1.A Case of Bronchiolar Papilloma.
Sang Hak LEE ; Chi Hong KIM ; Hwa Sik MOON ; Jeong Sup SONG ; Sung Hak PARK ; Eun Deok JANG
Tuberculosis and Respiratory Diseases 1996;43(5):792-797
A 59-year-old woman was admitted to the hospital because of intermittent fever and right side chest pain. She has a same episode eight months before this entry. Chest CT scan demonstrated ill-defined parenchymal consolidation containing dilated bronchi of right lower lung field, but no endobronchial mass in the bronchial trees. Fiberoptic bronchoscopy seeking the cause of recurrent pneumonia revealed a small, round mass nearly completely obstructing the lumen of basal segmental bronchus of right lower lobe. The diagnosis of bronchiolar papilloma was made from the biopsy specimens of the bronchoscopic examination. The patient was treated with right lower lobectomy because of irreversible secondary changes below the obstructed bronchus. This thoracotomic excision resulted in complete relief of symptoms and the postoperative course was uneventful for 12 months. Here we report a extremely rare tumor with a brief review of literatures.
Biopsy
;
Bronchi
;
Bronchoscopy
;
Chest Pain
;
Diagnosis
;
Female
;
Fever
;
Humans
;
Lung
;
Middle Aged
;
Papilloma*
;
Pneumonia
;
Tomography, X-Ray Computed
;
Trees
2.A Case of Bronchiolar Papilloma.
Sang Hak LEE ; Chi Hong KIM ; Hwa Sik MOON ; Jeong Sup SONG ; Sung Hak PARK ; Eun Deok JANG
Tuberculosis and Respiratory Diseases 1996;43(5):792-797
A 59-year-old woman was admitted to the hospital because of intermittent fever and right side chest pain. She has a same episode eight months before this entry. Chest CT scan demonstrated ill-defined parenchymal consolidation containing dilated bronchi of right lower lung field, but no endobronchial mass in the bronchial trees. Fiberoptic bronchoscopy seeking the cause of recurrent pneumonia revealed a small, round mass nearly completely obstructing the lumen of basal segmental bronchus of right lower lobe. The diagnosis of bronchiolar papilloma was made from the biopsy specimens of the bronchoscopic examination. The patient was treated with right lower lobectomy because of irreversible secondary changes below the obstructed bronchus. This thoracotomic excision resulted in complete relief of symptoms and the postoperative course was uneventful for 12 months. Here we report a extremely rare tumor with a brief review of literatures.
Biopsy
;
Bronchi
;
Bronchoscopy
;
Chest Pain
;
Diagnosis
;
Female
;
Fever
;
Humans
;
Lung
;
Middle Aged
;
Papilloma*
;
Pneumonia
;
Tomography, X-Ray Computed
;
Trees
3.A Familial Case Presented with Various Clinical Manifestations Caused by OPA1 Mutation
Jun Ho LEE ; Jaeho KANG ; Yeoung deok SEO ; Jeong Ik EUN ; Hyunyoung HWANG ; Sungyeong RYU ; Junseok JANG ; Jinse PARK
Journal of the Korean Neurological Association 2023;41(1):60-63
Ataxia is presented by various etiologies, including acquired, genetic and degenerative disorders. Although hereditary ataxia is suspected when typical symptom of ataxia with concurrent is identified, it is sometimes difficult to diagnose hereditary ataxia without genetic test. Clinically, next generation sequencing technology has been developed and widely used for diagnosis of hereditary disease. Hereby, we experienced cases of genetically confirmed OPA1 mutation, which are presented with various clinical manifestations including ataxic gait and decreased visual acuity.
4.Intramucosal Colon Cancer Developing in an Inverted Hyperplastic Polyp.
Hyun Ho CHOI ; Sung Ha BAE ; Eun Chul JANG ; Sun Young KIM ; Ju Ok YEOM ; Soo Yeon LEE ; Eun Deok CHANG ; Young Seok CHO
Gut and Liver 2013;7(1):126-127
No abstract available.
Colon
;
Colonic Neoplasms
;
Polyps
5.Changes of lip morphology following mandibular setback surgery using 3D cone-beam computed tomography images.
