Acardic twining is a rare congenital anomaly, usually in monozygotic twins. This condition is characterized by the absence or rudimentary development of fetal hear, and associated with various anomaly(especially with anecephalus). The acardiac malformations are uniformly fatal in the affected twin, and mortality in the co-twin is as high as 55%. We recently experienced a case of acardius acephalus associated with a normal term male infant, so present with a brief review of the literature.
Humans ; Infant ; Male ; Mortality ; Twins* ; Twins, Monozygotic

No abstract available.
Female ; Mucins* ; Ovary*

Dipeptidyl peptidase (DPP)-4 inhibitors, or gliptins, are a class of oral hypoglycemic drugs that have been widely used as a second-line treatment for type 2 diabetes. Gliptins, which were introduced for clinical use a decade ago, have been shown to be beneficial against nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NASH) in animals and humans. Cenicriviroc (CVC), a dual antagonist of C-C chemokine receptor type 2 and 5, is currently under investigation against NASH and fibrosis. It was previously discovered that evogliptin (EVO) reduces hepatic steatosis in diet-induced obese animals but the effectiveness of EVO on NASH remains unexplored. Here, we compared the effectiveness of EVO and CVC against NASH and fibrosis in mice fed a high-fat and high-fructose diet (HFHF). Biochemical and histological analyses showed that mice fed a HFHF for 20 weeks developed severe hepatic steatosis and inflammation with mild fibrosis. Administration of EVO (0.2% wt/wt) for the last 8 weeks of HFHF feeding significantly reduced hepatic triglyceride accumulation, inflammation, and fibrosis as well as restored insulin sensitivity, as evidenced by lowered plasma insulin levels and the improvement in insulin tolerance test curves. Treatment of mice with CVC (0.1% wt/wt) inhibited hepatic inflammation and fibrogenesis with similar efficacy to that of EVO, without affecting hepatic steatosis. CVC treatment also reduced plasma insulin concentrations, despite no improvement in insulin tolerance. In conclusion, EVO administration efficiently ameliorated the development of NASH and fibrosis in HFHF-fed mice, corroborating its therapeutic potential.
Animals ; Diet ; Dipeptidyl-Peptidase IV Inhibitors ; Fatty Liver ; Fibrosis ; Humans ; Hypoglycemic Agents ; Inflammation ; Insulin ; Insulin Resistance ; Mice ; Non-alcoholic Fatty Liver Disease ; Plasma ; Triglycerides

Purpose: This study examined the association between nurse staffing and in-hospital 30-day mortality among stroke patients considering the stroke type in the intensive care units in Korea using the Health Insurance Review and Assessment Service-National Inpatient Sample 2018 (HIRA-NIS 2018). Methods: The data included a total of 2,876 stroke patients admitted to intensive care units across 72 general hospitals and 39 tertiary hospitals between January and November 2018. Nurse staffing levels were measured using the nurse staffing grades of adult intensive care units in the 2nd quarter of 2018. The relationship between nurse staffing levels and mortality were analyzed using multi-level logistic regression analysis after controlling for patient and hospital characteristics. Results: In patients with ischemic stroke, the risk of death was lower in nurse staffing Grade 5 to 6 compared to Grade 1 (Odds ratio [OR] 0.43, 95% Confidence interval [CI] 0.24~0.75). In hemorrhagic stroke patients, the risk of death tended to be higher in nurse staffing grade 5 to 6 compared to Grade 1 (OR 2.11, 95% CI 1.00~4.45), which was marginally significant (p=.050). Conclusion Health policies for adequate nurse staffing in intensive care units should be implemented to enhance the quality of care and lead to better outcomes in patients with stroke.

Adipose tissue (AT) inflammation is strongly associated with obesity-induced insulin resistance. When subjected to metabolic stress, adipocytes become inflamed and secrete a plethora of cytokines and chemokines, which recruit circulating immune cells to AT. Although sirtuin 6 (Sirt6) is known to control genomic stabilization, aging, and cellular metabolism, it is now understood to also play a pivotal role in the regulation of AT inflammation. Sirt6 protein levels are reduced in the AT of obese humans and animals and increased by weight loss. In this review, we summarize the potential mechanism of AT inflammation caused by impaired action of Sirt6 from the immune cells’ point of view. We first describe the properties and functions of immune cells in obese AT, with an emphasis on discrete macrophage subpopulations which are central to AT inflammation. We then highlight data that links Sirt6 to functional phenotypes of AT inflammation. Importantly, we discuss in detail the effects of Sirt6 deficiency in adipocytes, macrophages, and eosinophils on insulin resistance or AT browning. In our closing perspectives, we discuss emerging issues in this field that require further investigation.

