No abstract available.
Cutaneous Fistula ; Glomerulonephritis, Membranous* ; Humans ; Sarcoma, Kaposi*

Tardive dyskinesia(TD) is a serious side effect of long-term treatment with neuroleptic medications. To investigate if glutamatergic hyperfunction is associated with TD, effect of MK-801 on the prevention and treatment of TD was studied using a rat model, i.e., vacuous chewing movements(VCM). When comparing VCM scores of Group I(haldol decanoate+MK-801) with that of Group II(hadol decanoate+phosphate buffer saline), late measured VCM scores of former were significantly lower than that of latter, meaning that MK-801 is effective in the prevention of VCM. Furthermore, when MK-801 is also effective in the treatment of VCM. From the above results, it is suggested that glutamatergic hyperfunction might be involved in the development of TD and MK801 could be effective in the prevention and treatment of it.
Dizocilpine Maleate* ; Mastication ; Models, Animal ; Movement Disorders*

BACKGROUND: Cellulitis is one of the most common infectious skin diseases in primary care units of military service in which personal hygiene could be easily neglected under special circumstances such as outdoor training. OBJECTIVE: This study was designed to elucidate the probable causes of the high incidence rate of cellulitis in military service. METHODS: We prospectively evaluated the clinical findings of 59 patients with cellulitis who were hospitalized in the medical detachment of the 1st Infantry Division of the ROK Army from May, 1995 to April, 1996. RESULTS: The mean age of patients was 21(19-25). Analysing the rank of the patients, the number of recruits was 3(5%), private 26(44%), private first class 17(29%), corporal 11(19%) and sergeant 2(3%). Seventy eight percent of them were included in ranks below corporal. The recurrence rate of cellulitis during the 2 1/2 year follow-up period was only 4%. Skin lesions noted were erythema(100%), tenderness(98%), swelling(98%), local heating(97%), lymphadenopathy(73%), pus (63%), fluctuation(32%), ulcer(27%), lymphangitis(14%), bullae(8%), etc. The most common route of infection was the previous wounds(46%) which allows a portal for invasion of microorganisms. Tinea pedis was also found to be in 39% of patients with cellulitis of the lower leg. The pus culture performed on 7 patients who had not been responsive to primary antibiotics resulted in 6 positive cases of Staphylococcus aureus. CONCLUSION: Considering the ranks of the patients and the routes of infection, we found that the incidence of cellulitis in the military service of the ROK Army could be reduced if more attention would be paid to preventive counterplans for secondary infection and tinea pedis.
Anti-Bacterial Agents ; Cellulitis* ; Coinfection ; Follow-Up Studies ; Humans ; Hygiene ; Incidence ; Leg ; Military Personnel ; Primary Health Care ; Prospective Studies ; Recurrence ; Skin ; Skin Diseases, Infectious ; Staphylococcus aureus ; Suppuration ; Tinea Pedis

OBJECTIVE: The aim of this study is to analyze relationships between dysphagia, and the timing and frequency of videofluoroscopic swallowing studies (VFSS) in patients with acute stroke. METHOD: We retrospectively reviewed the medical records of 111 patients with acute stroke whose dysphagia were evaluated by VFSS. The data were analyzed with descriptive statistics, t-test, and one-way ANOVA; Pearson correlation coefficient was also reported for all analyses. RESULT: Dysphagia was significantly different by transit time from stroke onset to arrival at the hospital (F=4.74, P=.011), paralysis site (F=3.05, P=.032), nasogastric tube (t=−3.81, P=.001), and diet just before the first VFSS (F=23.27, P<.001). VFSS timing was significantly different by smoking (t=2.88, P=.005), underlying disease (t=−3.58, P=.001), transit time from stroke onset to arrival at the hospital (F=5.90, P=.004), type of stroke (t=−5.24, P<.001), paralysis site (F=5.89, P=.001), nasogastric tube (t=−4.86, P=.001), surgery or angiography (t=−2.22, P=.032), level of consciousness (F=6.07, P=.000), length of stay (F=53.73, P=.001), department (F=16.37, P<.001), and diet just before the first VFSS (F=5.38, P=.006). VFSS frequency was significantly different by type of stroke (t=2.69, P=.008), nasogastric tube (t=−5.11, P=.001), length of stay (F=19.41, P=.001), department (F=7.18, P<.001), and the diet just before the first VFSS (F=16.67, P<.001). There was a significant correlation between dysphagia degree and the timing and frequency of VFSS. CONCLUSION: The more severe the degree of dysphagia, the longer the VFSS timing, and the greater VFSS frequency. The findings could be used for establishing systematic nursing care plans and active nursing intervention for dysphagia-related characteristics.
Angiography ; Consciousness ; Deglutition Disorders* ; Deglutition* ; Diet ; Humans ; Length of Stay ; Medical Records ; Methods ; Nursing ; Paralysis ; Patient Care Planning ; Retrospective Studies ; Smoke ; Smoking ; Stroke*

