1.Antiretroviral drug resistance among drug-naive HIV-1 infected patients.
Seo Rin KIM ; Eun Kyung RHEU ; Young Mi SEOL ; Dong Heuck CHA ; Su Jin LEE ; Yeun Kyung YOON ; Soon Mi PARK ; Heyung Hoe KIM ; Hak Sun RHEU ; Soon Chul AHN ; Sun Hee LEE ; Im Su KWAK ; Goon Jae CHO
Korean Journal of Medicine 2007;73(3):243-250
BACKGROUND: The prevalence of HIV drug resistance mutations in drug-naive patients has been shown to differ with geographic origin. The purpose of this study is to assess the prevalence of transmitted antiretroviral drug resistance mutations in drug-naive patients in Korea. METHODS: Genotypic resistance was determined by the use of the Viroseq Genotyping System in 42 antiretroviral treatment naive HIV-infected patients between March 2005 and July 2006. Transmitted drug resistance was estimated according to the IAS-USA 2005 definition, taking into account only major mutations in the protease and all mutations in the reverse transcriptase, including revertant mutations at codon 215. RESULTS: The median age of the patients was 42 years and 37 (88%) were male. The median CD4+T cell count was 136/mm3 and the mean plasma RNA level was 4.98 log copies/mL. Among 42 patients studied, 37 (88%) were newly diagnosed patients. None of the patients were recent seroconverters; 38 patients (90%) were infected with subtype B and 4 patients were infected (10%) with the non-B subtype strains (2 patients with CRF01-AE 1 as CRF02-AG; 1 patient with subtype A). Of the 42 subjects tested, we found 2 (4.8%) mutations in NRTI (V118I), but did not find a mutation in NNRTI as well as in the PI region. CONCLUSIONS: The prevalence of transmitted antiretroviral drug resistance in drug-naive patients is still low in Korean patients.
Cell Count
;
Codon
;
Drug Resistance*
;
HIV
;
HIV-1*
;
Humans
;
Korea
;
Male
;
Plasma
;
Prevalence
;
RNA
;
RNA-Directed DNA Polymerase
2.Prevention of Mother-to-child Transmission of HIV: Experiences from an University Teaching Hospital.
Young Mi SEOL ; Eun Kyung RHEU ; Su Eun PARK ; Gi Hyeong KIM ; Sun Hee LEE ; Im Su KWAK ; Goon Jae CHO
Infection and Chemotherapy 2007;39(2):95-99
The number of HIV infected women continues to rise sharply these days and 58% of these women were childbearing age. The increase in the number of AIDS cases among childbearing women has led to an increase in the maternal - infant transmission of human acquired immunodeficiency virus. The aim of our study is to assess the available evidence for preventing mother-to-infant transmission of HIV infection by experience from University Teaching Hospital. Four pregnant women with HIV infection delivered in Pusan National University Hospital from 1999 to 2005 years. Three women visitied at 3rd trimester, only one woman delivered by planned perinatal care. They received antiretroviral therapy during pregnancy, labor, after delivery, and infant received antiretroviral therapy by consideration of their situation. They were compliant with treatment and had a sustained virologic response below the detectable level. Just 2% of infants were trasmitted by human acquired immunodeficiency virus, if HIV infected women had an appropriate prophylaxis. Therefore HIV infected women must be identified early for prevention of maternal-infant transmission, they must receive effective antiretrovirus therapy.
Busan
;
Female
;
HIV Infections
;
HIV*
;
Hospitals, Teaching*
;
Humans
;
Infant
;
Perinatal Care
;
Pregnancy
;
Pregnant Women
3.Prevention of Mother-to-child Transmission of HIV: Experiences from an University Teaching Hospital.
Young Mi SEOL ; Eun Kyung RHEU ; Su Eun PARK ; Gi Hyeong KIM ; Sun Hee LEE ; Im Su KWAK ; Goon Jae CHO
Infection and Chemotherapy 2007;39(2):95-99
The number of HIV infected women continues to rise sharply these days and 58% of these women were childbearing age. The increase in the number of AIDS cases among childbearing women has led to an increase in the maternal - infant transmission of human acquired immunodeficiency virus. The aim of our study is to assess the available evidence for preventing mother-to-infant transmission of HIV infection by experience from University Teaching Hospital. Four pregnant women with HIV infection delivered in Pusan National University Hospital from 1999 to 2005 years. Three women visitied at 3rd trimester, only one woman delivered by planned perinatal care. They received antiretroviral therapy during pregnancy, labor, after delivery, and infant received antiretroviral therapy by consideration of their situation. They were compliant with treatment and had a sustained virologic response below the detectable level. Just 2% of infants were trasmitted by human acquired immunodeficiency virus, if HIV infected women had an appropriate prophylaxis. Therefore HIV infected women must be identified early for prevention of maternal-infant transmission, they must receive effective antiretrovirus therapy.
