1.Invasive carcinoma after a simple hysterectomy for microinvasive carcinoma of uterine cervix: a case report.
Dae Jin KANG ; Kee Eun LIM ; Jung Bae YOO ; Hyung MOON ; Doo Sang KIM
Korean Journal of Obstetrics and Gynecology 1993;36(2):264-267
No abstract available.
Cervix Uteri*
;
Female
;
Hysterectomy*
2.Electroencephalographic Abnormalities in the Screening for Pilot Applicants in Korea.
Dan A OH ; Hyeyun KIM ; Eun Kee BAE
Journal of Clinical Neurology 2018;14(2):212-214
BACKGROUND AND PURPOSE: Electroencephalography (EEG) is often used as a screening tool for selecting pilots despite controversy regarding its contribution to aviation safety. We investigated EEG abnormalities in Korean commercial pilot applicants in order to identify the usefulness of EEG screening in this population. METHODS: We retrospectively analyzed the EEG results of 740 unselected pilot applicants who underwent waking EEG at Inha University Hospital from January 2013 to May 2017. EEG recording was performed for 30 minutes, which included 3 minutes of hyperventilation and intermittent photic stimulation. RESULTS: The pilot applicants were predominantly male (95.3%) and had a mean age of 27.8 years (range: 16–40 years). Nine of them (1.2%) exhibited EEG abnormalities; the most common abnormality (six applicants) was a small amount of generalized irregular slow activities, while the other three applicants (0.4%) exhibited epileptiform discharges, with two showing generalized spike-and-wave complexes and one showing a few spike-and-wave complexes in the left frontotemporal area. The two applicants with generalized spike-and-wave complexes were found to have experienced clinical seizures by a neurologist during detailed history-taking. CONCLUSIONS: This study found that 2 of 740 pilot applicants (0.3%) were diagnosed with epilepsy by routine EEG screening in an unselected population. Considering the low predictive value of EEG without the relevant clinical history in an unselected healthy young population, our findings raise questions regarding the cost-effectiveness of the current EEG screening protocol applied to pilot applicants. We suggest that a more-targeted and standardized EEG screening approach be applied to pilot applicants with epilepsy risk factors or a seizure history as determined by thorough medical history-taking.
Aviation
;
Electroencephalography
;
Epilepsy
;
Humans
;
Hyperventilation
;
Korea*
;
Male
;
Mass Screening*
;
Photic Stimulation
;
Retrospective Studies
;
Risk Factors
;
Seizures
3.A study on the CT density of the antibiotics
Kee Hyun CHANG ; Eun Chul CHUNG ; Sang Hoon BAE ; Wee Saing KANG ; Man Chung HAN
Journal of the Korean Radiological Society 1982;18(1):3-9
The study was undertaken to assess the CT density of the antibiotics solution. CT scan of six antibioticssolution-streptomycin, chloramphenicol, Na-penicillin, ampicillin, kanamycin and cefamezine-in concentration ofabout 33% (approximatly single dose of intramuscular injection) was performed, using plastic syringes. Variousconcentrations of striptomycin, chloramphenicol and Na-panicillin were also examined for evaluation of relationbetween concentration and the CT density of the antibiotics. In addition, relationship between CT number andmathematically calculated effective atomic number and electron density of the antibiotics was evaluated. Theresults are as follows; 1. The CT densities of all antibiotics reveal high density (CT number 80–150) inconcentration of single intramuscular injection dose. 2. CT number of striptomycin, chloramphenicol andNa-penicillin gradually increased with increase of concentration of the antibiotics, producing linear proportionto concentration, effective atomic number and electron density of the antibiotics. 3. Therefore, density ofantibiotics should be included in differential diagnosis when high density on CT scan is observed.
Ampicillin
;
Anti-Bacterial Agents
;
Chloramphenicol
;
Diagnosis, Differential
;
Injections, Intramuscular
;
Kanamycin
;
Plastics
;
Syringes
;
Tomography, X-Ray Computed
4.Fyn Tyrosine Kinase-mediated Tyrosine Phosphorylation of Roundabout (Robo), the Slit Receptor.
