Two hundreds fifty seven cases of normal mammogram were analysis for classification of types of breasts.Ranging from 20 to 79 years of age, mean age was 45 years. Two projections, craniocaudal & mediolateral, were used. Age, nutrient condition, familial tendency and hormonal factors influence to breats hisologically. Normalbreats were classified into the standard (9.75%), ductal (71.7%), glandular (6.2%) and atrophic (12.4%) types.Ductal type was further subclassified into intraductal, periductal and mixed types. Atrophic type was susbdividedinto fibrous and fatty, Standard type was observed in younger women, instead of atrophic type was seen in olderage group, especially after menopause. Periductal type was most common (65.4%), Glandular type was mostly intwenty to thirty year group. According to increase of age, gladular or ductal type transformed into atrophic type.
Classification ; Female ; Humans ; Menopause

Cerebrovascular accident (CVA) is the most common cause of neurologic disorder accompanying grave prognosisand its mortality above 50%. Prior to introduction of the CT, the diagnosis have been depended on clinicalfindings and spinal puncture. Radiologic diagnostic methods, such as angiography, ventriculography andradioisotope scanning are invasive and less sentitive in diagnosis of CVA than CT. The size, location andextension of the intracranial pathology and ventricular penetration are accureately and rapidly portrayed by CT.Consequently, CT plays impotant role in effective tratement and evaluation of prognosis in CVA. Authors analyzed63 cases of diagnosed CVA who were performed CT scan in Korea General Hospital from November 1981 to April 1982.The results were as follows. 1. The most prevalent age group of CVA was 6th decade, and then 7th and 5th decadesin decreasing order. The sex ration between male and female was 1.2:1. 2. The causes of CVA were hypertensivehemorrhage (50.8%), vascular occlusive disease(22.2%), anurysm ruture (4.8%), arteriovenous malformation (3.2%)and hemorrhage of unknown etiology (19.0%). 3. The most common site of hemorrhage was basal ganglia (34.6%) andthen thalamus(21.8%) and cerebral lobes(20.5%). In infarction, the common sites were the lobes(64.7%) and thebasal ganglia (35.3%) 4. Round or oval shaped hematomas of high density (85.9%) were frequent findings ofhemorrhage and mass effect occured in 75.6%. 5. All infarctions were low in density ; Most of the lesion wasinhomogeneous(70.6%) and the rests were homogeneous. Mass effects were seen in 29.4%.
Angiography ; Arteriovenous Malformations ; Basal Ganglia ; Diagnosis ; Female ; Ganglia ; Hematoma ; Hemorrhage ; Hospitals, General ; Humans ; Infarction ; Korea ; Male ; Mortality ; Nervous System Diseases ; Pathology ; Prognosis ; Spinal Puncture ; Stroke ; Tomography, X-Ray Computed

Diagnostic ultrasound has become one of the most useful tools in the practice of obstetics. It has been ofparticular utility in the placental localization. We analyzed 34 patients of placenta previa scanned byultrasound. The reults were as follows; 1. The age of patient ranged from 22 to 39 years, showing the highestincidence in 26 to 30 years. 2. The accuracy of correct localization was 70.6%. 3. Among 13 cases diagnosed byultrasound as total placenta previa, 2 cases were partial placenta previa and 1 was low-lying placenta at the timeof delivery. 4. Among 9 cases diagnosed by ultrasound as partial placenta previa, 1 case was total palcenta previaand 1 case was low-lying placenta and 1 case was upper segment placenta. 5. Among 10 cases diagnosed by utrasoundas low-lying placenta, 2 cases were partial placenta previa. 6. Among 2 cases diagnosed by utlrasound as uppersegment placenta, 1 case was total placental previa and 1 case was partial placenta previa. 7. Among 9 cases doneserial ultrasoud, 3 cases revealed that the placenta migrates toward fundus in the course of pregnancy, Therefore,the palcental scanning should be repeated in the last month before term to decide the mode of delivery.conclusively, ultrasonography is the imaging modality of choice in the evaluation of placental localization becuseit provides speedy and repeatable way without any known risk to both mother and fetus itself. Careful performanceand accurate interpretation shold be needed for more correct palcental localization.
Fetus ; Humans ; Mothers ; Placenta Previa ; Placenta ; Pregnancy ; Ultrasonography

Transportation between the cytoplasm and the nucleoplasm is critical for many physiological and pathophysiological processes including gene expression, signal transduction, and oncogenesis. So, the molecular mechanism for the transportation needs to be studied not only to understand cell physiological processes but also to develop new diagnostic and therapeutic targets. Recent progress in the research of the nuclear transportation (import and export) via nuclear pore complex and four important factors affecting nuclear transport (nucleoporins, Ran, karyopherins, and nuclear localization signals/nuclear export signals) will be discussed. Moreover, the clinical significance of nuclear transport and its application will be reviewed. This review will provide some critical insight for the molecular design of therapeutics which need to be targeted inside the nucleus.
Active Transport, Cell Nucleus* ; Carcinogenesis ; Cell Physiological Processes ; Cytoplasm ; Gene Expression ; Karyopherins ; Nuclear Localization Signals ; Nuclear Pore ; Nuclear Pore Complex Proteins ; Signal Transduction ; Transportation

