1.Acute Renal Failure in Children: Underlying Disease and Management according to Age.
Eun Joung PARK ; Joung Sim KIM ; Jai Bok YOO ; Joung Sook SUL ; Si Whan KOH ; Phil Soo OH ; I Suk KANG ; Moon Soo PARK ; Heung Jae LEE ; Dong Kyoo JIN
Journal of the Korean Pediatric Society 1998;41(5):654-662
PURPOSE: It has been stressed that age itself as well as multiple organ failure are important prognostic factors in acute renal failure (ARF) in children. This study was performed to find out the significance of age factor and underlying disease of ARF in children. METHODS: We tried to review 58 pediatric ARF cases, retrospectively, in the pediatric intensive care unit (excluding the neonatal and surgical intensive care unit cases) of the Samsung Seoul Hospital of Sung Kyun Kwan University from Sept., 1994. to Dec., 1996. RESULTS: We classified the enrolled 58 cases into 5 age groups and more than half were younger than 1 year old. As underlying causes, heart and gastrointestinal disease were predominant in less than 1 month of age group. After 1 year of age, intrinsic renal disease was the most common cause (43-50%). Among the renal disease, systemic lupus erythematosus (10-15 year group), hemolytic uremic syndrome (1-10 year group), and obstructive uropathy (less than 1 year age group) were common etiologies. The mortality was the highest (46.7%) in less than 1 year group and lowest (21.4%) in 10-15 year age group. CONCLUSION: The underlying disorders of ARF in children were different among the age group. Among intrinsic renal diseases, hemolytic uremic syndrome was the most common cause. The difference in the mortality was dependent on age and underlying disease.
Acute Kidney Injury*
;
Age Factors
;
Child*
;
Gastrointestinal Diseases
;
Heart
;
Hemolytic-Uremic Syndrome
;
Humans
;
Critical Care
;
Intensive Care Units
;
Lupus Erythematosus, Systemic
;
Mortality
;
Multiple Organ Failure
;
Retrospective Studies
;
Seoul
2.WebChemDB: An Integrated Chemical Database Retrieval System.
Bo Kyeng HOU ; Eun Joung MOON ; Sung Chul MOON ; Hae Jin KIM
Genomics & Informatics 2009;7(4):212-216
WebChemDB is an integrated chemical database retrieval system that provides access to over 8 million publicly available chemical structures, including related information on their biological activities and direct links to other public chemical resources, such as PubChem, ChEBI, and DrugBank. The data are publicly available over the web, using two-dimensional (2D) and three-dimensional (3D) structure retrieval systems with various filters and molecular descriptors. The web services API also provides researchers with functionalities to programmatically manipulate, search, and analyze the data.
Databases, Chemical
;
Subject Headings
3.Regulation of LIF Gene Expression by Interleukin-1 in the Mouse Peri-implantation Embryos and Uterine Endometiral Cells.
Joung Woul KIM ; Hye Young YANG ; Hyoung Eun RYU ; Ji Youn LEE ; Moon Kyoo KIM ; Jung Bok LEE ; Hyun Soo YOON
Korean Journal of Fertility and Sterility 2000;27(2):183-190
No abstract available.
Animals
;
Embryonic Structures*
;
Gene Expression*
;
Interleukin-1*
;
Mice*
4.A Clinical Study on Hereditary Spherocytosis.
