1.A Case of Newborn Scpsis Caused by Streptococcus pneumoniae.
Eun Ha CHOI ; Seong Hee JANG ; Eun Sil DONG ; Young Min AHN
Journal of the Korean Pediatric Society 1995;38(12):1690-1693
No abstract available.
Humans
;
Infant, Newborn*
;
Streptococcus pneumoniae*
;
Streptococcus*
2.Diabetic Muscle Infarction in a Young Patient with Prader-Willi Syndrome and Type 2 Diabetes Mellitus
Eun-Jeong KWON ; Eun-Ji LEE ; Hak Chul JANG ; Eun Ha KANG ; Yun Jong LEE ; You-Jung HA
Journal of Korean Diabetes 2020;21(4):227-234
Diabetic muscle infarction (DMI), also known as diabetic myonecrosis, is a rare complication of diabetes mellitus (DM); hence, it is often underdiagnosed. Thus, timely diagnosis and treatment are essential for a better prognosis. We describe a 24-year-old woman with Prader-Willi syndrome and an 8-year history of uncontrolled type 2 DM, who presented with a sudden onset of fever and subacute painful swelling of her left thigh. She was finally diagnosed with DMI based on magnetic resonance imaging and muscle biopsy after excluding other infectious and inflammatory diseases of proximal muscles. The patient was treated with bed rest, strict glycemic control, and analgesics, and her symptoms gradually resolved. DMI should be considered in the differential diagnosis of patients with poorly controlled DM, who present with subacute pain and swelling of lower extremity muscles, without a history of trauma.
3.Diabetic Muscle Infarction in a Young Patient with Prader-Willi Syndrome and Type 2 Diabetes Mellitus
Eun-Jeong KWON ; Eun-Ji LEE ; Hak Chul JANG ; Eun Ha KANG ; Yun Jong LEE ; You-Jung HA
Journal of Korean Diabetes 2020;21(4):227-234
Diabetic muscle infarction (DMI), also known as diabetic myonecrosis, is a rare complication of diabetes mellitus (DM); hence, it is often underdiagnosed. Thus, timely diagnosis and treatment are essential for a better prognosis. We describe a 24-year-old woman with Prader-Willi syndrome and an 8-year history of uncontrolled type 2 DM, who presented with a sudden onset of fever and subacute painful swelling of her left thigh. She was finally diagnosed with DMI based on magnetic resonance imaging and muscle biopsy after excluding other infectious and inflammatory diseases of proximal muscles. The patient was treated with bed rest, strict glycemic control, and analgesics, and her symptoms gradually resolved. DMI should be considered in the differential diagnosis of patients with poorly controlled DM, who present with subacute pain and swelling of lower extremity muscles, without a history of trauma.
4.Issues in Air Pollution Epidemiologic Studies.
Korean Journal of Preventive Medicine 2001;34(2):109-118
The purpose of this review is to discuss the debate concerning the interpretation of epidemiologic studies on particles and health effects. Study of the 1952 air pollution disaster in London established that very high levels of particulate-based smog can cause dramatic increases in daily mortality. However, recent epidemiologic studies have reported statistically significant health effects and mortality due to low levels of air pollution. The statistical significance does not prove causation in observational studies; therefore it is necessary to evaluate these associations. There are arguments for and against each of the numerous studies using Hill's criteria, however the body of accepted evidence supports the causal association. In particular, a high level of consistency in the estimated effect of PM10 has been observed across studies worldwide. The mechanism of the relationship between air pollution and health effects is not obvious. The mechanism of particle-induced injury may involve the production of an inflammatory response by the particulate. The harvesting and the threshold effect are also major concerns regarding the health effects of air pollution. However, current epidemiologic findings indicate that linear models lacking a threshold are appropriate for assessing the effect of particulate air pollution on daily mortality even at current levels.
Air Pollution*
;
Disasters
;
Epidemiologic Studies*
;
Linear Models
;
Mortality
;
Smog
5.A Case of Prader-Willi Syndrome with Diabetes Mellitus.
