1.Effects of the C3G/D3G anthocyanins-rich black soybean testa extracts on improvement of lipid profiles in STZ-induced diabetic rats.
So Young PARK ; Sujeong PAK ; Song Joo KANG ; Na Young KIM ; Da Saem KIM ; Min Jin KIM ; Seon Ah KIM ; Ji Young KIM ; So Yeon PARK ; So Hyun PARK ; Cho Rong YOUN ; Bo Ram LEE ; Hyo Eun LEE ; So Young CHOI ; Hee Won CHOI ; Jin Yeo HEO ; A Yeong HWANG ; Myoung Sook LEE
Journal of Nutrition and Health 2015;48(4):299-309
PURPOSE: The purpose of this study was to examine the effect of black soybean (CJ-3) testa extracts on lipid profiles in streptozotocin (STZ)-induced diabetic rats. METHODS: One control group and four STZ-induced diabetic groups with different doses of black soybean (CJ-3) testa extracts treatment [0 mg/kg (diabetic control, EX), 250 mg/kg (EX-250), 500 mg/kg (EX-500), 1,000 mg/kg (EX-1000)] were orally administered for 4 weeks. RESULTS: All CJ-3 treatment groups had remarkably lower serum triglyceride (TG) levels than that of EX group (p < 0.05) whereas hepatic TG contents did not show any differences. Results from serum total cholesterol (TC) concentrations of EX-250 and EX-1000 groups were decreased compared to EX group (p < 0.05). Furthermore, protein levels of 3-hydroxy-3-methyl-glutaryl-Coenzyme A (HMG-CoA) reductase from the liver decreased in all treatment groups (p < 0.05). However, significant differences were not observed in serum glucose and insulin, and glucose transporter 4 (GLUT-4) protein expression in skeletal muscle tissue. CONCLUSION: These results suggest that black soybean testa extracts could be useful for improvement of hyperlipidemia and hypercholesteremia in diabetes.
Animals
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Anthocyanins
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Blood Glucose
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Cholesterol
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Glucose Transport Proteins, Facilitative
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Hypercholesterolemia
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Hyperlipidemias
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Insulin
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Liver
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Muscle, Skeletal
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Oxidoreductases
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Rats*
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Soybeans*
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Streptozocin
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Triglycerides