1.Correlation of the Intestinal Metaplasia Subtypes and Gastric Carcinoma.
Hwa Eun OH ; Mee Ja PARK ; Jong Sang CHOI
Korean Journal of Pathology 1997;31(12):1272-1281
Helicobacter pylori, loss of basement membrane, atrophy, type III intestinal metaplasia, adenomatous polyposis coli (APC) gene mutations and altered p53 function were believed as a factor to develop the gastric adenocarcinomas. To investigate the incidence and prevalence of Helicobacter pylori, intestinal metaplasia and atrophy, 120 gastrectomy specimens collected from patients with gastric adenocarcinoma (100 cases) and non-neoplastic conditions (20 cases) were studied. Intestinal metaplasia can be classified as type I (complete), type II (incomplete, sulfomucin-negative) and type III (incomplete, sulfomucin-positive) by Filipe and Jass. The incidence of intestinal metaplasia of gastric adenocarcinoma was 96% compared with the incidence of 75% in non-neoplastic conditions. The type I and type II were more common than type III and were present in both non-neoplastic conditions (75%) and adenocarcinoma (74%). In contrast, type III intestinal metaplasia was seen in only 20% of intestinal metaplasia-positive cases, all of which (22 of 22) were from patients with adenocarcinoma. The high specificity of type III intestinal metaplasia might be acceptable for screening purposes, but its sensitivity of 22% for gastric adenocarcinoma is low. Helicobacter pylori were detected in 96% of adenocarcinoma cases and 100% of non-neoplastic cases. Atrophy was detected in 50% of non-neoplastic cases and in 57% of adenocarcinoma cases. The data thus confirms a significant relation between incomplete sulfomucin-secreting intestinal metaplasia (type III) and gastric carcinoma, especially intestinal type (p<0.01). Thus, the type III intestinal metaplasia should be considered a risk factor and its presence in a biopsy specimen should prompt close surveillance.
Adenocarcinoma
;
Adenomatous Polyposis Coli
;
Atrophy
;
Basement Membrane
;
Biopsy
;
Gastrectomy
;
Helicobacter pylori
;
Humans
;
Incidence
;
Mass Screening
;
Metaplasia*
;
Prevalence
;
Risk Factors
;
Sensitivity and Specificity
2.The Effect on the Self-Esteem Promotion Program on Self-Esteem and Mental Health of Adolescents with Minor Delinquency.
Journal of Korean Academy of Nursing 2001;31(7):1181-1188
This research was performed to investigate the effectiveness of self-esteem promotion program(SEPP) to adolescents with minor delinquency on self-esteem and mental health. Samples of this study were 36 adolescents with signs of minor delinquency in the third grade of middle schools who reside in K city. Data analysis was conducted by chi-square test which tests the general homogeneity between the experiment group and the control group. To test hypothesis how SEPP affects on self-esteem, mental health, and delinquency, paired t-test was performed. The results were summarized as follow; 1. After the experimental treatment, self-esteem score was not statistically significant. 2. After the experimental treatment, mental health score was statistically significant. 3. After the experimental treatment, self reported delinquency score was statistically significant. As the result of this research, the SEPP increased the degree of mental health and decreased that of delinquency of the adolescents who committed minor delinquency. Self-esteem is difficult to be changed by itself in number for a short time, but there is potential effect, which can be expected the preceding changes of mental health and behavior of participants.
Adolescent*
;
Humans
;
Mental Health*
;
Self Report
;
Statistics as Topic
3.Quantification of Hepatitis C Virus RNA in Patients Sera by Competitive RT-nested PCR.
Sae Gwang PARK ; Eun Young JE ; Jae Eun PAIK ; Hee Kyung OH ; In Hak CHOI
Journal of the Korean Society for Microbiology 2000;35(5):351-351
No Abstract Available.
Hepacivirus*
;
Hepatitis C*
;
Hepatitis*
;
Humans
;
Polymerase Chain Reaction*
4.Quantification of Hepatitis C Virus RNA in Patients Sera by Competitive RT-nested PCR.
Sae Gwang PARK ; Eun Young JE ; Jae Eun PAIK ; Hee Kyung OH ; In Hak CHOI
Journal of the Korean Society for Microbiology 2000;35(5):351-351
No Abstract Available.
Hepacivirus*
;
Hepatitis C*
;
Hepatitis*
;
Humans
;
Polymerase Chain Reaction*
5.Detection of proteinase resistant protein from scrapie-affected mice and hamsters.
Yong Sun KIM ; Eun Kyoung CHOI ; Sung Wook YOON ; Yang Suk OH
Journal of the Korean Society of Virology 1992;22(1):91-95
No abstract available.
Animals
;
Cricetinae*
;
Mice*
6.Effect of GABA on the Contractility of Canine Trachealis Muscle.
Cheol Hoe KOO ; Oh Chul KWON ; Eun Mee CHOI ; Kang Youn LEE ; Won Joon KIM
Yeungnam University Journal of Medicine 1994;11(2):314-322
This study aimed to investigate the existence of GABA receptor and the mechanisms of action of GABA and diazepam of the trachealis muscle isolated from dog. Horizontal muscle strips of 2mm×15mm were prepared from canine trachea, and isometric myography in isolated muscle chamber bubbled with 95/5%-O₂/CO₂ at 36℃, at the pH of 7.4 was performed. Muscle strips contracted responding to the electrical field stimulation (ESP) by 2~20 Hz, 20 msec, monophasic square wave of 60 VDC. GABA and diazepam suppressed the EFS-induced contractions to the similar extent, significantly. (p<0.05). Bicuculline, a GABA(A) receptor antagonist blocked both GABA- and diazepam-inhibitions; but DAVA, a GABA(B) receptor antagoinst did not affect either of them. These results suggest than in the canine trachealis muscle, there may be only GABA(A) receptor, and GABA and diazepam inhibit the contractility via GABA(A) receptor.