Hee Ran CHOI ; Eun Ha CHOI ; Seong Hee JANG ; Young Min AHN
Journal of the Korean Pediatric Society 1994;37(4):565-572
Prader-Willi syndrome is characterized by infantile hypotonia, mental retardation, hyperhagia, hypogonadism and obesity. Approximately 60% of all PLW syndrome show an interstitial deletion of chromosome 15, 37% have apparently normal chromosome, and 3.6% have a variety of other abnormalities involving chromosome 15. Diabetes mellitus has been considered a component of PLW syndrome and the incidence is about 7%. We experienced a 17-year-old female who revealed mental retardation, hypogonadism, obesity, and non-insulin dependent type DM, compatible with Prader-Willi syndrome.
Adolescent
;
Chromosomes, Human, Pair 15
;
Diabetes Mellitus*
;
Female
;
Humans
;
Hypogonadism
;
Incidence
;
Intellectual Disability
;
Muscle Hypotonia
;
Obesity
;
Prader-Willi Syndrome*
6.Characteristics of Potassium Channel in the Isolated Rat Detrusor Muscle.
Myeong Soo JANG ; Eun Mee CHOI ; Jeoung Hee HA ; Kang Youn LEE ; Won Joon KIM
Yeungnam University Journal of Medicine 1994;11(2):363-374
The purpose of this study was to investigate the characteristics or the potassium channels existing in the rat urinary bladders. Smooth muscle strips of rat detrusor urinae were examined by isometric myography. Relaxation responses of detrusor muscle strips to the three potassium channel openers pinacidil, a cyanoguanidine derivative, BRL 38227, a benzopyran derivative and RP 52891, a tertrahydrothiopyran derivative were examined. The potassium channel openers reduced the basal tone, and the rank order of potency was RP 52891>pincidil>BRL 38227. Procaine, an inhibitor of the voltage-sensitive potassium channel tended to increase the basal tone, but it did not affect the relaxant effects of the calcium-activated potassium channel opener did not antagonize the relaxant effects, but it reduced the Emax of RP 52891 and BRL 38227. Glibenclamide, an inhibitor of the ATP-sensitive potassium channel, antagonized the relaxant effects of pinacidil, RP 52891 and BRL 38227 reducing the Emax of RP 52891 and BRl 38227. Galanin which inhibits secretion of insulin through opening the ATP-sensitive potassium channels in pancreatic β-cells rather increased the basal tone of the isolated detrusor strips. These results suggest that the urinary bladder of the rat has mainly the ATP-sensitive, glibenclamide sensitive potassium channel, which is a different type from that in the pancreatic β-islet cells.
Animals
;
Cromakalim
;
Galanin
;
Glyburide
;
Insulin
;
KATP Channels
;
Muscle, Smooth
;
Myography
;
Pinacidil
;
Potassium Channels*
;
Potassium Channels, Calcium-Activated
;
Potassium*
;
Procaine
;
Rats*
;
Relaxation
;
Urinary Bladder
7.Therapeutic Response for Functional Abdominal Pain in Children with Occult Constipation: Laxatives versus Prokinetic Drugs.
Eun Kyo HA ; Homin JANG ; Su Jin JEONG
Journal of Korean Medical Science 2017;32(1):102-107
The relationship between functional abdominal pain (FAP) and occult constipation (OC) in children who did not meet the Rome III criteria for constipation has rarely been reported. This study aimed to estimate the prevalence of OC in patients with FAP and to compare the effectiveness of prokinetic drugs and laxatives for FAP and OC. Pediatric outpatients (n = 212; aged 4–15 years) who satisfied the Rome III criteria for childhood FAP were divided into 2 groups based on Leech scores: group 1 < 8; group 2 ≥ 8. Group 2 received either prokinetic drugs or laxatives and pain severity was assessed after 2 weeks, 1 month, and 3 months. A total 52.4% (111/212) of patients had OC in this study. More patients who received laxatives had reduced pain scores compared with those who received prokinetic drugs. Those treated with laxatives in group 2 had a better response than those treated with prokinetic drugs throughout the study period (P < 0.001, P < 0.001, and P = 0.002 after 2 weeks, 1 month, and 3 months, respectively). OC was frequently encountered in children with FAP. Laxatives can be more effective than prokinetic drugs for relieving symptoms of FAP in children with a Leech score ≥ 8 and suspected OC.