Eun Sook JEON ; Kee Won BAE ; Hwan Tae PARK
Korean Journal of Anatomy 2004;37(3):275-281
In this study, the molecular mechanism of tyrosine phosphorylation of Roundabout (Robo), the transmembrane receptor for slits, was investigated. The tyrosine phosphorylation of intracellular portion of Robo was increased by the treatment of tyrosine phosphatase inhibitors in human embryonic kidney cells transfected with Robo. The Robo tyrosine phosphorylation was inhibited by the treatment of Src family kinase inhibitor, PP2. The co-transfection of constitutively active form of Fyn, not the dominant negative form of Fyn, and Robo dramatically enhanced the tyrosine phosphorylation of Robo. Furthermore, the SH2 domain of Fyn, which binds to phosphorylated tyrosine residues, interact with Robo, and the interaction was increased by the inhibition of tyrosine phosphatases. These findings indicate that the tyrosine phosphorylation of Robo is regulated by Fyn.
Humans
;
Kidney
;
Phosphoric Monoester Hydrolases
;
Phosphorylation*
;
Phosphotransferases
;
src Homology Domains
;
Tyrosine*
6.Adverse Skin Reactions with Antiepileptic Drugs Using Korea Adverse Event Reporting System Database, 2008–2017
Hyun Kyung KIM ; Dae Yeon KIM ; Eun Kee BAE ; Dong Wook KIM
Journal of Korean Medical Science 2020;35(4):e17-
BACKGROUND:
Severe and life-threatening drug eruptions include drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). One class of medications that has been highly associated with such drug eruptions is antiepileptic drugs (AEDs). We attempt to investigate drug eruptions associated with AEDs as a class, as well as with individual AEDs, in Korea.
METHODS:
We used the Korea Institute of Drug Safety and Risk Management - Korea Adverse Event Reporting System (KIDS-KAERS) database, a nationwide database of adverse events reports, between January 2008 and December 2017 to investigate the reporting count of all drug eruptions and calculated the ratio of DRESS/SJS/TEN reports for each AED.
RESULTS:
Among a total of 2,942 reports, most were of rash/urticaria (2,702, 91.8%), followed by those of DRESS (109, 3.7%), SJS (106, 3.6%), and TEN (25, 0.85%). The common causative AEDs were lamotrigine (699, 23.8%), valproic acid (677, 23%), carbamazepine (512, 17.4%), oxcarbazepine (320, 10.9%), levetiracetam (181, 6.2%), and phenytoin (158, 5.4%). In limited to severe drug eruptions (DRESS, SJS, and TEN; total 241 reports), the causative AEDs were carbamazepine (117, 48.8%), lamotrigine (57, 23.8%), valproic acid (20, 8.3%), phenytoin (15, 6.3%), and oxcarbazepine (10, 4.2%). When comparing aromatic AED with non-aromatic AED, aromatic AEDs were more likely to be associated with severe drug eruption (aromatic AEDs: 204/1,793 versus non-aromatic AEDs: 37/1,149; OR, 3.86; 95% CI, 2.7–5.5). Death was reported in 7 cases; DRESS was the most commonly reported adverse event (n = 5), and lamotrigine was the most common causative AED (n = 5).
CONCLUSION
Although most cutaneous drug eruptions in this study were rash or urticaria, approximately 8% of reports were of severe or life-threatening adverse drug reactions, such as SJS, TEN, or DRESS. When hypersensitivity skin reactions occurred, aromatic AEDs were associated with 4 fold the risk of SJS/TEN/DRESS compared with non-aromatic AEDs. Our findings further emphasize that high risk AEDs should be prescribed under careful monitoring, and early detection and prompt interventions are needed to prevent severe complications.
7.Genetic Contributions to Childhood Obesity: Association of Candidate Gene Polymorphisms and Overweight/Obesity in Korean Preschool Children.
Kee Hwan YOO ; Hyung Eun YIM ; Eun Soo BAE ; Young Sook HONG
Journal of Korean Medical Science 2017;32(12):1997-2004
This study was aimed to investigate the association of candidate gene polymorphisms and obesity or overweight in young Korean children. A total of 190 Korean preschool children (96 control, 48 overweight, and 46 obese children) were genotyped for the angiotensin converting enzyme (ACE) insertion (I)/deletion (D), angiotensin II type 2 receptor (AT2) C3123A, transforming growth factor (TGF)-β1 T869C, vascular endothelial growth factor (VEGF) T460C, and tumor necrosis factor (TNF)-α G308A polymorphisms. No differences were found among the groups with respect to age, sex, birth weight, blood pressure levels, and serum concentrations of glucose and total cholesterol. Obese children showed a higher incidence of ACE DD genotype and D allelic frequency compared to the controls (odds ratio [OR], 2.7, 95% confidence interval [CI], 1.01–7.21; OR, 2.5, 95% CI, 1.49–4.19; all P < 0.05). The frequency of TC genotype and C allele in the TGF-β1 T869C polymorphism (OR, 2.08, 95% CI, 1.01–4.27; OR, 1.93, 95% CI, 1.15–3.21) and that in the VEGF T460C polymorphism (OR, 2.5, 95% CI, 1.19–5.28; OR, 2.15, 95% CI, 1.26–3.68) was also higher in obese children than in control subjects (all P < 0.05). Overweight children exhibited a higher frequency of the A allele in the AT2 C3123A polymorphism compared to the controls (OR, 1.72, 95% CI, 1.03–2.88, P < 0.05). There were no differences in the TNF-α G308A polymorphism among the groups. The ACE I/D, AT2 C3123A, TGF-β1 T869C, and VEGF T460C polymorphisms can affect susceptibility to obesity or overweight in Korean children.