PURPOSE: A number of genes and their products are induced early or late following exposure of cells to ionizing radiation. These radiation-induced genes have various effects on irradiated cells and tissues. Suppression subtractive hybridization (SSH) based on PCR was used to identify the differentially expressed genes by radiation in cervix carcinoma cells. MATERIASL AND METHODS: Total RNA and poly (A)+ mRNA were isolated from irradiated and non-irradiated HeLa cells. Forward- and reverse-subtracted cDNA libraries were constructed using SSH. Eighty-eight clones of each were used to randomly select differentially expressed genes using reverse Northern blotting (dot blot analysis). Northern blotting was used to verify the screened genes. RESULTS: Of the 176 clones, 10 genes in the forward-subtracted library and 9 genes in the reverse-subtracted library were identified as differentially expressed radiation-induced genes by PCR-select differential screening. Three clones from the forward-subtracted library were confirmed by Northern blotting, and showed increased expression in a dose-dependent manner, including a telomerase catalytic subunit and sodium channel-like protein gene, and an ESTs (expressed sequence tags) gene. CONCLUSION: We identified differentially expressed radiation-induced genes with low-abundance genes with SSH, but further characterization of theses genes are necessary to clarify the biological functions of them.
Blotting, Northern ; Cervix Uteri* ; Clone Cells ; Expressed Sequence Tags ; Female ; Gene Library ; HeLa Cells ; Humans ; Mass Screening ; Polymerase Chain Reaction ; Radiation, Ionizing ; RNA ; RNA, Messenger ; Sodium ; Telomerase

Chickenpox (varicella) is caused by the varicella zoster virus and can be associated with noncutaneous complications, including encephalitis, pneumonitis, and ocular disease. Previously described ocular complications resulting from chickenpox were conjunctival and corneal lesions, iridocyclitis, glaucoma, chorioretinitis, and optic nerve lesions. Most of the reported cases were anterior uveitis with self-limited disease course and patients usually recovered good vision or had but a partial visual defect. We treated a patient who developed permanent visual loss after chickenpox. A 24-year-old female who developed the typical rash of chickenpox four days before she complained of a sudden loss of vision in her left eye. The exact cause of central retinal artery occlusion in our patient is not known, but its coincidence with chickenpox is interesting.
Chickenpox* ; Chorioretinitis ; Encephalitis ; Exanthema ; Female ; Glaucoma ; Herpesvirus 3, Human ; Humans ; Iridocyclitis ; Optic Nerve ; Pneumonia ; Retinal Artery Occlusion* ; Retinal Artery* ; Uveitis, Anterior ; Young Adult

Neutrophilic eccrine hidradenitis (NEH) usually occurs in patients receiving chemotherapy for acute myelogenous leukemia or other malignant diseases. We experienced a case of NEH occurring in an HIV (human immunodeficiency virus)-positive 35-year-old male patient. The patient presented with a 1-year history of recurrent erythematous papule on his upper extremity. Laboratory studies showed that Anti-HIV is positive and HIV RNA PCR is 1.02x106. Histopathologic study showed neutrophilic infiltration within and around the eccrine glands and degeneration of the eccrine glands.
Acquired Immunodeficiency Syndrome ; Adult ; Eccrine Glands ; Hidradenitis ; HIV ; Humans ; Leukemia, Myeloid, Acute ; Male ; Neutrophils ; Polymerase Chain Reaction ; RNA ; Upper Extremity