Joung Chul PARK ; Jun Eun PARK ; Yoon Jeong KIM ; Jong Jin SEO ; Hyung Nam MOON ; Thad GHIM
Korean Journal of Pediatric Hematology-Oncology 2000;7(1):9-15
PURPOSE: The aim of this study was to investigate the clinical and laboratory findings of hereditary spherocytosis comparing those of different age groups. METHODS: The clinical and laboratory findings of hereditary spherocytosis from June 1989 to August 1998 at Asan Medical Center were analyzed retrospectively according to two different age groups, Group I (9 patients diagnosed under 10 years of age) and Group II (19 patients diagnosed at or over 10 years of age). RESULTS: 1) Mean age at diagnosis was 2.4+/-1.97 and 28.2+/-18.81 years, and family history was positive in 44% and 47% in Group I and II patients respectively. 2) Splenectomy was carried out in 33% and 79% of Group I and II patients respectively, and accessory spleen was found in 100% and 20% of splenectomized patients respectively. 3) Gallstone was found in 11% and 42% of Group I and II patients respectively, and aplastic crisis developed in 0% and 10% respectively. 4) Post-splenectomy hematological parameters improved as follows: Group I; from hemoglobin at diagnosis of 8.5+/-3.59 g/dL to post-splenectomy level of 12.6+/-0.86 g/dL, hematocrit 24.5+/-10.25% to 38.1+/-4.86%, corrected reticulocyte 9.0+/-4.16% to 1.2+/-0.84%, total bilirubin 3.2+/-1.53 mg/dL to 2.2+/-1.34 mg/dL. Group II ; from hemoglobin at diagnosis of 8.9+/-2.95 g/dL to post-splenectomy level of 12.6+/-1.27 g/dL, hematocrit 24.9+/-7.85% to 37.4+/-2.89%, corrected reticulocyte 4.8+/-2.74% to 2.0+/-1.12%, total bilirubin 5.2+/-5.05 mg/dL to 1.1+/-0.49 mg/dL. CONCLUSION: There were no age related differences in hematologic findings at diagnosis and many of the patients with milder form of the disease could be detected later in adult life. The frequency of gallstone was up to 42% in patients whose diagnosis was delayed after 10 years of age, and aplastic crisis was a rare complication. Splenectomy was an effective treatment leading to normal hemoglobin concentrations in all patients. Accessory spleen was found in 33% of splenectomized patients, which emphasizes the necessity of spleen scan before splenectomy.
Adult
;
Bilirubin
;
Chungcheongnam-do
;
Diagnosis
;
Gallstones
;
Hematocrit
;
Humans
;
Reticulocytes
;
Retrospective Studies
;
Spleen
;
Splenectomy
5.Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells.
Youn Hee JOUNG ; Eun Joung LIM ; Moon Young LEE ; Jong Hwan PARK ; Sang Kyu YE ; Eui U PARK ; Sang Yoon KIM ; Zheng ZHANG ; Kwang Jeon LEE ; Dong Ki PARK ; Taekyu PARK ; Won Kook MOON ; Young Mok YANG
Experimental & Molecular Medicine 2005;37(4):353-364
Hypoxia, a common consequence of solid tumor growth in breast cancer or other cancers, serves to propagate a cascade of molecular pathways which include angiogenesis, glycolysis, and various cellcycle control proteins. As we have shown previously, hypoxia activates STAT5 (signal transducer and activator of transcription 5) and increases its binding activity to the GAS element in mammary epithelial cells. In this study we attempted to elucidate the mechanism by which cyclin D1 is regulated by the STAT5 protein under hypoxic conditions. Our data demonstrate that hypoxia (2% O2) or desferrioxamine (DFO) induces tyrosine and serine phosphorylation of STAT5 in human breast cancer cells (MCF-7) and mammary epithelial cells (HC11). Imunoprecipitation and subsequent Western analysis showed that Jak2 leads to the tyrosine phosphorylation and activation of STAT5a or STAT5b under hypoxic conditions. Using a transfected COS-7 cell model system, we demonstrate that the activity of a cyclin D1 promoter-luciferase construct increased under hypoxic conditions or DFO treatment. The activity of the STAT5b/cyclin D1 promoter increased significantly by 12 h of hypoxia, whereas the activity of the STAT5a/cyclin D1 promoter was unaffected under hypoxic conditions. These increases in promoter activity are predominantly mediated by the Jak2/ STAT5b signaling pathway. We have shown by EMSA that hypoxia induces STAT5 to bind to the cyclin D1 promoter (GAS-1) in MCF-7 and HC11 cells. These data suggest that STAT5b may mediate the transcriptional activation of cyclin D1 after hypoxic stimulation.
Anaerobiosis/genetics
;
Animals
;
Breast Neoplasms/*genetics/metabolism
;
COS Cells
;
Cell Hypoxia/genetics
;
Cercopithecus aethiops
;
Cyclin D1/*genetics
;
Deferoxamine/pharmacology
;
Female
;
*Gene Expression Regulation, Neoplastic
;
Humans
;
Phosphorylation/drug effects
;
Promoter Regions (Genetics)
;
Protein-Tyrosine Kinase/*metabolism
;
Proto-Oncogene Proteins/*metabolism
;
Research Support, Non-U.S. Gov't
;
Serine/metabolism
;
Tumor Cells, Cultured
;
Tyrosine/metabolism
6.Prenatal 3D-ultrasound diagnosis of Otocephaly and Holoprosencephaly-Cyclopia.
