1.Clinical and Statistical Observation for Low Birth Weight Infants.
Chong Ok LEE ; Eun Hee KOH ; Sang Man SIN ; Sang Jhoo LEE
Journal of the Korean Pediatric Society 1981;24(12):1142-1148
No abstract available.
Humans
;
Infant*
;
Infant, Low Birth Weight*
;
Infant, Newborn
2.Effect of intravenous pulse cyclophosphamide in the treatment of Churg-Strauss syndrome with refractory neuropathy to high-dose steroid treatment.
Young Hee LIM ; Sang Pyo LEE ; Eun Mi KOH ; Dong Chull CHOI
Journal of Asthma, Allergy and Clinical Immunology 2000;20(1):113-121
No abstract available.
Churg-Strauss Syndrome*
;
Cyclophosphamide*
3.Hydrochlorothiazide induced photosensitivity.
Woo Seok KOH ; Sang Eun MOON ; Bang Soon KIM ; Jai Il YOUN
Korean Journal of Dermatology 1992;30(3):373-376
Hydrochlorothiazide is a diuretic drug used in the treatement of edema and hypertension. We report a case of hydrochlorothiazide induced photosensitivity in a 54 year old woman who had taken hydrochlorothiazide for 3 years for hypertension. She complained of itching and burning sensation with erythematous papules and lichenified plaques on light-exposed areas. Fhototest showed marked decrease of the minimal erythema dose(MED) for UVA. The symptoms subsided after the use of topical steroid and the substitution atenolol for hydrochlorothiazide.
Atenolol
;
Burns
;
Edema
;
Erythema
;
Female
;
Humans
;
Hydrochlorothiazide*
;
Hypertension
;
Middle Aged
;
Pruritus
;
Sensation
4.Resistance to Chemotherapy on Tumor Through Cathepsin B-dependent Activation of the NLRP3 Inflammasome.
Eun Jeong KWON ; Young Sang KOH
Journal of Bacteriology and Virology 2013;43(3):233-234
Anticancer drugs kill tumor cells and increase host anti-tumor immunity. Interestingly, gemcitabin (Gem) and 5-fluorouracil (5-FU), widely used anticancer drugs, lead to IL-1beta secretion releasing cathepsin B which activates Nlrp3 inflammasome in myeloid derived suppressor cells (MDSCs). MDSC derived IL-1beta enhance secretion of IL-17 by CD4+ T cells. This mechanism limits the antitumor efficacy of the drugs and promotes tumor growth.
Cathepsin B
;
Cathepsins
;
Fluorouracil
;
Interleukin-17
;
T-Lymphocytes
5.A Histologic Classification of Diffuse Interstitial Lung Disease and Its Clinical Significance.
Eun Suk KOH ; Dong Wha LEE ; So Young JIN ; Sang Ho CHO
Korean Journal of Pathology 1996;30(11):998-1010
Diffuse interstitial lung disease(DILD) is a large group of heterogeneous diseases that diffusely involve the pulmonary connective tissues, principally subpleural, interlobular and alveolar wall portions. Terminology and classification of these diseases are not uniform, and the cause and the pathogenesis are unknown in many entities. It is generally accepted that the response to therapy is related to the relative degree of cellularity and fibrosis present, therefore a histologic evaluation of the relative extent and severity of these changes is required. We reviewed 52 cases of DILD from January 1990 to May 1995 diagnosed by open lung biopsy to reappraise classification and quantitative assessment of the histopathologic features. Differential histopathologic features between usual interstitial pneumonia(UIP) and nonspecific interstitial pneumonia(NIP) were examined with a correlation of HRCT findings and clinical findings. Among 52 cases of DILD, 18 cases(34.6%) were UIP, 6 cases(11.5%) were hypersensitivity pneumonia was NIP was 5 cases(9.6%), interstitial lung diseases associated with the connective tissue diseases were 5 cases(9.6%), inorganic dusts were 4 cases(7.7%), infections were 4 cases(7.7%), durgs were 2 cases(3.8%), acute interstitial pneumonia was 1 case(1.9%), sarcoidosis was 1 case(1.9%) in order of frequency plus 6 other cases(11.5%). UIP was the most frequent DILD in this study which seemed to be a criteria bias of patient selection on open lung biopsy. Quantitative assessment of histopathologic features was useful in the differential diagnosis of DILD and differentiation of UIP from NIP was possible based on histopathologic features and supported by HRCT. UIP disclosed a significantly high score of fibrotic changes, especially in the interstitial fibrosis, smooth muscle proliferation and honeycombing, otherwise NIP appeared relatively high score in inflammatory changes. Correlation between histopathologic scores and the clinical outcome after steroid therapy or no therapy in UIP was not evident.
Diagnosis, Differential
;
Biopsy
6.Ultrasonographic Study of Median Nerve According to Changed Wrist Position in Diabetics and Normal Subjects.
