To evaluate the ultrastructural changes and the mechanism causing liver injury by lead, light and electron microscopic(LM and EM) examination using Timm sulphide silver method(TSM) was done. Sprague-Dawley rats were divided into a control and 3 experimental groups. The experimental groups were orally administered 0.5% lead acetate(LA). Group 1 received a one time dose of 10 ml of LA by gastric intubation. Groups 2 and 3 continuously received LA instead of drinking water. The control group was composed of 3 rats in each group which did not receive any treatment. Rats of group 1, 2 and 3 and control were sacrificed at 1/2, 1, 1 1/2 hours, 2 days, and at 1, 2, 4, 6 and 8 weeks later, except group 3. Before sacrifice, they were perfused with 0.1% sodium sulphide and 2.5% glutaraldehyde through the abdominal aorta for TSM. The liver was taken for LM and EM examinations. Blood lead concentration began to increase from the 2nd day up to 3.29 microgram/ml at 2nd week, and the urinary delta-ALA level showed a steady increase from the 2nd day. LM and EM examination of liver revealed that absorbed lead granules in group 1 were transported into sinusoidal spaces, Kupffer cells, and the hepatocytes within 1 hour and then disappeared 1/2 hour thereafter. In group 2 deposited lead was found in the hepatocytic cytosol bound to mitochondria. That in turn inhibited mitochondrial respiration with resultant mitochondrial swelling at the 1st week and thereafter at 6th week myelin figure formation and condensation of mitochondria, and peroxisomes were increased at 8th week. Based on these results it can be concluded that a transient intake of subletal dose of LA is biotransformed completely by periportal hepatocytes within 1 1/2 hours, but excessively accumulated lead can induce liver cell injury due to lipid peroxidation of membrane by direct toxic effect of lead and by products of lipid peroxidation. We postulate that lead acetate triggers presumably primarily mitochondrial membrane injury and then other organellar changes may play a role in disturbance of a network of interacting of key events capable of causing cell death.
Rats ; Animals

No abstract available.

No abstract available.
Female ; Humans ; Pregnancy ; Pregnancy Trimester, Second* ; Pregnancy*

BACKGROUND AND OBJECTIVES: Malignant orbital tumors represent a diverse group of neoplasms such as malignant salivary tumors, squamous cell carcinoma, sarcoma, melanoma etc. A number of orbital tumors have a potential for lymphatic metastasis, but only a little information about the lymphatic drainage and treatment for malignant orbital tumors has been published. The purpose of this study was to review lymphatic spread of malignant orbital tumors and its surgical treatment of orbital cancer when metastasized to the parotid gland. MATERIALS AND METHODS: Five orbital cancer patients with lymph node metastasis of parotid gland were evaluated retrospectively. They had been treated by resection of primary tumor, parotidectomy, neck dissection and postoperative radiotherapy (except one case) from 1994 to 2000. Histopathology revealed squamous cell carcinoma in three patients, malignant melanoma in one and rhabdomyosarcoma in one. RESULTS: There were no complications postoperatively. Four cases had metastasis to intraglandular lymph nodes in the parotid gland and only one case had metastasis to preauricular lymph node. Two cases had metastasis to preglandular lymph nodes and prevascular lymph nodes in the level I lymph node. Three were NED (no evidence of disease), rhabdomyosarcoma case was DOD (died of disease) due to recurrence in submental area and breast and malignant melanoma case was AWD (alive with disease). CONCLUSION: Most orbital cancers with lymph nodes of the parotid gland have metastasis to intraglandular lymph nodes, but some of them does to extraglandular lymph nodes also. The examination of the parotid gland and the cervical lymph node must be considered in orbital cancers that have a potential for lymphatic metastasis. The results of this study indicates the need to include deep lobe and extraglandular lymph node of parotid gland for surgical removal of disease.
Breast ; Carcinoma, Squamous Cell ; Drainage ; Humans ; Lymph Nodes* ; Lymphatic Metastasis ; Melanoma ; Neck Dissection ; Neoplasm Metastasis* ; Orbit* ; Parotid Gland* ; Radiotherapy ; Recurrence ; Retrospective Studies ; Rhabdomyosarcoma ; Sarcoma

Background: Riehl’s melanosis of the face and neck has been reported in middle-aged women who have darker skin types. Recently, cases of Riehl’s melanosis have been on the rise in Korea, which might reflect the increased use of various cosmetic products and procedures. Objective: This study was designed to analyze the clinicopathological characteristics and treatment outcomes of Riehl’s melanosis in Korean patients. Methods: We closely observed 80 patients with Riehl’s melanosis diagnosed in Asan Medical Center and Hanyang University Medical Center between 2005 and 2015. A skin biopsy was analyzed in 51 patients, and a patch test was carried out in 16 patients. Results: Patients with chronic Riehl’s melanosis (＞12 months) had an increased frequency of previous laser treatments. Patients with acute Riehl’s melanosis (＜3 months) reported a previous history of dry skin, itching, or irritation as a result of the use of hair dye. Patients older than 50 years, with darker skin type, and with a longer disease duration (＞12 months) had poor response rates. Chronic Riehl’s melanosis may be preceded by repeated irritation of barrier-compromised skin, and acute Riehl’s melanosis seems to be an allergic form of Riehl’s melanosis. Conclusion Riehl’s melanosis has different clinical manifestations according to disease duration and different treatment responses based on disease duration.

