OBJECTIVE : Bone mineral density is influenced by genetic, hormonal and exogenous factor that adversely affect peak mineral density include cigarette smoking, physical disability, poor calcium intake and certain medication include steroid and anticonvulsant drugs. We studied epileptic children receiving 6months above, to document change of bone mineral density by anticonvulsant drugs. METHODS: From July 1, 1996 to September 1, 1996 lumbar bone mineral density was measured by dual-energy X-ray absorptiometry in 27 children treated with anticonvulsant drugs 6months above (age ranged : 4-13 year) in Soonchunghyang University hospital. The subjects were classified into 3 groups : treated with carbamazepine alone, valproate alone and combined group. RESULTS: 1) Mean age of carbamazepine group was 10.2+/-2.42yrs(6-l4yr), duration of therapy was 22.1+/-13.9 months(6-44 months), mean value of bone mineral densities were 0.668+/-0.128g/cm2(0.548-0.927). Though it was lower than control group in 8, 9, 10, 12, 13 year, had not statistical significance. 2) Mean age of valproate group was 9.8+/-2.92yrs(6-l3yr), duration of therapy was 40.5 +/-22.2months(17-79month), mean value of bone mineral densities were 0.618+/-0.097g/cm2(0.516-0.788). Though it was lower than control group in 7, 10, 13 year, had not statistical significance. 3) Mean age of combined group was 7.9+/-3.2yrs(4-l4yr), duration of therapy was 37.5 +/-24.7months(12-88month), mean value of bone mineral densities were 0.602+/-0.109 g/cm2(0.552-0.807). Though it was lower than control group in 7, 8, 10 year, had not statistical significance. CONCLUSION: Because growing children is more sensitive than adult, in case of receiving long-term anticonvulsant therapy, it is important that early detection and prevention of abnormal bone mineralization by appropriate monitoring.
Absorptiometry, Photon ; Adult ; Anticonvulsants* ; Bone Density* ; Calcification, Physiologic ; Calcium ; Carbamazepine ; Child* ; Humans ; Smoking ; Valproic Acid

No abstract available.
Urinary Tract Infections* ; Urinary Tract*

Majocchi's disease is one of chronic vascular disorders of the skin, histologically showing capillaritis with lymphoid cell infiltration. Although the hypothesis of delayed type hypersensitivity reaction against foreign antigen is proposed as the mechanism producing this condition, there are much yet to be defined. We tried to examine the lesional skin of five patients with Majocchi's disease by the direct immunofluorescence with anti-human immunoglobulins, C 3, and fibrin. As a result we found the deposition of immunoglobulins (M, and G) in papillary blood vessels in four patients, and C 3 and fibrin were found in all five patients. C3 was also found at the dermoepidermal junction in three patients. These findings suggest the posssibility that antibody mediated immunologic processes may alsobe involved in the pathogenesis of this disorder. With this observation Majocchis disease could be considered as a chronic immune vasculitis.
Blood Vessels ; Fibrin ; Fluorescent Antibody Technique, Direct ; Humans ; Hypersensitivity ; Immunoglobulins ; Lymphocytes ; Skin ; Vasculitis

No abstract available.
Aorta*

We reports a woman's death caused by massive intraabdominal hemorrhage, who was in chronic alcoholic state with advanced liver cirrhosis and found dead in her room. No macroscopic source for the bleeding was found in her intraabdomen and there was no circumstances of traumatic forces to the individual's body around the death. The presenting unsuspected death could be consistent with the forensic pathological cases described as sudden, unexpected death due to massive nontraumatic intraabdominal hemorrhage in association with liver cirrhosis by DiMaio in 1987.
Alcoholics ; Hemorrhage* ; Humans ; Liver Cirrhosis* ; Liver*

No abstract available.
Angiomyoma ; Ear

No abstract available.
Biopsy*

No abstract available.
Prurigo

Pigmented neurofibroma, a variant of neurofibroma, has rarely been observed in patients with or without neurofibromatosis. Pigmented neurofibroma is characterized histologically by the coexistence of scattered melanin-laden cells and benign spindle cells with neural differentiation. We report a case of pigmented neurofibroma in a 22-year-old female patient.
Female ; Humans ; Neurofibroma* ; Neurofibromatoses ; Young Adult

No abstract available.
Adipose Tissue* ; Apoptosis ; Lipodystrophy*