The measurement of tumor cell proliferation is becoming inueasingly recognized in defining prognostic groups. Boliferatirg cell nuclear antigen(PCNA) imrnunolocalimtion can be used as an index of cell proliferation and rnay define the extent of deppature from norrmil gmwth control. PCNA is eonsidered to be maker of cell proliferation. The aim of this study was to evnlunte the expreeion of PCNA in epithelial ocarian cancer as well as the possible correlation with degree of differentiation, tumor etage and overall survival. The material consisted of 35 epithehal ovarian cancer. The PCNA labelling index (Ll) ranged from 7.5% to 92.5% with a median value of 46.7%. PCNA labelling index (LI) is 30% in grade 1, 63% in grade 2, and 100% in grade 3 in epithelial ovarian cancer(p>0.05). Also, a positive correlation was found between PCNA labelling index (LI) and clinical stage (P<0.05) The estimated 3 year survival in patients with a tumor LI below the median (low proliferative group) was higher than those with a tumor LI greater than the median(high proliferation group) (87.5% VS 50%, P<0.05).
Cell Proliferation ; Humans ; Ovarian Neoplasms ; Prognosis* ; Proliferating Cell Nuclear Antigen*

The measurement of tumor cell proliferation is becoming inueasingly recognized in defining prognostic groups. Boliferatirg cell nuclear antigen(PCNA) imrnunolocalimtion can be used as an index of cell proliferation and rnay define the extent of deppature from norrmil gmwth control. PCNA is eonsidered to be maker of cell proliferation. The aim of this study was to evnlunte the expreeion of PCNA in epithelial ocarian cancer as well as the possible correlation with degree of differentiation, tumor etage and overall survival. The material consisted of 35 epithehal ovarian cancer. The PCNA labelling index (Ll) ranged from 7.5% to 92.5% with a median value of 46.7%. PCNA labelling index (LI) is 30% in grade 1, 63% in grade 2, and 100% in grade 3 in epithelial ovarian cancer(p>0.05). Also, a positive correlation was found between PCNA labelling index (LI) and clinical stage (P<0.05) The estimated 3 year survival in patients with a tumor LI below the median (low proliferative group) was higher than those with a tumor LI greater than the median(high proliferation group) (87.5% VS 50%, P<0.05).
Cell Proliferation ; Humans ; Ovarian Neoplasms ; Prognosis* ; Proliferating Cell Nuclear Antigen*

Meningioma of unusual age of onset, location, histogenesis and histologic type is reported. The patient, 4 year-old girl, had an intradural spinal meningioma arising from lumbar nerve root with no dural attachement. The meningioma revealed glycogen-rich, clear cell type with extensive and blocky hyalinization of the stroma. The tumor shared common fibrous sheath with attached lumbar nerve, and nerve fibers were scattered within the tumor. Ultrastructurally, the tumor cells had abundant glycogen particles, intermediate filaments and intercellular desmosomes. Hyalinized material revealed large amianthoid collagen fibers.
Child ; Male ; Female ; Humans ; Meningioma

The pinch graft is one type of skin graft and is indicated in small, chronic stubborn wounds or ulcers where cosmetic results are not paramount. It is a common procedure for the rapid healing of leg ulcers in countries where these are very common, such as in western society. However, it is an unfamiliar procedure to dermatologists in Korea where leg ulcers are quite rare. We treated a case of leg ulcer in systemic sclerosis using pinch grafts with satisfactory results. The pinch graft may be a useful treatment method for skin ulcers in dermatologic surgery under adverse conditions.
Dermatologic Surgical Procedures ; Korea ; Leg Ulcer* ; Leg* ; Scleroderma, Systemic* ; Skin ; Skin Ulcer ; Transplants* ; Ulcer ; Wounds and Injuries

No abstract available.
Humans ; Patient Education as Topic* ; Primary Health Care*

Nickel is widely known as a common source of contact dermatitis and nickel sensitivity amounts to nearly 10 percent of allergic contact dermatitis patients. Common sources of nickel dermatitis are well known as necklaces, watches, rings, hooks, earrings and spectacle frames. Recently, we have seen five cases of nickel dermatitis the suspected sources of which were metal spectacle frames. The interim patch test result in our occupational and environmental clinic suggests that the metal spectacle frame is one of the most common sources of nickel dermatitis. Out of 84 medical students 27 wore metal spectacle frames. We have done a dimethylglyoxime spot test to the metal spectacle frames and got a positive result in 12 out of 27(44.4%). We conclude that metal spectacle frame seems to be one of the dominant causes of nickel dermatitis and it will be an increasing problem in our society.
Dermatitis ; Dermatitis, Allergic Contact ; Dermatitis, Contact* ; Ear ; Humans ; Nickel ; Patch Tests ; Students, Medical

Formalin is a 37 5pg aqueous solution of formaldehyde gas and formaldehyde may be present in products as an active ingredient, preservative or contaminant. This contamination may be from the container, the package material or in situ formation by degradation of the formaldehyde releasers. The free formaldehyde content was determined in the 50 kinds of Korean shampoos by quantitative analysis recently described, the lutidine method, which is simple, rapid and used for colored products which cannot be analysed by the chrornotropic acid method. Formaldehyde has been found in 46 out of the 0 samples, i.e., 90g., and the concentration ranged from 0. 1 to 78. 6 pg/ml(0. 1 78. 6 ppm).
Formaldehyde*

Thin-layer (uni-dimensional and bi-dimensional) chrornatography studies were performed on 60 brownish stockings from 12 companies in Korea to search for Disperse Yellow 3 and Disperse Orange 3, which are known as common sensitizers in textiles. The results were as follows : 1) Mixture of various-colored dyes were being used to reveal the brownish hue in the stockings. 2) TLC demonstrated the presence of Disperse Yellow 3 in 53 stocking. 3) TLC demonstrated the presence of Disperse Orange 3 in 3 stockings, Although lack or more sophisticsted tests such as spectroseopic, infra red or nuclear spectra identification. These results suggest a strong clue to the presence of Disperse Yellow 3 and Disperse Orange 3 in the commercial stocking now being used in Korea.
Chromatography* ; Citrus sinensis* ; Coloring Agents ; Korea ; Textiles

No abstract available.
Alcoholism* ; Primary Health Care*

This study was undertaken to observe the difference of patch test and prick test positive reactions in three groups, 20 atopic dermatitis patients, 20 chronic urticaria patients, and 20 normal controls, Twenty commercial antigens (ToriiCo.) and twenty three frozen and boiled antigens of fishes and shellfishes were used as test materials. The results were as follows: 1. No positive reaction was observed in all sixty subjects in patch test. 2 In prick test, difference in reactivity was observed among atopic dermatitis (14. 7%), chronic urticaria (8.7%), and normal control(1. 5%) 3. There was significant difference in reactivity between Torii and frozen antigens in atopic dermatitis group, but no significance in chronic urticaria and control groups. 4. Boiling altered the reactivity in tested materials in all three groups of subjects singificantly. 5. Patients with past or family history of allergic diseases showed double fold higher reactivity tban patients without any history.
Dermatitis, Atopic* ; Fishes ; Humans ; Patch Tests ; Shellfish* ; Urticaria*