Min Jeoung KIM ; Hyo Jin KIM ; Min Jeoung HA ; Jeoung Min MOON ; Eun Young JI ; In Yang PARK ; Soo Young HUR ; Gui Sera LEE ; Joung Chul SHIN ; Sa Jin KIM
Korean Journal of Obstetrics and Gynecology 2005;48(10):2422-2427
Otocephaly is a rare malformations comprising hypoplasia or absence of the mandible (agnathia), ventromedial displacement and often fusion of external ears (synotia or otocephaly), and hypoplasia of the oral cavity (microstomia) and tongue (hypoglassia). This developmental complex represents a malformation of the first and second branchial arches and occurs sometimes with holoprosencephaly. We present the ultrasound detection of otocephaly and holoprosencephaly with cyclopia in a fetus of 27 gestational weeks 6 days. The use of three-dimensional (3-D) ultrasound made additional diagnostic ultrasound tomograms possible, and the volume reconstructions improved the imaging and the understanding of the condition.
Branchial Region
;
Diagnosis*
;
Ear, External
;
Fetus
;
Holoprosencephaly
;
Mandible
;
Mouth
;
Tongue
;
Ultrasonography
7.Prostate Specific Membrane Antigen mRNA in Blood as a Potential Predictor of Biochemical Recurrence after Radical Prostatectomy.
Jae Young JOUNG ; Kang Su CHO ; Han Soo CHUNG ; In Chang CHO ; Jung Eun KIM ; Ho Kyung SEO ; Jinsoo CHUNG ; Weon Seo PARK ; Moon Kyung CHOI ; Kang Hyun LEE
Journal of Korean Medical Science 2010;25(9):1291-1295
We investigated whether the detection of prostate specific membrane antigen (PSMA) in blood preoperatively has predictive value for biochemical recurrence (BCR) after radical prostatectomy in patients with prostate cancer. All 134 patients scheduled to receive radical prostatectomy for prostate cancer were prospectively enrolled. The authors used nested reverse transcriptase-polymerase chain reaction (RT-PCR) assay to detect PSMA mRNA-bearing cells in peripheral blood, and analyzed the ability of PSMA mRNA positivity to predict BCR after surgery. PSMA-mRNA was detected in 24 (17.9%) patients by RT-PCR. Over a median follow-up of 20 months (range, 3 to 46 months), BCR developed in 15 patients (11.2%) and median time to BCR was 7 months (range, 3 to 25 months). Kaplan-Meier analysis revealed a significant difference between those positive or negative for PSMA in terms of recurrence-free actuarial probability (log rank P=0.0039). Multivariate analysis showed that positivity for PSMA mRNA (HR: 3.697, 95% CI 1.285-10.634, P=0.015) and a biopsy Gleason score of > or =7 (HR: 4.500, 95% CI 1.419-14.274, P=0.011) were independent preoperative predictors of BCR. The presence of PSMA mRNA in peripheral blood can be used to predict BCR after radical prostatectomy.
Aged
;
Antigens, Surface/*blood/genetics
;
Glutamate Carboxypeptidase II/*blood/genetics
;
Humans
;
Male
;
Middle Aged
;
Neoplasm Recurrence, Local/blood/*diagnosis
;
Predictive Value of Tests
;
*Prostatectomy
;
Prostatic Neoplasms/blood/*diagnosis/surgery
;
RNA, Messenger/*blood
;
Reverse Transcriptase Polymerase Chain Reaction
;
Severity of Illness Index
;
Time Factors
8.A Case of Parovarian Serous Cystadenocarcinoma of Borderline Malignancy.
Moon Young JEONG ; Kyoung Yun SEO ; Jin Hwi KIM ; Yun Jung LEE ; Min Joung KIM ; Soo Young HUR ; Sa Jin KIM ; Eun Jung KIM ; Jeana KIM ; Jong Sup PARK
Korean Journal of Obstetrics and Gynecology 2004;47(12):2485-2489
Although parovarian cysts constitute 10-20% of all adnexal masses, malignant parovarian tumors are extremely rare. Due to the rarity of this lesion, there are controversies concerning the origin, clinical behavior, and prognosis of these tumors. Currently, it is suggested that these paovarian tumors should be treated similarly to their ovarian counterparts. We experienced one case of parovarian serous cystadenocarcinoma of borderline malignancy, and report this with a brief review of the literatures.
