No abstract available.
Cutaneous Fistula ; Glomerulonephritis, Membranous* ; Humans ; Sarcoma, Kaposi*

Tardive dyskinesia(TD) is a serious side effect of long-term treatment with neuroleptic medications. To investigate if glutamatergic hyperfunction is associated with TD, effect of MK-801 on the prevention and treatment of TD was studied using a rat model, i.e., vacuous chewing movements(VCM). When comparing VCM scores of Group I(haldol decanoate+MK-801) with that of Group II(hadol decanoate+phosphate buffer saline), late measured VCM scores of former were significantly lower than that of latter, meaning that MK-801 is effective in the prevention of VCM. Furthermore, when MK-801 is also effective in the treatment of VCM. From the above results, it is suggested that glutamatergic hyperfunction might be involved in the development of TD and MK801 could be effective in the prevention and treatment of it.
Dizocilpine Maleate* ; Mastication ; Models, Animal ; Movement Disorders*

BACKGROUND: Cellulitis is one of the most common infectious skin diseases in primary care units of military service in which personal hygiene could be easily neglected under special circumstances such as outdoor training. OBJECTIVE: This study was designed to elucidate the probable causes of the high incidence rate of cellulitis in military service. METHODS: We prospectively evaluated the clinical findings of 59 patients with cellulitis who were hospitalized in the medical detachment of the 1st Infantry Division of the ROK Army from May, 1995 to April, 1996. RESULTS: The mean age of patients was 21(19-25). Analysing the rank of the patients, the number of recruits was 3(5%), private 26(44%), private first class 17(29%), corporal 11(19%) and sergeant 2(3%). Seventy eight percent of them were included in ranks below corporal. The recurrence rate of cellulitis during the 2 1/2 year follow-up period was only 4%. Skin lesions noted were erythema(100%), tenderness(98%), swelling(98%), local heating(97%), lymphadenopathy(73%), pus (63%), fluctuation(32%), ulcer(27%), lymphangitis(14%), bullae(8%), etc. The most common route of infection was the previous wounds(46%) which allows a portal for invasion of microorganisms. Tinea pedis was also found to be in 39% of patients with cellulitis of the lower leg. The pus culture performed on 7 patients who had not been responsive to primary antibiotics resulted in 6 positive cases of Staphylococcus aureus. CONCLUSION: Considering the ranks of the patients and the routes of infection, we found that the incidence of cellulitis in the military service of the ROK Army could be reduced if more attention would be paid to preventive counterplans for secondary infection and tinea pedis.
Anti-Bacterial Agents ; Cellulitis* ; Coinfection ; Follow-Up Studies ; Humans ; Hygiene ; Incidence ; Leg ; Military Personnel ; Primary Health Care ; Prospective Studies ; Recurrence ; Skin ; Skin Diseases, Infectious ; Staphylococcus aureus ; Suppuration ; Tinea Pedis

OBJECTIVE: The aim of this study is to analyze relationships between dysphagia, and the timing and frequency of videofluoroscopic swallowing studies (VFSS) in patients with acute stroke. METHOD: We retrospectively reviewed the medical records of 111 patients with acute stroke whose dysphagia were evaluated by VFSS. The data were analyzed with descriptive statistics, t-test, and one-way ANOVA; Pearson correlation coefficient was also reported for all analyses. RESULT: Dysphagia was significantly different by transit time from stroke onset to arrival at the hospital (F=4.74, P=.011), paralysis site (F=3.05, P=.032), nasogastric tube (t=−3.81, P=.001), and diet just before the first VFSS (F=23.27, P<.001). VFSS timing was significantly different by smoking (t=2.88, P=.005), underlying disease (t=−3.58, P=.001), transit time from stroke onset to arrival at the hospital (F=5.90, P=.004), type of stroke (t=−5.24, P<.001), paralysis site (F=5.89, P=.001), nasogastric tube (t=−4.86, P=.001), surgery or angiography (t=−2.22, P=.032), level of consciousness (F=6.07, P=.000), length of stay (F=53.73, P=.001), department (F=16.37, P<.001), and diet just before the first VFSS (F=5.38, P=.006). VFSS frequency was significantly different by type of stroke (t=2.69, P=.008), nasogastric tube (t=−5.11, P=.001), length of stay (F=19.41, P=.001), department (F=7.18, P<.001), and the diet just before the first VFSS (F=16.67, P<.001). There was a significant correlation between dysphagia degree and the timing and frequency of VFSS. CONCLUSION: The more severe the degree of dysphagia, the longer the VFSS timing, and the greater VFSS frequency. The findings could be used for establishing systematic nursing care plans and active nursing intervention for dysphagia-related characteristics.
Angiography ; Consciousness ; Deglutition Disorders* ; Deglutition* ; Diet ; Humans ; Length of Stay ; Medical Records ; Methods ; Nursing ; Paralysis ; Patient Care Planning ; Retrospective Studies ; Smoke ; Smoking ; Stroke*

Fine needle biopsy of nodules on the thyroid is simple diagnostic method and it is generally a safe procedure. The main side effect is pain and hematoma. Secondary hemangioma development after biopsy is extremely rare. A 63-year-old woman presented with a 5-year history of solitary erythematous papule on neck. Spontaneous bleeding recorded six times within 5 years. There is not vascular anastomosis in ultrasonographic imaging. A histopathologic study showed vessel-like arteriole around small veins in dermis. No arteriovenous hemangioma case has been previously reported to be related to fine needle biopsy. Our case showed possibilities of arteriovenous hemangioma developments after fine needle biopsy.
Arterioles ; Biopsy ; Biopsy, Fine-Needle ; Dermis ; Female ; Hemangioma ; Hematoma ; Hemorrhage ; Humans ; Neck ; Thyroid Gland ; Veins