Abdominal Pain*
;
Child*
;
Constipation*
;
Gastrointestinal Diseases
;
Humans
;
Laxatives*
;
Outpatients
;
Pediatrics
;
Prevalence
8.A case of immunologic trombocytopenic purpura in pregnancy.
Yong Eun LEE ; Seung Jin OH ; Ha Jong JANG ; Jung Sik CHO ; Huk JUNG ; Jong Il JUNG ; Sae Jun HAN
Korean Journal of Obstetrics and Gynecology 1991;34(10):1463-1469
No abstract available.
Pregnancy*
;
Purpura*
9.A Case of Respiratory Syncytial Virus Infection Presented with Apnea.
Eun Ha CHOI ; Seong Hee JANG ; Young Min AHN
Journal of the Korean Pediatric Society 1996;39(4):558-561
Respiratory syncytial virus(RSV) is currently implicated as the most common and otentially serious viral respiratory pathogen of young infants. Apnea in association with RSV infection occurred in about 18% of the infants. Premature birth and a young postnatal age were risk factors for development of apnea with RSV disease. We experienced a case of RSV infection in a 37 day-old premature girl. The presenting complaint was apnea, with respiratory signs and symptoms developing later. She required mechanical ventilation.
Apnea*
;
Female
;
Humans
;
Infant
;
Premature Birth
;
Respiration, Artificial
;
Respiratory Syncytial Viruses*
;
Risk Factors
10.The Statistical Analysis on Legal Autopsy Performed in Korea during 2013 Year.
Seon Jung JANG ; Jong Pil PARK ; Byung Ha CHOI ; Nak Eun CHUNG ; Han Young LEE ; Joong Seok SEO
Korean Journal of Legal Medicine 2014;38(4):145-154
Medicolegal autopsy is a vital tool for obtaining reliable injury mortality data. This study statistically analyzed data obtained from medicolegal autopsies performed in Korea in 2013. The aim of this study was to analyze various aspects of the 4,861 deaths that were categorized as unusual in Korea in 2013. A total of 4,861 deaths were analyzed by gender, age, manner of death, and cause of death. Of the 4,861 deaths, 3,542 (73.3%) were of men and 1,302 (26.7%) were of women. With respect to the manner of death, 54.4% were recorded as unnatural deaths, 38.8% were natural deaths, and 6.9% had unknown causes. Of the 2,642 unnatural deaths, 45.0% were determined to be accidental deaths, 26.3% suicidal, 16.9% homicidal, and 11.8% undetermined. Of the total number of unnatural deaths, 42.1% were trauma-related deaths, for which falling down accounted for 33.8%. Asphyxiation accounted for 16.0% of unnatural deaths, and of these, the predominant cause was hanging (58.8%). In addition, 14.4% of deaths were due to drowning, 12.9% poisoning, 11.0% thermal injuries, 1.8% complications arising from medical procedures, and 0.8% electrocution, starvation, or neglect. Among the 1,886 natural deaths, heart diseases accounted for 52.0% and vascular diseases accounted for 16.9%. Of the 196 deaths among children under the age of 10 years, 41.8% were recorded as unnatural deaths, 45.1% were natural deaths, and 1.5% had unknown causes.
Autopsy*
;
Cause of Death
;
Child
;
Data Interpretation, Statistical
;
Drowning
;
Female
;
Heart Diseases
;
Humans
;
Korea
;
Male
;
Mortality
;
Poisoning
;
Starvation
;
Vascular Diseases