Cystadenocarcinoma, Serous*
;
Female
;
Parovarian Cyst
;
Prognosis
9.Effect of Sex Offenders Treatment Programme on Cognitive and Emotional Characteristics of Mentally Ill Sex-Offenders.
Jeong Hyun KIM ; Sang Sub CHOI ; Moon Sung RHEE ; Sun Bum KIM ; Ji Sook JOUNG ; Eun Hye KIM ; Mi Kyung LYU
Journal of Korean Neuropsychiatric Association 2007;46(6):579-586
OBJECTIVES: This study was investigated to prove the effectiveness of Cognitive Behavior Treatment Program in mentally ill sex offenders and to be used as basic data for development of optimized treatment program for mentally ill sex offenders. METHODS: Cognitive Behavior Treatment Program was carried out over 10 weeks for 30 mentally ill sex offenders. With Interpersonal Responsiveness Index (IRI), UCLA Loneliness Scale (UCLALS), Coping Using Sex Inventory (CUSI) and Rape Myth Acceptance Scale (RMAS), the effectiveness of the treatment programme was evaluated. The data was analyzed with paired t-test. RESULTS: The results with 23 subjects showed no significant score changes after treatment program in IRI and UCLALS. However, there was a statistically significant improvement in the scores of CUSI and RMAS. CONCLUSION: Despite several limitations, this study showed significant effects of Cognitive Behavior Treatment Program on mentally-ill sex offenders. Therefore, treatment focused on the changes of cognitive and emotional characteristics of sex offenders along with the treatment for main psychiatric illness should be provided for mentally ill sex offenders to prevent recidivism. More studies to develope optimized treatment programme for mentally ill sex offenders are needed in the future.
Criminals*
;
Humans
;
Loneliness
;
Mentally Ill Persons*
;
Rape
10.Biochemical Markers as Predictors of In-Hospital Mortality in Patients with Severe Trauma: A Retrospective Cohort Study.
Ha Nee JANG ; Hyun Oh PARK ; Tae Won YANG ; Jun Ho YANG ; Sung Hwan KIM ; Seong Ho MOON ; Joung Hun BYUN ; Chung Eun LEE ; Jong Woo KIM ; Dong Hun KANG ; Kyeong Hee BAEK
Korean Journal of Critical Care Medicine 2017;32(3):240-246
BACKGROUND: Initial evaluation of injury severity in trauma patients is an important and challenging task. We aimed to assess whether easily measurable biochemical parameters (hemoglobin, pH, and prothrombin time/international normalized ratio [PT/INR]) can predict in-hospital mortality in patients with severe trauma. METHODS: This retrospective study involved review of the medical records of 315 patients with severe trauma and an injury severity score >15 who were managed at Gyeongsang National University Hospital between January 2005 and December 2015. We extracted the following data: in-hospital mortality, injury severity score, and initial hemoglobin level, pH, and PT/INR. The predictive values of these variables were compared using receiver operation characteristic curves. RESULTS: Of the 315 patients, 72 (22.9%) died. The in-hospital mortality rates of patients with hemoglobin levels <8.4 g/dl and ≥8.4 g/dl were 49.8% and 9.9%, respectively (P < 0.001). At a cutoff hemoglobin level of 8.4 g/dl, the sensitivity and specificity values for mortality were 81.9% and 86.4%, respectively. At a pH cutoff of 7.25, the sensitivity and specificity values for mortality were 66.7% and 77.8%, respectively; 66.7% of patients with a pH <7.25 died versus 22.2% with a pH ≥7.25 (P < 0.001). The in-hospital mortality rates for patients with PT/INR values ≥1.4 and <1.4 were 37.5% and 16%, respectively (P < 0.001; sensitivity, 37.5%; specificity, 84%). CONCLUSIONS: Using the suggested cutoff values, hemoglobin level, pH, and PT/INR can simply and easily be used to predict in-hospital mortality in patients with severe trauma.
Acidosis
;
Biomarkers*
;
Cohort Studies*
;
Hospital Mortality*
;
Humans
;
Hydrogen-Ion Concentration
;
Injury Severity Score
;
International Normalized Ratio
;
Medical Records
;
Mortality
;
Prothrombin
;
Retrospective Studies*
;
Sensitivity and Specificity