Seung Jae PAEK ; Ji Yong YOO ; Jang Won LEE ; Won Jong PARK ; Young Deok CHEE ; Moon Gi CHOI ; Eun Joo CHOI ; Kyung Hwan KWON
Maxillofacial Plastic and Reconstructive Surgery 2016;38(10):38-
BACKGROUND: The aims of this study are to evaluate the lip morphology and change of lip commissure after mandibular setback surgery (MSS) for class III patients and analyze association between the amount of mandibular setback and change of lip morphology. METHODS: The samples consisted of 14 class III patients treated with MSS using bilateral sagittal split ramus osteotomy. Lateral cephalogram and cone-beam CT were taken before and about 6 months after MSS. Changes in landmarks and variables were measured with 3D software program Ondemand™. Paired and independent t tests were performed for statistical analysis. RESULTS: Landmarks in the mouth corner (cheilion, Ch) moved backward and downward (p < .005, p < .01). However, cheilion width was not statistically significantly changed. Landmark in labrale superius (Ls) was not altered significantly. Upper lip prominence angle (ChRt-Ls-ChLt °) became acute. Landmarks in stomion (Stm), labrale inferius (Li) moved backward (p < .005, p < .001). Lower lip prominence angle (ChRt-Li-ChLt °) became obtuse (p < .001). Height of the upper and lower lips was not altered significantly. Length of the upper lip vermilion was increased (p =< 0.01), and length of the lower lip vermilion was decreased (p < .05). Lip area on frontal view was not statistically significantly changed, but the upper lip area on lateral view was increased and change of the lower lip area decreased (p > .05, p < .005). On lateral view, upper lip prominent point (UP) moved downward and stomion moved backward and upward and the angle of Ls-UP-Stm (°) was decreased. Lower lip prominent point (LP) moved backward and downward, and the angle of Stm-LP-Li (°) was increased. Li moved backward. Finally, landmarks in the lower incisor tip (L1) moved backward and upward, but stomion moved downward. After surgery, lower incisor tip (L1) was positioned more superiorly than stomion (p < .05). There were significant associations between horizontal soft tissue and corresponding hard tissue. The posterior movement of L1 was related to statistically significantly about backward and downward movement of cheilion. CONCLUSIONS: The lip morphology of patients with dento-skeletal class III malocclusion shows a significant improvement after orthognathic surgery. Three-dimensional lip morphology changes in class III patients after MSS exhibited that cheilion moved backward and downward, upper lip projection angle became acute, lower lip projection angle became obtuse, change of upper lip area on lateral view was increased, change of lower lip area decreased, and morphology of lower lip was protruding. L1 was concerned with the lip tissue change in statistically significant way.
Cone-Beam Computed Tomography*
;
Humans
;
Incisor
;
Lip*
;
Malocclusion
;
Mouth
;
Orthognathic Surgery
;
Osteotomy, Sagittal Split Ramus
6.Small Bowel Volvulus Induced by Mesenteric Lymphangioma in an Adult: a Case Report.
Jin Hee JANG ; Su Lim LEE ; Young Mi KU ; Chang Hyeok AN ; Eun Deok CHANG
Korean Journal of Radiology 2009;10(3):319-322
Mesenteric lymphangiomas are rare abdominal masses that are seldom associated with small bowel volvulus, and especially in adult patients. We report here on an unusual case of small bowel volvulus that was induced by a mesenteric lymphangioma in a 43-year-old man who suffered from repeated bouts of abdominal pain. At multidetector CT, we noticed whirling of the cystic mesenteric mass and the adjacent small bowel around the superior mesenteric artery. Small bowel volvulus induced by the rotation of the mesenteric lymphangioma was found on exploratory laparotomy. Lymphangioma should be considered as a rare cause of small bowel volvulus in adult patients.
Abdominal Pain/etiology
;
Adult
;
Contrast Media/diagnostic use
;
Diagnosis, Differential
;
Humans
;
Intestinal Volvulus/*diagnosis/etiology/surgery
;
Intestine, Small/*radiography/surgery
;
Lymphangioma/*complications/surgery
;
Male
;
Mesenteric Artery, Superior/*radiography/surgery
;
Radiographic Image Enhancement/methods
;
Rare Diseases
;
Tomography, X-Ray Computed
7.Lidocaine attenuates the expression of ERK1/2 and CREB in a neuropathic pain model of rats.