OBJECTIVES: This study was to investigate the factors affecting general coping styles, especially the correlations between coping styles and the variables related to disease history in chronic renal failure patients. METHODS: The subjects included 97 chronic renal failure patients who were hospitalized or treated through outpatient service. The Coping Styles Questionnaire (CSQ), Beck Depression Inventory-II and Beck Anxiety Inventory were administered. RESULTS: The patients who were more anxious or depressive used less rational and detachment coping and more emotional and avoidance coping. There were no significant difference in coping styles according to sex, age, education, marital state, occupation, economic state and religion. Number of previous admission was correlated positively with depression and anxiety, and also with emotional and avoidance coping. Duration of illness was correlated positively with detachment and avoidance coping. Duration of dialysis was correlated positively with avoidance coping. After controlling for depression and anxiety, number of previous admission was correlated positively with avoidance coping. CONCLUSION: These results suggest that maladaptive coping has an important role in development and maintenance of depression and anxiety in chronic renal failure patients. Psychotherapeutic strategies for lessening the maladaptive coping, especially emotional coping, would be necessary for chronic renal failure patients with emotional distress.
Anxiety ; Depression ; Dialysis ; Education ; Humans ; Kidney Failure, Chronic* ; Occupations ; Outpatients ; Surveys and Questionnaires

Therapeutic irradiation can induce angiosarcoma. Radiation-induced angiosarcoma constitutes 20% of all angiosarcomas. Although its common site of origin is the skin and subcutaneous tissue, it rarely arises in small or large bowels with a presentation as multifocal abdominal angiosarcomatosis. We report a case of intra-abdominal angiosarcomatosis involving the jejunum, ileum, transverse colon, mesentery and right ovary in a 63-year-old female. It developed 10 years after therapeutic irradiation for squamous cell carcinoma of uterine cervix. She developed panperitonitis due to intestinal perforation. She died from sepsis 3 days after segmental resection of the small bowel and right oophorectomy. We reviewed the previously reported cases and describe the clinicopathologic features of this tumor.
Carcinoma, Squamous Cell ; Cervix Uteri ; Colon, Transverse ; Female ; Hemangiosarcoma ; Humans ; Ileum ; Intestinal Perforation ; Jejunum ; Mesentery ; Middle Aged ; Ovariectomy ; Ovary ; Sepsis ; Skin ; Subcutaneous Tissue

PURPOSE: The purpose of this study was to identify congruence between self-perception and objective status of obesity according to %Fat, and to investigate health promotion lifestyle in college women. METHODS: The participants were a convenience sample of 392 college women who were eligible and agreed to participate in this study. Respondents were asked questions using a health promotion lifestyle profile and were evaluated for their body composition using InBody 3.0. The data were analyzed with SPSS 14.0 program, which was used for Chi square, ANOVA, and post-hoc comparison with Scheffe. RESULTS: The major findings were as follows; 1) Overall, 41.8% of participants misclassified their perceived status of weight by %Fat standards and kappa was 0.329. 2) Two percent were underweight by BMI but overweight by %Fat and 39.0% normal weight by BMI but overweight by %Fat. 3) There were significant differences in health promotion lifestyle according to self-perception of body weight but there was no difference in health promotion lifestyle according to %Fat standards. CONCLUSION: These findings suggest the necessity for development and application of tailored health promotion program based on self-perception of body weight and %Fat in order to reform incorrect body image and health behavior in college women.
Adolescent ; Adult ; Body Composition ; Body Mass Index ; Female ; Health Behavior ; *Health Promotion ; Humans ; *Life Style ; Obesity/*psychology ; Overweight ; Questionnaires ; *Self Concept ; Universities ; Women/*psychology ; Young Adult

