1.The effect of both oophorectomy on serotonin level in cerebral cortex and hippocampus of the female Sprague-Dawley rat.
Eun Mi KO ; Hyun Ae JEON ; Man Chul PARK
Korean Journal of Obstetrics and Gynecology 2000;43(11):1926-1931
OBJECTIVE: The purpose of this study is to investigate the effect of chronic deprivation of estradiol on the serotonin level in Sprague-Dawley rat's cerebral cortex and hippocampus. METHODS: One hundred of female Sprague-Dawley rats were taken care for seven to eight weeks, then they were randomly assigned into two group; fifty rats underwent bilateral oophorectomy & the remaining rats were the control group. Six months after oophorectomy, brain tissue was extracted from cerebral cortex and hippocampus and then homogenated: this was done in the both groups. The upper layer of the homogenated substance was taken and frozen and finally dried up. The next process was marking with PITC, quantification through HPLC and comparing with authentic serotonin. Protein quantity was measured by using Bradford method. RESULTS: Comparison between the bilateral oophorectomy group and the control group for serotonin content in the cerebral cortex was 134.2+/-14.3 nmol/mg protein(mean+/-SEM) and 122.5+/-11.6 nmol/mg protein in each group. As for the serotonin content in the hippocampus was 148.8+/-13.9 nmol/mg protein and 132.9+/-13.7 nmol/mg protein in each group. It shows that, there was no significant difference in the serotonin level, in the two areas mentioned above. CONCLUSION: The effect of estradiol on the serotonin level may be dependent on the hormonal change duration. Chronic effect of hypoestrogenism might have no effect on tryptophan hydroxylase and monoamine oxidase, thus not changin the serotonin level. These data supported the previous findings that chronic hypoestrogenism had no effect on serotonin level.
Animals
;
Brain
;
Cerebral Cortex*
;
Chromatography, High Pressure Liquid
;
Estradiol
;
Female
;
Female*
;
Hippocampus*
;
Humans
;
Monoamine Oxidase
;
Ovariectomy*
;
Rats*
;
Rats, Sprague-Dawley*
;
Serotonin*
;
Tryptophan Hydroxylase
2.A Case of Conjoined Twins.
Hyun Joo CHOI ; Eun Sil KIM ; In Sang JEON ; Myung Chul CHO ; Kwang Jeon KIM ; Nae In LIM
Journal of the Korean Pediatric Society 1990;33(11):1562-1566
No abstract available.
Twins, Conjoined*
3.A case of Goldenhar's syndrome.
Jin Eun HYUN ; Eun Hee PARK ; Hee Young JEON ; Whwa Jin BYEUN ; Young Mok HWANG
Journal of the Korean Pediatric Society 1992;35(1):135-139
No abstract available.
4.Adhesion and invasion of shed endometrium in an in-vitro model for endometriosis using amnion.
Mi Gyung KOONG ; Jin Hyun JEON ; Gyung Nam KO ; Eun Soo KIM ; Jong Young JEON ; In Soo KANG
Korean Journal of Obstetrics and Gynecology 2000;43(12):2237-2242
No abstract available.
Amnion*
;
Endometriosis*
;
Endometrium*
;
Female
5.A Case of Thanatophoric Dysplasia.
Eun Sil KIM ; Hyun Joo CHOI ; Mi Ran PARK ; Jae Yun KIM ; In Sang JEON ; Kwang Jeon KIM ; Bum Woo YUM
Journal of the Korean Pediatric Society 1990;33(11):1593-1597
No abstract available.
Thanatophoric Dysplasia*
6.Effects of Music Therapy and Rhythmic Exercise on Quality of Life, Blood Pressure and Upper Extremity Muscle Strength in Institution-Dwelling Elderly Women.
Eun Young JEON ; Sook Young KIM ; Hyun Suk YOO
Journal of Korean Academy of Nursing 2009;39(6):829-839
PURPOSE: The purpose of this study was to determine the effects of music therapy and rhythmic exercise on health related quality of life, blood pressure and upper extremity muscle strength in the institution-dwelling elderly women. METHODS: The study was designed using a nonequivalent control group pretest-posttest design. The participants consisted of 35 elders (18 in the experimental group and 17 in the control group). The music therapy and rhythmic exercise were developed by the investigators. The experimental group took part in this program twice a week for 8 weeks. The Short Form 36 health survey questionnaire, blood pressure and grasp power scale were used as instruments. The data were analyzed using SPSS 14.0. RESULTS: Repeated measures ANOVA revealed that music therapy and rhythmic exercise had positive effects on quality of life, especially on vitality, general health and mental health. Also, there were statistically significant differences in diastolic blood pressure and upper extremity muscle strength between the pretest and posttest in the experimental group. CONCLUSION: The study suggests that this program can be applied for older women in long-term facilities to improve quality of life, blood pressure and upper extremity muscle strength.
Aged
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Aged, 80 and over
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Blood Pressure/*physiology
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*Exercise Therapy
;
Female
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Health Status
;
Humans
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Muscle Strength/*physiology
;
*Music Therapy
;
Nursing Homes
;
Program Evaluation
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*Quality of Life
;
Questionnaires
;
Upper Extremity
7.Diagnostic Significance of Total Lactate Dehydrogenase(LD) and LD Isoenzyme Measurement in the Body Fluids.
