PURPOSE: To examine the cardiac function, incidence and natural history of cardiac hypertrophy (CH) and the association of side effects with CH after pulse dexamethasone therapy in infants with bronchopulmonary dysplasia. METHODS: Twelve infants, gestational age 28.6+/-1.6(26-31)weeks, birth weight 1243+/-186 (1010- 1620)g, received a pulse course of dexamethasone, starting at 0.5mg/kg/d for three days and readministered ten days thereafter at a median of 19 days of age. Serial echocardiographic measurement of septal thickness(ST), left ventricular(LV) posterior wall thickness(PWT), LV diameter(LVD), LV length(LVL), LV mass, ejection fraction(EF) and acceleration time to right ventricular ejection time ratio(AT/RVET) were taken before, and 4, 11 days after starting dexamethasone. For infants diagnosed as CH, echocardiography was performed weekly until the parameters were normalized. Side effects of dexamethasone such as leukocytosis, hypertension, hyperglycemia and insulin therapy were recorded and compared. RESULTS: CH occurred in 5 of 12 infants(47%). ST, PWD, and AT/RVET increased significantly at 4 days and 11 days after starting dexamethasone than baseline. LVD decreased significantly at 4 days and 11 days after the administration of dexamethasone than before. Other parameter such as LVL, LV mass and EF were not changed and the evidence of left ventricular outflow obstruction was not observed. The incidence of hyperglycemia and insulin therapy were higher in CH group than in no CH group(p<0.05). Five infants with CH recovered until five weeks after starting dexamethasone on serial echocardiography, CONCLUSION: Infants receiving a pulse course of dexamethasone developed evidence of septal hypertrophy, thickened left ventricular wall and impaired filling of left ventricle immediately after starting dexamethasone but always resolved within five weeks Serial echocardiography is not probably routinely required in preterm infants with bronchopulmonary dysplasia receiving pulse dexamethasone therapy.
Acceleration ; Birth Weight ; Bronchopulmonary Dysplasia* ; Cardiomegaly ; Dexamethasone* ; Echocardiography ; Gestational Age ; Heart Ventricles ; Humans ; Hyperglycemia ; Hypertension ; Hypertrophy ; Incidence ; Infant* ; Infant, Newborn ; Infant, Premature ; Insulin ; Leukocytosis ; Natural History ; Ventricular Outflow Obstruction

This study was undertaken to observe the difference of patch test and prick test positive reactions in three groups, 20 atopic dermatitis patients, 20 chronic urticaria patients, and 20 normal controls, Twenty commercial antigens (ToriiCo.) and twenty three frozen and boiled antigens of fishes and shellfishes were used as test materials. The results were as follows: 1. No positive reaction was observed in all sixty subjects in patch test. 2 In prick test, difference in reactivity was observed among atopic dermatitis (14. 7%), chronic urticaria (8.7%), and normal control(1. 5%) 3. There was significant difference in reactivity between Torii and frozen antigens in atopic dermatitis group, but no significance in chronic urticaria and control groups. 4. Boiling altered the reactivity in tested materials in all three groups of subjects singificantly. 5. Patients with past or family history of allergic diseases showed double fold higher reactivity tban patients without any history.
Dermatitis, Atopic* ; Fishes ; Humans ; Patch Tests ; Shellfish* ; Urticaria*

Low back pain patients an controls of shipyard workers were surveyed between June 1995 and september 1995 to identify risk factors of industrial low back pain. The patients were 17 male workers who had got medical treatment for over 3 days because of industrial back pain controls were 51 male workers who had not have musculoskeletal disorder for one year before the survey. By univariate analysis, the workers who did overtime work 4 times or more for the last 2 weeks showed odds ratio of 3.67 on low back pain with the workers who did less overtime work. Carrying heavy materials was also associated with the low back pain and the odds ratio increased with the increase of carrying weight. work space and work posture were not associated with the low back pain significantly. The welder had higher odds ratio than the other workers on low back pain. The duration of employment and job satisfaction did not affect the risk of low back pain. Multiple logistic regression analysis showed that frequency of overtime work for the last 2 weeks and carrying heavy materials among the risk factors were associated significantly with the low back pain. We found that important risk factors of low back pain of shipyard workers are work intensity factors such as overtime work and carrying heavy weight.
Back Pain ; Employment ; Humans ; Job Satisfaction ; Logistic Models ; Low Back Pain* ; Male ; Odds Ratio ; Posture ; Risk Factors*