Busan
;
Female
;
HIV Infections
;
HIV*
;
Hospitals, Teaching*
;
Humans
;
Infant
;
Perinatal Care
;
Pregnancy
;
Pregnant Women
4.Correlation between Chlamydia pneumonia Infection and Childhood Asthma.
Hye Yung YUM ; Jung Yun CHOI ; Jung Woo RHEU ; Kyung Eun LEE ; Cheol Hong KIM ; Myung Hyun SHON ; Kyu Earn KIM ; Ki Young LEE
Pediatric Allergy and Respiratory Disease 2000;10(3):218-224
PURPOSE: Chlamydia pneumonia infection causes chronic recurrent infection, and is related to a broad spectrum of respiratory disease, and the specific antibody titer increases with age. As the interest in correlation between Chlamydia pneumonia infection and asthma has been recently increased, significant correlation with nonatopic asthma in adults has been proved, and in children the study results by using molecular biological techniques such as PCR and culture of patient's serum or nasal aspirate have been reported. We investigated the association between Chlamydia pneumonia infection and asthma with serum Chlamydia pneumonia specific antibody by ELISA of asthma patients who visited the hospital. METHODS: We collected the sera from patient group who visited the pediatric department of Yonsei University Medical Center to be diagnosed as asthma and from control group who had no evidence of asthma, respiratory or infectious disease. Centrifused sera were kept in -20 degrees C refregerator. To detect the serum Chlamydia pneumonia specific IgG and IgA of patient and control groups, we used ELEGANCE Chlamydia pneumonia IgG ELISA and ELEGANCE Chlamydia pneumonia IgA ELISA (Bioclone, Varrickville, Australia) kits. RESULTS: Serum Chlamydia pneumonia specific IgG and IgA ELISA were performed on patient group (55 males, 45 females) and control group (28 males, 29 females). The mean ages of patient and control groups were 6.8+/-2.8 and 6.3+/-3.4 years each and there was no significant difference. Positive rate to IgG in patient and control groups was 23.0% and 17.5% each (P=0.34). Positive rate to IgA in patient and control groups was 24.0% and 14.0% each (P=0.22). Positive rate to IgG and IgA in patient and control groups was 21.0% and 8.8% each (P=0.047). CONCLUSION: There was significant correlation between Chlamydia pneumonia infection and childhood asthma by the result of serum Chlamydia pneumonia specific IgG and IgA ELISA of patient and control groups.
Academic Medical Centers
;
Adult
;
Asthma*
;
Child
;
Chlamydia*
;
Communicable Diseases
;
Enzyme-Linked Immunosorbent Assay
;
Humans
;
Immunoglobulin A
;
Immunoglobulin G
;
Male
;
Pneumonia*
;
Polymerase Chain Reaction
5.A Case of Malignant Lymphoma during Treatment with Methotrexate for Rheumatoid Arthritis.
Moo Gon KIM ; Juhn Yeob LEE ; Jong Seok BAE ; Young Jin SEO ; Kyung Jin LIM ; Seung Hie CHUNG ; Hyundae YOON ; Eun Young KIM ; Wern Chan YOON ; Hun Mo RHEU ; Chae Gi KIM ; Yong Ho SONG ; Chang Ho CHO ; Jung Yoon CHOE
The Journal of the Korean Rheumatism Association 2002;9(1):63-67
Rheumatoid arthritis (RA)is a multisystemic inflammatory disease with a prevalance of approximately 1%of the population.The use of disease modifying anti-rheumatic drug (DMARD)is an essential regimen for the treatment of RA. Among DMARDs,methotrexate (MTX)is used worldwide with confirmed effectiveness.However,cytopenia,pulmonary injury,and hepatic toxicity are a few side effects limiting its use.In addition,although the oncogenic potential of MTX is low,several cases have been reported.Recently an increased risk of developing lymphoproliferative disorders has been reported in patients with RA. The incidence is higher in elderly individuals with severe longstanding seropositive RA,those with Sjogren's or Felty's syndrome,and in patients with RA treated with prolonged low dose MTX.We describe a case of RA who developed non-Hodgkin's lymphoma during low dose MTX therapy.
Aged
;
Arthritis, Rheumatoid*
;
Humans
;
Incidence
;
Lymphoma*
;
Lymphoma, Non-Hodgkin
;
Lymphoproliferative Disorders
;
Methotrexate*