Jin Deok JOO ; Jang Hyeok IN ; Hong Soo JUNG ; Yong Shin KIM ; Dae Woo KIM ; Woo Young CHOI ; Eun Young SHIN ; Yeon Soo JEON
Korean Journal of Anesthesiology 2009;56(3):319-324
BACKGROUND: In addition to causing the loss of voluntary sensory and motor function, spinal cord injury (SCI) often creates a state of central neuropathic pain. Rats given SCI display increases in the activated form of transcription factors ERK 1/2, p38 MAPK, and CREB in the spinal cord, which correspond to allodynia in a model of neuropathic pain. The current study was designed to determine if lidocaine had an effect on the development of neuropathic pain in response to SCI. METHODS: Male Sprague Dawley rats were anesthetized and then received a L5-L6 spinal nerve ligation (neuropathic rats). The levels of intracellular cell-signaling protein, ERK 1/2 and CREB were then assessed by western blot analysis of samples collected from a sham operated (control) group, a neuropathic pain and normal saline (NP + NS) group, and a neuropathic pain and 5% lidocaine (NP + Lido) group. RESULTS: The increased levels of ERK 1/2 and CREB protein that were observed in the neuropathic pain model were reduced by continuous infusion of 5% lidocaine. CONCLUSIONS: The current results suggest that lidocaine therapy may be an effective method of preventing and treating central neuropathic pain following SCI, and that these effects may occur via the reduced expression of ERK 1/2 and CREB in the intracellular cell-signaling pathway.
Animals
;
Blotting, Western
;
Cyclic AMP Response Element-Binding Protein
;
Humans
;
Hyperalgesia
;
Lidocaine
;
Ligation
;
Male
;
Neuralgia
;
p38 Mitogen-Activated Protein Kinases
;
Rats
;
Rats, Sprague-Dawley
;
Salicylamides
;
Spinal Cord
;
Spinal Cord Injuries
;
Spinal Nerves
;
Transcription Factors
8.Expression of Neutrophil Gelatinase-Associated Lipocalin in Calcium-Induced Keratinocyte Differentiation.
Jeung Hoon LEE ; Kyung Chae KYE ; Eun Young SEO ; Kyungmoon LEE ; Sang Keun LEE ; Jong Soon LIM ; Young Joon SEO ; Chang Deok KIM ; Jang Kyu PARK
Journal of Korean Medical Science 2008;23(2):302-306
In a previous search for the differentially expressed genes in keratinocyte differentiation, we identified neutrophil gelatinase-associated lipocalin (NGAL) as a calcium- induced gene. In this study, we further verified the expression of NGAL in cultured keratinocytes as well as in several skin diseases. Reverse transcription-polymerase chain reaction (RT-PCR), Western blot, and ELISA clearly showed that NGAL expression was markedly increased in calcium-induced keratinocyte differentiation in vitro. However, in our previous report, NGAL expression was not detected in normal skin tissue except for hair follicle by in situ hybridization and immunohistochemistry, indicating the difference of cell status between in vitro and in vitro conditions. Interestingly, NGAL expression was highly increased in psoriasis-like inflammatory disorders (lichen planus and pityriasis rubura pilaris) and skin cancers (keratoacanthoma and squamous cell carcinoma), implying that NGAL may be related with the epidermal hyperplasia. Collectively, these results reveal the potential importance of NGAL in the maintenance of skin homeostasis.
Acute-Phase Proteins/*biosynthesis
;
Calcium/*metabolism
;
Cell Differentiation
;
Culture Media
;
Culture Media, Conditioned
;
Enzyme-Linked Immunosorbent Assay
;
*Gene Expression Regulation
;
Homeostasis
;
Humans
;
Keratinocytes/enzymology
;
Lipocalins/*biosynthesis
;
Models, Biological
;
Proto-Oncogene Proteins/*biosynthesis
;
Psoriasis/enzymology
;
Reverse Transcriptase Polymerase Chain Reaction
;
Skin/*metabolism
;
Skin Neoplasms/enzymology
9.Low dose ketamine reduces the induction of ERK1/2 and CREB signaling protein in a neuropathic pain model of rats.
