1.A Case of Metatropic Dwarfism.
Eun Ok RHEE ; Nam Joo HWANG ; Yaung Sook CHOI ; Son Sang SEO ; Hye Kyoung YOON
Journal of the Korean Pediatric Society 1989;32(8):1167-1173
No abstract available.
Dwarfism*
2.Clinical Studies of Human Rotavirus Gastroenteritis.
Eun Ok RHEE ; Nam Joo HWANG ; Yaung Sook CHOI ; Son Sang SEO
Journal of the Korean Pediatric Society 1989;32(10):1369-1376
No abstract available.
Gastroenteritis*
;
Humans*
;
Rotavirus*
4.A Case of Glycogenosis I.
Se Yoon EUN ; Sung Hwan KIM ; Sang Il RHEE ; Sang Woo KIM ; Hye Je CHO ; In Ki PARK
Journal of the Korean Pediatric Society 1984;27(4):401-406
No abstract available.
Glycogen Storage Disease*
5.Karyotype of Fasciola sp. obtained from Korean cattle.
Jae Ku RHEE ; Gil Soo EUN ; Sang Bork LEE
The Korean Journal of Parasitology 1987;25(1):37-44
As a series of systematic classification for Korean common liver fluke, Fasciola sp., karyotype was investigated by means of the modified air-drying technique and of the regular Giemsa staining, Also, C-staining method was applied for detailed karyological analysis from the germ cells of the fluke. The following is a brief summary of the leading facts gained through the experiment. Korean Fasciola sp. was classified into three types based on their chromosomal complements; individuals with 20 or 30 chromosomes and with a 20/30 mosaic constitution. Worms having 30 chromosomes represent a triploid form with 3 sets of 10 basic chromosomes, while those with 20 chromosomes were diploid and mosaic individuals were 2n/3n mixoploid. The frequency of the individual type calculated is as follows; 67.45% of 212 flukes examined was of diploid, 10.85%, triploid, and the rest, 21.7%, mixoploid, respectively. In many cases, two or three types were found in the peculiar bovine host while single type inhabitant was about 20% out of 52 cases. The twenty chromosomes consisted of 1 parir of large metacentrics, 4 pairs of medium-sized subtelocentrics, and 5 pairs of small submetacentrics, while constitution of the thirty chromosomes was nearly interpreted as a triploid form with 3 sets of 10 basic chromosomes. The high centromeric indexes of both types are the first pairs among all the examined, and 37.93% was of diploid and 47.93%, triploid, respectively. In mixoploid individuals, constitution of the chromosomes of diploid or triploid cells was the same as that of diploid or triploid individuals. All the chromosomes of the germ cells in both types showed C-band around the centromeic region and especially the chromosomes no's 3, 7, and 8 showed a remarkable C-band distinguished from other chromosomes. The variance for the sizes of the worms and the eggs were not parallel with three different genotypes in Korean common liver fluke.
parasitology-helminth-trematoda
;
Fasciola sp.
;
karyotype
;
taxonomy
6.Effects of Vitamin-C on Sepsis Rat Model Induced by Endotoxin.
Joong Eui RHEE ; Sang Do SHIN ; Chang Hae PYO ; Gil Joon SUH ; Sung Eun JUNG ; Yeo Kyu YOUN
Journal of the Korean Society of Emergency Medicine 1999;10(4):522-530
BACKGROUND: Multi-organ failure from sepsis is very lethal disease entity, which is suspected to be caused by activated inflammatory cells. Inflammatory cells activated by endotoxins generate oxidants and cytokines such as TNF-alpha and IL-6, which in turn stimulate macrophages and neutrophils. Augmented inflammation makes an organ-injury deteriorate into an organ-failure, which may progress to multi-organ failure. This study is designed to evaluate the therapeutic effects of vitamin-C, a scavenger of oxidants, in sepsis. METHODS: Male Sprague-Dawley rats were divided into 3 groups : a control group, a group injected intrapetoneally with LPS(lipopolysaccharide), and a group injected intraperitoneally with LPS and vitamin-C. Each eight rats were sacrified 24 hours and 48 hours after injection, and samples of the blood, the liver and the lung were obtained. Biochemical assays of TNF-alpha level in the blood and malondialdehyde(MDA) level, catalase activity and nitric oxide synthase(NOS) activity in the liver and the lung tissues were performed. RESULTS: Serum TNF-alpha level, tissue lipid peroxidation and tissue i-NOS activity were dramatically increased, and tissue catalase activity was exhausted rapidly in sepsis. High dose vitamin-C administration decreased serum TNF-alpha level, tissue lipid peroxidation and tissue i-NOS induction, and protected against catalase exhaustion. CONCLUSION: high dose vitamin-C therapy was proved to have definite antioxidant effect in septic condition.
Animals
;
Antioxidants
;
Catalase
;
Cytokines
;
Endotoxins
;
Humans
;
Inflammation
;
Interleukin-6
;
Lipid Peroxidation
;
Liver
;
Lung
;
Macrophages
;
Male
;
Models, Animal*
;
Neutrophils
;
Nitric Oxide
;
Oxidants
;
Rats*
;
Rats, Sprague-Dawley
;
Sepsis*
;
Tumor Necrosis Factor-alpha
7.Development and Validation of a Deep Learning Based Diabetes Prediction System Using a Nationwide Population-Based Cohort
Sang Youl RHEE ; Ji Min SUNG ; Sunhee KIM ; In-Jeong CHO ; Sang-Eun LEE ; Hyuk-Jae CHANG
Diabetes & Metabolism Journal 2021;45(4):515-525
Background:
Previously developed prediction models for type 2 diabetes mellitus (T2DM) have limited performance. We developed a deep learning (DL) based model using a cohort representative of the Korean population.