The pinch graft is one type of skin graft and is indicated in small, chronic stubborn wounds or ulcers where cosmetic results are not paramount. It is a common procedure for the rapid healing of leg ulcers in countries where these are very common, such as in western society. However, it is an unfamiliar procedure to dermatologists in Korea where leg ulcers are quite rare. We treated a case of leg ulcer in systemic sclerosis using pinch grafts with satisfactory results. The pinch graft may be a useful treatment method for skin ulcers in dermatologic surgery under adverse conditions.
Dermatologic Surgical Procedures ; Korea ; Leg Ulcer* ; Leg* ; Scleroderma, Systemic* ; Skin ; Skin Ulcer ; Transplants* ; Ulcer ; Wounds and Injuries

Nickel is widely known as a common source of contact dermatitis and nickel sensitivity amounts to nearly 10 percent of allergic contact dermatitis patients. Common sources of nickel dermatitis are well known as necklaces, watches, rings, hooks, earrings and spectacle frames. Recently, we have seen five cases of nickel dermatitis the suspected sources of which were metal spectacle frames. The interim patch test result in our occupational and environmental clinic suggests that the metal spectacle frame is one of the most common sources of nickel dermatitis. Out of 84 medical students 27 wore metal spectacle frames. We have done a dimethylglyoxime spot test to the metal spectacle frames and got a positive result in 12 out of 27(44.4%). We conclude that metal spectacle frame seems to be one of the dominant causes of nickel dermatitis and it will be an increasing problem in our society.
Dermatitis ; Dermatitis, Allergic Contact ; Dermatitis, Contact* ; Ear ; Humans ; Nickel ; Patch Tests ; Students, Medical

This clinical and histopatholgical study was performed with 149 cases of acquired melanocyticnevi, which were obtained as surgical specimens from 1975 to 1985 at Depa.rtment of Clinical Pathology, Seoul Red Cross Hopital. The results were as follows: 1) Histologic subdivision of melanocytic nevus into junctional(,J), IJC, compound (C,"), ICI, and intradermal(I) is used. IJC is a lesion in an intermediate state between ,junctional and compound nevus, and ICI, between compound and intradermal nevus. 2) The age distribution of the excisional melanocytic nevus peaks during the third decade of life, with 47% of patients between 21 40 year old of age. 3) Of l49 specimens with excisional melanocytic nevus, the number of junctional, IJC, compound, ICI and intradermal nevus were 17, 4, 21, 32 and 75 in each group And so, it is likely that evolution of the melanocytic nevus have an increased opportunity for surgical excision. 4) Among the 17 cases of junctional nevus, one case is found in 5th and the other one in 7th decade. 5) In distvibution of melanocytic nevus, head including face is the most common site among the body area and then trunk, neck, lower and upper extremity in decreasing orders.
Adult ; Age Distribution ; Head ; Humans ; Neck ; Nevus ; Nevus, Intradermal ; Nevus, Pigmented* ; Pathology, Clinical ; Red Cross ; Seoul ; Upper Extremity

No abstract available.
Tenosynovitis*

We report a case of hidradenoma papilliferum of the left nipple in a 23-year-old female patient. Hidradenoma papilliferum occurs only in women, usually on the labia majora or in the perineal or perineal region and represents an adenoma with apocrine dif ferentiation. Histologic examination of the lesion revealed findings consistent with hidradenoma papilliferurn. She had been performed surgical excision
Acrospiroma* ; Adenoma ; Female ; Humans ; Nipples* ; Young Adult

Thin-layer (uni-dimensional and bi-dimensional) chrornatography studies were performed on 60 brownish stockings from 12 companies in Korea to search for Disperse Yellow 3 and Disperse Orange 3, which are known as common sensitizers in textiles. The results were as follows : 1) Mixture of various-colored dyes were being used to reveal the brownish hue in the stockings. 2) TLC demonstrated the presence of Disperse Yellow 3 in 53 stocking. 3) TLC demonstrated the presence of Disperse Orange 3 in 3 stockings, Although lack or more sophisticsted tests such as spectroseopic, infra red or nuclear spectra identification. These results suggest a strong clue to the presence of Disperse Yellow 3 and Disperse Orange 3 in the commercial stocking now being used in Korea.
Chromatography* ; Citrus sinensis* ; Coloring Agents ; Korea ; Textiles

Formalin is a 37 5pg aqueous solution of formaldehyde gas and formaldehyde may be present in products as an active ingredient, preservative or contaminant. This contamination may be from the container, the package material or in situ formation by degradation of the formaldehyde releasers. The free formaldehyde content was determined in the 50 kinds of Korean shampoos by quantitative analysis recently described, the lutidine method, which is simple, rapid and used for colored products which cannot be analysed by the chrornotropic acid method. Formaldehyde has been found in 46 out of the 0 samples, i.e., 90g., and the concentration ranged from 0. 1 to 78. 6 pg/ml(0. 1 78. 6 ppm).
Formaldehyde*