BACKGROUND: In patients with myocardial infarction, one needs to know the location, extent and severity of wall motion abnormalities to assess prognosis and guide therapy. Thus more precise quantatative estimates of regional ventricular function are required. Regional wall motion has generally been assessed by displaying the multiple cardiac images of RVG as endless-loop movie, but the cinematic display was not objective. We used the usefulness of the phase analysis in evaluating the global left ventricular function and regional wall motion abnormalities of patients with myocardial infarction. The accuracy of the RVG cinematic display in detecting regional wall motion abnormalities in patients with myocardial infarction was also evaluated. METHODS: Studied cases were 97 patients with myocardial infarction and 20 normals with low likelihood of coronary artery disease. Coronary angiography and contrast left ventriculography were performed in all patients with myocardial infarction. The regional wall myocardial infarction(presence) is defined when the EKG presented the evidence of myocardial infarction, left ventriculogram showed RWMA(regional wall motion abnormality) along with stenosis of 50% or greater of the regional supplying coronary artery. Each patient was imaged in 45 left anterior oblique(LAO) view, anterior(Ant) view and left lateral(Lt Lat) view. We evaluated Left ventricular ejection fraction(LVEF) from time-activity curve. We constructed the histogram for the left ventricle and both ventricle separately to obtain the global and total phase angle(GPA, TPA), standard deviation of phase angle(GSDPh, TSDPh), full width half maximum(GFWHM, TFWHM). The left ventricle was divided into 7 segments. LAO projection ; septal, apical, basal lateral, apical lateral, Ant projection ; anterolateral, Lt Lat projection ; inferior, posterior, Phase angle(RPA) and full width half maximum(RFWHM) from the histogram (regional 7 segments) were examined. On the RVG cinematic display, the standard 4 grading system was used, normal, hypokinesia, akinesia, dyskinesia. The observer evaluated regional wall motion abnormality of the 7 segments for all cases. The sensitivity of the above parameters and RVG cinematic display was evaluated. We analyzed the regional parameters among the patents with regional wall myocardial infarction(presence), those without regional wall myocardial infarction(absence) and control group using the t-test. The statistical analysis was done by one way ANOVA between regional phase analysis and RVG cinematic display. RESULTS: The sensitivity of LVEF was lowest(70.1%) and the GFWHM was highest among the global parameters(89.1%). But RFWHM showed even higher sensitivity(96.9%), thus regional phase analysis was also required. The RVG cinematic display was also sensitive(92.7%), but less sensitive than the RFWHM. On regional phase analysis the RPA of septal, apical, inferior, posterior walls of the left ventricle was able to separate presence group from absence group and also presence group from control group and the RPA of the apical lateral wall could separate presence group from absence group. The RPA of basal lateral and anterolateral wall was inaccurate in diagnosing the regional wall myocardial infarction, because basal lateral wall was overlapped by adjacent vascular structures, and the area of anterolateral wall dose not correlate completely beteen the RVG & the left ventriculogram, also the anterolateral wall can be supplied by the obtuse marginal branch of left circumflex artery. The RFWHM of all regional walls of left ventricle could separate presence group from absence group and presence group from control group. We found good correlation between regional phase analysis & left ventriculogram for detection of regional wall myocardial infartion. On RVG cinematic display, the RPA of the normal group was different from that of dyskinesia, akinesia and hypokinesia groups. The RPA of the dyskinesia group was also different from that of skinesia and hypokinesia groups by oneway ANOVA(p<0.05). The RFWHM of the dskinesia group was different from that of the normal group and hypokinesia group. RVG cinematic display correlated well with regional phase analysis and also quantitation of wall motion. CONCLUSIONS: Thus RVG cinematic display was useful and can not be replaced by phase analysis. But the regional phase analysis was sensitive and objective in diagnosing the wall motion abnormality in myocardial infarction.
Ants ; Arteries ; Constriction, Pathologic ; Coronary Angiography ; Coronary Artery Disease ; Coronary Vessels ; Dyskinesias ; Electrocardiography ; Heart Ventricles ; Humans ; Hypokinesia ; Myocardial Infarction* ; Prognosis ; Radionuclide Ventriculography ; Ventricular Function ; Ventricular Function, Left

STUDY DESIGN: External linkage type of spine motion analyzer and special programs for calculation of the relative angular motion and graphical display were developed and used to measure relative thoracic and lumbar motion patterns in healthy subjects. OBJECTIVES: To examine the dynamic relationship of thoracic and lumbar spines during various trunk motions and to measure main and coupling motions in three-dimensional spinal kinematics. SUMMARY OF LITERATURE REVIEW: Many kinds of methods, such as inclinometer, stereoradiography, electrogoniometer, cadaveric study etc., were introduced for measuring lumbar spine motion. But, there is no reliable method for measuring accurate dynamic three-dimensional motion patterns of whole thoracic and lumbar spines. MATERIALS AND METHODS: Thirty healthy men, ranging in age from 21 to 29 years, participated in the study. The developed device was tested to measure spine motion patterns in flexion, extension, lateral bending and axial rotation. RESULTS: The average range of motion for flexion was 71.30degrees/16.54degrees(lumbar/thoracic), for exten-zion 25.11degrees/12.67degrees, for one side lateral bending 27.42degrees/31.71degrees, for one side axial rotation 30.86degrees/24.38degrees. There were more coupling motions in lateral bending and axial rotation than in flexion and extension. Coupling motion pattern were found to be relatively consistent among subjects in active axial rotation, and the direction of coupling motion was flexion plus ipsilateral side bending. CONCLUSIONS: It was rather simple and reliable method thor spine motion analysis. There were similarities between motion patterns of lumbar and thoracic spine. But, range of motion in sagittal plane was much greater in lumbar spine than in thoracic
Biomechanical Phenomena ; Cadaver ; Humans ; Male ; Range of Motion, Articular ; Spine*