Gyeong Sin KIM ; Seong Eun KOH ; Jong Moon KIM ; Jin Sang CHUNG
Journal of the Korean Geriatrics Society 2003;7(1):75-84
BACKGROUND: To compare the diagnostic value between Phalen's test and reverse Phalen's test using a morphological change of the median nerve and the carpal tunnel in diabetics and normal controls seen by high-resolution ultrasonography and to research on an ultrasonography as an available tool for the screening and follow up aid-test of the carpal tunnel syndrome(CTS). METHODS: A cross-sectional area and a flattening ratio of the median nerve, and a cross-sectional area of the carpal tunnel were measured in neutral, maximally flexed(Phalen's test), and maximally extended (reverse Phalen's test) positions in 59 wrists of 30 normal controls and 60 wrists of 30 diabetics. RESULTS: 1) In controls and diabetics, the mean cross-sectional area of median nerve at the hamatum were 8.8/10.2 mm2, 8.0/9.5 mm2, 8.3/9.4 mm2, the mean flattening ratio were 3.0/3.0 mm2, 2.4/2.0 mm2, 3.2/3.0 mm2, the mean cross-sectional area of carpal tunnel were 176.5/197.7 mm2, 157.9/187.0 mm2, 170.6/192.5 mm2 in neutral, maximal flexion and maximal extension. 2) In controls, the cross-sectional area of median nerve and carpal tunnel were significantly decreased in maximal flexion(p<0.01), and in maximal extension(p<0.01). 3) In controls, the mean flattening ratio of median nerve was revealed significant change in maximal flexion(p<0.01), and in maximal extension(p<0.01). 4) In diabetics, the flattening ratio was significantly decreased in maximal flexion(p<0.01) with com- paring to neutral position. 5) In diabetics, the cross-sectional area of median nerve and carpal tunnel were significantly increased in all positions(p<0.05), and the mean flattening ratio of median nerve was similar to controls. CONCLUSION: In diabetics, increased cross-sectional area of median nerve can be explained by swelling of median nerve, also increased cross-sectional area of carpal tunnel is can be said to have taken place by the decreasing of the useful space in between the median nerve and carpal tunnel, this show that the diabetics have the high risk of the CTS. Phalen's test reveals higher degree of irritation to median nerve, The high-resolution ultrasonography is suggested as an available tool for the screening and follow up aid-test for the CTS
Carpal Tunnel Syndrome
;
Follow-Up Studies
;
Mass Screening
;
Median Nerve*
;
Ultrasonography
;
Wrist*
7.Five Cases of Hemorrhagic Disease of Infancy.
Jung Sook MOON ; Eun Hee KOH ; Sang Man SHIN ; Sang Jhoo LEE
Journal of the Korean Pediatric Society 1982;25(5):518-522
A hemorrhagic disease due to acquired prothrombin complex deficiency is presented in five infants from 3 weeks to 2 months of age. There are 2 cases of intracranial hemorrhage, 1 case of hemothorax, 2 cases of gastrointestinal bleeding, 1 case of epistaxis and 3 cases of petechia, purpura or bleeding from injection site. After the administration of vitamin K, bleeding ceased and prolonged prothrombin time was corrected promptly. Vitamin K dependent coagulation factor deficiency due to vitamin K deficiency is accounted for the pathogenesis of bleeding. Diarrhea, treatment with antimicrobial agents and a diet low in vitamin K are suggested as etiologic factors acting together.
Anti-Infective Agents
;
Blood Coagulation Factors
;
Diarrhea
;
Diet
;
Epistaxis
;
Hemorrhage
;
Hemothorax
;
Humans
;
Infant
;
Intracranial Hemorrhages
;
Osteopetrosis
;
Prothrombin
;
Prothrombin Time
;
Purpura
;
Vitamin K
;
Vitamin K Deficiency
8.Five Cases of Hemorrhagic Disease of Infancy.
Jung Sook MOON ; Eun Hee KOH ; Sang Man SHIN ; Sang Jhoo LEE
Journal of the Korean Pediatric Society 1982;25(5):518-522
A hemorrhagic disease due to acquired prothrombin complex deficiency is presented in five infants from 3 weeks to 2 months of age. There are 2 cases of intracranial hemorrhage, 1 case of hemothorax, 2 cases of gastrointestinal bleeding, 1 case of epistaxis and 3 cases of petechia, purpura or bleeding from injection site. After the administration of vitamin K, bleeding ceased and prolonged prothrombin time was corrected promptly. Vitamin K dependent coagulation factor deficiency due to vitamin K deficiency is accounted for the pathogenesis of bleeding. Diarrhea, treatment with antimicrobial agents and a diet low in vitamin K are suggested as etiologic factors acting together.
Anti-Infective Agents
;
Blood Coagulation Factors
;
Diarrhea
;
Diet
;
Epistaxis
;
Hemorrhage
;
Hemothorax
;
Humans
;
Infant
;
Intracranial Hemorrhages
;
Osteopetrosis
;
Prothrombin
;
Prothrombin Time
;
Purpura
;
Vitamin K
;
Vitamin K Deficiency
9.Regional hyperperfusion in early stage of herpes simplex encephalitis demonstrated by 99mTc-HMPAO brain SPECT.
Sang Eun KIM ; Chang Woon CHOI ; Dong Soo LEE ; June Key CHUNG ; Myung Chul LEE ; Chang Soon KOH
Korean Journal of Nuclear Medicine 1991;25(1):129-130
No abstract available.
Brain*
;
Encephalitis, Herpes Simplex*
;
Herpes Simplex*
;
Technetium Tc 99m Exametazime*
;
Tomography, Emission-Computed, Single-Photon*
10.Regional hyperperfusion in early stage of herpes simplex encephalitis demonstrated by 99mTc-HMPAO brain SPECT.
Sang Eun KIM ; Chang Woon CHOI ; Dong Soo LEE ; June Key CHUNG ; Myung Chul LEE ; Chang Soon KOH
Korean Journal of Nuclear Medicine 1991;25(1):129-130
No abstract available.
Brain*
;
Encephalitis, Herpes Simplex*
;
Herpes Simplex*
;
Technetium Tc 99m Exametazime*
;
Tomography, Emission-Computed, Single-Photon*