The incidence and distribution of the human rotavirus G types (VP7 associated: G1~G4) and P types (VP4 associated: P[4], P[6], P[8], P[10]) were determined from 89 rotavirus strains isolated from diarrhea patients between 2001 and 2002 using reverse transcription and multiplex polymerase chain reaction. G types were identified from 83 (95.5%) and P types were from 82 (92.1%) strains. The predominant genotypes were P[4]G2 (28.1%) and P[6]G4 (27%) with much lower incidence of genotypes P[10]G1 (1.1%) and P[10]G3 (1.1%). P[9] type was not detected. A significant genotypic shift was observed that P[4] was the most prevalent genotype that accounted for 75% during the spring season of 2001, coinfection with P[4] and P[6] for 17.5%. P[6] increased gradually to account for 53% of the strains analysed in the following 2002 spring season. Mixed G types revealing coinfections G2/G3 and G3/G4 were found at low frequency (2.2%).
Coinfection ; Diarrhea* ; Genotype ; Humans ; Incidence ; Multiplex Polymerase Chain Reaction* ; Reverse Transcription ; Rotavirus* ; Seasons ; Seoul*

Aseptic subcutaneous abscesses are characterized by deep, round lesions histologically consisting of neutrophils, without evidence of microorganisms on culture. Although these are sometimes reported in healthy individuals, most are reported in patients with inflammatory bowel disease, including Crohn's disease and ulcerative colitis. A 79-year-old man without underlying disease presented with multiple skin-colored nodules and masses on his face and extremities 4 years ago. All of the microbiology studies for bacteria and fungi were negative and he did not respond to antibiotics. However, the lesions improved markedly after systemic prednisolone treatment. We diagnosed his lesions as aseptic subcutaneous abscesses. Further studies to evaluate inflammatory bowel disease were negative. Here, we report a case of multiple aseptic subcutaneous abscesses without an underlying disease.
Abscess* ; Aged ; Anti-Bacterial Agents ; Bacteria ; Colitis, Ulcerative ; Crohn Disease ; Extremities ; Fungi ; Humans ; Inflammatory Bowel Diseases ; Neutrophils ; Prednisolone

BACKGROUND: The clinical presentation of lichen planus varies depending on the area involved. It occurs in less than 1% of the world's population: also, the prevalence in Korea is relatively low. However, the number of our outpatients has been increasing rapidly. OBJECTIVE: We studied the clinical characteristics of 100 patients with biopsy proven lichen planus. METHODS: We reviewed the medical records and clinical photographs of 100 patients who had been diagnosed with lichen planus during the last 10 years, from January 2002 to December 2011. RESULTS: Over the past 10 years, patients with Lichen Planus accounted for 0.196% among the new outpatients of this dermatology. The rate of Lichen Planus increased when it occurred on the skin, except for the Mucosal area. Of the 100 outpatients, 62% were men and 38% were women. The mean age at diagnosis was 54 years, and more than half of the patients were between 40 and 60 years of age. The most common site of lichen planus was the lip, which was found in 44% of the patients. Oral lesions were the second most commonly involved site at 28%, followed by the body at 20% and the genital area at 8%. The patients complained of various symptoms such as pain, burning sensation, pruritus, and irritation. Various treatments had been tried by all patients. CONCLUSION: This study of domestic patients with Lichen Planus is the biggest clinical research performed at a single center. The clinical features of patients in this survey share many similarities with those reported previously, but showed some differences too.
Biopsy ; Burns ; Dermatology ; Female ; Humans ; Korea ; Lichen Planus ; Lichens ; Lip ; Male ; Medical Records ; Outpatients ; Prevalence ; Pruritus ; Sensation ; Skin