Purpose: This study aimed to examine the mediating effects of posttraumatic stress and depression on the relationship between perceived stress and suicidality, and to explore the moderating and moderated mediating effects of resilience in this relationship. Methods: This secondary data analysis utilized data from the 2023 G metropolitan city mental health survey, which included 1,000 participants. The analysis was conducted using SPSS/WIN 25.0 and the PROCESS macro 4.3, with significant values of resilience identified using the Johnson- Neyman method. Results: Posttraumatic stress and depression were found to mediate the effect of perceived stress on suicidality. Additionally, resilience moderated the relationships between perceived stress and posttraumatic stress, as well as between posttraumatic stress and depression. Furthermore, resilience had a moderated mediating effect on the relationship between stress and suicidality. Specifically, when resilience levels were between 84.14 and 84.90, posttraumatic stress did not significantly affect depression, and the dual mediating effect of posttraumatic stress and depression on the relationship between stress and suicidality was not observed. Conclusion The findings suggest that developing resilience training programs may be essential for suicide prevention, even in contexts of severe stress or trauma.

Purpose: This study aimed to examine the mediating effects of posttraumatic stress and depression on the relationship between perceived stress and suicidality, and to explore the moderating and moderated mediating effects of resilience in this relationship. Methods: This secondary data analysis utilized data from the 2023 G metropolitan city mental health survey, which included 1,000 participants. The analysis was conducted using SPSS/WIN 25.0 and the PROCESS macro 4.3, with significant values of resilience identified using the Johnson- Neyman method. Results: Posttraumatic stress and depression were found to mediate the effect of perceived stress on suicidality. Additionally, resilience moderated the relationships between perceived stress and posttraumatic stress, as well as between posttraumatic stress and depression. Furthermore, resilience had a moderated mediating effect on the relationship between stress and suicidality. Specifically, when resilience levels were between 84.14 and 84.90, posttraumatic stress did not significantly affect depression, and the dual mediating effect of posttraumatic stress and depression on the relationship between stress and suicidality was not observed. Conclusion The findings suggest that developing resilience training programs may be essential for suicide prevention, even in contexts of severe stress or trauma.

Purpose: This study aimed to examine the mediating effects of posttraumatic stress and depression on the relationship between perceived stress and suicidality, and to explore the moderating and moderated mediating effects of resilience in this relationship. Methods: This secondary data analysis utilized data from the 2023 G metropolitan city mental health survey, which included 1,000 participants. The analysis was conducted using SPSS/WIN 25.0 and the PROCESS macro 4.3, with significant values of resilience identified using the Johnson- Neyman method. Results: Posttraumatic stress and depression were found to mediate the effect of perceived stress on suicidality. Additionally, resilience moderated the relationships between perceived stress and posttraumatic stress, as well as between posttraumatic stress and depression. Furthermore, resilience had a moderated mediating effect on the relationship between stress and suicidality. Specifically, when resilience levels were between 84.14 and 84.90, posttraumatic stress did not significantly affect depression, and the dual mediating effect of posttraumatic stress and depression on the relationship between stress and suicidality was not observed. Conclusion The findings suggest that developing resilience training programs may be essential for suicide prevention, even in contexts of severe stress or trauma.

Purpose: This study aimed to examine the mediating effects of posttraumatic stress and depression on the relationship between perceived stress and suicidality, and to explore the moderating and moderated mediating effects of resilience in this relationship. Methods: This secondary data analysis utilized data from the 2023 G metropolitan city mental health survey, which included 1,000 participants. The analysis was conducted using SPSS/WIN 25.0 and the PROCESS macro 4.3, with significant values of resilience identified using the Johnson- Neyman method. Results: Posttraumatic stress and depression were found to mediate the effect of perceived stress on suicidality. Additionally, resilience moderated the relationships between perceived stress and posttraumatic stress, as well as between posttraumatic stress and depression. Furthermore, resilience had a moderated mediating effect on the relationship between stress and suicidality. Specifically, when resilience levels were between 84.14 and 84.90, posttraumatic stress did not significantly affect depression, and the dual mediating effect of posttraumatic stress and depression on the relationship between stress and suicidality was not observed. Conclusion The findings suggest that developing resilience training programs may be essential for suicide prevention, even in contexts of severe stress or trauma.

The purpose of this study was to compare the changes of retentive force in different stud attachment systems for implant retained overdenture. Two commercially available attachments with different retentive forces were investigated: Kerator (pink, blue, red) and O-ring (orange, red). Two implant fixtures were vertically embedded in base mountings. Five pairs of each attachment were evaluated. A universal testing machine was used to evaluate the retentive force of two attachments during wear simulation. Surface characteristics of each attachment system were evaluated with scanning electron microscopy. Five pairs of each attachment were evaluated. Kerator pink showed the highest initial retention. After 2,500 cycles of wear-simulation, Kerator pink noted the largest decrease in retention. According to results of surface analysis, Worn surfaces were obtained in matrices and patrices. Heavy wears were observed in matrices. After 2 year-wear simulation, most attachments exhibited retention loss. Attachments using different kind of material exhibited dissimilar surface alterations.
Denture, Overlay* ; Microscopy, Electron, Scanning