The gastric epithelium is continuously regenerated by gastric stem cells, which give rise to various kinds of daughter cells, including parietal cells, chief cells, surface mucous cells, mucous neck cells, and enteroendocrine cells. The self-renewal and differentiation of gastric stem cells need delicate regulation to maintain the normal physiology of the stomach. Recently, it was hypothesized that cancer stem cells drive the cancer growth and metastasis. In contrast to conventional clonal evolution hypothesis, only cancer stem cells can initiate tumor formation, self-renew, and differentiate into various kinds of daughter cells. Because gastric cancer can originate from gastric stem cells and their self-renewal mechanism can be used by gastric cancer stem cells, we review here how critical signaling pathways, including hedgehog, Wnt, Notch, epidermal growth factor, and bone morphogenetic protein signaling, may regulate the self-renewal and differentiation of gastric stem cells and gastric cancer stem cells. In addition, the precancerous change of the gastric epithelium and the status of isolating gastric cancer stem cells from patients are reviewed.
Bone Morphogenetic Proteins ; Cell Differentiation ; Clonal Evolution ; Enteroendocrine Cells ; Epidermal Growth Factor ; Epithelium ; Hedgehogs ; Humans ; Neck ; Neoplasm Metastasis ; Neoplastic Stem Cells ; Nuclear Family ; Stem Cells ; Stomach ; Stomach Neoplasms

The generation and maintenance of consciousness are fundamental but difficult subjects in the fields of psychology, philosophy, neuroscience, and medicine. However, recent developments in neuro-imaging techniques coupled with network analysis have greatly advanced our understanding of consciousness. The present review focuses on large-scale functional brain networks based on neuro-imaging data to explain the awareness (contents) and wakefulness of consciousness.Despite limitations, neuroimaging data suggests brain maps for important psychological and cognitive processes such as attention, language, self-referential, emotion, motivation, social behavior, and wakefulness. We considered a review of these advancements would provide new insights into research on the neural correlates of consciousness.

The generation and maintenance of consciousness are fundamental but difficult subjects in the fields of psychology, philosophy, neuroscience, and medicine. However, recent developments in neuro-imaging techniques coupled with network analysis have greatly advanced our understanding of consciousness. The present review focuses on large-scale functional brain networks based on neuro-imaging data to explain the awareness (contents) and wakefulness of consciousness.Despite limitations, neuroimaging data suggests brain maps for important psychological and cognitive processes such as attention, language, self-referential, emotion, motivation, social behavior, and wakefulness. We considered a review of these advancements would provide new insights into research on the neural correlates of consciousness.

PURPOSE: This study was conducted to evaluate the process & outcome of a Health promotion program(Growing Younger & More Active) for the community resident older adults from March to December, 2001. METHOD: A quasi experimental research(one group pretest-posttest design) was used in this study. The subjects were 82 older adults(but 40 older adults 4 weeks after the program). Program had 5 sessions(10 hours) once a week. Data were collected before the program, immediately after & 4 weeks after the program and were analyzed with paired t-test. RESULT: The levels of Satisfaction, Interest & Understanding of the Program were high. Significant differences were found in health knowledge, health promoting behaviors, perceived health status and life satisfaction between before program and immediately after program as well as between before program and 4 weeks after program, but no significant differences in Health attitude. Self efficacy has significant difference only between before program and immediately after program , but no significant differences between before program and 4 weeks after the program. CONCLUSION: This results suggest that a Health promotion program for the community resident older adults developed this study is effective. So this program can be recommended as an effective nursing intervention for the health promotion of the older adults living in community.
Adult* ; Attitude to Health ; Health Promotion* ; Humans ; Nursing ; Self Efficacy

PURPOSE: The purpose of this study was to describe the subjective health status of joints, flexibility of joints, muscle strength and state of joint exercise in elderly people living in the community. METHOD: The participants were 74 elderly people in a health program of the Gerontological Health Research Center at G University. The data were collected from March to July, 2003. The instrument for the study included items on general characteristics (5 items), subjective health status of joints (10 items), flexibility of joints and strength of muscle (8 items), and state of joint exercise (7 items). RESULTS: The score for subjective health status of joints was 3.70 (range 1-5). Knee and waist joints were in the worst state. Neck extension and flexion were 17.38+/-1.80 and .60+/-1.08(cm) respectively. Trunk extension and flexion were 68.24+/-4.47 and 58.00+/-4.91(cm) respectively. Flexibility of the Rt./Lt. shoulder joints was 14.63+/-12.51/18.82+/-13.80(cm). Muscle strength of the Rt./Lt. leg was 30.47+/-19.68/29.67+/-21.22 (sec.). Shoulder joints were more flexible for men and people in their sixties compared to women and people in their seventies. Hand grip was stronger for men compared to women. The score for state of joint exercise was 2.83(range 1-4). The state of handgrip correlated with the state of joint exercise [r=.423 (Rt.)/r=.273(Lt.)]. CONCLUSION: To prevent falls and disorders in neuromuscular function, it is important to develop systemic joint exercise programs for elderly people.
Aged* ; Female ; Hand ; Hand Strength ; Humans ; Joints* ; Knee ; Leg ; Male ; Muscle Strength ; Neck ; Pliability ; Shoulder Joint

PURPOSE: This study was conducted from March to August, 2003 to evaluate the process and outcomes of a program to promote healthy joints in older adults residing in the community. METHOD: A quasi experimental research design (one group pretest-posttest design) was used in this study. The participants were 26 older adults (but 74 older adults also participated in a program immediately after the study program). Program had 4 sessions (8 hours) once a week. Data were collected before the program, immediately after and 4 weeks after the program was completed and were analyzed with paired t-test. RESULTS: The level of a satisfaction, interest and understanding of the program were high. Significant differences were found in the health state, the flexibility of neck and shoulder joints and joint exercise habits between the scores before the program started and 4 weeks after it finished. CONCLUSION: This results suggest that the joint health promotion program for older adults in the community developed this study is effective. So this program can be recommended as an effective nursing intervention for joint health promotion in older adults living in the community.
Adult* ; Health Promotion ; Humans ; Joints* ; Neck ; Nursing ; Pliability ; Research Design ; Shoulder Joint