;
Umbilical Arteries*
5.A Case of Hemophilic Arthropathy due to A. H. G. Deficiency
The Journal of the Korean Orthopaedic Association 1970;5(3):115-119
One of the most important aspect of hemophilia is repeated bleeding into the joint. The frequency of such hemorrhages varies with the severity of the disease. In moderate or severe cases, repeated hemorrhages result in considerable impairment of joint structure and function: Contractures and gross deformity are frequent end result. This paper described a case of hemophilia A, 24-year-old male, who developed deformity of the shoulder, elbow, ankle and knee joint because of repeated hemoarthrosis. Author attempted to treat this patient by transfusion of fresh whole blood and traction, which resulted in some clinical improvement.
Ankle
;
Congenital Abnormalities
;
Contracture
;
Elbow
;
Hemophilia A
;
Hemorrhage
;
Humans
;
Joints
;
Knee Joint
;
Male
;
Shoulder
;
Traction
;
Young Adult
6.Mitomycin C vs. bacillus calmette-guerin: comparison of prophylactic efficacy to high risk superficial bladder tumor.
Eun Sik LEE ; Moon Soo PARK ; Chongwook LEE
Journal of the Korean Cancer Association 1991;23(1):101-106
No abstract available.
Bacillus*
;
Mitomycin*
;
Urinary Bladder Neoplasms*
;
Urinary Bladder*
7.Study on the various factors affecting growth of human renal cell carcinoma cell lines.
Eun Sik LEE ; Jae Gahb PARK ; Chongwook LEE
Journal of the Korean Cancer Association 1991;23(1):65-75
No abstract available.
Carcinoma, Renal Cell*
;
Cell Line*
;
Humans*
8.Management of Neurogenic Fecal Incontinence and Constipation in Myelodysplastic Children by Malone Antegrade Colonic Enema Procedure: Early Experiences.
Hyeon JEONG ; Sung Eun JUNG ; Eun Sik LEE ; Kwang Myung KIM ; Sang Eun LEE ; Hwang CHOI
Korean Journal of Urology 2000;41(2):265-269
No abstract available.
Child*
;
Colon*
;
Constipation*
;
Enema*
;
Fecal Incontinence*
;
Humans
9.Expression of E-cadherin in Experimental Bladder Carcinogenesis Induced by N-butyl-n-4-hydroxybutyl Nitrosamine.
Yun Chan CHOI ; Eun Sik LEE ; Won Hee PARK
Korean Journal of Urology 2000;41(7):838-843
No abstract available.
Cadherins*
;
Carcinogenesis*
;
Urinary Bladder*
10.Biochemical Analysis on Postmortem Specimens.
Nak Eun CHUNG ; Young Sik CHOI ; Han Young LEE
Korean Journal of Legal Medicine 2000;24(2):28-36
Because the postmortem changes rapidly distort values of many constituents in the body fluids, the determination of postmortem chemical changes and relation among body fluids is very important in medicolegal community. A laboratory result is not useful if appropriate data for comparison are lacking. The aim of this paper is to determine the reference ranges and the postmortem changes for chemical constituents in postmortem specimen. We examined 17 clinical laboratory parameters in cadaveric blood and vitreous humor obtained from 51 autopsy cases. The mean, standard error, standard deviation and confidence interval of all measured constituents were shown in Table 2 & Figure 1. The postmortem blood level of amylase, phosporus, LDH, ALT, AST and CPK are very higher than those of antemortem blood. The postmortem vitreous level of total bilirubin, triglyceride, GGT, alkaline phosphatase, albumin, total protein and cholesterol are very low and is not reliable. The ratio of vitreous/blood in calcium, BUN, creatine and uric acid are 0.74, 0.68, 0.29 and 0.23 in decreasing orders(Table 3,4). For the medical examiner or pathologist, routine chemical examinations of the vitreous humor can provide evidence of abnormality not apparent in gross or microscopic examination of the tissue. A more extensive study will be required, using a larger number of subjects, to establish the full range of variability.
Alkaline Phosphatase
;
Amylases
;
Autopsy
;
Bilirubin
;
Body Fluids
;
Cadaver
;
Calcium
;
Cholesterol
;
Confidence Intervals
;
Coroners and Medical Examiners
;
Creatine
;
Humans
;
Postmortem Changes
;
Reference Values
;
Triglycerides
;
Uric Acid
;
Vitreous Body