Alleles
;
Angiogenic Proteins
;
Birth Weight
;
Blood Pressure
;
Child
;
Child, Preschool*
;
Cholesterol
;
Genetic Variation
;
Genotype
;
Glucose
;
Humans
;
Incidence
;
Obesity
;
Overweight
;
Pediatric Obesity*
;
Peptidyl-Dipeptidase A
;
Receptor, Angiotensin, Type 2
;
Renin-Angiotensin System
;
Transforming Growth Factors
;
Tumor Necrosis Factor-alpha
;
Vascular Endothelial Growth Factor A
8.Impaired angiogenesis in the enalapril-treated neonatal rat kidney.
Hyung Eun YIM ; Kee Hwan YOO ; Eun Soo BAE ; Young Sook HONG ; Joo Won LEE
Korean Journal of Pediatrics 2016;59(1):8-15
PURPOSE: Nephrogenesis is normally accompanied by a tightly regulated and efficient vascularization. We investigated the effect of angiotensin II inhibition on angiogenesis in the developing rat kidney. METHODS: Newborn rat pups were treated with enalapril (30 mg/kg/day) or vehicle (control) for 7 days after birth. Renal histological changes were checked using Hematoxylin & Eosin staining. We also investigated the intrarenal expression of vascular endothelial growth factor (VEGF)-A, VEGF receptor 1 (VEGFR1), VEGFR2, platelet-derived growth factor (PDGF)-B, and PDGF receptor-beta with Western blotting and immunohistochemical staining at postnatal day 8. Expression of the endothelial cell marker CD31 was examined to determine glomerular and peritubular capillary density. RESULTS: Enalapril-treated rat kidneys showed disrupted tubules and vessels when compared with the control rat kidneys. In the enalapril-treated group, intrarenal VEGF-A protein expression was significantly higher, whereas VEGFR1 protein expression was lower than that in the control group (P<0.05). The expression of VEGFR2, PDGF-B, and PDGF receptor-beta was not different between the 2 groups. The increased capillary CD31 expression on the western blots of enalapril-treated rat kidneys indicated that the total endothelial cell protein level was increased, while the cortical capillary density, assessed using CD31 immunohistochemical staining, was decreased. CONCLUSION: Impaired VEGF-VEGFR signaling and altered capillary repair may play a role in the deterioration of the kidney vasculature after blocking of angiotensin II during renal development.
Angiotensin II
;
Animals
;
Blotting, Western
;
Capillaries
;
Enalapril
;
Endothelial Cells
;
Eosine Yellowish-(YS)
;
Growth and Development
;
Hematoxylin
;
Humans
;
Infant, Newborn
;
Kidney*
;
Parturition
;
Platelet-Derived Growth Factor
;
Rats*
;
Receptors, Vascular Endothelial Growth Factor
;
Vascular Endothelial Growth Factor A
9.The Author's Response: Genetic Contributions to Childhood Obesity: Association of Candidate Gene Polymorphisms and Overweight/Obesity in Korean Preschool Children
Kee Hwan YOO ; Hyung Eun YIM ; Eun Soo BAE ; Young Sook HONG
Journal of Korean Medical Science 2018;33(7):e71-
No abstract available.
Child, Preschool
;
Humans
;
Pediatric Obesity
10.Pulmonary lymphangioleiomyomatosis: case reports.
Kyung Soo LEE ; Eun Wan CHOI ; Byoung Ho LEE ; Won Kyung BAE ; Yong Hoon KIM ; Chang Jin KIM ; Joong Kee NOH
Journal of the Korean Radiological Society 1991;27(2):240-244
No abstract available.
Lymphangioleiomyomatosis*