Animals
;
Bicuculline
;
Diazepam
;
Dogs
;
gamma-Aminobutyric Acid*
;
Hydrogen-Ion Concentration
;
Myography
;
Receptors, GABA
;
Receptors, GABA-A
;
Trachea
7.Effects of Histamine and Hydroxyzine on the Bladder Contraction of Rat.
Sung Kyu HONG ; Eun Chan PARK ; Seung June OH ; Hwang CHOI
Korean Journal of Urology 2000;41(3):435-443
No abstract available.
Animals
;
Histamine*
;
Hydroxyzine*
;
Rats*
;
Urinary Bladder*
8.Dexmedetomidine Use in Patients with 33degrees C Targeted Temperature Management: Focus on Bradycardia as an Adverse Effect.
Hyo Yeon SEO ; Byoung Joon OH ; Eun Jung PARK ; Young Gi MIN ; Sang Cheon CHOI
Korean Journal of Critical Care Medicine 2015;30(4):272-279
BACKGROUND: This study aimed to investigate bradycardia as an adverse effect after administration of dexmedetomidine during 33degrees C target temperature management. METHODS: A retrospective study was conducted on patients who underwent 33degrees C target temperature management in the emergency department during a 49-month study period. We collected data including age, sex, weight, diagnosis, bradycardia occurrence, target temperature management duration, sedative drug, and several clinical and laboratory results. We conducted logistic regression for an analysis of factors associated with bradycardia. RESULTS: A total of 68 patients were selected. Among them, 39 (57.4%) showed bradycardia, and 56 (82.4%) were treated with dexmedetomidine. The odds ratio for bradycardia in the carbon monoxide poisoning group compared to the cardiac arrest group and in patients with higher body weight were 7.448 (95% confidence interval [CI] 1.834-30.244, p = 0.005) and 1.058 (95% CI 1.002-1.123, p = 0.044), respectively. In the bradycardia with dexmedetomidine group, the infusion rate of dexmedetomidine was 0.41 +/- 0.15 microg/kg/h. Decisions of charged doctor's were 1) slowing infusion rate and 2) stopping infusion or administering atropine for bradycardia. No cases required cardiac pacing or worsened to asystole. CONCLUSIONS: Despite the frequent occurrence of bradycardia after administration of dexmedetomidine during 33degrees C target temperature management, bradycardia was completely recovered after reducing infusion rate or stopping infusion. However, reducing the infusion rate of dexmedetomidine lower than the standard maintenance dose could be necessary to prevent bradycardia from developing in patients with higher body weight or carbon monoxide poisoning during 33degrees C targeted temperature management.
Atropine
;
Body Weight
;
Bradycardia*
;
Carbon Monoxide Poisoning
;
Dexmedetomidine*
;
Diagnosis
;
Emergency Service, Hospital
;
Heart Arrest
;
Humans
;
Hypothermia, Induced
;
Logistic Models
;
Odds Ratio
;
Retrospective Studies
9.Exercise induced delayed bronchoconstriction in children with asthma.
Eun Jin CHOI ; Hyo Kung SHIN ; Un Ki YOON ; Ji Sub OH
Journal of the Korean Pediatric Society 1992;35(6):769-775
No abstract available.
Asthma*
;
Asthma, Exercise-Induced
;
Bronchoconstriction*
;
Child*
;
Humans
10.Leiomyosarcoma of the Pancreas: A case report.
Bong Kyung SHIN ; Jung Suk MOON ; Hwa Eun OH ; Nam Hee WON ; Jong Sang CHOI
Korean Journal of Pathology 1999;33(9):733-736
Most of the malignant tumors of the pancreas are adenocarcinomas arising from the ductal epithelium. Primary leiomyosarcoma of the pancreas, even though it is the most common sarcoma of the pancreas, is very rare. We present a case of leiomyosarcoma of the pancreas, probably primary, with metastases to the stomach, lymph nodes, and abdominal wall. A 52-year-old woman visited the hospital with vague right upper abdominal pain and weigh loss of 6 kg for 2 months. The radiological and endoscopic examination revealed that she had a large heterogeneous mass, 11 cm in size, in the pancreatic body and tail, a 4 cm-sized mass in the paraaortic area, and a 3 cm-sized polypoid mass in the stomach. Histologically, they were all similar to one another and composed of markedly pleomorphic cells. Immunohistochemical and electron microscopic studies showed definite smooth muscle differentiation of the tumor cells. Two months later, the patient underwent an excision of a new 3 cm mass in the right lower abdominal wall, showing features of well differentiated leiomyosarcoma.
Abdominal Pain
;
Abdominal Wall
;
Adenocarcinoma
;
Epithelium
;
Female
;
Humans
;
Leiomyosarcoma*
;
Lymph Nodes
;
Middle Aged
;
Muscle, Smooth
;
Neoplasm Metastasis
;
Pancreas*
;
Sarcoma
;
Stomach