Cutaneous plasmacytosis is a rare disorder characterized by multiple red-brown plaques, mainly on the trunk, which histologically show a marked hyperplasia of mature plasma cells with no mitotic figures or cellular atypia. It is sometimes accompanied by extracutaneous symptoms like lymphadenopathy or interstitial pneumonia, but without plasma cell infiltration. Although many treatments such as corticosteroid lesional injection, cyclophosphamide, melphalan, systemic PUVA, and local tacrolimus application have been introduced for cutaneous plasmacytosis, there is no reported post-treatment data on cutaneous plasmacytosis in Korea. We report a case of a Korean male patient who was diagnosed with cutaneous plasmacytosis which was improved by PUVA therapy.
Cyclophosphamide ; Humans ; Hyperplasia ; Korea ; Lung Diseases, Interstitial ; Lymphatic Diseases ; Male ; Melphalan ; Plasma Cells ; PUVA Therapy* ; Tacrolimus

Etoposide is a semi-synthetic podophyllotoxin that binds to microtubular proteins to inhibit cell division. It has been used extensively in the treatment of both solid and hematologic malignancies. Chemotherapy-induced acral erythema is a distinctive syndrome of painful, symmetric, well-defined swelling and erythema of the palms and soles seen in patients receiving high-dose chemotherapy. It occurs most commonly with fluorouracil, doxorubicin, and especially cytosine arabinoside. Although etoposide, mercaptopurine and methotrexate have also been implicated. Here we report a case of acral erythema induced by etoposide in a 15-year-old child with neuroblastoma.
6-Mercaptopurine ; Adolescent ; Cell Division ; Child ; Cytarabine ; Doxorubicin ; Erythema ; Etoposide ; Fluorouracil ; Hand-Foot Syndrome ; Hematologic Neoplasms ; Humans ; Methotrexate ; Podophyllotoxin ; Proteins

BACKGROUND: The clinical presentation of lichen planus varies depending on the area involved. It occurs in less than 1% of the world's population: also, the prevalence in Korea is relatively low. However, the number of our outpatients has been increasing rapidly. OBJECTIVE: We studied the clinical characteristics of 100 patients with biopsy proven lichen planus. METHODS: We reviewed the medical records and clinical photographs of 100 patients who had been diagnosed with lichen planus during the last 10 years, from January 2002 to December 2011. RESULTS: Over the past 10 years, patients with Lichen Planus accounted for 0.196% among the new outpatients of this dermatology. The rate of Lichen Planus increased when it occurred on the skin, except for the Mucosal area. Of the 100 outpatients, 62% were men and 38% were women. The mean age at diagnosis was 54 years, and more than half of the patients were between 40 and 60 years of age. The most common site of lichen planus was the lip, which was found in 44% of the patients. Oral lesions were the second most commonly involved site at 28%, followed by the body at 20% and the genital area at 8%. The patients complained of various symptoms such as pain, burning sensation, pruritus, and irritation. Various treatments had been tried by all patients. CONCLUSION: This study of domestic patients with Lichen Planus is the biggest clinical research performed at a single center. The clinical features of patients in this survey share many similarities with those reported previously, but showed some differences too.
Biopsy ; Burns ; Dermatology ; Female ; Humans ; Korea ; Lichen Planus ; Lichens ; Lip ; Male ; Medical Records ; Outpatients ; Prevalence ; Pruritus ; Sensation ; Skin

BACKGROUND: Although vitiligo does not cause direct physical impairment or life-threatening conditions, it can produce significant psychosocial problems. Nevertheless, its effect on the psychosocial well-being of patients has been neglected. OBJECTIVE: This study compared quality of life (QOL) in patients with vitiligo and in healthy controls, and assessed the impact of vitiligo on the patients' QOL using Skindex-29. METHODS: This study recruited 105 vitiligo patients and 105 healthy controls, and the QOL scores of the groups were compared using Skindex-29. Statistical analyses were performed to examine the relationship between QOL and clinical characteristics. RESULTS: The total Skindex-29, emotion, and function scores, but not the symptom scores, were significantly higher in the vitiligo group than in the healthy controls. QOL, including symptom, function, and emotion scores, was significantly impaired in women, the elderly, married patients, and patients with a longer duration of disease, greater area of vitiligo, and lesions appearing on the exposed sites. But, symptom scores generally did not differ significantly. All aspects of QOL were impaired in patients with a previous treatment history, longer duration of treatment, and relatively low levels of satisfaction with treatment. CONCLUSION: Vitiligo can impair a patient's QOL. Therefore, it is important for the dermatologist to recognize and manage psychological problems to improve the QOL of vitiligo patients.
Aged ; Female ; Humans ; Quality of Life ; Vitiligo

Chickenpox (varicella) is caused by the varicella zoster virus and can be associated with noncutaneous complications, including encephalitis, pneumonitis, and ocular disease. Previously described ocular complications resulting from chickenpox were conjunctival and corneal lesions, iridocyclitis, glaucoma, chorioretinitis, and optic nerve lesions. Most of the reported cases were anterior uveitis with self-limited disease course and patients usually recovered good vision or had but a partial visual defect. We treated a patient who developed permanent visual loss after chickenpox. A 24-year-old female who developed the typical rash of chickenpox four days before she complained of a sudden loss of vision in her left eye. The exact cause of central retinal artery occlusion in our patient is not known, but its coincidence with chickenpox is interesting.
Chickenpox* ; Chorioretinitis ; Encephalitis ; Exanthema ; Female ; Glaucoma ; Herpesvirus 3, Human ; Humans ; Iridocyclitis ; Optic Nerve ; Pneumonia ; Retinal Artery Occlusion* ; Retinal Artery* ; Uveitis, Anterior ; Young Adult