Jin Woo CHOI ; Jang Hyeok IN ; Yong Shin KIM ; Yoo Jin KANG ; Yong Gul LIM ; Su Min CHO ; Eun Young SHIN ; Jin Deok JOO
Korean Journal of Anesthesiology 2009;57(2):210-216
BACKGROUND: In addition to causing the loss of voluntary sensory and motor function, spinal cord injury (SCI) often creates a state of central neuropathic pain. Rats given SCI display increases in the activated form of transcription factors ERK 1/2 MAPK and CREB in the spinal cord, which correspond to allodynia in a model of neuropathic pain. This study was conducted to determine if low dose ketamine had an effect on the activation of ERK 1/2 and CREB in the development of neuropathic pain. METHODS: This study was conducted to evaluate ERK 1/2 and CREB protein in a sham operated (control) group, neuropathic pain and normal saline (NP + NS) group and neuropathic pain and ketamine (NP + Keta) group. To accomplish this, male Sprague-Dawley rats were anesthetized and then subjected to L5-L6 spinal nerve ligation (SNL, neuropathic rats). The total amounts of ERK 1/2 and CREB protein were then assessed by western blot analysis. In addition, changes in the amounts of ERK 1/2 and CREB mRNA were evaluated by RT-PCR. RESULTS: There was a significant increase in the amount of ERK 1/2 and CREB in the NP + NS group when compared with the sham group. However, the amount of ERK 1/2 and CREB protein induced due to SNL were significantly reduced by continuous infusion with ketamine in the NP + Keta group. CONCLUSIONS: The results of this study revealed a positive linkage between NMDA receptors and the ERK-CREB signaling pathway. Therefore, NMDA receptors could be the target of future therapeutic approaches. Additionally, the results of the present study provide additional evidence that low dose ketamine effectively prevents and treats central neuropathic pain following SNL.
Animals
;
Blotting, Western
;
Cyclic AMP Response Element-Binding Protein
;
Humans
;
Hyperalgesia
;
Ketamine
;
Ligation
;
Male
;
Neuralgia
;
Rats
;
Rats, Sprague-Dawley
;
Receptors, N-Methyl-D-Aspartate
;
RNA, Messenger
;
Salicylamides
;
Spinal Cord
;
Spinal Cord Injuries
;
Spinal Nerves
;
Transcription Factors
10.Combined trial of fish oil and exercise training prevents impairment in insulin action on glucose transport of skeletal muscle induced by high-fat diet in rats.
Ji Hyun LEE ; Jong Yeon KIM ; Yong Woon KIM ; So Young PARK ; Woon Ki YOUN ; Eung Chan JANG ; Deok Il PARK ; Suck Jun KIM ; Eun Jung KIM ; Suck Kang LEE
The Korean Journal of Physiology and Pharmacology 2000;4(2):91-97
The purpose of the present study was to determine the preventive effects of combined interventional trial of fish oil treatment and exercise training on insulin resistance of skeletal muscle in high-fat fed rats. Male Wistar rats were randomly divided into chow diet (CD), high-fat diet (HF), high-fat diet with fish oil (FO), high-fat diet with exercise training (EX), and FO+EX groups. The rats in control group were fed chow diet containing, as percents of calories, 58.9% carbohydrate, 12.4% fat, and 28.7% protein. High-fat diet provided 32% energy as lard, 18% as corn oil, 27% as carbohydrate and 23% as casein. The fish oil diet had the same composition as the high fat diet except that 100 g menhaden oil was substituted for corn oil. Insulin sensitivity was assessed by in vitro glucose transport in the soleus muscle after diet treatment and treadmill running for 4 weeks. While the FO or EX only partially prevented insulin resistance on glucose transport and visceral obesity induced by high-fat diet, these interventions completely corrected hyperinsulinemia and hyperglycemia from the high-fat diet. The rats in the FO+EX showed normalized insulin action on glucose transport, plasma chemicals and visceral fat mass. Insulin-mediated glucose transport was negatively associated with total visceral fat mass (r=-0.734; p<0.000), plasma triglyceride (r=-0.403; p<0.05) and lepin (r=-0.583; p<0.001) concentrations with significance. Multiple stepwise regression analysis showed that only total visceral fat mass was independently associated with insulin-mediated glucose transport (r=-0.668; p<0.000). In conclusion, combined interventional trial of FO+EX recovered insulin resistance on glucose transport of skeletal muscle induced by high-fat diet. Visceral fat mass might be more important factor than plasma TG and leptin to induce insulin resistance on glucose transport of skeletal muscle in high-fat fed rats.
Animals
;
Caseins
;
Corn Oil
;
Diet
;
Diet, High-Fat*
;
Glucose*
;
Humans
;
Hyperglycemia
;
Hyperinsulinism
;
Insulin Resistance
;
Insulin*
;
Intra-Abdominal Fat
;
Leptin
;
Male
;
Muscle, Skeletal*
;
Obesity, Abdominal
;
Plasma
;
Rats*
;
Rats, Wistar
;
Running
;
Triglycerides