Chang Ho JEON ; Eun Kyung BAE ; Seok Il HONG ; Chung Sook KIM ; Young Hyun LEE
Yeungnam University Journal of Medicine 1986;3(1):193-199
Body fluid Lactate dehydrogenase and its isoenzyme Measurement was performed in 132 patients: 8 cases with peritonitis, 21 cases with malignant ascites, 43 cases with liver cirrhosis, 48 cases with tuberculous pleuritis, 12 cases with malignant pleural effusion respectively. Body fluid protein and glucose contents, red blood cell counts, white blood cell counts, cytologic examination were also performed as a comparative study. The results were as follows: 1. Measurement of total LD and protein amount could differentiate between transudate and exudates in the ascitic fluids. 2. In the malignant exudate of ascites and pleural fluid, the activity of LD2 isoenzyme was statistically increased compared with that of inflammatory exudates and the activity of LD4 isoenzyme was also incereased compared with that of serum (P<0.05). 3. The inflammatory exudates of pleural fluid and ascites demonstrated the increase of LD5 isoenzyme activity statistically compared with that of serum and malignant exudates (P<0.05). 4. A difference of total LD activity between malignant ascites and inflammatory ascites was significant statistically, while this was not observed in the pleural exudate. 5. Total LD and LD5 isoenzyme activity didn't correlated with the number of white blood cells in the exudate.
Ascites
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Ascitic Fluid
;
Body Fluids*
;
Erythrocyte Count
;
Exudates and Transudates
;
Glucose
;
Humans
;
L-Lactate Dehydrogenase
;
Lactic Acid*
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Leukocyte Count
;
Leukocytes
;
Liver Cirrhosis
;
Peritonitis
;
Pleural Effusion, Malignant
;
Pleurisy
8.A Case of Steroid-induced Atrophy of External Genitalia.
Jee Hyun JEON ; Jee Min PARK ; Eun Gyong YOO ; Duk Hee KIM
Journal of Korean Society of Pediatric Endocrinology 2001;6(2):160-164
Skin atrophy is one of the most common side effects of topical steroid use and results from decreased skin proalphaI collagen mRNA production due to specific alterations in collagen gene transcription or from reduced collagen mRNA stability. This report describes a case of a 8 year-old-girl who visited our hospital with a complaint of ambiguous genitalia. She was observed to have atrophic labia majora and atrophic striae resembling scrotal rugae. However, her serum levels of FSH, LH, 17-KS, 17-OHCS, 5-DHT, DHT and DHEA-S were all in normal range and her karyotype was 46,XX. Abdominal and pelvic ultrasonogram showed a normal uterus and ovaries. Careful history taking revealed frequent use of steroid ointment due to vulvar pruritus for 2 years and she was finally diagnosed to have atrophy of external genitalia induced by long-term use of topical steroid.
Atrophy*
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Collagen
;
Disorders of Sex Development
;
Female
;
Genitalia*
;
Karyotype
;
Ovary
;
Pruritus
;
Reference Values
;
RNA Stability
;
RNA, Messenger
;
Skin
;
Ultrasonography
;
Uterus
9.The Usefulness of Endo-rectal Coil MRI in the Staging of Clinically Localized Prostate Cancer.
Eun Tak KIM ; Seong Soo JEON ; Soo Eung CHAI ; Bo Hyun KIM ; Han Yong CHOI
Korean Journal of Urology 2001;42(5):500-505
PURPOSE: We evaluated the ability of endo-rectal coil MRI (ER-MRI) to predict the local pathological stage of prostate cancer prior to radical prostatectomy and compared the results with those of transrectal ultrasonography (TRUS). MATERIALS AND METHODS: ER-MRI using high field magnets (1.5 Tesla) were performed in 22 patients (mean age 62.8 years, range 51-73) with clinically localized prostate cancer before radical prostatectomy. Of the 22 patients, 17 patients were also assessed by TRUS. The results of the imaging techniques were compared with the post-operative histopathological findings. As one patient with pelvic lymph node metastasis, which was detected on frozen-section examination during surgery, was spared radical prostatectomy, the final evaluation included 21 patients. RESULTS: DSeven of the 21 patients (33%) were found to have extraprostatic extension (EPE), and 5 had seminal vesicle invasion (SVI). The sensitivity and specificity for diagnosing EPE using ER-MRI were 62.5% and 84.6%, respectively, and 16.7% and 100% with TRUS. The sensitivity and specificity for diagnosing SVI were 80.0% and 93.8%, respectively with ER-MRI, and 0% and 92.3% with TRUS. The accuracy of predicting SVI was 90.5% with ER-MRI compared to 70.6% with TRUS. CONCLUSIONS: ER-MRI was significantly better than TRUS for determining the local extent of prostatic cancer and for prediction of SVI in the preoperative staging of clinically localized prostate cancer.
Humans
;
Lymph Nodes
;
Magnetic Resonance Imaging*
;
Neoplasm Metastasis
;
Prostate*
;
Prostatectomy
;
Prostatic Neoplasms*
;
Seminal Vesicles
;
Sensitivity and Specificity
;
Ultrasonography
10.A Case of Edward Syndrom.
Youn Hong CHOI ; Hyun Joo CHOI ; Eun Hwa SHIN ; Ju Hong CHA ; Kwang Jeon KIM
Journal of the Korean Pediatric Society 1989;32(3):396-401
No abstract available.