Methods:
This study was conducted on the basis of the National Health Insurance Service-Health Screening (NHIS-HEALS) cohort of Korea. Overall, 335,302 subjects without T2DM at baseline were included. We developed the model based on 80% of the subjects, and verified the power in the remainder. Predictive models for T2DM were constructed using the recurrent neural network long short-term memory (RNN-LSTM) network and the Cox longitudinal summary model. The performance of both models over a 10-year period was compared using a time dependent area under the curve.
Results:
During a mean follow-up of 10.4±1.7 years, the mean frequency of periodic health check-ups was 2.9±1.0 per subject. During the observation period, T2DM was newly observed in 8.7% of the subjects. The annual performance of the model created using the RNN-LSTM network was superior to that of the Cox model, and the risk factors for T2DM, derived using the two models were similar; however, certain results differed.
Conclusion
The DL-based T2DM prediction model, constructed using a cohort representative of the population, performs better than the conventional model. After pilot tests, this model will be provided to all Korean national health screening recipients in the future.
8.Development and Validation of a Deep Learning Based Diabetes Prediction System Using a Nationwide Population-Based Cohort
Sang Youl RHEE ; Ji Min SUNG ; Sunhee KIM ; In-Jeong CHO ; Sang-Eun LEE ; Hyuk-Jae CHANG
Diabetes & Metabolism Journal 2021;45(4):515-525
Background:
Previously developed prediction models for type 2 diabetes mellitus (T2DM) have limited performance. We developed a deep learning (DL) based model using a cohort representative of the Korean population.
Methods:
This study was conducted on the basis of the National Health Insurance Service-Health Screening (NHIS-HEALS) cohort of Korea. Overall, 335,302 subjects without T2DM at baseline were included. We developed the model based on 80% of the subjects, and verified the power in the remainder. Predictive models for T2DM were constructed using the recurrent neural network long short-term memory (RNN-LSTM) network and the Cox longitudinal summary model. The performance of both models over a 10-year period was compared using a time dependent area under the curve.
Results:
During a mean follow-up of 10.4±1.7 years, the mean frequency of periodic health check-ups was 2.9±1.0 per subject. During the observation period, T2DM was newly observed in 8.7% of the subjects. The annual performance of the model created using the RNN-LSTM network was superior to that of the Cox model, and the risk factors for T2DM, derived using the two models were similar; however, certain results differed.
Conclusion
The DL-based T2DM prediction model, constructed using a cohort representative of the population, performs better than the conventional model. After pilot tests, this model will be provided to all Korean national health screening recipients in the future.
9.A Case of Herpes Zoster Ophthalmicus with Isolated Trochlear Nerve Involvement.
Key Chung PARK ; Sung Sang YOON ; Jeong Eun YOON ; Hak Young RHEE
Journal of Clinical Neurology 2011;7(1):47-49
BACKGROUND: Herpes zoster ophthalmicus (HZO) can involve the oculomotor nerve; however, isolated trochlear nerve palsy has rarely been reported. CASE REPORT: An 83-year-old man who suffered from HZO in the right frontal area and scalp subsequently developed vertical diplopia and severe pain. Cerebrospinal fluid examination and brain MRI revealed no abnormalities. Isolated right trochlear nerve palsy was diagnosed based on the findings of neuro-ophthalmological tests. CONCLUSIONS: Isolated trochlear nerve involvement associated with HZO is very rare and may be easily overlooked. Physicians should carefully examine oculomotor involvement in HZO.
Aged, 80 and over
;
Brain
;
Diplopia
;
Herpes Zoster
;
Herpes Zoster Ophthalmicus
;
Humans
;
Scalp
;
Trochlear Nerve
;
Trochlear Nerve Diseases
10.Treatment of a Recurrent Chest Wall Desmoid Tumor Using a CT-Guided Steroid Injection.
Sun Jung RHEE ; Sang Hyun PAIK ; Hwa Kyoon SHIN ; Jai Soung PARK ; Eun Hye LEE
Korean Journal of Radiology 2012;13(3):342-344
We report on a 41-year-old woman with a chest wall desmoid tumour who was successfully treated with a computed tomography (CT)-guided steroid injection. She presented with a palpable mass in the right upper chest wall and was treated by surgical excision and postoperative radiation therapy due to recurrence of the mass at the surgical site. At 20 months after the second operation, a recurrent mass was again detected in the anterosuperior portion of the previous surgical site on CT. We performed a CT-guided steroid injection weekly for 4 weeks by applying a mixture of 3 mL of triamcinolone acetonide (40 mg/mL) and 3 mL of 1% Lidocaine, administering 4-6 mL of the mixture, to the lesion. Six months later, CT showed a marked decrease in the size of the mass.
Adult
;
Female
;
Fibromatosis, Aggressive/*drug therapy/*radiography
;
Glucocorticoids/*therapeutic use
;
Humans
;
Lidocaine/therapeutic use
;
*Radiography, Interventional
;
Recurrence
;
Thoracic Wall/*pathology
;
*Tomography, X-Ray Computed
;
Triamcinolone/*therapeutic use